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  • Article
    Federal Reserve Interest Rates, Investment Behavior, and Arbitrage in Exchange Traded-Funds
    (Conscientia Beam, 2026) Sobati, Pegah; Koy, Ayben; Colak, Andac Batur
    This study investigates the influence of U.S. Federal Reserve interest rate policy on investor behavior, liquidity, and arbitrage efficiency in 29 iShares exchange-traded funds (ETFs) spanning large-, mid-, and small-cap benchmarks from 2013 to 2024. Using weekly data and econometric techniques combining time-series and panel approaches, the analysis incorporates key macroeconomic indicators, interest rates, the U.S. dollar index, economic activity measures, and market volatility to assess their combined effect on ETF market dynamics. Findings show that interest rate shifts significantly influence asset allocation, sector preferences, and risk tolerance, with higher rates often strengthening the dollar and increasing the appeal of fixed-income assets. Active trading is associated with narrower bid-ask spreads through enhanced liquidity, while passive investment widens spreads. ETF volatility is positively related to spreads, reflecting increased uncertainty and transaction costs in turbulent markets. The results provide empirical evidence on the behavioral channels linking monetary policy, market conditions, and trading efficiency, offering implications for policymakers, asset managers, and market participants. The major contribution of the study is to the empirical finance literature by integrating time-series and panel econometric methods to quantify the joint effects of interest rate policy, macroeconomic indicators, and investor sentiment on ETF market microstructure. Findings offer statistically robust insights into liquidity formation, volatility transmission, and arbitrage efficiency in diversified ETF markets.
  • Article
    Positioning School Readiness as Ecological Fit: The School Readiness Ecological Approach (SERA) for Occupational Therapy and Education
    (Routledge Journals, Taylor & Francis Ltd, 2026) Aydoner Bektas, Selen
    Traditional perspectives on school readiness have emphasized child-level competencies such as cognitive, language, and behavioral skills. While important, the narrow focus overlooks the ecological systems - families, teachers, and communities - that shape children's adaptation to school. The participation-oriented perspective of occupational therapy has also been largely absent from the discourse. The School Readiness Ecological Approach (SERA) reframes school readiness as a matter of ecological fit rather than merely a set of children's skills. Based on Bronfenbrenner's ecological systems theory and the Person - Environment - Occupation model, SERA conceptualizes readiness as the outcome of dynamic exchanges between children, families, educators, schools, and policy environments. SERA addresses key gaps by: (1) shifting focus from isolated child attributes to participation in real-life contexts; (2) integrating occupational therapy's holistic perspective into readiness; and (3) providing a multi-level framework to guide research, practice, and policy. SERA emphasizes four domains - child, family, educational environment, and community - as interconnected contributors to school readiness trajectories. As a conceptual bridge across education, health, and social systems, SERA will broaden theoretical scope, foster interdisciplinary collaboration, and promote inclusive, and sustainable strategies. Reconceptualizing school readiness as ecological fit will help move beyond deficit-based views and support more equitable and effective school transitions.
  • Article
    Development and Psychometric Properties of the Self-Efficacy Scale for Symptom Management and Self-Care in Patients with Cardiac Surgery
    (Springer Publishing Co, 2025) Aksut, Rabia Saglam; Capik, Canturk; Elmas, Tugce Bozkurt
    Background and Purpose: Evaluating self-efficacy for symptom management and self-care is crucial for ensuring follow-up care after cardiac surgery. As there is not yet a validated measurement tool for this evaluation, the aim of this study was to develop the Self-Efficacy Scale for Symptom Management and Self-Care (SESMSC: Cardiac Surgery) in patients with cardiac surgery and to examine its psychometric properties. Methods: The Symptom Management Theory and Bandura's Self-Efficacy Theory were used as the theoretical background for scale development. A multiphase design was utilized. The initial development phase consisted of item generation and expert panel review. The second phase comprised a three-step validation process: (a) face and content analysis (CFA) for construct validity, and (c) Cronbach's alpha, test-retest, and item- total correlation analysis to assess internal consistency reliability. The sample (n = 401) was randomly divided into two subsamples for EFA and CFA (EFA group: n = 201; CFA group: n = 200). Results: EFA suggested a 20-item, two-factor structure with factor loadings of .342-.782. The two subscales of the scale were labeled symptom management self-efficacy and self-efficacy for ch's alpha, test-retest, and item-total correlation results demonstrated acceptable internal consistency reliability. Implications for Practice: The SESMSC: Cardiac Surgery may be a useful tool to evaluate self-efficacy for symptom management and self-care after cardiac surgery. Further evaluation in independent samples is needed to investigate its psychometric properties and usefulness in clinical practice.
