Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7
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Article Comprehensive Proteomic and Metabolomic Analysis of Novel Substituted Fluoroquinolone Derivatives in Escherichia Coli Isolates(John Wiley and Sons Ltd, 2026) Nigiz Ş.; Kulabaş N.; Türe A.; Kablan S.; Koçak E.; Özkul C.; Küçükgüzel İ.; Koçak, Engin; Nigiz, Şeyma; Kablan, Sevilay Erdoğan; Özkul, Ceren; Kulabaş, Necla; Küçükgüzel, İlkay; Türe, AslıAntimicrobial resistance is one of the most important global problems, and new antibiotic requirements have been emerging as a key point in this issue. In the present work, we focused on the efficiency of two novel promising fluoroquinolone derivatives on resistant Escherichia coli isolates at the molecular level. Their mode of action and adaptation process were evaluated by using proteomics and metabolomics analysis. Proteomics analysis showed that two compounds have an effect mainly on the ribosomal process and energy metabolism. Moreover, we observed compounds that affect various important antimicrobial targets, such as ribosomal subunits, phosphotransacetylase, and chaperone proteins. In metabolomics analysis, we found that compounds altered bacterial metabolism directly. Pathway analysis showed that cofactor biosynthesis and energy metabolism were affected mainly by undertreated groups. Our experiments demonstrated that novel fluoroquinolone derivatives have promising results at the molecular level and results will contribute to further studies. © 2026 John Wiley & Sons Ltd.Article Fully Synthetic, Nature-Inspired Exosome-Mimetics for Melanoma Therapy(Elsevier B.V., 2026) Arda Ozturk N.Z.; Majchrzak O.B.; Ulivi G.; Kirmizibayrak P.B.; Borchard G.; Patrulea V.; Ozer O.; Ozturk, Nahide Zeren Arda; Borchard, Gerrit; Ozer, Ozgen; Patrulea, Viorica; Majchrzak, Oliwia Barbara; Arda Ozturk, Nahide Zeren; Kirmizibayrak, Petek Ballar; Ulivi, GianlucaFully synthetic exosome-mimetics (FSEMs) represent a nature-inspired drug delivery system designed to replicate the key physicochemical and biological properties of natural exosomes, while offering the potential to address limitations in scalability and reproducibility associated with natural exosomes. In this study, we prepared FSEMs at the laboratory scale. We loaded them with (–)-epigallocatechin-3-gallate (EGCG) and microRNA-23a (miR-23a), aiming to co-deliver therapeutic small molecules and nucleic acids for the treatment of melanoma. FSEMs were fabricated using three methods: thin-film hydration, ethanol injection, and microfluidics. They were surface-functionalized with either CD9, a tetraspanin involved in membrane fusion, or TSP-1, an adhesion protein promoting cellular interactions. Through physicochemical characterization via dynamic light scattering, we found that FSEMs were ∼ 100 nm in size, of low polydispersity (∼0.2) and showed a negative zeta potential (∼–55 mV). Both EGCG and miR-23a were efficiently encapsulated. SDS-PAGE analysis confirmed successful protein incorporation and correct positioning. In vitro release studies showed minimal premature leakage, supporting their suitability for cellular uptake-mediated delivery. When tested on melanoma cells (MDA-MB-435) and progenitor human dermal fibroblasts (FE002-SK2), FSEMs selectively killed melanoma cells while sparing fibroblasts. Importantly, EGCG within FSEMs was more effective than the free compound. Compared to conventional DOTAP-based liposomes, FSEMs were more selective and induced less off-target cytotoxicity. This study presents a proof-of-concept for fully synthetic, protein-functionalized FSEMs as dual carriers for both chemical and gene-based agents, offering a safer and potentially more effective alternative to traditional cationic liposomes. These results lay the groundwork for future in vivo validation and translational cancer research. © 2026 The Author(s)Book Part Human-Centered Safety and Ergonomic Design for Women in High-Risk Industrial Occupations: A Systematic Review within Intelligent Systems Context(AHFE International, 2026) Aytac S.; Akalp H.G.; Yamankaradeniz N.; Arlı N.B.; Arlı, Nuran Bayram; Akalp, Hüsre Gizem; Aytac, Serpil; Yamankaradeniz, NurettinWomen’s participation in high-risk sectors such as mining, construction, transportation, and healthcare continues to increase, yet industrial safety and ergonomics remain dominated by gender-neutral design assumptions. This systematic review synthesizes evidence on physical, psychosocial, and organizational challenges faced by women in hazardous environments through a human-cantered systems lens. Following PRISMA 2020 guidelines, 24 peer-reviewed studies (2010–2025) from Scopus, Web of Science, and PubMed were analyzed. The literature highlights exposure to musculoskeletal disorders (MSDs), PPE mismatch, postural load, and inequitable access to safety resources. Thematic analysis reveals that ergonomic inequalities intersect with exclusion from safety training and organizational barriers in risk management. Findings underscore the need for interdisciplinary approaches integrating ergonomics, intelligent systems, and gender studies to enable safer and more inclusive workplaces for women in high-risk occupations. © 2026 The Authors.Book Part Preventing Violence in Schools: A Psychoeducation Program Examining the Effects on Teachers Perceptions and Attitudes Toward Violence and Bullying(AHFE International, 2026) Tunca O.O.; Kaya A.G.; Cikrikci