WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Citation - WoS: 14Citation - Scopus: 15The Best Whey Protein Powder Selection Via Vikor Based on Circular Intuitionistic Fuzzy Sets(Mdpi, 2023) Buyukselcuk, Elif Caloglu; Sari, Yigit Can; Çaloğlu Büyükselçuk, ElifPeople try very hard to have a symmetrical, strong, and beautiful body. The human body needs high amino acids for muscle protein synthesis. Whey protein is a good choice that contains all amino acids, which increases muscle protein synthesis and improves body shape with resistance exercise. For this reason, those who do sports, especially professionals, prefer to use these products frequently. A large number of commercial whey protein powders are sold on the market, and to achieve maximum purpose, individuals want to use the best one. Intuitionistic fuzzy sets are used in order to minimize the negative effects of the uncertainty environment and ambiguous information encountered in the decision-making process on the solution. In this study, VIKOR, based on the circular intuitionistic fuzzy set, has been used to determine the best whey protein supplement. In line with the comprehensive literature review and expert opinions, the evaluation criteria affecting the selection process have been determined, and the solution of the problem has been focused.Article Citation - WoS: 10Citation - Scopus: 8Experiences of Hearing Parents of Children With Hearing Loss: a Qualitative Study(Mdpi, 2023) Dikec, Gul; Turk, Eda; Yuksel, Esin; Celebi, Kubra; Ozdemir, MeltemThis qualitative study was carried out with a phenomenological design to determine the life experiences of the parents of children with hearing loss. The study sample consisted of twenty parents, who did not have hearing loss, of children with hearing loss registered in a special education and rehabilitation center. The data were collected through in-depth interviews in Istanbul between December and January 2022. Colaizzi's phenomenological interpretation method was used for qualitative data analysis. It was determined that parents of children with hearing loss experienced anxiety, sadness, and happiness during diagnosis. They needed more information at first, but then they gained knowledge in the process, and it took work to accept this process. They stated that having a child with hearing loss requires more time, responsibility, and effort than other children. This situation affects their social life, and they experience interpersonal conflicts. When parents were asked how they coped, they said they did it through prayer, social support, or time to themselves. It can be recommended to apply psychosocial intervention programs to the parents of children with hearing loss, especially their mothers, from the first diagnosis process.Review Citation - WoS: 3Citation - Scopus: 3Seroprevalence of <i>coxiella Burnetii</I> in Human and Animal Populations in Tiirkiye: Meta-Analysis(Kafkas Univ, veteriner Fakultesi dergisi, 2023) Kilbas, Imdat; Kahraman Kilbas, Elmas Pinar; Ciftci, Ihsan HakkiThis study aims to reveal Coxiella burnetii by examining the studies reporting Q fever seroprevalence in humans and animals in the last 25 years in Turkiye. In this study, based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), various databases were searched between January 1997 and October. 2022. A literature review was carried out using data analyses performed using the IBM SPSS Version 25.0 statistical package program and Comprehensive Meta-Analysis (CMA) program. Overall prevalence of C. burnetii in humans was 22.78% (95% CI: 16.43%-29.12%), overall prevalence in animals was 13.49% (95% CI: 10.04-16.93%) was detected. The mean prevalence of C. burnetii in sheep was 19.1%+/- 10.88, 10.46 +/- 6.39% in cattle, 15.21 +/- 10.01% in studies including cattle and sheep together, 11.17 +/- 10.74 in cattle, sheep and goats, and 12.4%+/- 1.15% in sheep and goats. As a result of this study, it was determined that the prevalence of Q fever in humans in Turkiye is high in those dealing with animals, women who had a miscarriage, and infertile individuals. Although it is known that this disease is seen in Turkiye, there are not enough case reports in the literature. Detailed studies on Q fever in humans and animals need to be conducted. Further studies are needed to evaluate Q fever risk factors and prevalence data together within the scope of One Health