  • Article
    Development and Psychometric Properties of the Home Programme Quality Evaluation Tool for Therapists, Clients and Caregivers: A Validity and Reliability Study
    (MA Healthcare Ltd, 2025) Akyurek, Gokcen; Bektas, Selen Aydoner; Sipahi, Busra
    Background/Aims Home programmes - where rehabilitation activities are carried out in the client's home - are frequently used in the rehabilitation process but there are no standardised measurements to assess preparation, delivery and quality. The aim of this study was to determine the validity and reliability of two different forms - one for therapists and one for client and caregivers - that were developed as part of the Home Programme Quality Evaluation tool. Methods Initially, two 38-item forms were created based on a comprehensive literature review and expert panel evaluation. These forms were piloted with 30 participants from each target group to assess grammatical clarity, comprehensibility and cultural appropriateness. Based on the pilot feedback, minor linguistic adjustments were made, and the refined 38-item forms were then administered to 179 physiotherapists, occupational therapists and speech and language therapists, and 185 clients/caregivers (100 clients, 85 caregivers) for psychometric analyses. Psychometric analyses were conducted to evaluate validity and reliability, including exploratory and confirmatory factor analyses (chi-square/degree of freedom ratio, Goodness-of-Fit Index, Tucker-Lewis Index, Comparative Fit Index, Incremental Fit Index, root mean square error of approximation, standardised root mean square residual and internal consistency (Cronbach's alpha) and test-retest reliability (intraclass correlation coefficient and Pearson correlation). Results Exploratory and confirmatory factor analyses supported a one-factor structure for both forms, resulting in the final 11-item therapist form and 8-item client/caregiver form. The Home Programme Quality Evaluation tool demonstrated a good model fit for both forms (therapist form: chi(2)/df=2.66, goodness-of-fit index=0.909, Tucker-Lewis Index=0.886, standardised root mean square residual=0.060; client/caregiver form: chi(2)/df=3.37, goodness-of-fit index=0.929, Tucker-Lewis Index=0.950, standardised root mean square residual=0.027). Cronbach's alpha was 0.868 for the therapist form and 0.932 for the client/caregiver form. Test-retest reliability revealed strong positive correlations (r=0.994, P<0.001; r=0.998, P<0.001) and excellent stability over time (intraclass correlation coefficient=0.998 and 0.990, respectively). Conclusions The Home Programme Quality Evaluation's therapist and client/caregiver forms were found to have strong validity and reliability. The therapist form can enable therapists to monitor themselves, while the client and caregiver form can help clients or caregivers provide feedback on the home programme. Future studies can explore its application across different clinical populations and rehabilitation settings to further refine and optimise home-based interventions. Implications for practice For allied health professionals, the Home Programme Quality Evaluation tool serves as a practical tool for improving home programme design and implementation. By systematically assessing home programme quality, therapists can identify areas for improvement, ensuring that programmes are clear, feasible and well-integrated into the daily life of clients and their caregivers. Integrating the Home Programme Quality Evaluation tool into routine clinical practice can contribute to more effective rehabilitation outcomes, promoting structured, high-quality home programmes that align with the needs and capabilities of both clients and caregivers.
