WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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Author: search.filters.author.Ertas, BusraScopus Q: search.filters.scopusQuartile.Q3

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  • Article
    In Vivo Antioxidant and Anti-Inflammatory Effects of Myrtus Communis Against Ionizing Radiation-Induced Gastrointestinal Injury: Trod-Grog Study
    (Kare Publishing, 2025) Kilic, Melisa Bagci; Varan, Melike Pekyurek; Atasoy, Ozum; Ozyilmaz, Nagehan; Pazarbasi, Seren Ede; Ertas, Busra; Atasoy, Beste Melek; Ercan, Feriha
    OBJECTIVE: This study aimed to investigate the in vivo radioprotective effects of Myrtus communis (MC) on the gastrointestinal system. METHODS: A total of 30 female rats were divided into four groups: i) Control; ii) irradiation (IR) only; iii) MC-pretreated; and iv) MC-treated. The rats received oral MC extract (100 mg/kg/day) for 4 days before exposure to 10 Gy IR or continued until sacrifice. On the fourth day of IR exposure, the rats were sacrificed, and histopathological and biochemical analyses were performed on the ileum, pancreas, and liver tissues. RESULTS: Malondialdehyde and myeloperoxidase levels decreased in both MC-treated groups, while glutathione levels and Na+-K+-ATPase activity increased (p<0.01), with significant histopathological improvements compared to the IR-only group. CONCLUSION: The results of this study demonstrate that MC significantly decreases ionizing radiation-induced oxidative and inflammatory damage in the gastrointestinal systems of rats. Therefore, it may be regarded as a new candidate with radioprotective potential for future clinical application.
  • Article
    Myrtus Communis Ameliorates Ionizing Radiation-Induced Cardiopulmonary Injury in Rats: Trod-Grog Study
    (Keai Publishing Ltd, 2026) Aytekin, Aynur; Isci, Oguzhan; Ozyilmaz, Nagehan; Karaoglu, Sumeyye Yilmaz; Ertas, Busra; Sen, Ali; Atasoy, Beste Melek; Yılmaz Karaoğlu, Sümeyye
    Objectives: Ionizing radiation (IR), widely used in diagnostic and therapeutic procedures, can damage vital organs such as the heart and lungs through oxidative stress. This study aims to assess the potential radioprotective effect of Myrtus communis (MC) against cardiopulmonary injury. Methods: Thirty female rats were divided into four groups. Control (C) and IR (R) groups received oral saline. The treatment (R+MC) and pretreatment (R+preMC) groups received MC (100 mg/kg) for 4 days (starting on the day of IR) and 8 days (starting 4 days before IR), respectively. All IR-exposed groups (R, R+MC, R+preMC) received a single 10 Gy whole-body irradiation. Histopathological changes were assessed by hematoxylin-eosin staining, while oxidative stress was evaluated by measuring malondialdehyde (MDA), glutathione (GSH), myeloperoxidase (MPO), nitric oxide (NO), superoxide dismutase (SOD), glutathione S-transferase (GST), and tissue factor activity (TFa) levels. Protein profiles in tissues were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Results: Histopathologically, MC reduced alveolar and cardiomyocyte damage in both R+MC and R+preMC groups. IR increased all oxidative stress markers and decreased antioxidant parameters in heart and lung tissues (p < 0.05-0.001). Both MC treatment and pretreatment reversed these effects, significantly reducing oxidative/inflammatory markers and restoring antioxidant enzyme activities (p < 0.05-0.001). The R+preMC group demonstrated a stronger protective effect than the R+MC group. Conclusion: Our study shows that MC has a radioprotective effect on the cardiopulmonary system by decreasing oxidative damage. MC appears to be a promising natural compound for advanced radioprotection research, and further molecular and clinical studies could clarify its mechanisms and potential applications<bold>.</bold>
  • Article
    Citation - WoS: 2
    The Effect of <i>myrtus Communis</I> L. Extract on Nephrolithiasis Model in Rats
    (Kare Publ, 2024) Ertas, Busra; Dorucu, Dogancan; Gulerturk, Oznur; Sen, Ali; Cevik, Ozge; Cetinel, Sule; Sener, Goksel
    OBJECTIVE: Nephrolithiasis is a common urological disease that can lead to renal failure. Oxidative stress has been shown to be a contributing factor for nephrolithiasis and many agents have been studied to prevent and treat oxidative stress-related nephrolithiasis and renal damage. Myrtus communis (MC) extract has been shown to be an important antioxidant in different animal models. In this study, MC extract was administered preventively or therapeutically to rats with kidney stones, and its effectiveness was investigated. METHODS: Wistar albino rats were divided into four groups (n=8); control (C), ethylene glycol (EG), EG+preventive MC, and EG+curative MC groups. The nephrolithiasis model was created by adding 0.75% EG to drinking water for 8 weeks. Ultimately, 24-hour urine was collected to measure calcium, citrate, and creatinine levels. After decapitation, kidney tissues were harvested for histological analyses, measurement of osteopontin and 8-hydroxydeoxyguanosine (8-OHdG) levels, and N-acetyl-beta-glucosaminidase (NAG), myeloperoxidase (MPO) and caspase-3 activities. RESULTS: In 24-hour urine samples, calcium, citrate and creatinine levels were decreased in the EG group, while oxalate levels were increased and in treatment groups these parameters returned to control levels. MPO, 8-OHdG, caspase-3 and NAG activity were significantly increased in tissue and these changes were reversed in both MC groups. Histological findings also supported the biochemical parameters. CONCLUSION: MC can reduce oxidative stress and histopathological changes in kidney tissues in rat nephrolithiasis model when used as either a preventive or therapeutic agent. If supported with further clinical trials, MC might have clinical implications in preventing oxidative renal cell injury and ultimately kidney stone formation.
