WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article DiSCNet: Directional Split Convolution for Compute-Efficient Brain Tumor Diagnosis(Elsevier Sci Ltd, 2026) Pacal, Ishak; Ganie, Shahid MohammadBrain tumor classification from magnetic resonance imaging (MRI) remains challenging because tumor appearance varies substantially across patients, while scanner- and protocol-related differences can alter image intensity distributions and weaken model generalization. This study aims to develop a compact yet highperforming deep learning framework that can classify heterogeneous brain MRI more reliably without relying on large-capacity backbones. To this end, we propose DiSCNet, a lightweight architecture built on an InceptionNeXt-inspired hierarchical design and centered on a novel Directional Split Convolution (DiSC) block. The proposed block diversifies receptive fields through complementary local and directional depthwise branches, while Global Response Normalization and Efficient Channel Attention are incorporated to improve feature stability and channel selectivity under acquisition variability. The model was evaluated on a unified benchmark constructed from five publicly available MRI repositories, comprising 17,888 images across four classes: glioma, meningioma, pituitary and non-tumor. Under a single training and evaluation protocol, DiSCNet was compared against 71 contemporary convolutional, transformer-based, and hybrid architectures. DiSCNet achieved the best overall performance, with 0.9922 accuracy, 0.9916 precision, 0.9930 recall, and 0.9923 F1-score, while using only 2.78 million parameters. Class-wise analysis further showed strong and balanced recognition across all diagnostic categories, and Grad-CAM visualizations indicated that the model predominantly focused on lesionrelevant regions. These findings demonstrate that a carefully designed lightweight architecture can outperform substantially larger models and provide an efficient, robust, and clinically relevant solution for four-class brain tumor MRI classification.Article Denta-Hybridonet: A Hybrid CNN-Transformer Architecture for Automated Detection of Developmental Dental Anomalies in Pediatric Panoramic Radiographs(Elsevier Sci Ltd, 2026) Eskibaglar, Busra Karaagac; Yavuz, Yelda Polat; Dogan, Gizem Karagoz; Algarni, Ali; Cakmak, Yigitcan; Pacal, IshakAccurate identification of developmental dental anomalies (DDAs) in children is clinically important; however, interpreting panoramic radiographs can still vary across readers because of mixed dentition, anatomical overlap, and variable image quality. This variability may delay recognition and complicate early interventional planning. In this study, we curated a pediatric panoramic dataset of 2,001 radiographs (ages 6-14 years) spanning five categories: Dilaceration, Ectopy, Hypodontia, Taurodontism, and Healthy. All images were independently labeled by three experienced pediatric dentists. To avoid patient-level leakage, the dataset was divided into training, validation, and held-out test sets using a patient-wise split. We propose Denta-HybridoNet, a hybrid convolution-transformer architecture designed to capture both fine-grained tooth morphology and broader, arch-wide contextual patterns. Its InceptionNeXt-gMLP block supports multi-scale local representation learning, which helps the model focus on subtle morphological cues, whereas the Swin-gMLP block provides efficient global context modeling across the dental arch. In addition, a gated multilayer perceptron (gMLP) module refines the feature transformation through context-dependent modulation, strengthening diagnostically relevant signals while reducing the influence of irrelevant variation and radiographic noise. To ensure a fair comparison, we benchmarked Denta-HybridoNet against 22 recent convolutional and transformer-based models under the same training protocol and evaluation conditions. On the held-out test set, the proposed method achieved 91.15% accuracy and 91.20% F1 score, representing the best overall performance among the compared architectures. Ablation studies quantified the contributions of hybrid design and gMLP, and Grad-CAM analyses supported interpretability by highlighting clinically meaningful regions.Article Investigating Text Neck Syndrome and Duration of Mobile Phone Use, Muscle Activity, Hand Grip Strength, Posture, and Disability(Elsevier Sci Ltd, 2026) Yasaci, Zeynal; Zirek, Emrah; Mustafaoglu, Rustem; Ozdincler, Arzu RazakNeck and shoulder musculoskeletal symptoms related to smartphone use are becoming increasingly prevalent, yet the underlying mechanisms including smartphone usage duration, muscle activity, hand grip strength, posture, and disability remain incompletely understood. This study examined