  • Conference Object
    Psycho-Social Impact of the Disaster on Employees in Terms of Occupational Health and Safety: The Case of Turkey
    (Springer-Verlag Singapore Pte Ltd, 2025) Aytac, Sevinc Serpil; Akalp, Husre Gizem; Bilir, Burcu Ongen; Mamaci, Merve
    The earthquakes that occurred in Maras, Turkey, on February 6, 2023, with intensities of 7.7 MW and 7.6 MW, deeply affected the lives of millions of people in economic, social and psychological terms within a few seconds and caused loss of life. The aim of this study is to examine the moderator role of disaster preparedness plans in workplaces on the relationship between post-traumatic stress levels and depression, anxiety, stress levels of people who are directly or indirectly exposed to these earthquakes and have an active work life. The data was obtained from a total of 206 blue-collar employees who were actively working in a private company and were directly and indirectly exposed to the effects of the earthquake. In data collection, demographic information form, The Impact of Event Scale-Revised (IES-R) and Depression Anxiety Stress Scale-21 (DASS-21) were used. According to the findings analyzed using structural equation modeling showed that having a disaster preparedness plan in workplaces weakens the strength of the relationship between post-traumatic stress level and depression, anxiety, stress levels.
  • Article
    Empowering a Mother of Children With Autism: a Case Report on the Impact of Tele-Occupational Performance Coaching on Parent-Child Relationships, Maternal Self-Efficacy, and Occupational Performance
    (Routledge Journals, Taylor & Francis Ltd, 2025) Bektas, Selen Aydoner; Bumin, Gonca; Aydoner Bektas, Selen
    This case report aimed at tele-occupational performance coaching to empower the mother of a child with autism spectrum disorder by enhancing occupational performance, parent-child relationships, and maternal self-efficacy. Over 8 weeks, the intervention addressed goals collaboratively identified by the mother, including self-care, productivity, and leisure-related tasks. Results revealed clinically significant improvements, with a two-point increase in Canadian Occupational Performance Measure scores for both performance and satisfaction. Significant score increases were also obtained on the Parent-Child Relationship Scale and the Early Intervention Parenting Self-Efficacy Scale. The findings underscore the effectiveness of tele-occupational performance coaching in enhancing family dynamics and parental capabilities while emphasizing the potential of telehealth as a scalable and accessible modality for delivering family-centered occupational therapy. Future research should expand on these findings by incorporating diverse populations and assessing long-term outcomes.
  • Article
    Evaluation of the Neuroprotective Effects of Korean Ginseng Root Extract in an Experimental Model of Multiple Sclerosis
    (Marmara Univ, Fac Medicine, 2025) Donmez, Muhammet Oguzhan; Sener, Goksel; Akbay, Tugba Tunali; Sivas, Guzin Goksun; Akakin, Dilek; Unlu, Hilal; Goren, Mehmet Zafer; Goksun Sivas, Guzin; Tunali Akbay, Tugba
    Objective: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterised by demyelination. The aim of this study was to evaluate the neuroprotective effects of Korean ginseng root extract (KGE) using a cuprizone-induced demyelination model. Materials and Methods: C57BL/6 mice were divided into control, demyelination and remyelination groups and each group was treated with KGE. Demyelination was induced with 0.2% cuprizone in the diet for four weeks. KGE (100 mg/kg) was administered by gavage during or after the cuprizone exposure. Body weight, food and water intake, and motor performance parameters were investigated. In addition, glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD) malondialdehyde (MDA), oligodendrocyte transcription factor-2 (OLIG2) and myelin basic protein (MBP) levels were measured in brain samples, while MBP and glial fibrillary acidic protein (GFAP) expression was assessed by immunohistochemistry and myelin status was examined using Luxol Fast Blue staining. Results: Korean ginseng root extract prevented myelin loss, promoted remyelination, and improved motor performance. It reduced oxidative stress by increasing GSH, GST, and SOD levels while decreasing MDA. KGE also suppressed demyelination by reducing astrogliosis and restoring OLIG2 and MBP levels. Conclusion: Korean ginseng root extract exhibits neuroprotective properties during demyelination and promotes remyelination, highlighting its therapeutic potential for MS.
