WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Assessment of the Nutritional Status of Syrian Refugee Women in the Lactation Period(Sage Publications Inc, 2026) Isik, Tulay; Garipagaoglu, MuazzezBackground: The Syrian civil war has caused large-scale displacement, with many Syrian refugee women migrating to T & uuml;rkiye. Lactation is a critical period requiring adequate nutrition for maternal and infant health. However, data on the nutritional status of lactating Syrian refugee women are limited. Aim: This study aimed to assess the nutritional status of lactating Syrian refugee women who migrated to T & uuml;rkiye due to the Syrian civil war. Methods: A cross-sectional study was conducted between October 5, 2017, and January 29, 2018, with 102 lactating Syrian refugee women with infants aged 0-6 months attending the Istanbul Al Farah Child and Family Support Center. Participants were selected using convenience sampling. Inclusion criteria were being a Syrian refugee woman in the lactation period, having an infant aged 0-6 months, and volunteering to participate in the study. Women with chronic illnesses or metabolic disorders were excluded. Data were collected through face-to-face interviews with the assistance of a translator, using a structured Turkish questionnaire covering demographic information, anthropometric measurements, and 3-day dietary records. Dietary intake was analyzed with the BEBIS9 program and compared to the T & uuml;rkiye Nutrition Guide recommendations. Although the dietary data were collected in 2017-2018, the analysis was conducted using the most up-to-date national guidelines to reflect current public health priorities. Results: Participants (n = 102) had an average age of 27.9 +/- 5.7 years, BMI of 27.3 +/- 4.6 kg/m(2), and monthly income of 1267 TL. Their daily energy intake was 1593.7 +/- 556.5 kcal/day. A large proportion of participants had inadequate intake of micronutrients, with the highest insufficiency observed for pyridoxine (88.2%), followed by vitamin A (81.4%), vitamin C (76.5%), thiamine (71.5%), riboflavin (63.7%), folic acid (81.4%), vitamin B12 (72.6%), iron (62.8%), and zinc (68.6%). Women with higher BMI in early lactation consumed more fat (p < 0.05). Significant associations were found between micronutrient intake and sociodemographic factors (p < 0.05). However, due to the small sample size and use of convenience sampling, the generalizability of the findings is limited. Future studies with larger and more representative samples are needed to confirm these results. Conclusion: Syrian refugee women in the lactation period showed inadequate intake of energy and essential micronutrients, likely due to poor socioeconomic and living conditions. Interventions such as culturally sensitive nutrition education, postpartum micronutrient supplementation, and improved access to migrant-friendly healthcare services are needed. Additionally, targeted policies and sustainable public health nutrition programs-such as food voucher schemes, fortified food distribution, and maternal support groups-should be developed in collaboration with health institutions and NGOs to improve maternal and infant health outcomes in this vulnerable population.Article New Age Negotiations of Power in Türkiye: A Representation of Diverse Profiles(Univ Pennsylvania Press, 2026) Aytimur, Hilal; Guney, H. SerhatNew Age spirituality intersects with power relations in complex ways. This exploratory study investigates how practitioners in T & uuml;rkiye navigate these intersections. Employing a Bourdieusian framework and utilizing survey data analyzed through cluster analysis, we ity and their interactions with its media and discourses. This analysis reveals distinct approaches to power relations within both the New Age field and the broader socio- political context. Our findings identify three distinct groups: vigilant adopters, negotiated readers, and devoted practitioners. This paper argues that these diverse engagements demonstrate that New Age spirituality in T & uuml;rkiye functions not as a unified challenge to or acceptance of power relations, but as a complex field needs, and social positioning, often resulting in nuanced or even contradictory stances towards societal structures.Article 1,2,4-Triazole Conjugates as HEGFR Inhibitors: Synthesis, Anticancer Evaluation, and in Silico Studies(Wiley-V C H Verlag GmbH, 2026) Bulbul, Bahadir; Kulabas, Necla; Gurboga, Merve; Ozakpinar, Ozlem