approach.Article Citation - WoS: 3Citation - Scopus: 3Antioxidants, Enzyme Inhibitory Activities, and Phytochemical Profiles of Seven Medicinal Plants Grown With Organic Farming Techniques(Tubitak Scientific & Technological Research Council Turkey, 2023) Zor, Murat; Ozupek, Burcin; Pekacar, Sultan; Deliorman Orhan, Didem; Orhan, Didem DeliormanIn this study, the potential antihyperlipidemic, antidiabetic, and antiobesity effects of extracts obtained via infusion techniques from Artemisia absinthium L., Achillea millefolium L., Calendula officinalis L., Fumaria officinalis L., Mentha piperita L., Origanum onites L., and Urtica dioica L. grown with organic farming techniques were investigated using enzyme inhibition methods (alpha-glucosidase, pan-creatic cholesterol esterase, pancreatic lipase, and alpha-amylase). It is important that natural compounds or extracts to be used in the treat-ment of metabolic problems have antioxidant effects. The antioxidant effects of these species were tested in terms of ABTS and DPPH radical scavenging activity, ferric reducing power, and metal chelating capacity. Extracts (2 mg/mL) of M. piperita (91.43 +/- 0.90%) and O. onites (70.18 +/- 2.02%) showed potent inhibitory effects on the alpha-glucosidase enzyme. Among all species, only O. onites extract ex-erted an inhibitory effect on the cholesterol esterase enzyme close to that of reference compound simvastatin. While all extracts were effective in the tested antioxidant activity methods, it was determined that the M. piperita and O. onites extracts displayed particularly significantly strong activities in terms of ferric reducing power, ABTS radical scavenging effect, and metal chelating capacity. The total flavonoid and phenolic contents of all extracts were determined. The compositions of the most active extracts were analyzed for pheno-lic acids and flavonoids using RP-HPLC. The results of RP-HPLC analysis showed that the levels of ellagic acid (0.923 +/- 0.000 g/100 g extract) in the M. piperita extract and rosmarinic acid (0.813 +/- 0.003 g/100 g extract) in the O. onites extract were high. As a result, all species grown with organic farming techniques except U. dioica were found to have high antioxidant effects. In light of these findings, it was concluded that M. piperita and O. onites grown with organic farming techniques showed strong inhibitory effects in terms of the tested activities, especially for alpha-glucosidase and pancreatic cholesterol esterase, and that in vivo studies and activity-guided isolation studies should be conducted on these species in the future.Article Citation - WoS: 4Citation - Scopus: 3Multidrug Resistance in Pathogens of Community-Acquired Urinary Tract Infections in Turkey: a Multicentre Prospective Observational Study(Tubitak Scientific & Technological Research Council Turkey, 2023) Sencan, Irfan; Karabay, Oguz; Altay, Fatma Aybala; Suzuk Yildiz, Serap; Simsek, Husniye; Gozukara, Melih Gaffar; Surme, Serkan; Engin, Derya Öztürk; Cag, Yasemin; Kul, Gülnur; Habip, Zafer; Kaya, Safak; Tasbakan, MeltemBackground/aim: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options.Materials and methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed. Results: Of the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advanced age, and having two or more risk factors showed a statistically significant relation with MDR existence (p < 0.001, p: 0.014, p < 0.001, respectively) that increasing number of risk factors or degree of advancing in age directly affects the number of antibiotic groups detected to have resistance by pathogens. In total, MDR isolates corresponded to 36.1% of our CAUTI samples; MDR existence was 35.7% in E. coli isolates and 57.2% in Klebsiella spp. isolates. Our results did not show an association between resistance or MDR occurrence rates and NUTS regions.Conclusion: The necessity of urine culture in outpatient clinics should be taken into consideration, at least after evaluating risk factors for antibacterial resistance individually. Community-acquired UTIs should be followed up time-and region-dependently. Antibiotic stewardship programmes should be more widely and effectively administrated.Article Citation - WoS: 2Citation - Scopus: 2Vegetable and Fruit Consumption and Its Relationship With Body Mass Index in Adults: a Cross-Sectional and Seasonal Research From Turkiye(Taylor & Francis Ltd, 