WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Investigation of Physical Parameters Influencing Body Awareness in Adults With Obesity: an Observational, Controlled Study
    (Elsevier, 2024) Eryildiz, Ezgi; Delibas, Elifnur; Kesgin, Ilayda Melek; Ozturk, Ipek Beyza; Huseyinsinoglu, Burcu Ersoz; Ersoz Huseyinsinoglu, Burcu
    Aim: The primary aim was to compare the body awareness (BA) level in adults with obesity and non-obese adults. The secondary aim was to investigate the physical parameters associated with BA and compare them between adults with obesity and non-obese adults. Method: Thirty-two adults with obesity and age and sex-matched 32 non-obese adults were included in the study. The outcome measures were the Body Awareness Questionnaire, International Physical Activity QuestionnaireShort Form and Functional Reach Test to detect BA, physical activity (PA), and dynamic balance level, respectively. Reaction time was assessed by the Nelson Foot Reaction Test and knee and trunk position error by inclinometer. Results: There was no significant difference between the obese and non-obese group in terms of BA score (p = 0.18) and PA level (p = 0.50). Lower dynamic balance was observed in the obese group (p = 0.003). Only the trunk position error was higher in the obese group in the measurement of joint position error (p = 0.010). There were no significant differences in the right and left feet reaction times between the groups (p = 0.68 and p = 0.23). There were no relationships between BA score and PA level (p = 0.93), dynamic balance (p = 0.82), joint position error (p = 0.14), and right (p = 0.33) and left (p = 0.25) reaction times. Conclusion: There was no significant difference in body awareness between the non-obese and the obese group and there was no association between body awareness and the physical parameters. However, adults with obesity had impaired balance and proprioception compared to non-obese ones.
  • Article
    Citation - WoS: 7
    Citation - Scopus: 6
    The Potential Role of Boron in the Modulation of Gut Microbiota Composition: an in Vivo Pilot Study
    (Mdpi, 2024) Senturk, Nermin Basak; Kasapoglu, Burcu; Sahin, Eray; Ozcan, Orhan; Ozansoy, Mehmet; Ozansoy, Muzaffer Beyza; Sahin, Fikrettin
    Background/Objectives: The role of the gut microbiome in the development and progression of many diseases has received increased attention in recent years. Boron, a trace mineral found in dietary sources, has attracted interest due to its unique electron depletion and coordination characteristics in chemistry, as well as its potential role in modulating the gut microbiota. This study investigates the effects of inorganic boron derivatives on the gut microbiota of mice. Methods: For three weeks, boric acid (BA), sodium pentaborate pentahydrate (NaB), and sodium perborate tetrahydrate (SPT) were dissolved (200 mg/kg each) in drinking water and administered to wild-type BALB/c mice. The composition of the gut microbiota was analyzed to determine the impact of these treatments. Results: The administration of BA significantly altered the composition of the gut microbiota, resulting in a rise in advantageous species such as Barnesiella and Alistipes. Additionally, there was a decrease in some taxa associated with inflammation and illness, such as Clostridium XIVb and Bilophila. Notable increases in genera like Treponema and Catellicoccus were observed, suggesting the potential of boron compounds to enrich microbial communities with unique metabolic functions. Conclusions: These findings indicate that boron compounds may have the potential to influence gut microbiota composition positively, offering potential prebiotic effects. Further research with additional analyses is necessary to fully understand the interaction between boron and microbiota and to explore the possibility of their use as prebiotic agents in clinical settings.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 2
    Apocynin Exhibits an Ameliorative Effect on Endothelial Dysfunction/ Atherosclerosis-Related Factors in High-Fat Diet-Induced Obesity in Rats
    (Marmara Univ, Fac Medicine, 2024) Ayci, Nurdan Bulbul; Ertas, Busra; Kaya, Rumeysa Keles; Sevinc, Sevgi Kocyigit; Amuran, Gokce Gullu; Ercan, Feriha; Cetinel, Sule; Keles Kaya, Rumeysa; Bulbul Ayci, Nurdan; Kocyigit Sevinc, Sevgi
    Objective: The aim of this study was to reveal the effect of apocynin (APO) on the factors involved in obesity-related endothelial dysfunction (ED) and atherosclerosis (AS). Materials and Methods: Male Wistar albino rats were divided into control (CNT), high-fat diet (HFD) and HFD+APO groups. HFD and HFD+APO groups were fed HFD for sixteen weeks. APO (25 mg/kg) was administered to the HFD+APO group for the last four weeks. The effects of APO on: AS-related metabolic parameters (triglyceride, total cholesterol, high-density lipoprotein-cholesterol, insulin and leptin), oxidative stress (OS), [ malondialdehyde, glutathione, nicotinamide adenine dinucleotide phosphate (NADPH)oxidase-2, oxidised-low-density lipoprotein (ox-LDL) and 8-hydroxy-2-deoxyguanosine], low-density lipoprotein and ox-LDL uptake potential (activin receptor-like kinase-1 and lectin-like oxidized low-density lipoprotein receptor-1, respectively), tissue inflammation inducible-nitric oxide synthase, nitric oxide), programmed cell death (terminal deoxynucleotidyl-transferase-dUTP-nick-end (alpha-smooth muscle actin), histology and ultrastructure of thoracic aorta were evaluated. Results: In obesity, APO had an ameliorative effect on metabolic parameters, OS, inflammation, ED, programmed cell death and oxLDL uptake potential, but not on foam cell formation and LDL uptake potential. Conclusion: Apocynin may improve ED and AS in obesity by suppressing OS-linked factors involved in the early stage of AS.
