Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7
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Article Selective Recovery and Preconcentration of Catechins from Wine Industry Residues Using Molecularly Imprinted Polymers: An Eco-Friendly Solid Phase Extraction Approach(Springer, 2026) Özen, Seda; Tütem, Esma; Ersoy, Şeyda KaramanMolecularly imprinted polymers (MIPs) are engineered materials that provide exceptional selectivity and stability for target molecule recognition. While most previous catechin-imprinted polymer (CAT-MIP) studies have focused on tea matrices, the present study applies CAT-MIP technology to wine industry residues, particularly grape seeds, which represent sustainable and underutilized sources of bioactive compounds. CAT-MIP was synthesized using CAT as the template molecule and polymerization parameters including functional monomer type, porogen composition, and template-to-monomer-to-crosslinker molar ratios were systematically optimized. Among the tested conditions, 4-vinylpyridine (4-VP) and an acetonitrile: dimethyl sulfoxide (ACN: DMSO, 98:2, v/v) solvent system provided the most favorable imprinting performance. Adsorption studies revealed heterogeneous binding behavior consistent with the Freundlich model, while Langmuir parameters were used for comparative evaluation. The optimized CAT-MIP was successfully applied as a molecularly imprinted solid-phase extraction (MISPE) sorbent, achieving selective recovery of 69.20 +/- 2.45% for CAT and 52.50 +/- 1.77% for epicatechin (ECAT) from white grape seed extracts, with comparable performance observed for red grape seed extracts. This MISPE based approach offers the first comprehensive study applying CAT-MIP technology to wine industry waste valorization, comparing red and white grape varieties, and establishing a fully validated HPLC-PDA (high performance liquid chromatography-photodiode array detection) method for CAT quantification. The eco-friendly approach addresses the growing need for sustainable extraction of valuable high-value natural antioxidants. from agro-industrial byproducts.Article Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin(Turkish Chemical Society, 2025) Başkan, Kevser Sözgen; Ersoy, Şeyda Karaman; Akyüz, Merve; Karaman Ersoy, Şeyda; Sözgen Başkan, KevserQuercetin (QUE) is the most active compound in the flavone family, commonly found in the leaves, fruits, and flowers of many plants. The separation of QUE from various plant matrices has been a key research area due to its antioxidant, anti-inflammatory, antiviral, and antitumor properties. In this study, the conditions for synthesizing MMIPs and their use in QUE recovery were examined. Iron (II) chloride tetrahydrate (FeCl2·4H2O) and iron (III) chloride hexahydrate (FeCl3·6H2O) were used to prepare magnetic nanoparticles, and Fe3O4 was synthesized. Tetraethyl orthosilicate (TEOS) was used to coat the resulting Fe3O4 surface with silica. [3-(methacryloxy)propyl] trimethoxysilane (γ-MPS) was used to functionalize the surface of the formed Fe3O4@TEOS structure. The synthesis was carried out using QUE as the template molecule; tetrahydrofuran (THF), ethanol (EtOH), and a solvent mixture of acetone and acetonitrile (ACN) (3:1, v/v) served as porogen solvents; acrylamide (AM), methacrylic acid (MAA), and 4-vinylpyridine (4-VP) were used as functional monomers; ethylene glycol dimethacrylate (EDMA) served as the cross-linker, and 2,2’-azobisisobutyronitrile (AIBN) was used as the initiator at different molar ratios (T:M:CrL, 1:4:20, 1:8:20, and 1:8:40). The recognition and selectivity properties of these polymers were evaluated based on absorbance values at 370 nm obtained through equilibrium assays, which used QUE solutions prepared in THF, ACN, and 50% (v/v) EtOH solvent mixtures at different ratios. It was established that the magnetic imprinted polymer prepared with a 50% (v/v) EtOH solvent mixture and molar ratios of 1:8:40 (QUE:4-VP:EDMA) exhibited the highest adsorption capacity and imprinting factor. Using the prepared QUE-MMIP, QUE was recovered with 33% efficiency from red onion peel extract.