Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7
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Book Part Cell-Based Therapy for Cancer in Regenerative Medicine(CRC Press, 2025) Sel, Figen Abatay; Oǧuz, Fatma SavranRegenerative medicine focuses on developing and applying new cell-based therapies to heal tissues and organs and restore function lost due to aging, disease, tissue damage, or cancer. Cancer is a complex disease. It can occur with dysfunction in multiple systems, including DNA repair and apoptotic and immune functions. One form of regenerative medicine is cancer immunotherapy. In cancer immunotherapy, the immune system is activated, replaced, engineered, or regenerated to fight cancer. Stem cells are the most widely used for cancer immunotherapy. Stem cells have a natural capacity for self-healing via asymmetric division. Mesenchymal stem cells (MSCs) are a specific group of stem cells that have the potential to be used most often in regenerative medicine. In addition to MSCs, induced pluripotent stem cells (iPSCs) and hematopoietic stem cells (HSCs) are used in regenerative medicine for cancer treatment. This chapter will discuss using different types of stem cells in other cancers and the pros and cons of using stem cell-based therapies. © 2025 Elsevier B.V., All rights reserved.Article Citation - WoS: 6Citation - Scopus: 4Exploring Effects of the Hep (homeostasis-Enrichment Approach as a Comprehensive Therapy Intervention for an Infant With Cerebral Palsy: a Case Report(Georg Thieme verlag Kg, 2022) Balikci, Aymen; Ballkcı, AymenCerebral palsy (CP) is a common non-progressive neurodevelopmental disorder which causes developmental disabilities in children. Varied interventions for CP exist to address medical and physical needs but with limited effectiveness evidence. Environmental enrichment (EE) is an animal model intervention for many neurodevelopmental disorders, including CP, with considerable positive effects. This case report defines the Homeostasis-Enrichment-Plasticity (HEP) approach, which is based upon principles of EE and ecological theories of development and describes its use to promote the developmental and functional skills of an infant with CP. Parent interviews and assessment data were completed before and after intervention. For the interested parameters data was gathered by developmental history, systematic observation of behaviors in the clinical setting and at home, Beck Anxiety Inventory (BAI), Infant-Toddler Symptom Checklist, the Sensory Profle Infant/Toddler, Peabody Developmental Motor Scales-2, Gross Motor Function Measurement-88 (GMFM-88), the Gross Motor Function Classification System (GMFCS), and Pediatric Evaluation of Disability Inventory (PEDI). The HEP approach intervention was implemented one time per week for 12 months. Following the HEP approach intervention, self-regulation and sensory processing scores improved. GMFM-88 total score improved from 45/264 to 123/264. The Peabody found all gross motor (54-110), fine motor (65-117), and total motor quotient (119-227) scores improved after intervention. Post-intervention observations showed obvious gross motor progress with movement from GMFCS Level IV to Level I. Performance on the Functional Skills Scales and Caregiver Assistance Scales of PEDI also demonstrated notable improvements. BAI scores revealed low anxiety scores for both the mother (13/63 points) and father (14/63) before intervention. These scores did not change after intervention. A definition and detailed description of the HEP approach intervention is presented here for the first time. The case report demonstrated preliminary evidence for the effectiveness of the HEP approach on self-regulation, sensory processing, motor development, functional skills, and caregiver assistance with an infant with CP. Additional studies are needed to validate the findings.