  • Article
    Citation - WoS: 1
    Morphological Andbiochemical Evaluation of Effects Of<i> Myrtus</I><i> Communis</I> L. Extract on Heart and Aorta in High Fat-Diet Obese Rats
    (Marmara Univ, Fac Medicine, 2023) Yay, Nagehan Ozyilmaz; Ayci, Nurdan Bulbul; Kaya, Rumeysa Keles; Sen, Ali; Sener, Goksel; Ercan, Feriha
    Objective: The purpose of this study was to examine the protective effects of Myrtus communis L. (MC) extract on high fat-diet (HFD) induced heart and aorta damage by evaluating oxidative stress and the endothelial nitric oxide system (eNOS).Materials and Methods: Wistar albino male rats were divided into 3 groups (n=7) as control, HFD, and HFD+MC. Rats in HFD and HFD+MC groups were HFD fed for 16 weeks and in the last 4 weeks saline or MC (100 mg/kg) was administered orally (5 days/week). Triglyceride, cholesterol, and high-density lipoprotein (HDL) were estimated in blood serum. Tissue oxidative stress and inflammatory parameters were evaluated biochemically. Tissue morphologies, eNOS, inducible NOS (iNOS), and NADPH oxidase-2 (NOX-2)-immunopositive and apoptotic cells were evaluated histologically.Results: Altered serum lipid profiles, degenerated heart, and aorta morphology, increased malondialdehyde, 8-hydroxy-2-deoxyguanosine, tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and myeloperoxidase levels, and iNOS, NOX-2 immunopositive and apoptotic cells, decreased NO levels, eNOS-immunopositive cells in both tissues were observed in HFD group. All these parameters improved in the HFD+MC group. Conclusion: This study revealed that HFD-induced obesity increased iNOS activation and oxidative stress in the cardiac and aortic tissues of the rats. MC improved oxidant/antioxidant balance and prevented heart and aorta damage via eNOS involvement.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 4
    Prevalence of Obesity in Prepubertal and Pubertal With Turkish Population Type 1 Diabetes
    (Springer Japan Kk, 2021) Ozkaya, Volkan; Eren, Erdal; Ozgen Ozkaya, Sebnem; Denkboy Ongen, Yasemin
    To determine the prevalence of prepubertal and pubertal obesity in children and adolescents with type 1 Diabetes Mellitus (Type 1 DM). One hundred fifty children and adolescents aged 6-18 years with Type 1 DM who attended the Pediatric Endocrinology Polyclinic and were diagnosed with type 1 DM were included in the study. Tanner staging was used to estimate pubertal status. Age- and gender-specific body mass index (BMI) percentile between 85 and 95% was accepted as overweight and > 95% as obese. It was determined that the overweight prevalence rates in children and adolescents with type 1 DM were 13.3% and the obesity rate was 14.3%. It was found that while the overweight prevalence rates (14.1%) were higher in males, the obesity prevalence was higher in females (19.0%). The obesity prevalence rates at the prepubertal and pubertal stages were found to be 17.1% and 13.8%, respectively. The obesity prevalence at the pubertal stage was higher in girls (22.4%) than boys (3.9%) (p < 0.05). The rates both of overweight and obesity in boys decreased from prepubertal to pubertal periods, while those rates increased in girls. Our results indicated that the obesity prevalence in prepubertal and pubertal children and adolescents with type 1 DM was higher compared to healthy peers in the literature. The authors believe that the risk factors for obesity in this population should be determined and obesity-prevention programs for diabetes should be prepared.