Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7
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Article Synthesis, Molecular Modeling, Anti-Cancer and COX-1/2 Inhibitory Activities of Novel Thiazolidinones Containing Benzothiazole Core(Bangladesh Pharmacological Society, 2024) Kulabas, Necla; Guven, Cansu Tamniku; Duracık, Merve; Bingol Ozakpinar, Ozlem; Küçükgüzel, İlkay; Ozakpinar, Ozlem BingolIn this study, new 1,3-thiazolidin-4-one derivatives containing arylmethylene groups in the 5-position were obtained from 6-(trifluoromethoxy)-1,3-benzo-thiazol-2-amine (riluzole). Synthesized compounds were characterized by spectral data and elemental analysis. In vitro, cytotoxic activities of the synthesized molecules were evaluated against the human lung cancer (A549) and human prostate cancer (PC-3) cell lines. Compounds were also tested on mouse embryonic fibroblast cells (NIH/3T3) to determine selectivity. Ten target compounds 3-12 were also screened for their COX-1 and COX-2 inhibitory activities. Of these compounds, 4 showed the highest COX-2 inhibition at 10 μM. Molecular docking calculations were performed to understand the binding interactions of compounds with COX-1 and COX-2 proteins. In silico studies of the tested compounds represented important binding modes that may be responsible for their anti-cancer activity via selective inhibition of the COX-2 enzyme. ADMET predictions were conducted to assess the drug-like properties of the novel compounds. © 2024 Elsevier B.V., All rights reserved.Book Part Cell-Based Therapy for Cancer in Regenerative Medicine(CRC Press, 2025) Sel, Figen Abatay; Oǧuz, Fatma SavranRegenerative medicine focuses on developing and applying new cell-based therapies to heal tissues and organs and restore function lost due to aging, disease, tissue damage, or cancer. Cancer is a complex disease. It can occur with dysfunction in multiple systems, including DNA repair and apoptotic and immune functions. One form of regenerative medicine is cancer immunotherapy. In cancer immunotherapy, the immune system is activated, replaced, engineered, or regenerated to fight cancer. Stem cells are the most widely used for cancer immunotherapy. Stem cells have a natural capacity for self-healing via asymmetric division. Mesenchymal stem cells (MSCs) are a specific group of stem cells that have the potential to be used most often in regenerative medicine. In addition to MSCs, induced pluripotent stem cells (iPSCs) and hematopoietic stem cells (HSCs) are used in regenerative medicine for cancer treatment. This chapter will discuss using different types of stem cells in other cancers and the pros and cons of using stem cell-based therapies. © 2025 Elsevier B.V., All rights reserved.