WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Citation - WoS: 1Citation - Scopus: 1Radioprotective Effect of Resveratrol for Early and Late Ionizing Radiation-Induced Damages on Colon and Rectum in Rats(Marmara Univ, 2023) Beceren, Ayfer; Aydemir, Sezgin; Atasoy, Beste Melek; Esin, A. K.; Ercan, Feriha; Sener, T. Emre; Sener, Goksel; Ak, Esin; Emre Şener, T.Radiotherapy, which is routinely used to treat a wide range of oncological disorders, primarily affects the malignant tissue in the targeted area, but also have negative effects in the surrounding tissues. Pelvic radiotherapy causes early and late effects on the colon and rectum. Resveratrol (RVT) has been revealed to have a number of pharmacological effects in a variety of experimental models and clinical circumstances, therefore it has piqued the interest of scientists in recent years. In this study, we aimed to investigate the potential protective effects of resveratrol (RVT), a strong antioxidant, anti-inflammatory and anti-mutagenic agent, against toxicity of colonic and rectal tissues seen in the early and late stages after pelvic radiation. The treatment durations of the current study were designed as one week and ten weeks interval by following radiation exposure. Sprague Dawley rats were divided into 5 groups (8 animals/group) as the control, radiation-early effects (Rd-E), radiation-late effects (Rd-L), and RVT-treated Rd-E (Rd-E+RVT) and RVT-treated Rd-L (Rd-L+RVT) groups. Ionizing radiation was performed to the pelvic area that covers colon and rectum in single fraction of 20 Gy in a linear accelerator using with 6 MV photon energy. RVT was orally administered (10 mg/kg/day) immediately following the radiation exposure and continued daily for 1 and 10 weeks for early and late groups, respectively. Pelvic radiation caused a significant decrease in glutathione level, while malondialdehyde levels, myeloperoxidase activity and 8-hydroxydeoxyguanosine were increased in both Rd-E and Rd -L groups in the colon and rectum tissues. Additionally, light microscopic evaluations (H & E staining) revealed degeneration of epithelium and inflammatory cell infiltration in the colonic and rectal tissues in radiation groups. RVT treatment reversed all conducted biochemical parameters and ameliorated histomorphological changes following early and late effects of pelvic radiation in tissues. In conclusion, resveratrol may be a candidate as a radioprotector for normal tissues during and after radiotherapy.Article Citation - WoS: 4Citation - Scopus: 3Multidrug Resistance in Pathogens of Community-Acquired Urinary Tract Infections in Turkey: a Multicentre Prospective Observational Study(Tubitak Scientific & Technological Research Council Turkey, 2023) Sencan, Irfan; Karabay, Oguz; Altay, Fatma Aybala; Suzuk Yildiz, Serap; Simsek, Husniye; Gozukara, Melih Gaffar; Surme, Serkan; Engin, Derya Öztürk; Cag, Yasemin; Kul, Gülnur; Habip, Zafer; Kaya, Safak; Tasbakan, MeltemBackground/aim: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options.Materials and methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed. Results: Of the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advanced age, and having two or more risk factors showed a statistically significant relation with MDR existence (p < 0.001, p: 0.014, p < 0.001, respectively) that increasing number of risk factors or degree of advancing in age directly affects the number of antibiotic groups detected to have resistance by pathogens. In total, MDR isolates corresponded to 36.1% of our CAUTI samples; MDR existence was 35.7% in E. coli isolates and 57.2% in Klebsiella spp. isolates. Our results did not show an association between resistance or MDR occurrence rates and NUTS regions.Conclusion: The necessity of urine culture in outpatient clinics should be taken into consideration, at least after evaluating risk factors for antibacterial resistance individually. Community-acquired UTIs should be followed up time-and region-dependently. Antibiotic stewardship programmes should be more widely and effectively administrated.Article Citation - WoS: 1Citation - Scopus: 1Evaluation of Coping Mechanism of Mothers of Children With Chronic Diseases During Coronavirus Disease 2019 Pandemic(Aves, 2024) Erkut, Zeynep; Kose, Selmin; Savaser, Sevim; Kaya, Gizem; Ogut, Nehir UluAIM: The aim of this study was to determine the problems, perceived stress, and coping with the stress of mothers of children with chronic diseases during the pandemic. METHODS: The study was conducted with cross-sectional design. The data were gathered from the mothers of children with chronic diseases who were followed up at the endocrine outpatient clinic of a hospital in Istanbul between February 1, 2021, and May 31, 2021. The data were collected by conducting face-to-face interviews with mothers of 117 children through information form, Perceived Stress Scale (PSS), and the Coping with Stress Scale (CSS). RESULTS: It was determined that 35.9% of the mothers stated that they had problems during the pandemic since their children suffered from chronic diseases. The mean scores of the mothers were 26.88 +/- 6.69 points for the PSS and 87.35 +/- 11.04 points for the CSS and there was a negative and weak correlation between their scale scores (r = -.190; p < .05). CONCLUSION: It was found that families faced many different problems during the pandemic, such as the treatment and control of their children. In case of extraordinary situations such as pandemics, nurses should provide planned guidance and counseling services to children with chronic diseases and their families in order to manage the negative situations they experience.Article Citation - WoS: 2Citation - Scopus: 2Global Health Emergencies During