Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7
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Article The Gut-Kidney Axis in Calcium Oxalate Nephrolithiasis: Nutritional and Microbial Insights(Kare Publ, 2026) Sener, Goksel; Marzi, Mahdi; Sener, Tarik EmreCalcium oxalate (CaOx) nephrolithiasis is the most common type of kidney stone disease worldwide. Recent studies show that its development cannot be explained solely by renal solute handling; instead, it reflects a broader interaction between dietary habits, the intestinal microbiota, and host metabolic responses. Intestinal absorption of calcium and oxalate-two central drivers of lithogenesis-is shaped by both microbial composition and dietary patterns. Although Oxalobacter formigenes was initially regarded as the main oxalate-degrading organism, newer studies indicate that a wider disturbance of the gut microbiota, especially the loss of short-chain fatty acid (SCFA)-producing species, may increase susceptibility to stone formation. In this review, nutritional, microbial, and mechanistic evidence is brought together to examine how diet-particularly salt, animal protein, calcium, oxalate, fruits, vegetables, and water intake-modulates the gut-kidney axis. Diets high in salt or animal protein tend to shift the microbiota toward more pro-inflammatory and acidogenic profiles, while fiber-rich, plant-based diets and adequate hydration appear to support microbial diversity, SCFA production, and epithelial barrier integrity. Probiotic and synbiotic interventions have also gained attention as potential strategies to reduce stone recurrence by targeting gut microbial function. Taken together, current findings suggest that the gut-kidney axis is a dynamic metabolic link between diet, microbial ecology, and renal physiology. Future studies combining multi-omics methods with personalized nutritional approaches may help develop more effective microbiota-based prevention and treatment strategies for CaOx nephrolithiasis.Article The Impact of Home-Based Telerehabilitation Pranayama on Sleep Quality and Wellbeing in Mild to Moderate Obstructive Sleep Apnea Syndrome. A Randomized Controlled Trial(BMC, 2026) Mustafaoğlu, Rüstem; Naci, Baha; Demir, Rengin; Önder, Ömer Önder; Atahan, Ersan; Kaçar Akkoç, ZeynepBackground Obstructive sleep apnea syndrome (OSAS) is a common disorder that causes repeated airway obstruction, disrupted breathing, and fragmented sleep. This study aimed to investigate the effects of Pranayama on sleep quality, daytime sleepiness, quality of life, fatigue, depression, and anxiety in patients with OSAS. Methods This study was designed as an open-label, prospective, randomized controlled trial. OSAS patients meeting the inclusion criteria were randomly assigned to either an Intervention group or a Control group. Pranayama training was applied to the Intervention group for 8 weeks, 7 days a week, and 3 times a day for 15 min. In addition, a single 15-minute session, 3 days a week, was conducted online under the supervision of a physiotherapist. The control group did not receive any intervention. Primary outcome was sleep quality (Pittsburgh Sleep Quality Index, PSQ). Secondary outcomes included daytime sleepiness (Epworth Sleepiness Scale, ESS), Fatigue Severity Scale (FSS), Functional Outcomes of Sleep Questionnaire (FOSQ), Nottingham Health Profile (NHP), and Hospital Anxiety and Depression Scale (HADS). All outcome measures were assessed at baseline and reassessed after the 8-week intervention period. Results Thirty-eight OSAS patients meeting the inclusion criteria were randomly assigned to either an Intervention group 6n = 19 ) or a Control group (n = 19) Four participants (two in each group) were lost to follow-up, leaving the data of participants (17 per group) available for inclusion in the final analysis. In the intervention group, PSQI scores decreased from 9.12 +4.71 to 6.88 +/- 4.45 (p < 0.001) whereas no improvement was observed in the control group. Regarding the primary outcome, the reduction in PSQI scores was significantly greater in the intervention group than in the control group (p < 0.001) The ESS scores also decreased significantly in the intervention group, from 9.41 +/- 6.15 to 7.41 +/- 6.18 6p = 0.006 with a significant between-group difference (p < 0.001) Fatigue severity decreased in the intervention group (FSS change: 0.53 +/- 0.70; p = 0.006 ), with a significant between-group difference 6p = 0.037 The FOSQ score improved markedly, with significant gains in FOSQ total score (-0.38 +/- 0.25 vs. 0.14 +/- 0.22 in controls; p < 0.001) and in activity level and vigilance subdomains (both p < 0.001). The HADS-anxiety scores decreased by 1.94 +/- 3.94 (p = 0.059) and depression scores by 3.06 +/- 2.05 (p < 0.001) in the intervention group, with significant between-group differences for both anxiety (p = 0.008) and depression (p < 0.001). Conclusion Pranayama was an effective adjunct therapy for these OSAS patients, and incorporating it into treatment strategies may enhance patient outcomes. Clinical trial registration number/date NCT04632147/22.10.2020.Article Short-Term Effects of Targeted Movement Training on Gait Kinematics in Children with Juvenile Idiopathic Arthritis: A Motion Analysis Study(MDPI, 2026) Argunsah, Hande; Dönmez, İrem; Ayaz, Nuray Aktay; Yekdaneh, Asena; Albayrak, Asya; Arman, Nilay; Aktay Ayaz, Nuray; Özbal, SibelBackground: Children with juvenile idiopathic arthritis (JIA) exhibit gait abnormalities, postural instability, and compensatory movement strategies due to joint pain, inflammation, and reduced neuromuscular control. These alterations negatively affect functional mobility and movement efficiency. Although gait retraining is commonly recommended in rehabilitation, objective evidence on its short-term biomechanical effects remains limited. This study aimed to evaluate the immediate impact of a single-session standardized movement training intervention on gait biomechanics in children with JIA. Methods: Seventeen children with JIA underwent pre-post gait assessments using the Xsens MVN Awinda wearable motion capture system. The intervention focused on step symmetry, stride length, heel-toe progression, and upright trunk posture, delivered by an experienced physiotherapist following a standardized protocol. Scalar kinematic outcomes were analyzed using paired statistical tests, and time-normalized kinematic waveforms were compared with healthy reference data from 25 age-matched participants derived from the COMPWALK-ACL dataset. Results: Significant improvements were observed in multiple gait parameters following the intervention. Trunk lateral lean decreased significantly (p = 0.0002; d = -1.35), indicating enhanced postural stability. Significant changes were also found in ankle dorsiflexion-plantarflexion (p = 0.0081; d = 0.83) and knee flexion-extension (p = 0.0252; d = 0.68). Waveform analyses showed increased similarity to healthy patterns, particularly in trunk and knee kinematics. Spatiotemporal parameters reflected a slower, more controlled gait pattern, with increased stride time and stance duration. Conclusions: A single session of standardized movement training can produce immediate improvements in gait biomechanics in children with JIA, especially in trunk control and lower-limb kinematics. Wearable motion analysis provides a sensitive tool for detecting these short-term adaptations and supports the inclusion of structured movement training in pediatric JIA rehabilitation.Article Article The Effect of Preoperative Melatonin Patches on Sleep Quality in Patients Undergoing Urological Surgery(Assoc Medica Brasileira, 2026) Akok, Selin Ayten; Akinci, Naile; Toprak, ÇağlaOBJECTIVE: The aim of this study was to determine the effects of transdermal melatonin patches on sleep quality in patients undergoing urological surgery. METHODS: This study is a randomized controlled trial. Fifty-seven patients hospitalized in the urology department of a university hospital in Istanbul were included. Patients were randomly assigned to two groups (melatonin and control). Patients in the melatonin group received transdermal melatonin containing 7 mg of melatonin at 11:00 PM in a quiet, darkened room the night before surgery. RESULTS: According to the results of this study, Richards-Campbell Sleep Scale sleep-quality scores increased significantly in the melatonin group (p<0.001). The control group showed lower sleep-quality scores. In addition, a statistically significant decrease was observed between the visual analog scale well-being scores before and after the application in the melatonin group (p<0.001). CONCLUSION: In this study, our results showed that melatonin patches improved sleep quality and psychological well-being in patients undergoing urological surgery.Article Protective Effects of Lactobacillus Rhamnosus GG Against Methotrexate-Induced Oxidative Renal Toxicity(Springer, 2026) Yanardag, Refiye; Bayrak, Bertan Boran; Sener, Goksel; Almurad, Bade; Donmez, Muhammet OguzhanMethotrexate (MTX) is commonly prescribed for various malignant and autoimmune conditions, but it can cause significant oxidative and functional impairment in renal tissue. Lactobacillus rhamnosus GG. (LGG) is a well-known probiotic with biological activities that support antioxidant balance. This study investigated the impact of LGG on MTX-induced kidney damage. Male Sprague-Dawley rats were divided into four groups: physiological saline-treated control group; a group receiving MTX alone; a group receiving MTX alongside a low dose of LGG; and a group receiving MTX alongside a high dose of LGG. MTX was administered as single dose (20 mg/kg/bw) intraperitoneally and LGG (low dose 1 x 