WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

Browse

Filters

2021 - 202626

Settings

Publication Index: search.filters.publicationIndex.ScopusPublisher: search.filters.publisher.Elsevier

Search Results

Now showing 1 - 10 of 26
  • Article
    Synthesis, Experimental and Quantum Mechanical Investigation of the Crystal Structures of Two Triazolyl-Indole Compounds, along with the Evaluation of Their Antioxidant Activity
    (Elsevier, 2026) Pınar, Deniz; Kurt-Şirin, Özlem; Ulusoy-Güzeldemirci, Nuray; Dincel, Efe Doğukan; Karayel, Arzu; Kuran, Ebru Didem
    In this study, two 1,2,4-triazolyl-indole compounds, 5-(1H-indol-3-yl)-4-propyl-2,4 dihydro-3H-1,2,4-triazole-3-thione (3a) and 5-(1H-indol-3-yl)-4-butyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (3b), were synthesized and the structures of these compounds were determined by X-ray diffraction method. These two compounds crystallize in the orthorhombic space groups, Pbca. The structures have been determined by direct methods and refined to R, 0.0459 (3a) and 0.0714 (3b). The molecular and crystal structures are stabilized by two intermolecular hydrogen bond for both molecules. The triazole parts of the molecules are almost perpendicular to propyl and butyl groups. NMR studies was also performed to enhance comprehension of the molecular structure of the compounds. The most stable states of the structures, as determined by both DFT analysis and experimental realizations (X-ray, NMR and FT-IR), are the thione form. Although the thione forms are thermodynamically more stable than the thiol forms (Delta H degrees approximate to-15 kcal/mol), they display higher chemical reactivity, as reflected by their smaller HOMO-LUMO energy gaps (Delta E = 4.374 eV for 3a and 4.377 eV for 3b). In addition, the antioxidant activities of both compounds were evaluated using ABTS, DPPH, and FRAP assays. Although both (3a) and (3b) exhibited measurable radical scavenging and reducing power, their antioxidant capacities were found to be lower than that of the reference compound quercetin.
  • Article
    Montelukast Attenuates Abdominal Aortic Aneurysm in Rats: Anti-Inflammatory and Antioxidant Effects
    (Elsevier, 2026) Tekin, Gozde; Cevik, Ozge; Cetinel, Sule; Sener, Goksel; Kizilay, Mehmet
    Objective: Oxidative stress and inflammation are widely recognized as central mechanisms in the pathogenesis of abdominal aortic aneurysm. This study sought to examine the potential protective properties of montelukast in a rat model of aortic aneurysm. Methods: Male Sprague-Dawley rats were randomly allocated into three experimental groups. Abdominal aortic aneurysm was induced using the calcium chloride (CaCl2) model, in which gauze soaked in 0.5 M CaCl2 was placed directly onto the adventitial surface of the infrarenal abdominal aorta for 15 minutes. After induction, the treatment group received daily intraperitoneal injections of montelukast (10 mg/kg) for 4 consecutive weeks. At the study end point, animals were euthanized, and infrarenal aortic tissues were harvested for biochemical and histological evaluations. Measured parameters included matrix metalloproteinase (MMP)-2 and MMP-9 expression, myeloperoxidase (MPO) activity, and 8-hydroxy-2 '-deoxyguanosine levels. Antioxidant capacity was assessed through superoxide dismutase (SOD) activity assays. Histopathological examinations were performed, and statistical analysis was conducted using GraphPad Prism v.5. Results: Exposure to CaCl2 triggered pronounced oxidative injury and inflammation, as evidenced by elevated 8-hydroxy-2 '-deoxyguanosine levels, increased MPO activity, reduced SOD activity, and upregulated MMP-2 and MMP-9 expression. Montelukast administration markedly attenuated these changes, normalizing oxidative and inflammatory markers while improving histopathological architecture. Conclusions: Montelukast effectively counteracted CaCl2-induced aortic damage. The protective effects of montelukast appear to be mediated through suppression of MMP activity, restoration of SOD levels, and reduction of MPO-driven oxidative injury. By mitigating both inflammatory and oxidative mechanisms, montelukast contributes to the preservation of aortic wall structure. Clinical Relevance: Abdominal aortic aneurysm remains a major vascular disorder without an effective pharmacological therapy to slow its progression. In this experimental study, montelukast, a leukotriene receptor antagonist widely used in asthma, attenuated abdominal aortic aneurysm formation in rats and was associated with increased superoxide dismutase activity, reduced myeloperoxidase levels, and suppressed matrix metalloproteinase activation. These combined antioxidant, anti-inflammatory, and matrix-stabilizing effects preserved aortic wall integrity. Given montelukast's established safety and clinical availability, these findings support its potential for future clinical investigation as a pharmacological approach to limit aneurysm progression. (JVS-Vascular Science 2026;7:100405.)
