Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7
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Article Citation - WoS: 1Citation - Scopus: 1Anti-Lipid Accumulation and Antioxidant Effects of the Root Extract From Rubus Discolor and Its Phytochemical Analysis(Springer Science and Business Media Deutschland GmbH, 2025) Şekerler, T.; Gülmez, G.; Algül, K.F.; Göger, F.; Şenkardeş, İ.; Şen, A.; Şener, A.Rubus species exhibit potent antioxidant properties due to their high phenolic compound content. In our study, phytochemical composition of the extract obtained from roots of Rubus discolor (RDE) was determined using LC-MS/MS. Subsequently, effect of this extract on lipid accumulation was investigated in HepG2 liver cells. For this purpose, HepG2 cells were treated with oleic acid to induce lipid accumulation. The effect of RDE on lipid accumulation was assessed using Oil-Red staining and measuring intracellular triglyceride, cholesterol levels. Melatonin was used as a positive control. Enzymes involved in lipid synthesis, including acetyl-CoA carboxylase (ACC1), fatty acid synthase (FAS), and transcription factor sterol regulatory element-binding protein 1 (SREBP-1c), as well as the antioxidant status, were evaluated by RT-PCR. As dose-dependent, RDE significantly reduced lipid accumulation and each concentrations (25, 50, 100 µg/mL) of RDE showed 78%, 48%, 38% ratio, respectively for Oil Red O staining. TG was found 1.92 ± 0.03, 1.76 ± 0.40, 1.22 ± 0.13, 1.41 ± 0.08 mg/mg protein for oleic acid and each concentrations (25, 50, 100 µg/mL) of RDE, respectively It significantly suppressed ACC1, FAS, and SREBP-1c (p < 0.001, p < 0.001, p < 0.01, respectively) at a dose of 50 µg/mL. The extract also exhibited in vitro strong antioxidant and good anti-inflammatory properties. Pedunculagin isomer, ellagic acid and ellagic acid pentoside compounds were found to be the main compounds of RDE with high total phenolic content. The results indicate that RDE has the potential to prevent lipid accumulation. These findings could provide a basis for further studies on the potential therapeutic effect of Rubus discolor in the treatment of NAFLD. © The Author(s) 2025.Conference Object Citation - Scopus: 1Cold Chain Logistics Firm Selection by Using Ahp-Vikor Integrated Method and a Case Study in Food Industry(Springer Science and Business Media Deutschland GmbH, 2020) Buyukselcuk, E.C.With the Industry 4.0, a new trend has started for all sectors and enterprises have entered into a period of intense working and investment to turn into intelligent systems. Cold chain logistics also has the same trend, and companies have pushed the button to be involved in this process. Due to changing lifestyles and generally decreasing prices, the world market for perishable products such as processed foods and cooled products is growing. Cold chain transportation is an important issue in basic food and health product logistics to prevent the growth of harmful microorganisms and to ensure that the products remain intact. In this study, it is aimed to determine the right cold chain logistics firm for company EDB that is a small and medium-sized enterprise (SME) operating in the food industry. Firstly, the selection criteria are defined according to the literature survey and expert views. AHP approach has been used to calculate the weight of them. After the determination of weight of criteria, VIKOR approach has been used to identify the best cold chain logistics firm for company EDB. The results were obtained by using Expert Choice 11.0 and Excel calculator finally the best one has been determined. © 2020, Springer Nature Switzerland AG.