WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Small Extracellular Vesicles in Tumor Metabolism and Immune Escape: Biomarkers and Therapeutic Opportunities(Springer, 2026) Ganjalikhani-Hakemi, Armita; Ghadiri, Nooshin; Ganjalikhani-Hakemi, Mazdak; Aru, Basak; Hosseini, RezaMetabolic reprogramming is a key characteristic of cancer. It is increasingly seen as a process influenced by ongoing communication between cells in the tumor microenvironment (TME). Small extracellular vesicles (sEVs) are 30-100 nm membrane-bound particles that tumor cells release in large amounts. These vesicles play an important role in the exchange of metabolic information. Besides proteins and nucleic acids, sEVs carry bioactive metabolites, lipids, and metabolic enzymes that can change the energy and building processes in recipient cells. Although there is growing evidence that sEVs contribute to metabolic changes, a complete understanding of how their varied contents relate to coordinated changes in metabolism across tumor, immune, and stromal areas is still lacking. In this review, we summarize recent findings showing that tumor-derived sEVs function like metabolic Trojan horses. They can trigger changes in glycolysis, accumulate lipids, and create dependencies on amino acids in recipient cells. This helps promote immune suppression, blood vessel growth, and resistance to treatment. We highlight the new idea of multi-metabolite sEV signaling as a factor in shaping the immunosuppressive environment of the TME. We also identify potential targets for intervention in sEV production, cargo loading, and cellular uptake, such as nSMase2, CD9/CD63-associated complexes, and macropinocytosis pathways. By combining insights from immunometabolism, cancer signaling, and the biology of extracellular vesicles, we propose that sEVs are not just biomarkers. They actively organize tumor metabolic systems and serve as valuable tools for precise immunology in cancer treatment.Article Statistical Analyses of Morphological Variations of Three Larroussius (Diptera: Psychodidae) Sister Species Collected in Leishmaniasis Endemic Foci of Adana in Turkiye(Wiley, 2026) Kavur, Hakan; Uckayabasi, Hale Oksuz; Alptekin, DavutSand flies are arthropod vectors responsible for transmitting Leishmania parasites to humans. Among them, Phlebotomus (P.) major, P. syriacus and P. neglectus are closely related sister species that play an important role in disease transmission in Türkiye. This study aimed to statistically analyse the morphological measurements of these three species and to identify reliable diagnostic characters. Seven morphometric traits were measured in both female and male specimens. Statistical analyses, including analysis of variance (ANOVA), discriminant function analysis (DFA) and principal component analysis (PCA), were performed to determine significant variables contributing to species differentiation. A total of 1729 sand flies were collected, comprising P. tobbi (44.58%), P. papatasi (21.26%), P. similis (20.30%), P. neglectus (8.50%), P. major (2.88%), P. syriacus (2.19%) and Sergentomyia (S.) fallax (0.27%). The female-to-male ratio was 1.42. ANOVA revealed significant interspecific differences (p < 0.001) in antennal, pharyngeal and genital characters. In females, P. neglectus exhibited shorter antennal segments A3 and A4 + A5, P. syriacus had the shortest pharynx (PHX), and P. major showed the longest epipharynx (EPI). In males, P. major had the longest coxite (CX), whereas P. neglectus displayed the shortest second style segment (S2) (p < 0.05). DFA confirmed clear species separation, with antennal and pharyngeal traits primarily driving differentiation in females, and genital characters being most informative in males. PCA explained 78.37% and 90.24% of the total morphometric variation in females and males, respectively, highlighting sex-specific patterns of morphological variation. Overall, these statistically supported morphometric differences provide robust diagnostic features that can complement molecular approaches, improving species identification and enhancing taxonomic resolution in sand fly vector studies.Article Oral Antipyretics for Fatigue Alleviation and Exercise Enhancement in Adults with Multiple Sclerosis: A Systematic Review and Meta-Analysis(Springer-Verlag Italia SRL, 2026) Hamdy, Ahmed Mohamed; Elmandrawi, Sara Wael; Ibrahim, Ismail A.; Shehata, Mazen Momtaz; Raza, Muhammad Liaquat; Elemam, Ahmed Mahmoud Elsayed; Elewa, MandyAims This review aims to explore the potential role of oral antipyretics (aspirin (ASA)/ acetaminophen), commonly known for fever and pain control, in managing