Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7
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Article Comparative Evaluation of Vision Transformers and Convolutional Networks for Breast Ultrasound Image Classification(Open Exploration Publishing Inc, 2026) Naral S.; Cakmak Y.; Pacal I.; Pacal, Ishak; Cakmak, Yigitcan; Naral, SuleymanAim: Interobserver variability continues to limit the consistency of breast ultrasound interpretation. This study compares two Vision Transformer (ViT) models and two Convolutional Neural Network (CNN) models for automated three-class breast ultrasound classification, with a specific focus on the tradeoff between predictive performance and computational efficiency. Methods: Swin Transformer Base and DeiT Base were evaluated alongside InceptionV3 and MobileNetV3 Large using the public Breast Ultrasound Images (BUSI) dataset, which contains 780 images labeled as benign, malignant, and normal. A consistent on-the-fly augmentation pipeline was applied during training to promote robustness and reduce sensitivity to incidental image variations. Results: Swin Transformer Base achieved the highest test accuracy (0.9167) and F1 score (0.8981). MobileNetV3 Large reached an accuracy of 0.8583 with substantially lower computational demand. The efficiency contrast was pronounced, with Swin requiring 30.33 GFLOPs versus 0.43 GFLOPs for MobileNetV3 Large. Conclusions: On this benchmark, ViT models can yield higher classification performance, while lightweight CNNs offer a strong efficiency profile that may better match deployment-constrained settings. These results suggest that model selection should be guided by both predictive accuracy and operational feasibility within the target clinical workflow. © The Author(s) 2026.Article Comprehensive Proteomic and Metabolomic Analysis of Novel Substituted Fluoroquinolone Derivatives in Escherichia Coli Isolates(John Wiley and Sons Ltd, 2026) Nigiz Ş.; Kulabaş N.; Türe A.; Kablan S.; Koçak E.; Özkul C.; Küçükgüzel İ.; Koçak, Engin; Nigiz, Şeyma; Kablan, Sevilay Erdoğan; Özkul, Ceren; Kulabaş, Necla; Küçükgüzel, İlkay; Türe, AslıAntimicrobial resistance is one of the most important global problems, and new antibiotic requirements have been emerging as a key point in this issue. In the present work, we focused on the efficiency of two novel promising fluoroquinolone derivatives on resistant Escherichia coli isolates at the molecular level. Their mode of action and adaptation process were evaluated by using proteomics and metabolomics analysis. Proteomics analysis showed that two compounds have an effect mainly on the ribosomal process and energy metabolism. Moreover, we observed compounds that affect various important antimicrobial targets, such as ribosomal subunits, phosphotransacetylase, and chaperone proteins. In metabolomics analysis, we found that compounds altered bacterial metabolism directly. Pathway analysis showed that cofactor biosynthesis and energy metabolism were affected mainly by undertreated groups. Our experiments demonstrated that novel fluoroquinolone derivatives have promising results at the molecular level and results will contribute to further studies. © 2026 John Wiley & Sons Ltd.Article Fully Synthetic, Nature-Inspired Exosome-Mimetics for Melanoma Therapy(Elsevier B.V., 2026) Arda Ozturk N.Z.; Majchrzak O.B.; Ulivi G.; Kirmizibayrak P.B.; Borchard G.; Patrulea V.; Ozer O.; Ozturk, Nahide Zeren Arda; Borchard, Gerrit; Ozer, Ozgen; Patrulea, Viorica; Majchrzak, Oliwia Barbara; Arda Ozturk, Nahide Zeren; Kirmizibayrak, Petek Ballar; Ulivi, GianlucaFully synthetic exosome-mimetics (FSEMs) represent a nature-inspired drug delivery system designed to replicate the key physicochemical and biological properties of natural exosomes, while offering the potential to address limitations in scalability and reproducibility associated with natural exosomes. In this study, we prepared FSEMs at the laboratory scale. We loaded them with (–)-epigallocatechin-3-gallate (EGCG) and microRNA-23a (miR-23a), aiming to co-deliver therapeutic small molecules and nucleic acids for the treatment of melanoma. FSEMs were fabricated using three methods: thin-film hydration, ethanol injection, and microfluidics. They were surface-functionalized with either CD9, a tetraspanin involved in membrane fusion, or TSP-1, an adhesion protein promoting cellular interactions. Through physicochemical characterization via dynamic light scattering, we found that FSEMs were ∼ 100 nm in size, of low polydispersity (∼0.2) and showed a negative zeta potential (∼–55 mV). Both EGCG and miR-23a were efficiently encapsulated. SDS-PAGE analysis confirmed successful protein incorporation and correct positioning. In