the interaction between text-neck syndrome and factors such as smartphone usage duration, muscle activity, hand grip strength, posture, and disability. Forty participants (Text Neck group: n = 18; 14 females or Control group: n = 22; 15 females) underwent neuromuscular assessment. Surface electromyography measured bilateral muscle activity in the upper trapezius (UT) and abductor pollicis brevis (APB) muscles during smartphone use. Secondary outcomes included the Visual Analogue Scale (VAS) to assess pain intensity, hand grip strength, New York Posture Rating Scale (NYPRS), Neck Disability Index (NDI), and Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. The Text Neck group demonstrated significantly higher smartphone use (p < 0.001), higher texting time (p = 0.006), and lower muscle activation at activity in the dominant APB (p = 0.011), dominant UT (p < 0.001), and non-dominant UT (p = 0.008). These findings provide novel insights into how excessive smartphone use alters muscle function and postural alignment in individuals with text-neck syndrome. Understanding these mechanisms may inform targeted prevention and rehabilitation strategies to mitigate musculoskeletal risk associated with modern technology use.Article Burn Rehabilitation: Evaluation of Physiotherapists' Knowledge and Awareness Levels(Elsevier Sci Ltd, 2025) Seyyah, Mine; Akkurt, Mustafa Ferit; Yilmaz, NergisObjective: The aim of this study was to evaluate the level of knowledge and awareness of physiotherapists working in Turkey about burn rehabilitation. Method: This was a cross-sectional study conducted between March and June 2025 and data were collected using Google Form. A total of 324 people were included in the study. The level of knowledge and awareness of the participants about burn rehabilitation was evaluated with 28 questions created by taking expert opinion. Results: While 25.6 % of participants had experience in burn rehabilitation, only 1.2 % frequently encountered burn patients. Although 60.5 % had taken courses on burn rehabilitation, only 15.1 % considered their knowledge sufficient. Correct response rates to key knowledge questions were 78.7 % for exercise applicability, 79.6 % for timing, 54.6 % for the most common burn type in Turkey, 35.8 % for edema management, and 13 % for pressure garment duration, revealing gaps in clinical knowledge. Additionally, 92.9 % believed early physiotherapy improves recovery, and 98.4 % reported positive effects on quality of life. Discussion: Our results indicate that although most physiotherapists had taken courses on burn rehabilitation, their knowledge remains insufficient, whereas their awareness is high, underscoring the need for targeted training and certification programs.Article Citation - WoS: 1Citation - Scopus: 1Effects of Nighttime Eating Behavior on Cardiometabolic Health and Sleep: A Crossover Study(Elsevier Sci Ltd, 2025) Kesgin, Yavuz Erkam; Hasbal, Nuri Baris; Copur, Sidar; Incir, Said; Kurtulus, Ozlem; Genc, Candan; Kanbay, MehmetBackground and aims: The impact of night-eating behavior (NEB) on metabolic health remains underexplored, particularly in healthy populations. We have hypothesized that NEB adversely affects metabolic parameters, liver function, and sleep via circadian disruption and neurohormonal alterations. Methods and results: In this single-center crossover study, sixteen healthy adults (aged 18-35 years) with no comorbidities, no medication use, and a body mass index between 18 and 30 kg/m(2) participated in two one-week dietary regimens: regular eating (no food after 7:30 p.m.) and nighttime eating (>= 25 % of daily caloric intake consumed after 9:30 p.m.). Clinical, biochemical, neurohormonal, and respiratory polygraphy data were obtained following each dietary period. The mean age of participants was 27 +/- 4 years. After adjusting for multiple comparisons, nighttime eating behavior (NEB) was associated with significant increases in albuminuria (p = 0.003), serum phosphate (p < 0.001), fasting triglycerides (p = 0.039), and C-reactive protein (CRP; p = 0.01). NEB also elevated serum leptin (p = 0.007), ghrelin (p < 0.001), cortisol (p = 0.041), fibroblast growth factor 21 (FGF-21; p < 0.001), and cytokeratin-18 (p < 0.001), while significantly decreasing melatonin levels (p < 0.001). Sleep study results demonstrated significant increases in the apnea-hypopnea index (AHI; p < 0.001), supine AHI (p < 0.005), oxygen desaturation (7 % +/- 2 % vs. 11 % +/- 3 %; p < 0.001). Conclusion: NEB significantly affects neurohormonal profiles and sleep-related respiratory metrics in healthy individuals, indicating potential adverse effects on cardiometabolic health during short-term evaluation in healthy subjects.Article Synergistic Effects of Amniotic Membrane