WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Sexual Problems of Women with Kidney Transplant: A Qualitative Study(Galenos Publ House, 2026) Akinci, Naile; Varisoglu, Yeliz Yildirim; Dogan, BayramObjective: This qualitative study aimed to explore the experiences, perspectives, and challenges faced by women who underwent kidney transplantation, particularly regarding the impact of transplantation on their own and their partner's sexual lives. Methods: The study was conducted with 15 women who had received kidney transplants at a private hospital in & Idot;stanbul. Data were gathered using a two-part semi-structured interview form developed by the researcher based on a review of the relevant literature. The data obtained from the interviews were analyzed using content analysis. Data analysis was carried out concurrently with data collection. This study adhered to the consolidated criteria for reporting qualitative research. Results: Based on a thematic analysis of the interviews, four main themes emerged: concerns about reproductive health, including subthemes of fear of infertility and anxiety about pregnancy; disease-associated sexual reluctance, including subthemes of reduced sexual interest, fatigue, weakness, sleep disturbances, and depression; perception of femininity and body image, including subthemes of feelings of incompleteness and inadequacy; concerns about the spouse/partner, including subthemes of fears about being unable to meet the sexual needs of the spouse/partner and feelings of guilt related to their partner's sexual dissatisfaction. Conclusion: In conclusion, sexual dysfunction continues to persist among women even after kidney transplantation due to various physical and psychological factors. To support patients in maintaining a healthy sexual life as part of their overall well-being, sexual health should be routinely assessed by a multidisciplinary team, including transplant surgeons, surgical and obstetric/ gynecology nurses, and psychologists.Article Post Challenge Effects of Ozg-38.61.3 Gamma Irradiated SARS-CoV Vaccine on Organ Protection in Transgenic Mouse Model(Marmara University, Institute of Health Sciences, 2025) Telci, Dilek; Akpınar, Gürler; Tuğlu, Mehmet İbrahim; Ovalı, Ercüment; Oztatlıcı, Hulya; Şahin, Fikrettin; Demir, Sevda; Kancagi, Derya Dilek; Turan, Raife Dilek; Oztatlici, Mustafa; Karakus, Gozde Sir; Yurtsever, BulutObjective: Coronavirus disease 2019 (COVID-19) is an infectious outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) and virus-related deaths are increasing day by day. For this reason, vaccine studies and their urgent use are of great importance to prevent the pandemic. In this study, multi-organ damages caused by SARS-CoV-2 virus in human- angiotensin-converting enzyme type 2 (ACE2) transgenic mice and the protective effects of OZG-38.61.3 gamma irradiated SARS-CoV-2 vaccine against viral damage were investigated. Methods: For this purpose, transgenic K18-hACE2 BALB/c mice were randomly allocated into 4 groups, negative control group (NC), positive control group (PC, SARS-CoV-2 infected), and 2 different doses of OZG-38.61.3 vaccine (Challenge 1, dose of 10 13 and Ch2, 10 14 viral particle after SARS-CoV-2 infection). After the administrations, lung, heart and kidney tissues were examined by histopathological, immunohistochemical and TUNEL analysis. Results: Our results showed that the vaccine doses decreased the apoptosis, oxidative stress and inflammation parameters caused by virus in lung, heart, and kidney tissues. It was also found that the vaccine protected the expressions of tight junction proteins in the kidneys. Conclusion: According to our findings, it is suggested that the OZG-38.61.3 can be an effective and protective vaccine that can be safely used against the SARS-CoV-2 virus.