vitro release studies showed minimal premature leakage, supporting their suitability for cellular uptake-mediated delivery. When tested on melanoma cells (MDA-MB-435) and progenitor human dermal fibroblasts (FE002-SK2), FSEMs selectively killed melanoma cells while sparing fibroblasts. Importantly, EGCG within FSEMs was more effective than the free compound. Compared to conventional DOTAP-based liposomes, FSEMs were more selective and induced less off-target cytotoxicity. This study presents a proof-of-concept for fully synthetic, protein-functionalized FSEMs as dual carriers for both chemical and gene-based agents, offering a safer and potentially more effective alternative to traditional cationic liposomes. These results lay the groundwork for future in vivo validation and translational cancer research. © 2026 The Author(s)Book Part Human-Centered Safety and Ergonomic Design for Women in High-Risk Industrial Occupations: A Systematic Review within Intelligent Systems Context(AHFE International, 2026) Aytac S.; Akalp H.G.; Yamankaradeniz N.; Arlı N.B.; Arlı, Nuran Bayram; Akalp, Hüsre Gizem; Aytac, Serpil; Yamankaradeniz, NurettinWomen’s participation in high-risk sectors such as mining, construction, transportation, and healthcare continues to increase, yet industrial safety and ergonomics remain dominated by gender-neutral design assumptions. This systematic review synthesizes evidence on physical, psychosocial, and organizational challenges faced by women in hazardous environments through a human-cantered systems lens. Following PRISMA 2020 guidelines, 24 peer-reviewed studies (2010–2025) from Scopus, Web of Science, and PubMed were analyzed. The literature highlights exposure to musculoskeletal disorders (MSDs), PPE mismatch, postural load, and inequitable access to safety resources. Thematic analysis reveals that ergonomic inequalities intersect with exclusion from safety training and organizational barriers in risk management. Findings underscore the need for interdisciplinary approaches integrating ergonomics, intelligent systems, and gender studies to enable safer and more inclusive workplaces for women in high-risk occupations. © 2026 The Authors.Article Integrating 3D-Printed Task-Specific Terminal Devices with a Standard Myoelectric Prosthesis in a Patient with Systemic Scleroderma and Transradial Amputation: A Case Report(Lippincott Williams and Wilkins, 2025) Öztürk B.; Öztürk, BaşarABSTRACT – Objective – The aim of the study was to evaluate the effectiveness of personalized task-specific 3D-printed terminal devices integrated with a standard myoelectric prosthesis in improving functional independence and comfort in a patient with systemic scleroderma and transradial amputation. Methods – A 57-year-old female patient with systemic scleroderma and a left transradial amputation used the following three task-specific 3D-printed adaptive terminal devices—a sock aid, buttoning tool, and jar opener—developed using Tinkercad and fabricated with PLA via FDM printing. These devices were integrated into her pre-existing standard myoelectric prosthesis (Ottobock MyoFacil, four-channel transradial model), which the patient had already been using for daily activities. Functional outcomes were assessed using the Canadian Occupational Performance Measure, Functional Independence Measure (FIM), and visual analog scale (VAS) for pain. Results – Canadian Occupational Performance Measure scores increased from 2/10 to 7–8/10 in performance and satisfaction. Functional Independence Measure scores improved from 4 to 6, reflecting reduced need for assistance in self-care. VAS scores decreased from 7/10 to 3/10, indicating reduced pain during activities of daily living. Conclusions – The integration of low-cost, patient-specific 3D-printed terminal devices with an existing myoelectric prosthesis significantly improved function, independence, and comfort. This case supports further exploration of additive manufacturing as a complementary strategy to enhance prosthetic function in individuals with rare and complex impairments. Clinical Relevance – 3D printing offers a scalable, adaptable solution for task-specific 3D-printed terminal devices, particularly in patients with systemic comorbidities. © 2025 Lippincott Williams & WilkinsBook Part Preventing Violence in Schools: A Psychoeducation Program Examining the Effects on Teachers Perceptions and Attitudes Toward Violence and Bullying(AHFE International, 2026) Tunca O.O.; Kaya A.G.; Cikrikci A.; Kılıc C.; Cicek H.S.; Cevher T.; Ergul E.B.; Cevher, Turker; Cicek, Havvane Sama; Kaya, Alp Giray; Tunca, Ozlem Ozden; Ergul, Esra Betul; Kılıc, Cetin; Cikrikci, AycaThis study experimentally examined changes in