and Human Milk Exosomes on Burn Wound Healing(Elsevier Sci Ltd, 2025) Isik, Ferda; Tufan, Elif; Sivas, Guzin Goksun; Ak, Esin; Muhan, Aleyna; Sener, Goksel; Tunali-Akbay, TugbaBackground: Thermal burns are one of the most common burns. Studies are ongoing to develop synthetic or biological wound dressings to ensure painless and scarless healing of burn wounds. Objectives: This study aimed to combine the human amniotic membrane with breast milk-based exosomes and investigate their effects on burn wound healing. Methods: 24 Wistar Albino rats weighing 200-250 g and of both genders were used. Rats were divided into control, burn, burn+human amniotic membrane (hAM) and burn+hAM+Exosomes (hAM+Exo) groups. Burn injury was induced by exposing the back of rats to 90 degrees C water for 10 s. Rats were treated with hAM and hAM+ Exo for seven days after injury. At the end of the 7th day, the skin samples were taken and analyzed biochemically and histologically. TNF-alpha, IL-1(i, type III collagen, malondialdehyde (MDA), glutathione (GSH), total protein, superoxide dismutase (SOD), and tissue factor (TF) activity were determined in skin samples. Results: In the burn group, skin TNF-alpha levels increased, IL-1(i and type III collagen levels decreased. Wound healing therapy reversed these results. In the hAM+Exo group, the TNF-alpha level was lower, and IL-1 beta and type III collagen levels were higher than in the hAM group. MDA and total protein levels increased, and GSH, tissue factor, and SOD activities decreased in the burn group. In hAM and hAM+Exo groups, MDA levels decreased, and GSH and SOD activity increased compared to the burn group. The GSH levels were significantly higher in the hAM+Exo group compared to the hAM group. Conclusion: In conclusion, combining exosomes and amniotic membrane induced changes consistent with better wound healing than amniotic membrane alone.Article Effects of Motor Imagery Adding To Physiotherapy and Rehabilitation Program in Children With Duchenne Muscular Dystrophy: Does It Make a Difference(Elsevier Sci Ltd, 2025) Umut, Gulsena Utku; Ozdincler, Arzu Razak; Ulug, Fitnat; Guler, Serhat; Saltik, Sema; Utku Umut, GülsenaIntroduction/background: The study aims to investigate the effects of the MI (Motor Imagery) program applied in addition to the PTR (Physiotherapy and Rehabilitation) program on gait and balance in children with DMD (Duchenne Muscular Dystrophy). Methods: The 38 boys with DMD were included in the study and randomized into two groups: the PTR group (mean age: 7.96 +/- 1.94 years) and the MI + PTR group (mean age: 9.03 +/- 1.71 years). In the PTR group, the PTR program was administered 2 days/week for 8 weeks, and in the MI + PTR group, the MI program was administered 5 days/week in addition to the PTR program. Groups were assessed by the Brooke Lower Extremity Functional Classification Scale, Modified Pediatric Mini Mental Scale, Movement Imagery Questionnaire (MIQc), Kinovea (R) Software Program, Timed Up & Go Test (TUG), Timed Function Tests (TFT), Two-Minute Walk Test (2MWT), and Motor Function Measure (MFM-32). Results: As a result of the study, in PTR Group, TFT-Stairs descending (p = 0.049) was improved. In MI + PTR Group, Kinovea (R) Software Program-Walking Speed (p = 0.003), 2MWT (p = 0.037), TFT-Stair descend and 10-m walk (respectively; p = 0.001; p = 0.039), and MFM-32-D1 (p = 0.036) were improved. According to the comparison between groups, the groups were not superior to each other (p > 0.05). Discussion/conclusion: Although the MI program applied in addition to the PTR program contributes to improvements in walking speed, walking distance, and functional performance in children with DMD, it does not demonstrate superiority over the PTR program alone.Article Citation - WoS: 1Citation - Scopus: 2Investigating the Relationship Between Caregiver Burden and Quality of Life in Burn Care(Elsevier Sci Ltd, 2025) Seyyah, Mine; Reyhanioglu, Duygu Aktar; Kardas, Ayse Sena YumbulAim: This study aimed to examine the relationship between caregiver burden and quality of life among primary caregivers of burn survivors receiving inpatient treatment in an acute care setting. Methods: This cross-sectional descriptive and correlational study included 53 primary caregivers of hospitalized burn patients, recruited from the Burn Care Unit of a tertiary hospital in Turkey between August 2022 and January 2023. Participants were aged 18 or older, identified as the primary caregiver, and able to communicate in Turkish. Individuals with psychiatric disorders were excluded. Data were collected through face-to-face structured interviews using the Zarit Burden Interview (ZBI) and the Short Form Health Survey (SF-36), in which higher scores indicate better quality of life. Descriptive