A.; Kılıc C.; Cicek H.S.; Cevher T.; Ergul E.B.; Cevher, Turker; Cicek, Havvane Sama; Kaya, Alp Giray; Tunca, Ozlem Ozden; Ergul, Esra Betul; Kılıc, Cetin; Cikrikci, AycaThis study experimentally examined changes in teachers’ and school counseling (SC) professionals’ perceptions and attitudes toward violence and peer bullying through the psychoeducational program “Preventing Violence in Schools: Where Do I Stand?”, developed by the researchers. An explanatory sequential mixed-methods design was employed. Following quantitative data collection, results were examined using a phenomenological design.The sample consisted of 36 participants 20 SC professionals and 16 subject-area teachers working in public schools in Istanbul. To test the significance of the psychoeducation, the sample was divided into two groups consisting of subject-area teachers showing similar distribution parallel to the SCs. Participants completed the Personal Information Form, “Teacher Attitudes Toward School Bullying Scale” before and after the eight-week intervention. Additionally, qualitative data were collected via the “Interview Form on Perceptions of Bullying and Violence” to obtain a deeper understanding of participants’ views. Results indicated no statistically significant differences between pre-test and post-test scores. Professional seniority and age showed significant positive correlations with the “harsh attitude” subdimension. When groups were compared, “harsh attitude” scores differed significantly, with subject teachers scoring higher. Participants’ number of children positively correlated with the “indifference attitude” dimension. Qualitative findings showed both groups perceived bullying as repetitive power dynamic. Subject teachers linked prevention gaps to systemic issues, while SCs identified stakeholders closedness to cooperation and administrative indifference as main difficulties. Regarding interventions, teachers prioritized disciplinary systems, observation, rules, whereas SCs favored child-centered consultation for all stakeholders. Both groups emphasized victim safety, emotional support, cooperation, a holistic approach in case analyses. © 2026 The Authors.Book Part Evaluation Awareness: A University Example(AHFE International, 2025) Akalp H.G.; Saklangıç U.; Aytaç S.; Saklangıç, Uğur; Akalp, Hüsre Gizem; Aytaç, SerpilIndividuals’ fire safety awareness directly affects individual and institutional safety as well as social safety. Fires are among the serious dangers that can cause loss of life and property in workplaces. Fire safety is one of the basic safety precautions that should be taken in workplaces. Reducing fire risks and increasing employees’ awareness are of great importance in terms of occupational health and safety. Fire safety awareness is a critical issue in terms of preventing occupational accidents and directly affects the effectiveness of safety precautions taken in workplaces. This study aims to evaluate the fire safety awareness level of 163 people working in a higher education institution in Turkey and reached by random sampling method, to analyze the effectiveness of current training programs and precautions and thus to reveal what kind of precautions can be taken in terms of occupational safety. The results revealed that employees have a general awareness of fire safety but they lack knowledge about emergency procedures. Within the scope of the study, it was suggested that training programs within the institution should be increased and fire drills should be carried out regularly in order to increase fire safety awareness. © 2025. Published by AHFE.Book Part Sick Relationship with Work Stress as a Psychosocial Risk: A Shopping Mall Example(AHFE International, 2024) Aytac S.; Bulbul S.; Akalp H.G.; Akalp, Husre Gizem; Aytac, Serpil; Bulbul, SahametRecently, buildings, residences, plazas, shopping malls, skyscrapers and towers that have been rising all over the world have begun to form our living spaces as smart structures where private, social and business lives are carried out. The fact that these closed spaces threaten the health of people living and working in them and cause diseases, has led to these buildings being called “sick building syndrome (SBS)”. Sick building syndrome results in the health of people who spend time and work in these buildings being affected both physically and psychologically. The aim of this study is to reveal the symptoms of sick building syndrome and its effects on stress, which is a psycho-social risk at workplace. A cross-sectional study conducted in two randomly selected shopping malls in Turkey involved 268 employees. Research findings indicate that employees suffer from symptoms like dry throat, runny nose, eye irritation, headaches, muscle-joint pain and fatigue. Additionally, it has been observed that these symptoms intensify during peak weekend traffic Moreover, the sick buildings phenomenon increases the stress levels of employees’ due to the conditions associated with enclosed spaces. © 2024. Published by AHFE.Article Social Media and Financial Decisions: The Influence of Socio-Demographics and Financial Literacy(John Wiley and Sons Inc, 2026) Altinbas, H.This study investigates the predictors of individuals' reliance on social media for financial decision-making within the context of Türkiye's high-inflation environment and the associated surge in retail investor participation. Data were collected via an online survey