Bingol; Cakmak, Ummuhan; Tuncay, Fulya Oz; Kucukguzel, IlkayA series of novel 1,2,4-triazole-acetamide derivatives was synthesized and evaluated for anticancer and hEGFR inhibitory activity. The compounds were obtained via multistep synthesis and characterized by spectroscopic methods. Cytotoxicity was tested against PC-3, MCF-7, A549, and K562 cell lines. Compounds <bold>18</bold>, <bold>19</bold>, and especially <bold>24</bold> showed notable antiproliferative effects, with compound <bold>24</bold> exhibiting higher selectivity and potency than gefitinib. It also induced apoptosis and inhibited migration in A549 and PC-3 cells, while selectively promoting invasion in PC-3, suggesting EMT-related behavior. In vitro kinase assays revealed compound <bold>20</bold> as the most potent hEGFR inhibitor (IC50 = 43.8 +/- 1.3 nM). Molecular docking and 200 ns molecular dynamics simulations confirmed its stable interaction with EGFR, particularly involving Cys797. These findings highlight compounds <bold>20</bold> and <bold>24</bold> as promising candidates for further development as EGFR-targeted anticancer agents.Article The Influence of Leisure Screen Time on Sleep Patterns and Feeding Behaviors in Primary School Children(Routledge Journals, Taylor & Francis Ltd, 2026) Aydoner Bektas, Selen; Bumin, GoncaThe increasing use of screen-based devices in children's daily lives has raised concerns about their effects on health behaviors such as sleep and feeding. This study investigated the relationship between leisure screen time and sleep and feeding problems in primary school children. A cross-sectional survey was conducted with 322 children aged 7-10 years and their parents. Parents completed questionnaires measuring children's daily leisure screen time, sleep patterns, and feeding behaviors. Results showed that weekend leisure screen time (M = 149.4 minutes/day) was higher than weekdays. Significant positive correlations were found between leisure screen time and both total feeding problem scores (weekdays: r = 0.22; weekends: r = 0.25, p < .01) and sleep disturbances (weekdays: r = 0.29; weekends: r = 0.32, p < .01). The most affected areas were selective eating and sleep initiation/maintenance. Regression analysis revealed that weekend leisure screen time significantly predicted feeding problems (beta = 0.22, p = .001) and sleep disturbances (beta = 0.27, p < .001), explaining 8% and 12% of the variance, respectively. The findings indicate the importance of managing children's screen time - particularly on weekends - to support healthier sleep and eating patterns and guide family-based interventions.Article Metformin Attenuates PTZ-Induced Seizures and Cognitive Impairment and Is Associated with Altered NOS/NO Signaling: Combined in Vivo and in Silico Evidence(Taylor & Francis Ltd, 2026) Ciltas, Arzuhan Cetindag; Sahin, Bilal; Hacisuleyman, Levent; Çetindağ Çiltaş, ArzuhanBackground: Epilepsy remains a major neurological disorder with high rates of drug resistance and cognitive decline. Repurposing neuroprotective drugs offers a promising approach. Metformin, a widely used antidiabetic agent, has shown anticonvulsant effects, yet its impact on nitric oxide synthase (NOS) isoforms in distinct brain regions remains unclear. Methods: Adult male Wistar rats were allocated into control, pentylenetetrazole (PTZ), or metformin+PTZ groups. Metformin (200 mg/kg, i.p.) was administered for 7 days before induction of acute PTZ seizures (45 mg/kg, i.p.). Seizure severity and latency were assessed using Racine's scale, and cognition was evaluated by the passive avoidance test (PAT). Nitric oxide (NO) and the expression of its synthesizing enzymes, inducible (iNOS), neuronal (nNOS), and endothelial (eNOS), were quantified in the cortex and hippocampus via enzyme-linked immunosorbent assay (ELISA). In silico analyses included target prediction and molecular docking to assess metformin - NOS interactions. Results: Metformin significantly reduced seizure severity, prolonged latency to the first myoclonic jerk, and prevented PTZ-induced memory impairment (all p < 0.001). These behavioral effects were accompanied by reductions in cortical and hippocampal nNOS and iNOS expression, decreased cortical eNOS levels, and lower NO accumulation. TargetNet predicted NOS isoforms among potential metformin targets, and docking indicated moderate binding affinity (-5.2 to -5.9 kcal/mol). Conclusion: Metformin exerted seizure-suppressing and cognition-preserving