WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Synergistic Effects of Amniotic Membrane and Human Milk Exosomes on Burn Wound Healing(Elsevier Sci Ltd, 2025) Isik, Ferda; Tufan, Elif; Sivas, Guzin Goksun; Ak, Esin; Muhan, Aleyna; Sener, Goksel; Tunali-Akbay, TugbaBackground: Thermal burns are one of the most common burns. Studies are ongoing to develop synthetic or biological wound dressings to ensure painless and scarless healing of burn wounds. Objectives: This study aimed to combine the human amniotic membrane with breast milk-based exosomes and investigate their effects on burn wound healing. Methods: 24 Wistar Albino rats weighing 200-250 g and of both genders were used. Rats were divided into control, burn, burn+human amniotic membrane (hAM) and burn+hAM+Exosomes (hAM+Exo) groups. Burn injury was induced by exposing the back of rats to 90 degrees C water for 10 s. Rats were treated with hAM and hAM+ Exo for seven days after injury. At the end of the 7th day, the skin samples were taken and analyzed biochemically and histologically. TNF-alpha, IL-1(i, type III collagen, malondialdehyde (MDA), glutathione (GSH), total protein, superoxide dismutase (SOD), and tissue factor (TF) activity were determined in skin samples. Results: In the burn group, skin TNF-alpha levels increased, IL-1(i and type III collagen levels decreased. Wound healing therapy reversed these results. In the hAM+Exo group, the TNF-alpha level was lower, and IL-1 beta and type III collagen levels were higher than in the hAM group. MDA and total protein levels increased, and GSH, tissue factor, and SOD activities decreased in the burn group. In hAM and hAM+Exo groups, MDA levels decreased, and GSH and SOD activity increased compared to the burn group. The GSH levels were significantly higher in the hAM+Exo group compared to the hAM group. Conclusion: In conclusion, combining exosomes and amniotic membrane induced changes consistent with better wound healing than amniotic membrane alone.Article Citation - WoS: 1Citation - Scopus: 2Investigating the Relationship Between Caregiver Burden and Quality of Life in Burn Care(Elsevier Sci Ltd, 2025) Seyyah, Mine; Reyhanioglu, Duygu Aktar; Kardas, Ayse Sena YumbulAim: This study aimed to examine the relationship between caregiver burden and quality of life among primary caregivers of burn survivors receiving inpatient treatment in an acute care setting. Methods: This cross-sectional descriptive and correlational study included 53 primary caregivers of hospitalized burn patients, recruited from the Burn Care Unit of a tertiary hospital in Turkey between August 2022 and January 2023. Participants were aged 18 or older, identified as the primary caregiver, and able to communicate in Turkish. Individuals with psychiatric disorders were excluded. Data were collected through face-to-face structured interviews using the Zarit Burden Interview (ZBI) and the Short Form Health Survey (SF-36), in which higher scores indicate better quality of life. Descriptive statistics, Pearson correlation, and linear regression were used to analyze the data. Results: The caregivers had a mean age of 38.75 +/- 10.76 years; 71.7 % were female, and 50.9 % had completed only primary education. The average caregiving duration was 10.6 days. The mean ZBI score was 22.54 +/- 15.11, indicating moderate burden. Demographic variables did not significantly affect caregiver burden (p > .05). A moderate negative correlation was found between caregiver burden and their emotional (r = -0.367, p = .007), psychological (r = -0.313, p = .023), and physical functioning (r = -0.355, p = .009) subdomains of the SF-36. Conclusion: A inverse relationship was observed between caregiver burden and caregiver quality of life, especially in emotional, psychological, and physical functioning domains. Although demographic factors were not influential, lower quality of life was associated with greater caregiver burden.Review Citation - WoS: 1Citation - Scopus: 1Nutrition Therapy in Pediatric Burns(Bentham Science Publ Ltd, 2021) Kunduraci, Yasemin E.; Garipagaoglu, MuazzezBackground: Burns are defined as injuries resulting from exposure to thermal radiation, electrical or chemical exposure of the skin or organic tissues. It has high mortality and morbidity in low and middle-income countries. Objective/Methods: The objective of this study is to evaluate the present knowledge principles of nutritional therapy for pediatric burns from the dietician's perspective, taking into account the epidemiology and physiology of the burn. The purpose of burn treatment is to provide survival and tissue repair and to increase immunity. Therefore, besides fluid electrolyte replacement and surgical interventions, nutritional therapy is quite important. Nutrition principles should aim to reduce inflammation and meet hypermetabolic needs. Results: In the clinical practice of children suffering from burns, daily energy need is calculated by adding the recommended energy expenditure to the burn percentage, but the most accurate method is the use of indirect calorimetry. Protein requirement is around 1.5-3.0 g/kg/day. Carbohydrate intake should be 55-60% of total energy intake, while lipids should be less than 30%. Vitamin supplements in the form of a multivitamin are recommended in addition to vitamin A, vitamin C, and Zinc. In cases where oral intake is insufficient, enteral nutrition should be applied as soon as possible. When enteral feeding is contraindicated, parenteral nutrition is preferred. Conclusion: Evaluating the nutritional status of children and meeting macro and micronutrient needs accelerate wound healing, shorten hospital stay, and reduce mortality.