statistics, Pearson correlation, and linear regression were used to analyze the data. Results: The caregivers had a mean age of 38.75 +/- 10.76 years; 71.7 % were female, and 50.9 % had completed only primary education. The average caregiving duration was 10.6 days. The mean ZBI score was 22.54 +/- 15.11, indicating moderate burden. Demographic variables did not significantly affect caregiver burden (p > .05). A moderate negative correlation was found between caregiver burden and their emotional (r = -0.367, p = .007), psychological (r = -0.313, p = .023), and physical functioning (r = -0.355, p = .009) subdomains of the SF-36. Conclusion: A inverse relationship was observed between caregiver burden and caregiver quality of life, especially in emotional, psychological, and physical functioning domains. Although demographic factors were not influential, lower quality of life was associated with greater caregiver burden.Article Citation - WoS: 2Citation - Scopus: 2Perfusion-Mri for Differentiating Cerebral Metastatic Lesions and Gliomas: an Evidence-Based Review(Elsevier Sci Ltd, 2025) Azab, Mohammed A.; El-Gohary, Nour; Atallah, Oday; Shama, Mohsen; Ibrahim, Ismail A.Background: Lesions affecting the brain are variable and have multiple pathologies. Brain metastasis is a common entity of lesions that can be misleading in diagnosis. Brain metastasis affects the patient's life and survival in about 40% of cases; all patients with metastatic brain lesions are indicated for surgery, so proper diagnosis is crucial for each patient. Non-invasive diagnosis is a promising way to confirm the diagnosis of cerebral metastatic lesions for patients who are not indicated for surgery for medical reasons. To our knowledge, this is the first evidence-based review article regarding utilizing perfusion-MRI for approaching cerebral metastatic lesions. Methods: A comprehensive database search on PubMed/Medline, Scopus and Google Scholar was done by the relevant keywords. Eligibility of articles was done by following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cochrane risk of bias assessment tool was used to determine the risk of bias among the included studies. Results: From 2989 articles, only 31 studies were eligible for the qualitative synthesis. A comprehensive summary of the included study was made according to population, intervention, comparator and outcomes (PICO) method. Conclusions: Diagnosing cerebral metastases, categorizing subtypes, and monitoring their response to treatment is a challenging endeavor for neurosurgeons, neuroradiologists, and oncologists. Technological advances in MRI software as perfusion-based MRIs are designated to facilitate diagnosis and follow-up for patients with cerebral metastases.Article Does Prolotherapy Have an Effect on the Care of Pressure Injuries? a Pilot Study(Elsevier Sci Ltd, 2025) Eroglu, Nermin; Kokkiz, Rukiye; Eroglu, Hatice Eda; Kocoglu, HasanBackground: This study contributes to wound healing with prolotherapy in people with pressure injuries. The study was planned and conducted as a randomized controlled trial to determine the effect of prolotherapy on the care of pressure injuries. Methods: The study was carried out with patients with pressure injuries in the intensive care unit of a city hospital between April and June 2023. A power analysis was performed, and the sample size was calculated as 20 patients, including 10 in the intervention and 10 in the control group. The patients in the experimental group were given wound care with gelofusine as prolotherapy in the morning and evening for three days, and the injury site was covered with a sterile sponge and fixation tape. The patients in the control group were treated with saline in the morning and evening for three days. In both groups, the wound width, depth, and length were measured and evaluated prior to each intervention for three days. Results: In the study, a significant difference was found between the mean ages of the participants in the experimental and control groups (p < 0.05). The decrease in width measurements in the experimental group was found to be statistically significant compared to the previous measurements, while the increase in width measurements in the control group was significant compared to the previous measurements (p < 0.05). Depth measurements decreased statistically significantly in the experimental group, while they increased significantly in the control group compared to previous measurement values (p < 0.05). Conclusion: In conclusion, it was determined that the administration of gelofusine for pressure injuries as prolotherapy in the experimental group may be more effective in wound healing than saline treatment applied in the control group. Further studies are warranted.