2023) Hizli-Guldemir, Hilal; Saleki, Neda; Sezer, Fatma Elif; Yoldas-Ilktac, Havvanur; Akman, Cansu; Ersoy, Gulgun; Garipagaoglu, MuazzezThis study examines the relationship between fruit and vegetable consumption and the BMI in Turkiye. In this cross-sectional study, which 6332 adults were included, fruit and vegetable consumption, and preferences were collected. The quantities of vegetables and fruits were classified based on the WHO and the national recommendations. Of the adults (33.39 +/- 12.59 years), 52.9% of men and 39.7% of women had an above-normal BMI. Based on WHO recommendations, overweight and obese people consumed less vegetables and fruits compared to their counterparts (ORs for women, overweight: 1.2, obese: 1.3; ORs for men, overweight: 1.3, obese: 1.5; 95% CI). The regression analysis revealed that the quantities of vegetable and fruit intake were higher in young individuals, men, and married people. Although the majority consume more than 400 g/day of vegetables and fruits, the intake is inadequate in people with obesity.Review Citation - WoS: 14Citation - Scopus: 18Managing Viral Emerging Infectious Diseases Via Current and Future Molecular Diagnostics(Mdpi, 2023) Altindis, Mustafa; Kilbas, Elmas Pinar Kahraman; Kahraman Kilbaş, Elmas PınarEmerging viral infectious diseases have been a constant threat to global public health in recent times. In managing these diseases, molecular diagnostics has played a critical role. Molecular diagnostics involves the use of various technologies to detect the genetic material of various pathogens, including viruses, in clinical samples. One of the most commonly used molecular diagnostics technologies for detecting viruses is polymerase chain reaction (PCR). PCR amplifies specific regions of the viral genetic material in a sample, making it easier to detect and identify viruses. PCR is particularly useful for detecting viruses that are present in low concentrations in clinical samples, such as blood or saliva. Another technology that is becoming increasingly popular for viral diagnostics is next-generation sequencing (NGS). NGS can sequence the entire genome of a virus present in a clinical sample, providing a wealth of information about the virus, including its genetic makeup, virulence factors, and potential to cause an outbreak. NGS can also help identify mutations and discover new pathogens that could affect the efficacy of antiviral drugs and vaccines. In addition to PCR and NGS, there are other molecular diagnostics technologies that are being developed to manage emerging viral infectious diseases. One of these is CRISPR-Cas, a genome editing technology that can be used to detect and cut specific regions of viral genetic material. CRISPR-Cas can be used to develop highly specific and sensitive viral diagnostic tests, as well as to develop new antiviral therapies. In conclusion, molecular diagnostics tools are critical for managing emerging viral infectious diseases. PCR and NGS are currently the most commonly used technologies for viral diagnostics, but new technologies such as CRISPR-Cas are emerging. These technologies can help identify viral outbreaks early, track the spread of viruses, and develop effective antiviral therapies and vaccines.Article Citation - WoS: 4Citation - Scopus: 4Whey Protein Concentrate Ameliorates the Methotrexate-Induced Liver and Kidney Damage(Cambridge Univ Press, 2023) Tufan, Elif; Sivas, Guezin Goksun; Gurel-Gokmen, Begum; Yilmaz-Karaoglu, Suemeyye; Dursun, Ercan; Caliskan-Ak, Esin; Tunali-Akbay, Tugba; Yllmaz-Karaoǧlu, SÜmeyye; Çallşkan-Ak, EsinMethotrexate (MTX) is a cytotoxic immunosuppressant that is widely used in the treatment of tumours, rheumatoid arthritis and psoriasis. This study aims to evaluate the effects of whey proteins on MTX-induced liver and kidney damage by focusing on oxidant-antioxidant systems and eating habits. The study was conducted in four groups of thirty Sprague-Dawley rats (control, control + whey protein concentrate (WPC), MTX, MTX + WPC). A single dose of 20 mg/kg MTX was administered intraperitoneally to the MTX groups. Control and MTX groups were given 2 g/kg WPC by oral gavage every day for 10 d. At the end of day 10, blood samples were drawn and liver and kidney tissues were removed. MTX administration increased the lipid peroxidation level and decreased glutathione level, superoxide dismutase and glutathione-S-transferase