WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
Browse
4 results
Search Results
Article Montelukast Attenuates Abdominal Aortic Aneurysm in Rats: Anti-Inflammatory and Antioxidant Effects(Elsevier, 2026) Tekin, Gozde; Cevik, Ozge; Cetinel, Sule; Sener, Goksel; Kizilay, MehmetObjective: Oxidative stress and inflammation are widely recognized as central mechanisms in the pathogenesis of abdominal aortic aneurysm. This study sought to examine the potential protective properties of montelukast in a rat model of aortic aneurysm. Methods: Male Sprague-Dawley rats were randomly allocated into three experimental groups. Abdominal aortic aneurysm was induced using the calcium chloride (CaCl2) model, in which gauze soaked in 0.5 M CaCl2 was placed directly onto the adventitial surface of the infrarenal abdominal aorta for 15 minutes. After induction, the treatment group received daily intraperitoneal injections of montelukast (10 mg/kg) for 4 consecutive weeks. At the study end point, animals were euthanized, and infrarenal aortic tissues were harvested for biochemical and histological evaluations. Measured parameters included matrix metalloproteinase (MMP)-2 and MMP-9 expression, myeloperoxidase (MPO) activity, and 8-hydroxy-2 '-deoxyguanosine levels. Antioxidant capacity was assessed through superoxide dismutase (SOD) activity assays. Histopathological examinations were performed, and statistical analysis was conducted using GraphPad Prism v.5. Results: Exposure to CaCl2 triggered pronounced oxidative injury and inflammation, as evidenced by elevated 8-hydroxy-2 '-deoxyguanosine levels, increased MPO activity, reduced SOD activity, and upregulated MMP-2 and MMP-9 expression. Montelukast administration markedly attenuated these changes, normalizing oxidative and inflammatory markers while improving histopathological architecture. Conclusions: Montelukast effectively counteracted CaCl2-induced aortic damage. The protective effects of montelukast appear to be mediated through suppression of MMP activity, restoration of SOD levels, and reduction of MPO-driven oxidative injury. By mitigating both inflammatory and oxidative mechanisms, montelukast contributes to the preservation of aortic wall structure. Clinical Relevance: Abdominal aortic aneurysm remains a major vascular disorder without an effective pharmacological therapy to slow its progression. In this experimental study, montelukast, a leukotriene receptor antagonist widely used in asthma, attenuated abdominal aortic aneurysm formation in rats and was associated with increased superoxide dismutase activity, reduced myeloperoxidase levels, and suppressed matrix metalloproteinase activation. These combined antioxidant, anti-inflammatory, and matrix-stabilizing effects preserved aortic wall integrity. Given montelukast's established safety and clinical availability, these findings support its potential for future clinical investigation as a pharmacological approach to limit aneurysm progression. (JVS-Vascular Science 2026;7:100405.)Article Harnessing Adaptive Urban Service Frameworks and Smart Technologies for Sustainable Urban Development in Rapidly Urbanising Cities(Elsevier, 2026) Agboola, Oluwagbemiga Paul; Uzun, Turkan Irgin; Cakir, Hulya Soydas; Soydaş Çakır, HülyaRapid urbanisation and escalating climate change impacts pose significant challenges for sustainable urban governance in developing nations, particularly where infrastructural inadequacies and resource inefficiencies persist. This study examines how urban systems in rapidly growing cities in Nigeria can utilise smart technologies to enhance resilience, inclusivity, and environmental sustainability. The study's aim is to develop and evaluate an Adaptive Urban Service Framework (AUSF) that integrates digital innovations to foster low-carbon, climate-resilient, and inclusive cities. Objectives of the study include (i) identifying adaptive urban service models that improve resource efficiency, environmental sustainability, and quality of life, and (ii) assessing the extent to which these services strengthen urban resilience and social inclusivity under demographic and infrastructural pressures. A structured survey involving 286 respondents from selected Nigerian cities was conducted, and the data were analysed using SPSS Version 22. The correlation results reveal a positive relationship between adaptive urban service mechanisms and sustainability outcomes (r = 0.987, p < 0.001), indicating that improvements in