the Pandemic and Their Solutions(Tubitak Scientific & Technological Research Council Turkey, 2021) Sencan, Irfan; Bulut, Dilek; Agalar, Canan; Sencan, Ismail HakkiAbstract: In this review, we evaluated health care problems, which were not common before pandemic outbreak but have been common issues after its appereance and approaches to control pandemic considering its influences on people. We revised current health care developing approaches under the light of experience obtained throughout the pandemic so far. The aim is to be prepared in advance for possible upcoming pandemics. As in Covid 19 pandemics, such long lasting and widely affecting situations, durability is also very important together with flexibility and quickness. To provide durability, we need global policies taking the health to its center as well as health system policies.Key words: Covid-19, health system, emergency, crisis, vulnerability, durabilityArticle Citation - WoS: 1Citation - Scopus: 1Functional Features and Benefits of Residential Gardens: the Case of Istanbul (european Side)(Aves, 2022) Bozkurt, Selvinaz Gulcin; Yener, Serife Doganay; Akdeniz, Nilufer SeyidogluThis article investigates the extent to which residential gardens affect human welfare in Istanbul (the European side). The developing technology, population growth, and immigration are factors which expose the city of Istanbul to intense construction. Consequently, the gardens in the houses located at the center of Istanbul are decreasing day by day, limiting outdoor activities for the residents, and affecting them physically and mentally. In this study, a questionnaire was applied to 400 people in Istanbul's European side to investigate the extent to which residential gardens affect human well-being. These questionnaires were applied according to five-point Likert scales and the results were analyzed in the SPSS program by applying correlation analysis. The data obtained from the applied questionnaires were analyzed in the SPSS program. As a result of the analysis, it was concluded that residential gardens have a positive influence on the physical and psychological development of people, and also contribute to the protection of nature and biological diversity. Statistically, it has been determined that people mostly use their gardens in the summer months (49.30%) and on the weekends, and spend an average of 0-2 hours (57.50%) in their gardens. In addition, these analyses were associated with participant characteristics such as age (18-25, 26-30, 31-40, 41-50, 51-60, 60 and older), gender (female/male), socioeconomic status (occupation and income) and social demography (change in population). As a result, this study showed that residential gardens in urban areas contribute significantly to people and nature, that more garden areas should be added to the residences to be built in urban areas, and that these areas should be designed in a functional and sustainable way for people to benefit from nature in the best way.Article Citation - WoS: 11Citation - Scopus: 9Antibiotic Use and Influencing Factors Among Hospitalized Patients With Covid-19: a Multicenter Point-Prevalence Study From Turkey(Galenos Publ House, 2022) Sencan, Irfan; Cag, Yasemin; Karabay, Oguz; Kurtaran, Behice; Guclu, Ertugrul; Ogutlu, Aziz; Agalar, Canan; Ergen, Pınar; Kul, Gülnur; Uzar, Hanife; Yiğit, Özge; Tasbakan, MeltemBackground: Broad-spectrum empirical antimicrobials arc frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective. and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age +/- standard deviation of the patients was 65.0 +/- 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (372%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005). presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein >10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p <0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings.Article Citation - WoS: 4Citation - Scopus: 4Evaluation of Psychosocial Outcomes of Living Liver Donors in Liver Transplantation(Aves, 2022) Ordin, Yaprak Sarigol; Seren, Arzu Kader Harmanci; Karayurt, Ozgul; Kul, Gulay Aksu; Kilic, Murat; Bozoklar, Cemal Ata; Tokat, Yaman; Harmancı Seren, Arzu KaderBackground: The purpose of this study was to evaluate the risk factors affecting psychosocial outcomes of living liver donors after liver transplantations. Methods: This was a descriptive, cross-sectional study. The sample consisted of living liver donors followed by 2 liver transplantation centers in 2 private hospitals in 2 different provinces, between August 2017 and October 2019. All the living liver donors were contacted without a time frame after donation and all the participants were evaluated once. The Beck Depression Scale, SF-36, General Self-Efficacy Scale, and Perceived Available Support Scale were used to collect data. The t-test, Kruskal-Wallis test, Mann-Whitney U-test, and Pearson correlation analysis were used for data analysis. Results: The mean age of the patients was 34.31 +/- 8.22 years. There was a positive, weak correlation between age and physical function. Gender, marital status, financial status, and education levels significantly affected physical components, social function, vitality, depression, and self-efficacy scores. High depression levels negatively affected the physical component, self-efficacy, and social support scores of the living liver donors. High self-efficacy positively affected social support. Conclusion: The study revealed that gender, marital status, employment status, and education levels were associated with psychosocial outcomes. The financial status was the main factor affecting each psychosocial variable. Financial status needs to be assessed in detail before and after the operation.