activities in the liver and kidney. Administration of WPC significantly reduced the damage caused by MTX in the liver and kidney. While a decrease in serum urea level and an increase in serum creatinine level were detected in the MTX group, WPC administration reversed these results up to control group levels. Administration of WPC to the MTX group significantly reversed the histopathological damage scores of the liver and kidney. WPC administration ameliorated the MTX-induced oxidative damage in the liver and kidney tissues due to its antioxidant properties. Liver and kidney damage can be prevented by using whey proteins as a nutraceutical in MTX therapy. In conclusion, whey proteins demonstrated a protective effect against MTX-induced liver and kidney damage.Review Citation - WoS: 5Citation - Scopus: 4A Systematic Review and Meta-Analysis for the Efficacy of Transcranial Direct Current Stimulation (tdcs) in Ocd Treatment: A Non-Pharmacological Approach To Clinical Interventions(Pergamon-elsevier Science Ltd, 2024) Ibrahim, Ismail A.; Nada, Ahmed Hosney; Asar, Nada Khalid; Ibrahim, Rand; Farouk, Rawan Ahmed; Al-Qiami, Almonzer; Noorbakhsh, Seyed AliObsessive-compulsive disorder (OCD) is a prevalent mental condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions), significantly disrupting daily functioning and social interactions. Transcranial direct current stimulation (tDCS) presents a promising non-invasive treatment modality aimed at alleviating symptoms. However, the evidence regarding its effectiveness remains inconclusive. This study seeks to address this gap by conducting a systematic review and meta-analysis of clinical trials, offering improved guidance for clinical intervention. A comprehensive search strategy was implemented across multiple databases, including PubMed, Cochrane CENTRAL, Embase, Scopus, and Web of Science. This search focused strictly on randomized controlled trials (RCTs) involving 147 patients. These trials evaluated the efficacy of tDCS in OCD patients. Subsequent data extraction, risk of bias assessment, and statistical analysis using Review Manager software revealed the potential efficacy of tDCS in reducing OCD symptoms. The meta-analysis not only fails to demonstrate significant superiority of active tDCS over sham tDCS but also suggests that sham tDCS may be more effective than active tDCS in reducing OCD symptoms. This finding diminishes the promise of tDCS as an effective treatment for OCD. Larger trials are warranted to further elucidate these findings.Article Citation - WoS: 5Citation - Scopus: 5The Effect of an Educational Peer-Based Intervention Program on Sexual and Reproductive Health Behavior(Wiley, 2024) Ogul, Zeynep; Sahin, Nevin HotunIntroductionThe fact that adolescent people experience risky sexual behavior and have insufficient knowledge of sexual and reproductive health (SRH) indicates the need for SRH education. This study investigates the impact of peer-educated SRH programs on the knowledge and behaviors of adolescents.MethodThis study was conducted as a randomized controlled trial on 275 university students. The subjects were randomly assigned to the peer educators (n = 25), intervention (n = 125) and control (n = 125) groups using systematic random sampling. Peer educators provided face-to-face SRH education to the intervention group. The researcher provided the same education to the control group via the online conference method. SRH knowledge and behavior evaluated with scales before, after, and 3 and 6 months after the SRH education. The obtained data were analyzed using SPSS version 25 through statistical tests and analysis of covariance.ResultsThe female and male ratio of the participants was almost equal (49.4%, 50.6%). The mean age was found to be 20.42 +/- 1.14 years. The mean scores of the students in the intervention group increased from 21.20 +/- 0.14 to 35.20 +/- 0.07 for sexual health knowledge questionnaire (SHKQ), and from 130.56 +/- 0.55 to 147,90 +/- 0,25 for reproductive health scale (RHS) after the education. Compared with the control group, these increases in the mean scores of SHKQ and RHS were found to be statistically significant.ConclusionThe findings show the important role of the SRH peer education method on the effect of transferring knowledge about sexual behaviors. Health and education policy-makers are advised to implicate SRH peer education.