  • Article
    Citation - WoS: 1
    Histological and Biochemical Effects of an Ethanolic Extract of <i>myrtus Communis</I> Leaf on the Pancreases of Rats Fed High Fat Diets
    (Taylor & Francis Ltd, 2024) Kabatas, Gul Sinemcan; Ertas, Busra; Sen, Ali; Sener, Goksel; Ercan, Feriha; Akakin, Dilek
    We investigated the effects of an ethanolic extract of Myrtus communis subsp. communis (MC) leaves on the pancreases of rats fed with a high fat diet (HFD). Wistar albino rats were fed either with standard lab chow (Control group) or with a 45% fat diet (HFD and HFD+MC groups) for 4 months, with the MC extract (100 mg/kg) being administered by orogastric gavage to rats in the HFD+MC group during the last month. Blood and pancreas samples were collected from all experimental groups at the end of the study. Insulin and leptin levels, and the lipid profile, were analyzed in the blood serum. Pancreatic injury was assessed histologically. Insulin, nuclear factor kappa beta (NF-kappa B), and alpha-smooth muscle actin (alpha-SMA) were assessed using immunohistochemistry. Apoptosis was assessed using terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) immunohistochemistry. In addition, oxidant/antioxidant activity was analyzed by biochemical methods. Increased body weight, serum insulin and leptin levels, blood glucose level and pancreatic tissue malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels, myeloperoxidase (MPO) activity and decreased tissue glutathione (GSH) level were observed in the HFD group compared to the Control group, in addition to dyslipidemia. An increased histopathological damage score, pancreatic islet area, insulin, TUNEL, NF-kappa B and alpha-SMA immunoreactivity were seen in animals from the HFD group compared to the Control group. However, such pathological changes were reduced in the HFD+MC group. Our data indicate further investigation of MC extract as a therapeutic adjuvant for HFD-induced pancreatic injury, acting via anti-inflammatory and antioxidant mechanisms, is worth carrying out.
  • Article
    Citation - WoS: 1
    Ameliorative Effects of Myrtus Communis L. Extract Involving the Inhibition of Oxidative Stress on High Fat Diet-Induced Testis Damage in Rats
    (Taylor & Francis Ltd, 2024) Coskunlu, Busra; Koroglu, M. Kutay; Hersek, Irem; Ertas, Busra; Sen, Ali; Sener, Goksel; Ercan, Feriha
    The possible protective effects of Myrtus communis L. (MC) extract on a high fat diet (HFD)-induced testicular injury in a rat model were investigated using histological and biochemical methods. Wistar albino rats were divided into three groups: a standard diet control group; a HFD group; and an HFD+MC group. The HFD and HFD+MC groups were fed with a HFD for 16 weeks. MC extract (100 mg/kg) was given orally five days a week to the rats in the HFD+MC group during the last four weeks of the experiment. Leptin, triglyceride, high-density lipoproteins, cholesterol, estrogen, testosterone, LH and FSH were analyzed in blood serum. Sperm parameters were evaluated from the epididymis. Testicular morphology, proliferative, apoptotic and NADPH oxidase-2 (NOX2)-positive cells were evaluated histologically. Testicular oxidative stress parameters were analyzed biochemically. In the HFD group, lipid and hormone profiles were changed, abnormal spermatozoa, degenerated seminiferous tubules with apoptotic and NOX2-positive cells were increased in number, and sperm motility and germinal proliferative cells decreased compared to the control group. Moreover, testicular malondialdehyde, 8-hydroxy-2-deoxyguanosine and myeloperoxidase levels increased, whereas glutathione and superoxide dismutase levels decreased in the HFD group compared to the control group. All these histological and biochemical features were ameliorated by MC treatment of HFD-fed rats. In conclusion, HFD caused alterations in sperm parameters and testicular morphology by increasing oxidative damage and apoptosis. MC extract may have potential protective effects by inhibiting oxidative damage.