effects in an acute PTZ model, associated with reductions in NOS isoform expression and NO levels, suggesting altered NOS/NO signaling and supporting its potential as an adjunctive candidate for mitigating seizure-related neuronal dysfunction.Article The Effect of Sportive Latin American Ballroom Dance on Foot and Ankle Posture(Amer Podiatric Med Assoc, 2025) Kayiskiran, Onurcan; Coskunsu, Dilber Karagozoglu; Isiklar, CagdasBackground: Correct use of the feet, step techniques, and positions constitute significant factors in the success of a dancer. Moreover, the type of dance has crucial effects on the posture of the foot and ankle. Therefore, the primary aim of our study was to determine whether there was a relationship between dancesport, dance experience (years), shoe-wearing time (hours), and shoe heel height (centimeters) in dance athletes performing Sportive Latin American Ballroom (SLAB) dance. Second, we aimed to compare the foot posture of SLAB dancers and nondancers with similar demographic characteristics. Methods: Twenty-six professional SLAB dancers and 26 nondancers who had similar demographic characteristics and did not use high-heeled shoes volunteered to take part in this study. Foot posture (using the Foot Posture Index [FPI]), foot pronation (using the navicular drop test [NDT]), tibiocalcaneal angle, hallux valgus angle (HVA) (using a goniometer), and ankle dorsiflexion range of motion (ROM) (using the weightbearing lunge test) were evaluated. Results: There was a positive moderate correlation between FPI score and shoe-wearing time on the dominant (P = .041; r = 0.40) and nondominant (P = .026; r = 0.43) sides. A positive very good correlation was found between shoe heel height and HVA (P < .001; r = 0.75). A negative good correlation was observed between years of dancing and nondominant ankle dorsiflexion ROM (P = .027; r =-0.43). When dancers and nondancers were compared, a statistically significant difference was found between FPI and NDT scores (P < .001). The FPI and NDT scores, tibiocalcaneal angle, HVA, and ankle dorsiflexion ROM were significantly greater in the dancer group compared with the nondancer group (P < .001) in all measurements of the dominant and nondominant sides. Conclusions: Revealing the relationship between dance experience and shoe-wearing time and the difference between the foot posture and deformities of athletes who perform SLAB dance and those of nondancers constitutes a pivotal endeavor that will increase awareness and knowledge among dancers and clinicians. (J Am Podiatr Med Assoc 115(6), 2025; doi:10.7547/24-030)Article Examination of the Relationship Between Mothers' Self-Confidence and Maternal Attachment in the Postpartum Period(Springer Publishing Co, 2025) Kilic, Melek; Yilmaz, Tulay; Kaya, Husniye Dinc; Gunaydin, Sevil; Dinç Kaya, HüsniyeOBJECTIVE: The relationship between self-confidence and maternal attachment during the postpartum period is critical to both the infant's healthy development and the mother's psychosocial adjustment. This study aimed to evaluate the association between mothers' self-confidence levels and maternal attachment during the postpartum period. METHOD: The study employed a descriptive and correlational design. A purposive sampling method was used in the study, and 147 mothers who were between 1 and 4 months postpartum, over the age of 18 years, able to communicate in Turkish and competent to fill out an online survey were included in the study. The data collection tools included the Descriptive Information Form, the Karitane Parenting Confidence Scale (KPCS), and the Maternal Attachment Inventory (MAI). The collected data were processed and analyzed using the Statistical Package for the Social Sciences for Windows, version 24.0. RESULTS: The participants' mean total KPCS score was 35.95 +/- 4.39, and the mean MAI score was 92.71 +/- 5.34. No statistically significant association was found between maternal attachment and parental confidence levels (p > .05). Additionally, no significant differences were observed between participants' sociodemographic characteristics and their scale scores (p > .05). CONCLUSIONS: The findings suggest that maternal confidence and attachment, although both essential components of postpartum adjustment, function as independent constructs influenced by different psychological and contextual mechanisms. Understanding these dimensions separately may provide insights for developing targeted