smart technologies, resource efficiency, environmental sustainability, and quality of life strongly reinforce sustainable urban performance. Similarly, experts' evaluations demonstrate a positive correlation between Adaptive Urban Services (AUS) and the enhancement of resilience and inclusivity within smart urban environments (r = 0.865, p < 0.001). These findings collectively underscore that adaptive, smart-driven frameworks exert substantial synergistic effects on environmental sustainability, social inclusivity, and urban resilience, confirming that the effective integration of smart technologies serves as a strong determinant of sustainability outcomes in rapidly urbanising Nigerian cities. The paper offers a methodology that integrates digital innovation with climate-responsive planning, which theoretically advances urban systems theory. In practical terms, it provides policymakers and urban planners with a scalable road map for implementing adaptive service solutions that connect sustainability, equity, and technology. Overall, within similar emerging urban environments, the study highlights the transformative potential of adaptive urban services in furthering climate adaptation, fostering inclusion, and attaining sustainable urban development.Article A Rare Presentation of Bilateral Periventricular Nodular Heterotopia With Intra-Axial Pontine Lesion: A Case Report and Treatment Approach(Elsevier, 2024) Shenno, Milad; Al-Qiami, Almonzer; Ibrahim, Ismail A.; Elhaw, Lojin; Nashwan, Abdulqadir J.This report presents a rare case of a 19-year-old male with bilateral periventricular nodular heterotopia (PVNH), a congenital brain abnormality resulting from failed neural cell migration, along with an intra-axial pontine lesion of unknown pathology. The differential diagnosis of childhood brainstem tumors in such cases commonly includes diffuse midline glioma (DMG), which is associated with a dismal prognosis due to H3 K27 gene mutation. However, this case exhibits a unique focal dorsal exophytic brainstem glioma variant, accounting for only a small percentage (approximately 10 %) of pontine tumors and carrying a more favorable prognosis. The lesion is suspected to be a pilocytic astrocytoma, presenting distinct neurological symptoms. In this case, the patient presented with symptoms include mainly occasional tonic-clonic seizures, right side mild spasticity with ataxic gait and right eye blurring of vision along with right side facial palsy. The patient's clinical evaluation, in conjunction with various medical diagnostic tests and MRI with and without contrast, led to the final diagnosis. Management began with anti-epileptic medication, with a plan for further treatment and follow-up.Article Citation - WoS: 1Neuroprotective Effect Of<i> Myrtus</I><i> Communis</I> Against Ionizing Radiation-Induced Brain Injury: Insights From Histopathological and Biochemical Analysis in Rats(Elsevier, 2024) Aslan, Dicle; Alan, Burcu; Yay, Nagehan Ozyilmaz; Karaoglu, Sumeyye Yilmaz; Ertas, Buesrara; Sen, Ali; Atasoy, Beste M.Aim: To investigate the potential radioprotective effects of Myrtus communis on brain tissue. Methods: Thirty female rats were divided into four groups. The control group (C) was applied with oral saline solution (SF) for four days. Myrtus communis (MC) groups started to receive MC (100 mg/kg, oral) either four days before (R + preMC) or immediately after (R + MC) irradiation for four days. Irradiation was applied 10 Gy in a single fraction. All rats were sacrificed on the fourth day of irradiation. Malondialdehyde (MDA), nitric oxide (NO), and glutathione (GSH) levels, myeloperoxidase (MPO), superoxide dismutase (SOD), and tissue factor activities (TFa) were determined for biochemical analysis. Hematoxylin&Eosin &Eosin staining was done for histopathological analyses, and electrophoretic analyses were performed. Results: NO, MDA, and MPO levels were higher in all irradiated groups compared with the C group. MC administration decreased NO, MDA, and MPO levels in R + preMC and R + MC groups. MC administration increased GSH levels. TFa activity decreased in R groups but did not change with MC administration compared to the C group. Radiation-induced brain tissue injury decreased, and morphologically normal neurons were observed in both MC-added groups. Conclusion: Myrtus communis has a potential neuroprotective effect on brain tissue, attributed to its antioxidative, anti-inflammatory, and anti-lipid peroxidative properties.