  • Article
    Harnessing Adaptive Urban Service Frameworks and Smart Technologies for Sustainable Urban Development in Rapidly Urbanising Cities
    (Elsevier, 2026) Agboola, Oluwagbemiga Paul; Uzun, Turkan Irgin; Cakir, Hulya Soydas; Soydaş Çakır, Hülya
    Rapid urbanisation and escalating climate change impacts pose significant challenges for sustainable urban governance in developing nations, particularly where infrastructural inadequacies and resource inefficiencies persist. This study examines how urban systems in rapidly growing cities in Nigeria can utilise smart technologies to enhance resilience, inclusivity, and environmental sustainability. The study's aim is to develop and evaluate an Adaptive Urban Service Framework (AUSF) that integrates digital innovations to foster low-carbon, climate-resilient, and inclusive cities. Objectives of the study include (i) identifying adaptive urban service models that improve resource efficiency, environmental sustainability, and quality of life, and (ii) assessing the extent to which these services strengthen urban resilience and social inclusivity under demographic and infrastructural pressures. A structured survey involving 286 respondents from selected Nigerian cities was conducted, and the data were analysed using SPSS Version 22. The correlation results reveal a positive relationship between adaptive urban service mechanisms and sustainability outcomes (r = 0.987, p < 0.001), indicating that improvements in smart technologies, resource efficiency, environmental sustainability, and quality of life strongly reinforce sustainable urban performance. Similarly, experts' evaluations demonstrate a positive correlation between Adaptive Urban Services (AUS) and the enhancement of resilience and inclusivity within smart urban environments (r = 0.865, p < 0.001). These findings collectively underscore that adaptive, smart-driven frameworks exert substantial synergistic effects on environmental sustainability, social inclusivity, and urban resilience, confirming that the effective integration of smart technologies serves as a strong determinant of sustainability outcomes in rapidly urbanising Nigerian cities. The paper offers a methodology that integrates digital innovation with climate-responsive planning, which theoretically advances urban systems theory. In practical terms, it provides policymakers and urban planners with a scalable road map for implementing adaptive service solutions that connect sustainability, equity, and technology. Overall, within similar emerging urban environments, the study highlights the transformative potential of adaptive urban services in furthering climate adaptation, fostering inclusion, and attaining sustainable urban development.