  • Article
    NADPH Oxidase-2 Inhibitor Apocynin Attenuates High-Fat Diet-Induced Kidney and Bladder Injury
    (Marmara Univ, Fac Medicine, 2025) Kanpalta Mustafaoglu, Fatma; Ertas, Busra; Sener, Goksel; Ercan, Feriha
    Objective: This study aimed to evaluate the effects of NADPH oxidase-2 (NOX-2) inhibitor apocynin (APC) on high-fat diet (HFD)induced renal and bladder injury. Materials and Methods: Wistar albino rats were divided into 4 groups: Control, HFD, HFD+dimetyl sulfoxide (DMSO), and HFD+APC. Rats in HFD, HFD+DMSO, and HFD+APC groups were fed with HFD for sixteen weeks. In the last 4 weeks of the experiment, either DMSO or APC (25 mg/kg, dissolved in DMSO) was applied to the HFD+DMSO or HFD+APC groups. Lipid profiles and leptin values were measured in blood serum. Renal and bladder oxidant/antioxidant parameters, histological changes in the tissues, NOX-2-, nuclear factor kappa B (NF-& kgreen;B)-immunopositive and apoptotic cells were evaluated. Results: At the end of the experiment, leptin, cholesterol, and triglyceride levels were higher and high-density lipoprotein levels were lower in the HFD and HFD+DMSO groups compared to controls. In these experimental groups, an increase in malondialdehyde, 8-hydroxy-deoxyguanosine and myeloperoxidase levels and a decrease in glutathione levels, as well as an increase in collagen, NOX-2-and NF & kgreen;-B-immunopositive and apoptotic cells were found. Also, a deterioration in kidney and bladder morphology was observed. All these biochemical and histopathological findings improved in the HFD+APC group. Conclusion: High-fed diet causes renal and bladder injury by increasing NOX-2 activity and inflammation via oxidative stress. APC might alleviate tissue injury by inhibiting oxidative stress.
  • Article
    The Effect of Vitamin D and Paricalcitol on Protein Disulfide Isomerase
    (Marmara Univ, Fac Pharmacy, 2024) Koksal, Muhammed Murat; Sekerler, Turgut; Sener, Azize
    Protein disulfide isomerase (PDI), a multifunctional protein plays an important role as oxidoreductase, isomerase and chaperone in the cell. Prior studies have identified PDI is highly expressed in many different cancer types and presented as a new potential target for cancer treatment. Here, we investigated vitamin D and its analogue paricalcitol in silico interaction of the human PDI and inhibition of PDI reductase activity in vitro. We observed a non-covalent mechanism where the main skeleton of the vitamin D3 and paricalcitol structure is located at the hydrophobic site in the b' domain of PDI and forms a hydrogen bond with a residue (His138) in this domain. They also form multiple weak hydrophobic interactions with various chemical groups of the b' subunit. For the first time, we demonstrate that 1,25dihydroxyvitamin D3 (1 alpha,25(OH)2 vitamin D3) and paricalcitol inhibit the PDI reductase activity in vitro and their IC50 values are 20.79 +/- 1.43 nmol/L and 32.82 +/- 3.15 nmol/L respectively. The two compounds can also block the denitrosation activity of PDI.
  • Article
    Relationship of Handwriting Skills With Cognitive Functions and Sensory Processing in the Older Adults
    (Routledge Journals, Taylor & Francis Ltd, 2025) Sirma, Gamze Cagla; Yucel, Hulya
    Aims: Handwriting involves complex processes, including cognitive function and sensory processing. Cognitive function and sensory processing change with aging. However, the relationship between these parameters remains unclear. The aim of this study is to investigate the relationship between cognitive function and sensory processing with handwriting skills in the older adults. Methods: Fifty-six community-dwelling individuals aged 65-75 years completed a sociodemographic questionnaire, the Adolescent/Adult Sensory Profile, the Montreal Cognitive Assessment (MoCA), and handwriting tasks. Results: The mean age was 70.62 +/- 3.49 years. The strongest correlations were observed between MoCA and the handwriting subtest. Low registration, sensory sensitivity, and sensation avoiding were positively correlated with handwriting subtests. Moreover, the results showed that these skills were also predictive of older adults' handwriting skills (p < 0.05). Conclusions: It is crucial for occupational therapists and physiotherapists to integrate handwriting skill assessment into their clinical settings in terms of its relationship with cognitive and sensory processing.