10(9) CFU/day and high dose 5 & times; 10(9) CFU/day, respectively) orally for five days. On day six, blood and kidney samples were collected and examined for oxidative indicators, enzymatic antioxidant responses, and renal functional markers. MTX significantly increased in glomerular filtration markers in serum and elevated key indicators of oxidative stress in renal tissues. More so, MTX demonstrated to disrupt renal ionic homeostasis, such as declined sodium/potassium-ATPase, paraoxonase, and increased lactate dehydrogenase, carbonic anhydrase, xanthine oxidase, myeloperoxidase, and arginase activities. In contrast, LGG supplementation has been shown to effectively reverse all MTX-induced biochemical alterations in both serum and renal tissue. We can suggest that LGG can provide significant protection against oxidative renal toxicity induced by MTX in rats.Article Fault-Tolerant QCA-Based Parity Pre-Filtering Circuits for Lightweight Edge-IoT Transaction Screening(MDPI, 2026) Ahmadpour, Seyed-Sajad; Ajlouni, Naim; Zohaib, Muhammad; Selvi, OsmanEdge Internet of Things (IoT) blockchain deployments increasingly rely on continuous transaction ingestion from resource-constrained IoT devices to nearby edge gateways over heterogeneous wireless links. In this setting, transient channel noise and packet corruption can inject invalid payloads into the edge processing pipeline and trigger unnecessary buffering, parsing, and, most critically, computationally expensive cryptographic operations such as digital signature verification. This leads to wasted computation, increased latency, and reduced energy efficiency at the edge, particularly under dense IoT traffic. This paper presents an energy-aware and fault-tolerant Quantum-Dot Cellular Automata (QCA)-based integrity pre-filter for IoT-to-edge blockchain transaction ingestion. At the circuit level, we adapt and modify a previously reported fault-tolerant five-input majority gate (MV5) structure and use it as a robust primitive for nanoscale integrity-screening circuits. Building on this modified MV5, we design a set of QCA integrity blocks, including a parity checker, a compact XNOR gate circuit, a parity-bit generation circuit, and a sender-to-channel/receiver nano-communication integrity workflow suitable for early screening of corrupted payloads. Compared with the best previously reported baseline considered in this study, the modified MV5 achieves 76.47% tolerance to single-cell omission defects, corresponding to a 17.47 percentage-point increase and an approximately 29.61% relative improvement over the prior 59% omission-tolerance result, while preserving 100% tolerance against extra-cell deposition defects. At the system level, the proposed circuit is discussed as a potential early screening stage for edge-IoT blockchain transaction ingestion. A bounded analytical model is used to estimate the possible reduction in unnecessary signature-verification workload under assumed corruption and detection conditions. This analysis is not intended as a deployment-level validation; full edge-node implementation, throughput measurement, queueing-delay evaluation, real traffic traces, retransmission behavior, and empirical signature-verification profiling remain future work. The proposed parity/chunk-parity pre-filter is designed for low-cost detection of random transmission-induced corruption and does not replace cryptographic authentication, hashing, digital signatures, CRC-based detection, or blockchain validation. All proposed designs are validated using QCADesigner tools.Article Essential Criteria for Proportional Fractional Generalized Hukuhara Differentiability for Goursat Problems with Application in Mhd Couple Stress Fluid Flowing through a Channel Embedded in a Porous Medium(World Scientific Publ Co Pte Ltd, 2026) Rashid, Saima; Fatima, Nida; Fatima, Tehreem; Chu, Yu-mingA novel category of fractional derivatives with an exponential kernel, the generalized proportional fractional (G-P-F) derivative has several uses in practical issues. This operator is currently employed for the first time with this sort of fluid circulation. Initially, we address Goursat problems with generalized proportional fractional Caputo's type generalized Hukuhara (gH) differentiability. Two distinct kinds of generalized proportional fractional Caputo type gH-differentiability and the second-order convoluted derivatives in Goursat equations illustrate complexity for solving Goursat problems. Furthermore, this method's capacity to create representations that more properly depict memory-effect mechanisms is one of its main advantages to transform Goursat problems into fuzzy integrals for analyzing similar structures in order to appropriately handle the convoluted derivatives and the two distinct kinds of generalized proportional fractional Caputo's type gH-differentiability. Meanwhile, the