  • Article
    New Diclofenac Hydrazones: Design, Synthesis, in Silico Studies and Anticancer Evaluation Against Breast Cancer
    (Elsevier, 2026) Birgul, Kaan; Oktay, Lalehan; Bekci, Hatice; Cikla-Suzgun, Pelin; Durdagi, Serdar; Kucukguzel, S. Guniz
    Breast cancer remains one of the most prevalent and lethal malignancies among women, highlighting the urgent need for novel therapeutic strategies that can overcome resistance mechanisms. The p38 alpha mitogen-activated protein kinase (MAPK14) plays a key role in inflammation-associated oncogenic signaling, making it an attractive molecular target for drug development. In this study, a novel series of diclofenac-based hydrazone derivatives (4a-4o) were designed, synthesized, and characterized using FT-IR, 1H- and 13C-NMR spectroscopy, thin-layer chromatography, and elemental analysis. Computational target profiling using SwissTargetPrediction identified MAPK14 as the primary predicted target. Molecular docking against the MAPK14 crystal structure (PDB ID: 1WBS) revealed high binding affinities (-11.41 to -8.34 kcal/mol), supported by MM/GBSA free energy calculations and molecular dynamics simulations, which confirmed stable ligand-protein interactions through hydrogen bonding with Asp168 and Glu71. In vitro cytotoxicity assays on MCF-7 (luminal A) and MDA-MB-231 (triple-negative) breast cancer cell lines demonstrated low-micromolar IC50 values, with compounds 4c, 4d, and 4e showing the strongest activity (2.1-4.5 mu M), surpassing the reference drug Tamoxifen. Overall, the results indicate that diclofenac hydrazones represent promising candidates anticancer properties through MAPK14 inhibition, providing a foundation for the development of next-generation therapeutics against breast cancer.
  • Article
    Safety and Efficacy of Colchicine in COVID-19 Treatment: Systematic Review and Meta-Analysis
    (Elsevier, 2025) Nada, Ahmed Hosney; Ibrahim, Ismail A.; Asar, Nada Khalid; Qenawy, Abdulrahman; Mohammed, Mariam M.; Wagdy, Mohamed; Farouk, Heidi Sherif
    Background: Colchicine is an anti-inflammatory drug used for the treatment of gout and other autoinflammatory conditions. Several trials reported promising results of the efficacy of colchicine in Covid-19 due to its antiinflammatory properties. However, applying these results to clinical settings remains the subject of ongoing research. Methods: We performed a systematic review and meta-analysis on the efficacy and safety of colchicine in the treatment of Covid-19. PubMed, Cochrane Library, Web of Science, and Scopus were searched for relevant studies. The primary outcomes were 28-day mortality, invasive mechanical ventilation, non-invasive mechanical ventilation, and ICU admissions. The risk ratio was used to compare effectiveness between the two groups. Subgroup analysis was done for C-reactive protein and duration of hospitalization. Results: 17 randomized controlled trials with a total of 25478 patients were included. The overall Risk ratio didn't favor any of the two groups in terms of 28-day mortality (RR =1.03, 95 % CI [0.93:1.15], P = 0.58), noninvasive mechanical ventilation (RR = 0.81, 95 % CI [0.44:1.48], P = 0.49), ICU admission (RR = 0.89, 95 % CI [0.56:1.41], P = 0.62). The overall mean difference (MD) did not show statistical significance between both groups in terms of Creactive protein (CRP) (mg/dl) (MD = -1.21, 95 % CI [-2.42:0.01], P = 0.05), lactate dehydrogenase (LDH) (U/ L) (MD = 50.95, 95 % CI [-92.07: 193.98], Ferritin (ng/ml) (MD = 128.08, 95 % CI [51.97:204.18], P = 0.001), ICU length of stay (MD = -0.09, 95 % CI [-0.34:0.15], P = 0.45) and duration of hospitalization (MD = -0.41, 95 % CI [-1.56:0.73], P = 0.48). Conclusion: In Covid-19 treatment, colchicine didn't result in significant benefits in terms of clinical outcomes. More large-scale randomized clinical trials with standardized dosages and long-term follow-up are needed for further investigation into the colchicine effect.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Novel Triazole-Urea Hybrids as Promising EGFR Inhibitors: Synthesis, Molecular Modeling and Antiproliferative Activity Studies Against Breast Cancer
