Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7
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Article Protective Effects of Lactobacillus Rhamnosus GG Against Methotrexate-Induced Oxidative Renal Toxicity(Springer, 2026) Yanardag, Refiye; Bayrak, Bertan Boran; Sener, Goksel; Almurad, Bade; Donmez, Muhammet OguzhanMethotrexate (MTX) is commonly prescribed for various malignant and autoimmune conditions, but it can cause significant oxidative and functional impairment in renal tissue. Lactobacillus rhamnosus GG. (LGG) is a well-known probiotic with biological activities that support antioxidant balance. This study investigated the impact of LGG on MTX-induced kidney damage. Male Sprague-Dawley rats were divided into four groups: physiological saline-treated control group; a group receiving MTX alone; a group receiving MTX alongside a low dose of LGG; and a group receiving MTX alongside a high dose of LGG. MTX was administered as single dose (20 mg/kg/bw) intraperitoneally and LGG (low dose 1 x 10(9) CFU/day and high dose 5 & times; 10(9) CFU/day, respectively) orally for five days. On day six, blood and kidney samples were collected and examined for oxidative indicators, enzymatic antioxidant responses, and renal functional markers. MTX significantly increased in glomerular filtration markers in serum and elevated key indicators of oxidative stress in renal tissues. More so, MTX demonstrated to disrupt renal ionic homeostasis, such as declined sodium/potassium-ATPase, paraoxonase, and increased lactate dehydrogenase, carbonic anhydrase, xanthine oxidase, myeloperoxidase, and arginase activities. In contrast, LGG supplementation has been shown to effectively reverse all MTX-induced biochemical alterations in both serum and renal tissue. We can suggest that LGG can provide significant protection against oxidative renal toxicity induced by MTX in rats.Article Lactobacillus Rhamnosus GG Alleviates Bisphenol-A Induced Oxidative Stress in Serum(Marmara University, Faculty of Pharmacy, 2025) Şener, Göksel; Tunali-Akbay, Tugba; Dorucu, Dogancan; Ede-Pazarbasi, Seren; Dede, Pınar; Ede-Pazarbas, SerenThe objective of this investigation was to identify changes in the serum oxidant-antioxidant balance of rats exposed to bisphenol A (BPA) and to investigate the impact of Lactobacillus rhamnosus GG (LGG) administration on those changes. Twenty-four rats (Wistar Albino, 250-300 grams, male) were divided into control, BPA, and BPA+LGG groups with an equal number of rats. BPA and LGG were applied to the rats in the relevant groups for six weeks, five days each week. Six weeks later, the blood samples were withdrawn and serum samples were prepared. Total oxidant and antioxidant status (TAS), glutathione, and lipid peroxidation determinations were determined in serum samples, and the oxidative stress index was calculated. BPA exposure decreased serum total antioxidant status and increased serum total oxidative status, oxidative stress index, and lipid peroxidation level compared to the control group. LGG administration improved the increased serum oxidative stress caused by BPA. Administration of LGG to BPA-treated rats reversed oxidative stress-induced changes. In conclusion, administration of Lactobacillus rhamnosus GG to rats for 30 consecutive days prevented oxidative stress in serum caused by bisphenol A.