WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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  • Article
    Protective Effects of Panax Ginseng against Bisphenol A-Induced Testicular Toxicity in Rats
    (Springer Nature, 2026) Cesur, Yasemin; Cam, Kamil; Pazarbasi, Seren Ede; Dorucu, Dogancan; Sener, Goksel; Abas, Burcin Irem; Cevik, Ozge
    Bisphenol A (BPA) is an endocrine-disrupting chemical known to cause testicular toxicity through oxidative stress and apoptosis. Panax ginseng (PG) is a natural product with anti-inflammatory effects. This study aimed to evaluate the protective effect of PG against BPA-induced testicular damage in rats. Thirty-two Wistar Albino rats aged 10-12 weeks were divided into four groups: Control, PG, BPA, and BPA + PG. BPA (50 mg/kg/day) and PG (100 mg/kg/day) were orally administered for 6 weeks. BPA significantly increased serum total oxidant status and decreased antioxidant status (p < 0.001, p < 0.001). Also, the levels of superoxide dismutase (an antioxidant enzyme) (p = 0.0005) and androgen receptor-mRNA (an androgen signaling marker) decreased (p = 0.014). However, caspase 3 (an apoptosis marker) (p = 0.0067), 8-hydroxy-2'-deoxyguanosine (a marker of oxidative DNA damage) (p < 0.001), and tumor necrosis factor-alpha (a proinflammatory cytokine) (p < 0.001) levels increased in testicular tissues. Rats treated with PG showed improvements in all oxidative and inflammatory markers and significantly restored androgen receptor expression. Histopathological examination revealed degeneration in seminiferous tubules and reduced spermatozoa in the BPA group, while the BPA + PG group showed marked improvement. These findings suggest that PG may alleviate oxidative stress-related testicular damage at both molecular and histological levels and may offer insights for future clinical studies.
  • Article
    Pathologies of the Modern Paradigm and the Refugee Question: A Critical Analysis
    (Springer Nature, 2026) Yamaner, Onur; Ozalp, Ahmet
    This article examines the internal contradictions and social pathologies generated by the modern paradigm, focusing especially on the issue of migration. Using epistemological critiques from thinkers like Adorno, Kuhn, Popper, Hayek, and the Frankfurt School, the paper argues that modernity's promise of universal rationality and scientific progress has frequently resulted in structures that are exclusionary, homogenizing, and sometimes even totalitarian. The paper then links these theoretical debates to contemporary migration. It emphasizes how refugee women-especially those facing the combined challenges of gender and displacement-experience complex layers of social invisibility and discursive erasure. By critically applying recognition theory and discourse analysis, the study highlights how modernity's promise of inclusion frequently hides the actual mechanisms of marginalization. In this part, the article demonstrates that these marginalization processes are linked to the scientific premises of the modern paradigm and considers the migration problem as an example of the pathology of the modern paradigm.