    (Elsevier, 2025) Ture, Asli; Gulcan, Mehmet Metehan; Birgul, Serap Ipek Dingis; Erdogan, Oguz; Erdogan, Omer; Tuncay, Fulya Oz; Kucukguzel, Ilkay; Öz Tuncay, Fulya; Dingiş Birgül, Serap İpek
    Breast cancer is the second leading cause of mortality among women globally. In this study, novel promising urea derivatives containing a 4-phenyl-5-sulphanylidene-4,5-dihydro-1H-1,2,4-triazole group were synthesized and evaluated for their biological activities against breast cancer. The cytotoxicity and apoptotic profiles of these compounds were assessed on the MCF7 breast cancer cell line and the L929 fibroblast cell line. Compound 5c exhibited the strongest anticancer activity against MCF7 cells with an IC50 value of 56.97+4.22 mu M, while it showed significantly lower cytotoxicity against L929 cells (IC50 = 1651+18.39 mu M). Compound 5c also induced early apoptosis in MCF7 cells, with an apoptosis rate of 18.40% and 5.28%, respectively. Additionally, the EGFR inhibitory activities of the synthesized compounds were evaluated, with compound 5i demonstrating the most potent EGFR inhibition, showing an IC50 value of 35.1 nM. These results suggest that compound 5c likely exerts its anticancer effects through mechanisms other than EGFR inhibition, while compound 5i has significant potential as an effective EGFR inhibitor. Molecular modeling studies were conducted to suggest putative binding interactions of compounds 5d, 5e and 5i with wildtype hEGFR. Further studies are warranted to explore their activity against other cancer types.
  • Article
    Turkish Validity and Reliability Study of the Kidney Transplant Understanding Tool (K-TUT) in Kidney Transplant Recipients
    (Elsevier, 2025) Akinci, Naile; Genc, Kadriye Nilay; Toprak, Cagla
    Aim: The study was conducted methodologically to evaluate the validity and reliability of the KTUT scale in kidney transplant recipients. Material and Method: The population of the study consisted of kidney transplant patients at a private hospital group in Istanbul, while the sample comprised patients who met the inclusion criteria and volunteered for the study. Based on ten times the number of scale items, 220 individuals were included in the sample to prevent data loss and to ensure high representativeness. In the study, data collection tools such as the "Patient Information Form" and the "KTUT" scale were employed. The test-retest study was repeated two weeks later with 50 participants. The participants in the retest were not included in other tests of the scale. Findings: The overall content validity index of the scale (S-CVI/Ave) was found to be 0.93. According to the experts' opinions, the content validity of the scale is high, and the majority of the items have been deemed appropriate for the measurement purpose. The internal consistency reliability coefficient of the scale (Cronbach's Alpha) was calculated as 0.789. This threshold indicates that the scale possesses an acceptable level of reliability for use at the group level. In addition, the results of the study reveal that the scores of the K-TUT scale show a significant difference in the 27 % lower and 27 % upper groups. Conclusion: As a result of the study, the K-TUT scale has been shown to reliably distinguish knowledge levels and to be an effective measurement tool in the field of kidney transplant. It is thought that using the Turkish version of the K-TUT to evaluate the knowledge levels of kidney transplant recipients will contribute to evaluation of developed programs and the improvement of patients' treatment processes.