fatigue, temperature regulation, and exercise capacity in patients with Multiple Sclerosis (MS), with a focus on nursing implications for symptom management. Design A systematic review of existing clinical studies assessing the effects of aspirin/ acetaminophen on MS-related fatigue, thermoregulation, and exercise performance. Data sources Electronic databases including Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, PubMed, Scopus, Web of Science, Wiley, Google Scholar, and ClinicalTrials.gov were searched up to March 2024. Review methods Quality assessment was conducted using the Cochrane risk of bias tool 2. to evaluate the methodological rigor of included studies. Outcomes analyzed included clinically assessed fatigue scores, exercise endurance, and postexercise thermoregulation, with attention to potential risks associated with aspirin use. Results After assessment of 57 reports for eligibility, only seven studies met inclusion criteria; results indicated that aspirin pretreatment significantly improved Time to Exhaustion (TTE) in heat-sensitive MS patients (p = 0.013), though one study reported no significant effect. Aspirin reduced post-exercise temperature rise by 56%, but this was not statistically significant in one trial (p = 0.178), while another showed significant reductions (p = 0.002). Conclusion Aspirin and acetaminophen may offer benefits in alleviating fatigue, enhancing thermoregulation, and improving exercise endurance in MS patients. These findings suggest that nurses should consider the potential role of aspirin in symptom management, with further research needed to confirm efficacy and safety. Impact This review highlights a potential adjunct therapy for nurses to incorporate into comprehensive MS care, emphasizing symptom control and quality of life improvements.Article Protective Effects of L-Theanine against Bisphenol A-Induced Oxidative Stress and Gut Microbiota Disruption in Wistar Rats(Springer, 2026) Sener, Azize; Marzi, Mahdi; Sener, Goksel; Donmez, Muhammet OguzhanBackground Gut microbiota homeostasis plays a central role in maintaining intestinal redox balance and immune regulation. Bisphenol A (BPA), a widely distributed environmental contaminant, has been associated with oxidative stress, inflammatory responses, and disturbances in intestinal microbial communities. L-theanine (LTN), a bioactive amino acid naturally present in green tea, possesses well-documented antioxidant and anti-inflammatory properties; however, its potential protective role against BPA-induced intestinal injury has not been fully clarified. Methods and Results In the present study, female Wistar albino rats were randomly allocated into three groups: control, BPA (50 mg/kg/day), and BPA + LTN (100 mg/kg/day) and treated for 30 days. Oxidative stress and inflammatory responses in intestinal and colonic tissues were assessed by measuring malondialdehyde (MDA), reduced glutathione (GSH) levels and myeloperoxidase (MPO), catalase (CAT) activities. BPA exposure significantly increased MDA (p < 0.001) level and MPO (p < 0.001) activity while reducing GSH content (p < 0.001) and CAT activity (p < 0.001) compared with the control group. Compared to the BPA group, LTN treatment led to significant changes in MDA, MPO, and GSH levels in both tissues. MDA and MPO levels were significantly reduced in the intestine and colon tissues of the BPA + LTN group (p < 0.001). GSH and CAT levels were significantly increased in both the intestine and colon compared to the BPA group (p < 0.001). In addition, fecal microbiota composition was analyzed using 16 S rRNA gene sequencing, with taxonomic profiling performed at the phylum, genus and species levels. BPA exposure was associated with reduced microbial stability and compositional shifts within the gut microbiota, whereas LTN treatment partially restored microbial richness and community structure. Conclusions Collectively, these findings indicate that LTN alleviates BPA-induced intestinal oxidative stress and microbiota dysbiosis, suggesting its potential as a protective dietary compound against environmental toxicant-related intestinal injury.Article Modulation of Brain Antioxidant Defense, Inflammation, and SIRT1 Activity by a Sunflower Oil-Based High-Fat Diet: Protective Role of L-Arginine in Rats(Springer, 2026) Şekerler, Turgut; Şener, Azize; Çavuşoğlu, Nuray; Doğan, ÖzgeBackgroundChronic consumption of omega-6-enriched dietary fat may disturb brain redox balance and neuroinflammatory homeostasis. Among the sirtuins, sirtuin 1 (SIRT1) exerts critical neuroprotective functions by suppressing oxidative stress and inflammatory