teachers’ and school counseling (SC) professionals’ perceptions and attitudes toward violence and peer bullying through the psychoeducational program “Preventing Violence in Schools: Where Do I Stand?”, developed by the researchers. An explanatory sequential mixed-methods design was employed. Following quantitative data collection, results were examined using a phenomenological design.The sample consisted of 36 participants 20 SC professionals and 16 subject-area teachers working in public schools in Istanbul. To test the significance of the psychoeducation, the sample was divided into two groups consisting of subject-area teachers showing similar distribution parallel to the SCs. Participants completed the Personal Information Form, “Teacher Attitudes Toward School Bullying Scale” before and after the eight-week intervention. Additionally, qualitative data were collected via the “Interview Form on Perceptions of Bullying and Violence” to obtain a deeper understanding of participants’ views. Results indicated no statistically significant differences between pre-test and post-test scores. Professional seniority and age showed significant positive correlations with the “harsh attitude” subdimension. When groups were compared, “harsh attitude” scores differed significantly, with subject teachers scoring higher. Participants’ number of children positively correlated with the “indifference attitude” dimension. Qualitative findings showed both groups perceived bullying as repetitive power dynamic. Subject teachers linked prevention gaps to systemic issues, while SCs identified stakeholders closedness to cooperation and administrative indifference as main difficulties. Regarding interventions, teachers prioritized disciplinary systems, observation, rules, whereas SCs favored child-centered consultation for all stakeholders. Both groups emphasized victim safety, emotional support, cooperation, a holistic approach in case analyses. © 2026 The Authors.Article Development and Preliminary Psychometric Properties of the Adolescent Sleep Health Belief Scale(Istanbul University-Cerrahpasa, Florence Nightingale Faculty of Nursing, 2025) Dikici H.; Kadıoğlu H.; Dikici, Hasret; Kadıoğlu, HasibeAIM: This study aimed to develop a scale based on the Health Belief Model that can reliably and validly evaluate adolescents’ beliefs toward sleep. METHODS: This study was conducted using a methodological design with 494 adolescents between September and October 2022 in Antalya, Türkiye . Eighty-one items about sleep were created according to the Health Belief Model. Validity was assessed in terms of content and construct validity, and reliability was assessed through internal consistency. Content validity was evaluated by ten expert opinions. The scale was tested for construct validity with exploratory factor analysis, after which the scale’s reliability was evaluated by examining item-total correlations using Pearson’s correlation analysis and assessing internal consistency with Cronbach’s Alpha. RESULTS: Item-level content validity index scores ranged between 0.80 and 1. The scale-level content validity index value was found to be 0.94. In the exploratory factor analysis of the 46-item scale, six factors were found with an eigenvalue greater than 1, explaining 57.7% of the total variance. The scale’s itemtotal correlations ranged from 0.26 to 0.79. Cronbach’s alpha coefficients for the subscales were 0.92 for perceived susceptibility, 0.90 for perceived severity, 0.90 for perceived benefits, 0.81 for self-efficacy, 0.79 for motivation, and 0.69 for perceived barriers. CONCLUSION: The Adolescent Sleep Health Belief Scale demonstrated good validity and reliability in adolescents. Its cross-cultural adaptation for use with adolescents in other countries is recommended. © 2025, Istanbul University-Cerrahpasa, Florence Nightingale Faculty of Nursing. All rights reserved.Book Part Evaluation Awareness: A University Example(AHFE International, 2025) Akalp H.G.; Saklangıç U.; Aytaç S.; Saklangıç, Uğur; Akalp, Hüsre Gizem; Aytaç, SerpilIndividuals’ fire safety awareness directly affects individual and institutional safety as well as social safety. Fires are among the serious dangers that can cause loss of life and property in workplaces. Fire safety is one of the basic safety precautions that should be taken in workplaces. Reducing fire risks and increasing employees’ awareness are of great importance in terms of occupational health and safety. Fire safety awareness is a critical issue in terms of preventing occupational accidents and directly affects the effectiveness of safety precautions taken in workplaces. This study aims to evaluate the fire safety awareness level of 163 people working