  • Article
    Evaluation of Hopelessness, Decision Regret and Desire for Retransplantation in Patients With Graft Loss After Kidney Transplantation
    (Elsevier, 2025) Akinci, Naile; Toprak, Cagla
    Aim: In this descriptive study, it was aimed to evaluate hopelessness, decision regret, and desire to be transplanted again in patients who developed graft loss after kidney transplantation. Material and Method: The study sample consisted of all patients who developed graft loss after kidney transplantation between January 2017 and February 2021 in a private hospital in XXX, who met the inclusion criteria and volunteered for the study. "Patient Information Form", 'Beck Hopelessness Scale' and 'Decision Regret Scale' were used as data collection tools in the study. Findings: It was determined that participants experienced a moderate level of hopelessness after graft rejection (13.370 +/- 4.379) while the average scores on the decision regret scale were generally high (66.435 +/- 18.213). Regarding the desire to be transplanted again, it was observed that the majority of the participants (52.2 %) did not want to be transplanted again. According to the results of the correlation analysis, there was a significant correlation between hopelessness and decision regret scores (p* < 0.05) while there was no significant correlation with the desire to be transplanted again (p > 0.05). In addition, hopelessness (p = 0.034) scores of individuals who were not employed were significantly higher than those who were employed, and both hopelessness (p = 0.000) and decision regret (p = 0.048) scores of those without religious belief were significantly higher than those with religious belief. Conclusion: The findings of the study emphasize the critical importance of monitoring and psychological support processes before and after kidney transplantation. Understanding the emotional processes individuals experience after kidney transplant graft loss is important for the development of psychological support and intervention strategies.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    The Effect of Neck Mobilization Vs. Combined Neck and Lumbar Mobilization on Pain and Range of Motion in People With Cervical Disc Herniation: a Randomized Controlled Study
    (Elsevier, 2025) Ozdincler, Arzu; Aktas, Dogan; Reyhanioglu, Duygu Aktar; Ozturk, Basar; Aktar Reyhanioglu, Duygu
    Background: To assess the effectiveness of Kaltenborn-Evjenth Orthopedic Manual Therapy (KEOMT) applied to cervical-only mobilization versus both lumbar and cervical regions on pain intensity and range of motion (ROM) in individuals with cervical disc herniation. Methods: Thirty-three participants were enrolled in the study. The patients were randomly assigned to two groups. Group A received cervical-only KEOMT, while Group B received combined lumbar and cervical KEOMT. Interventions were administered three times a week for four weeks. Pain was measured using the Visual Analog Scale (VAS), ROM was assessed for flexion and lateral flexion, and Neck Pain and Disability Index (NPDI) and Short-Form 36 Health Survey (SF-36) were used for evaluation. Results: In intra-group measurements, a statistically significant difference was observed in all parameters of pain, ROM, disability, and quality of life for the mobilization methods applied in both groups (p < 0.05). Group B demonstrated significantly greater improvements in ROM/flexion, pain, and disability outcomes compared to Group A in inter-group measurements (p < 0.05). Physical and emotional sub-groups of quality of life measures also favored Group B in intergroup analysis (p < 0.05). However, the power values for ROM and quality of life parameters were found to be low. Conclusions: The cervical plus lumbar KEOMT technique is more effective than cervical-only mobilization in improving pain and disability. However, low power values for ROM and quality of life suggest these results may lack clinical significance, warranting further research.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 5
    The Effects of Rational Emotive Behavior Therapy and Motivational Interviewing on Emotions, Automatic Thoughts, and Perceived Performance of Elite Female Volleyball Players
    (Elsevier, 2023) Urfa, O.; Asci, F. H.
    Objectives: The aim of this study was to examine the effect of Rational Emotive Behavior Therapy intervention alone (REBT-A) or with motivational interviewing (REBT + MI) on the emotions, automatic thoughts, and perceived performance of elite female volleyball players. Design: and method: Single-case, staggered multiple-baseline AB and ABC designs were adapted in the study. Five female volleyball players participated in the study, of which three players participated in the REBT-A and two players participated in the REBT + MI. The athletes were competing in the national volleyball league (Mage = 28, SD = 5.52). All participants were elite athletes with at least ten years of sports experience. Three scores (T1, T2, T3) were calculated for the athletes' perceived performance, emotion, and automatic thoughts. T1 was the baseline score calculated before the sessions. T2 was calculated after the first two sessions (the first three sessions for REBT + MI) and T3 was calculated after the last three sessions. In the data analysis, percentage changes, effect size, and visual analyzes were used in the T1, T2, and T3 scores. Results: REBT-A and REBT + MI interventions increased perceived performance, positive emotions, and positive automatic thoughts, and decreased negative emotions and negative automatic thoughts. REBT + MI was more advantageous than REBT-A in increasing positive emotion, positive automatic thought, and perceived performance. Conclusions: As a result, REBT alone or with motivational interviewing has a positive effect on perceived performance, emotions, and automatic thoughts, but REBT + MI has greater potential to increase positive constructs.