signaling; however, the impact of sunflower oil-based high-fat diets (SO-HFD) on brain SIRT1 activity has not been investigated.ObjectiveThis study aimed to investigate the effects of SO-HFD on oxidative stress parameters, inflammatory markers, and SIRT1 activity in rat brain tissue, and to evaluate the potential modulatory role of L-arginine supplementation.MethodsFour-week-old female Sprague-Dawley rats were allocated into three groups: control, SO-HFD, and SO-HFD + L-arginine. Both SO-HFD groups were fed a diet containing sunflower oil for 16 weeks; from week 10 onward, 1.5% L-arginine was supplemented in the drinking water of the SO-HFD + L-arginine group. Following the 16-week protocol, serum and brain specimens were collected. Serum biochemical parameters and adiponectin were quantified; brain homogenates were assayed for lipid peroxidation (MDA), reduced glutathione (GSH), protein thiols (protein-SH), nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha) levels, and SIRT1 activity.ResultsAlthough brain MDA levels were not significantly elevated, SO-HFD animals exhibited reduced GSH and protein-SH content together with diminished SIRT1 activity. The SO-HFD increased TNF-alpha and NO levels. L-arginine supplementation decreased MDA and increased GSH, protein-SH, and SIRT1 activity. L-arginine also suppressed TNF-alpha levels in brain tissue compared to the SO-HFD group. NO levels in the SO-HFD + L-arginine group were lower than in the SO-HFD group, though not significantly.ConclusionThese findings suggest that chronic exposure to an omega-6-dominant dietary environment disturbs redox regulation and inflammatory balance in brain tissue, accompanied by reduced SIRT1 activity. L-arginine may attenuate cerebral oxidative stress and neuroinflammation by reinforcing endogenous antioxidant mechanisms, highlighting its potential as a nutritional strategy against SO-HFD-induced brain oxidative stress.Article Exploring Parents’ Perspectives on the Positive Discipline Program for Children Aged 0–6: A Qualitative Study(Routledge Journals, Taylor & Francis Ltd, 2026) Dayilar Candan, Hatice; Kaya Meral, Deniz; Arkan, BurcuThis qualitative phenomenological study explored the experiences of 18 mothers in an eight-session online the Positive Discipline Program. Findings revealed two primary themes: Reconstructing Parenting and The Social and Experiential Dimension. Participants reported increased self-awareness and emotional regulation, alongside adopting more reflective and empathic parenting practices. They perceived greater sensitivity to children's emotional needs and a shift away from authoritarian approaches. Furthermore, the group-based structure facilitated perceived peer support and normalization of challenges. Overall, parents experienced the program as a supportive, relationship-oriented intervention that enhanced their sense of parental competence and improved family interactions during early childhood.Article Deferoxamine Attenuates Seizure Stages, Oxidative Stress, and Apoptosis via Iron Chelation in a PTZ-Induced Epilepsy Model(Pleiades Publishing Ltd, 2026) Cetindag, Arzuhan; Hacisuleyman, LeventRecent evidence suggests that excessive iron accumulation contributes to oxidative stress and neuronal injury, which is a key factor in epilepsy development. To address this, our study evaluated the effects of deferoxamine (DFO), an iron chelator, on seizure severity, oxidative stress, and apoptosis in a rat model of epilepsy triggered by pentylenetetrazole (PTZ). Eighteen male Wistar albino rats were randomly allocated into three experimental groups: Control, PTZ, and PTZ + DFO. Animals received either DFO (250 mg/kg, i.p.) or saline 30 minutes prior to PTZ administration (45 mg/kg, i.p.). Seizure onset and severity were assessed using Racine's Convulsion Scale. Hippocampal tissues were analyzed for total oxidant status (TOS) and total antioxidant status (TAS) as well as caspase-3 and caspase-9 levels. DFO pretreatment significantly reduced seizure stage and prolonged the latency to both the first myoclonic jerk and generalized tonic-clonic seizures relative to the PTZ group. Biochemical analyses revealed that DFO significantly reduced TOS and increased TAS in hippocampal tissue. Additionally, caspase-3 and caspase-9 levels were significantly lower in the PTZ + DFO group relative to the PTZ group. Deferoxamine attenuates seizure severity and delays seizure onset, likely through mechanisms involving iron chelation, antioxidant defense enhancement, and inhibition of apoptosis. These results highlight DFO's neuroprotective capacity, underscoring its possible utility in the management