utilizing the OECD's financial literacy toolkit. The results indicate that gender, family structure, high-risk asset preferences, and financial literacy predict social media usage for financial information. Specifically, males, individuals who invest in stocks or cryptocurrencies, and those with higher financial literacy demonstrate a greater propensity to access financial information on social media; conversely, households with children exhibit lower reliance on social media information. © 2026 American Association of Family and Consumer Sciences.Article “Our Lives Have Gone” Experiences in and After Kahramanmaraş\Türkiye Earthquake: A Qualitative Research(Istanbul University-Cerrahpasa, Florence Nightingale Faculty of Nursing, 2025) Gümüş, F.; Dikeç, G.AIM: This study aimed to examine the experiences and emotions of individuals who experienced the Kahramanmaraş earthquake. METHODS: This study’s data, which were collected using qualitative research methods, were collected through face-to-face individual interviews between March 20 and March 21, 2023, after the earthquake in Hatay and Diyarbakır. The purposive sample method, one of the purposeful random sampling methods, was used in the research. A total of 35 individuals formed the study’s sample. Colaizzi’s phenomenological interpretation method was used in the analysis of the data. RESULTS: The data obtained from the individual interviews with the participants were gathered under three main themes: earthquake moment, emotions, and after the earthquake. In the study, it was determined that the participants stated that they were terrified by the noise and shaking at the time of the earthquake; they could not go out immediately, it was cold when they went out, and they witnessed that everywhere was dark and destroyed. It was determined that the emotions experienced by the participants were anger, helplessness, guilt, hope, and hopelessness, and they expressed their needs after the earthquake, the difficulties in getting help, and the losses they experienced. CONCLUSION: Remarkably, the study results are often parallel to acute stress, loss, and grief reactions, and the needs of individuals are the basic principles of psychological first aid. © 2025, Istanbul University-Cerrahpasa, Florence Nightingale Faculty of Nursing. All rights reserved.Article Peloid Therapy Versus Hot Pack Treatment in Patients with Chronic Low Back Pain: Effects on Pain, Function, and Quality of Life(Romanian Association of Balneology, 2025) Akkurt, B.; Alptekin, H.K.; Aydin, T.This study aimed to compare the efficacy of peloid and hotpack for chronic low back pain (CLBP) due to lumbar disc herniation (LDH). Sixty individuals aged 18–50 years with CLBP due to LDH were randomized into two groups: peloid therapy (n=30) and hot pack therapy (n=30). Treatments were applied five days a week for 15 sessions, and all partici-pants received 20 minutes of lumbar TENS per session. Evaluations were conducted before and after treatment, including pain (VAS), Back Pain Functional Scale (BPFS), Oswestry Disability Index (ODI), quality of life (SF-36), range of motion, and finger-floor distance (FFD). Peloid group showed significant improvements in BPFS, physical functioning, role limitations due to emotional problems, vitality, emotional well-being, pain, and general health compared to the hot pack group (p<0.05). Both groups showed significant reducti-ons in VAS, ODI and FFD scores (p<0.05), with no significant between-group differences (p>0.05). In conclusion, while both treatments were effective in reducing pain and disabili-ty, peloid therapy provided superior improvements in functional status and quality of life compared to hot pack therapy. © 2025 by the authors.Conference Object Classification of Noisy Histopathology Images with Bayesian and Ensemble Deep Learning(SPIE, 2025) Akturk, B.; Bilgin, G.The classification of histopathology image data using deep learning algorithms is a pivotal aspect in cancer diagnosis, offering crucial benefits in terms of accuracy and rapid decision-making for pathologists, technologists, clinicians, and researchers. However, the complex process of data structuring and labeling often involves the presence of noisy or outlier labels and images, which inevitably diminish the training and predictive efficacy of classification models. This study introduces an innovative approach for classifying histopathology images with noisy characteristics, presenting a learning process resilient to noise. In this dataset, where classification performance is inherently challenged, popular transfer learning models are integrated with Bayesian deep learning and ensemble learning algorithms. This integration helps mitigate common problems such as overfitting and underfitting in outlier data predictions, yielding more stable outcomes. These hybrid methods, unaffected by the noise and uncertainty in data structures, demonstrate performance comparable to, or even surpassing, transfer learning algorithms. Consequently, the viability of addressing real-world noisy dataset scenarios is enhanced. Experimental results indicate that the proposed ensemble Bayesian transfer learning algorithms match the success of pre-trained transfer learning algorithms and offer an alternative to time-consuming model validation techniques, underscoring the practical application of ensemble Bayesian transfer learning in enhancing uncertainty assessments. · © 2025 SPIE · 0277-786X ·