idea of fixed-point analysis is employed to address whether generalized proportional fractional fuzzy Goursat problems possess unique results as for C([j -gH] )and C[jj -gH] differentiability. Inspired by these considerations, the idea of G-P-F derivatives is presented in this study for simulating coupled stress fluid (CSF) while taking into account the simultaneous impacts of mass transport and heat. According to the impact of external pressure, the magnetohydrodynamic (MHD) flow of CSF is examined in a conduit comprising porous media. The lateral plate moves continuously, whereas the reverse plate stays still, which causes the CSF to migrate. The implicit finite difference approach is used to computationally address the non-dimensional G-P-F mathematical model of CSF, which is defined in the Laplace transform sense with an exponential kernel. The outcomes are shown schematically to show how different factors affect the temporal, concentration, and velocity aspects. As the proportionality index increases, the MHD coupling pressure substance CSF in a conduit containing porous medium exhibits decreasing flow, temperature, and concentration characteristics. According to visual outcomes, the G-P-F approaches CSF circulation in the path are significantly precise compared to both fractional and classical solutions. Furthermore, in contrast to the fractional framework, the G-P-F model offers a more precise description of memory impacts in the fluctuation of CSF. Lastly, the Sherwood number, Nusselt number, and skin friction are calculated and shown in tabulated style.Article Evaluation of University Students’ Awareness and Knowledge of Human Papillomavirus (HPV) Infection, HPV Vaccination, and HPV-Related Cancers(Marmara Univ, FAC Pharmacy, 2026) Marzi, Mahdi; Karacali Tunç, Ayşe; Marzi, Sebnem; Tunc, Ayse Karacali; Tunc, YunusHuman papillomavirus (HPV) is the most common sexually transmitted infection and a major cause of cervical and other cancers. This cross-sectional study aimed to assess university students' knowledge of HPV infection, testing, vaccination, and HPV-related cancers across different regions of Türkiye. Data were collected from 1,856 students enrolled in associate, undergraduate, and postgraduate programs using a validated HPV Knowledge Scale. Statistical analyses included descriptive statistics, t-tests, ANOVA, and Pearson correlations. Overall, awareness of HPV (76.3%), HPV testing (70.1%), and HPV vaccination (77.5%) was relatively high, while only 11.3% of participants had been vaccinated. The mean total knowledge score was 13.19 +/- 8.64, indicating moderate knowledge. Higher scores were associated with female gender, higher education level, family history of cancer, and prior knowledge of sexually transmitted infections or cervical cancer (p<.05). Regional variations were observed, with the Aegean, Central Anatolia, and Marmara regions showing higher knowledge levels. A weak but significant positive correlation was found between age and knowledge (r=0.206, p<.001). The findings highlight persistent gaps in HPV vaccination and screening awareness among university students. Targeted educational interventions, particularly for male and non-health students, and national inclusion of HPV vaccination programs could strengthen preventive strategies against HPVrelated cancers.Article Effectiveness of Escape Room–Based Learning for Patient Safety Education in Nursing Students(BMC, 2026) Demet, Inangil; Kokkiz, Rukiye; Semiz, Demet; Turkmen, KübraBackground Ensuring patient safety is a cornerstone of nursing practice, and its foundation is established during nursing education. The study evaluates the effectiveness of escape room-based learning designed in accordance with the International Patient Safety Goals on nursing students' self-efficacy about patient safety. Methods The study was conducted with senior nursing students from February to May 2024. Data were collected using the Student Information Form, Patient Safety Self-Efficacy Questionnaire, and Satisfaction with Training Methods Scale. The escape room was structured in three phases-prebriefing, simulation, and debriefing-following INACSL standards. Clinical trial number: NCT07179367. Results The average age of the participants was 23.5, and 43.5% had previously completed an elective course on patient safety. Analyses revealed that participants spent the most time, averaging 2.59 min, in the room dedicated to information questions. The average self-efficacy score before the intervention was 61.26, which increased to 71.32 after the intervention, and participants reported a high level of satisfaction. Conclusion This study's findings indicate that patient safety-themed escape room training significantly enhances students' self-efficacy in patient safety, as well as their overall satisfaction and motivation.