in a higher education institution in Turkey and reached by random sampling method, to analyze the effectiveness of current training programs and precautions and thus to reveal what kind of precautions can be taken in terms of occupational safety. The results revealed that employees have a general awareness of fire safety but they lack knowledge about emergency procedures. Within the scope of the study, it was suggested that training programs within the institution should be increased and fire drills should be carried out regularly in order to increase fire safety awareness. © 2025. Published by AHFE.Book Part Sick Relationship with Work Stress as a Psychosocial Risk: A Shopping Mall Example(AHFE International, 2024) Aytac S.; Bulbul S.; Akalp H.G.; Akalp, Husre Gizem; Aytac, Serpil; Bulbul, SahametRecently, buildings, residences, plazas, shopping malls, skyscrapers and towers that have been rising all over the world have begun to form our living spaces as smart structures where private, social and business lives are carried out. The fact that these closed spaces threaten the health of people living and working in them and cause diseases, has led to these buildings being called “sick building syndrome (SBS)”. Sick building syndrome results in the health of people who spend time and work in these buildings being affected both physically and psychologically. The aim of this study is to reveal the symptoms of sick building syndrome and its effects on stress, which is a psycho-social risk at workplace. A cross-sectional study conducted in two randomly selected shopping malls in Turkey involved 268 employees. Research findings indicate that employees suffer from symptoms like dry throat, runny nose, eye irritation, headaches, muscle-joint pain and fatigue. Additionally, it has been observed that these symptoms intensify during peak weekend traffic Moreover, the sick buildings phenomenon increases the stress levels of employees’ due to the conditions associated with enclosed spaces. © 2024. Published by AHFE.Article Effects of Combined Triflow, Deep Breathing and Coughing Exercises on Postoperative Pulmonary Function After Mitral Valve Replacement: A Randomized Controlled Trial(BMC, 2026) Akinci, Naile; Eren, EsraBackground Postoperative pulmonary complications remain a major cause of morbidity after cardiac valve surgery. Although incentive spirometry (Triflow) is routinely used in postoperative care, evidence regarding the additional benefits of combining Triflow with deep breathing and coughing exercises remains limited. This study aimed to evaluate the effects of combined Triflow, deep breathing, and coughing exercises on postoperative pulmonary function in adult patients undergoing mitral valve replacement. Methods This randomized controlled, single-blind trial was conducted between May and August 2025 in a private hospital in Istanbul. A total of 60 adult patients undergoing mitral valve replacement were randomly allocated to an experimental group (n = 30) or a control group (n = 30) using simple randomization. The experimental group performed Triflow combined with deep breathing and coughing exercises, while the control group performed Triflow alone. Results Postoperative SpO(2) levels were significantly higher in the experimental group at T1 (p = 0.009; 95% CI: 0.46-3.14), T2 (p < 0.001; 95% CI: 1.57-3.43), and T3 (p < 0.001; 95% CI: 2.72-4.54). The FEV1/FVC ratio increased significantly in the experimental group compared with the control group at discharge (p < 0.001; 95% CI: 4.46-6.41). Respiratory rate was significantly higher in the experimental group at T1 (p < 0.001; 95% CI: 1.68-4.45), T2 (p < 0.001; 95% CI: 3.34-6.26), and T3 (p < 0.001; 95% CI: 5.23-8.37). Hematocrit levels were significantly lower in the experimental group at T1 (p = 0.039; 95% CI: -8.32 to - 0.24), T2 (p = 0.007; 95% CI: -8.29 to - 1.40), and T3 (p = 0.034; 95% CI: -6.54 to - 0.28). Pain scores were significantly lower in the experimental group at T1 (p < 0.001; 95% CI: -2.82 to - 1.71) and T2 (p < 0.001; 95% CI: -1.98 to - 1.08). Time to first mobilization was significantly shorter in the experimental group (p < 0.001; 95% CI: -2.94 to - 1.26). No postoperative pulmonary complications were observed in either group. Conclusion The combined application of Triflow, deep breathing, and coughing exercises was associated with significant improvements in postoperative pulmonary function, oxygen saturation, pain reduction, and earlier mobilization compared with Triflow alone in patients undergoing mitral valve replacement. These findings suggest that a structured, combined respiratory exercise protocol may provide additional clinical benefits in the early postoperative period.