interventions to support mothers in the early postpartum period.Article Evaluation of Pulmonary Function Test and Peripheral Muscle Strength in Smoking and Non-Smoking University Students(Georg Thieme Verlag KG, 2025) Tekeoglu Tosun, Anil; Yilmaz, Nergis; Uysal, Ogulcan; Aydin, Buket; Cambel, Ilayda; Karagozoglu Coskunsu, DilberObjective This study was conducted to compare pulmonary function and peripheral muscle strength in smoking and non-smoking university students. Materials and Methods Data were collected from 120 volunteer university students aged between 18 and 25 years, who were divided into two groups regardless of gender after their smoking status had been determined. Data were collected using a sociodemographic form, the Pulmonary Function Test (PFT), and the Five Times Sit-to-Stand and Six-Minute Walk tests to assess peripheral muscle strength. These tests were applied to both smoking and non-smoking groups. Results According to GLI 2012 reference values, female non-smokers exhibited significantly higher FEV1 and FEV1/FVC z-scores compared to female smokers (p<0.001 and p=0.008, respectively), whereas no significant differences were observed among males. No significant differences were found between smokers and non-smokers in peripheral muscle strength tests overall; however, gender-specific analyses revealed significant differences in some tests. Conclusion Significant differences were found in some pulmonary function tests between smoking and non-smoking university students, while no overall difference was observed in peripheral muscle strength. Gender-based subgroup analyses suggested varying effects on muscle strength and pulmonary function. Developing targeted smoking awareness programs for university students is important for public health.Article The Futures of New Diplomatic History in a Shifting International Order(Brill, 2025) Papuccular, HazalThis essay reflects on the agenda of globalizing diplomatic history as put forward in the manifesto "Provincializing `New' Diplomatic History." It first emphasizes that the Manifesto overlooks key structural dynamics, such as the transformation of the global order. These structural shifts have the potential to significantly influence the trajectories of global diplomatic history. This signifies that the suggestion for global diplomatic history is not merely an epistemic endeavor, but one that must also grapple with the politics of writing global - diplomatic - history in an age of rising disconnections and in an increasingly post-Western world order. Second, the essay points out that New Diplomatic History remains useful in many contexts, even if in a somewhat parochial form, because in many non-Western settings, it still represents a nascent approach to study diplomatic history. Thus, it still holds the potential to generate novel contributions to the historiography of diplomacy.Article In Vivo and In Silico Evaluation of the Effects of Parsley (Petroselinum Crispum L.) Extract on Small Intestinal Tissue in Scopolamine-Induced Cognitive Dysfunction Model(Wiley-VCH Verlag GmbH, 2025) Ertik, Onur; Sacan, Ozlem; Sener, Goksel; Pazarbasi, Seren Ede; Yanardag, RefiyeThe brain-small intestine connection has become important in neurodegenerative diseases in recent years. In particular, the discovery of the relationship between Alzheimer's disease (AD) and the small intestine and the examination of the effects of AD on this tissue are important in this respect. Our study aimed to understand the effects of the experimentally created AD model in rats on the small intestinal tissue and the protective effect of the extract prepared from parsley leaves (PE). The experimental animals were divided into four groups in the study; Control, Scopolamine (Scop), Scop + PE and Scop + Galantamine (GAL). Oxidative stress parameters and activities of some important enzymes were examined in small intestinal tissues taken as a result of the experimental protocol. Additionally, in silico studies were carried out for bioactive molecules found in parsley leaves using data obtained from in vivo enzyme activity results. It was found that parameters examined for the damaged group, Scop, were reversed by PE and GAL treatment. As a result of in silico studies, it was determined that oxypeucedanin and phylloquinone had higher binding affinity than rutin for acetylcholinesterase (AChE). It has been observed that oxidative damage in the small intestine due to AD can be treated by the PE.