of epileptic disorders.Article Comparison of Integrative Lighting Scenarios: Insights from an Office Field Study(Taylor & Francis Inc, 2026) Ozturk, Leyla Dokuzer; Kaplan, ElifLight exerts hormonal, circadian, and behavioral influences beyond its visual function, yet consensus is lacking on the optimal illuminance and correlated color temperature (CCT) for various workplace tasks within the scope of integrative lighting. This study investigates and compares five lighting scenarios-one dynamic and four static-in a real office environment to explore the balance between visual comfort, biological effectiveness, and user preference. The static scenarios comprised horizontal desk-plane illuminance and CCT settings of 500 lx at 4000 K, 1000 lx at 5500 K, 1250 lx at 4000 K, and 1500 lx at 5500 K, while the dynamic scenario varied between 500-1000 lx and 3500-5500 K at the desk plane over the day. Lighting conditions were assessed through objective measurements, melanopic equivalent daylight illuminance calculations, and subjective surveys over short- and long-term exposures. The study found that high illuminance and cool light enhanced alertness and energy, but participants preferred neutral light with elevated illuminance. The scenario with 1250 lx at 4000 K was most favored, providing an optimal balance between visual and nonvisual effects. These findings guide integrative lighting design to enhance office comfort, well-being, and productivity.Article Visual Tracking Efficiency across Different Spacing Widths: A Text-Free Eye-Tracking Study(Routledge Journals, Taylor & Francis Ltd, 2026) Akyurek, Gokcen; Akcay, Arif; Aydoner Bektas, SelenThis study examined how spatial spacing influences visual tracking efficiency using a novel text-free eye-tracking paradigm designed to minimize the influence of reading-related processes. Twenty participants visually followed straight, curved, and angular paths with five different widths (0.5-3 cm), while eye movements were recorded using a Tobii Eye Tracker T120. Results showed that narrow angular paths (0.5-1 cm) were associated with significantly higher fixation counts and longer fixation durations compared to wider angular paths and other paths. For angular paths, fixation counts differed significantly between 0.5 cm and 2.5 cm (p = .005), and between 0.5 cm and 3 cm (p = .003). Total fixation counts and total fixation durations were significantly greater for angular paths than for straight and curved paths. The findings indicate that narrower spatial constraints increase visual-perceptual load and reduce oculomotor fluency, whereas moderate spacing (approximately 2.5 cm) facilitates smoother visual guidance. The results are limited to visual tracking and oculomotor control within constrained geometric layouts and do not reflect reading behavior. The study highlights the utility of text-free visual tracking tasks for isolating low-level perceptual and oculomotor processes and informing future research on spatial layout and visual guidance in digital environments.Article Women’s Biopsychosocial Experiences Following Embryo Transfer: A Qualitative Study(Elsevier Masson, Corp Off, 2026) Baltacı, Nurşah Boylu; Aslan, Ergül; Coşkun, MervePurpose: This study explored the physical, psychological, and social experiences of women during the waiting period following embryo transfer (ET) in In Vitro Fertilization (IVF) and provides recommendations regarding psychosocial support needs. Materials and methods: A descriptive phenomenological design with thematic analysis was used. Semi-structured telephone interviews (30-45 min) were conducted with 29 women who underwent ET at a private IVF center in Istanbul from April to July 2025. Data were coded and analyzed using MAXQDA 24, and themes and subthemes were identified. Results: Participants had a mean age of 32.8 years, infertility duration of 2.8 years, 2.2 of IVF attempts, and 2.5 ETs. Most women were employed (69%), 72% had no previous pregnancies, and 86% had undergone multiple IVF attempt. Four main themes emerged in the thematic analysis: physical effects, psychological effects, social effects, and coping strategies. Subthemes varied by marital duration, previous IVF experience, and number of ETs; effects were stronger among women with multiple ETs. Conclusion: Women experience multidimensional challenges following ET and adopt various coping strategies. Physical changes disrupt daily life, emotional fluctuations stem from uncertainty and anxiety, and partner/social support and trust in healthcare professionals are critical for mitigating anxiety and improving quality of life and treatment adherence.