TR-Dizin İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9
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Article The Correlation Between Vitamin D Levels and Thyroid Functions in Early Pregnancy(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Dinmez, Sinem; Özlem, Dülger; Oğul, Zeynep; Dülger, ÖzlemVitamin D deficiency (serum vitamin D <10 ng/ml) and thyroid dysfunctions are prevalent issues globally, particularly during pregnancy. Evidence suggests a potential link between thyroid function and vitamin D levels. This study aims to investigate the correlation between serum vitamin D levels and thyroid functions in wome n during the first trimester of pregnancy. The study was conducted retrospectively at a University Education and Research Hospital’s pregnancy clinic, covering data from August 2023 to March 2024. The sample group consisted of first -trimester pregnant women who attended routine pregnancy check-ups and had complete vitamin D levels and thyroid function tests (n=185). The sociodemographic data form and blood serum level assessment forms were used as data collection tools. The data were analyzed using descriptive statistics and correlation analysis. The average age of the pregnant women participating in our study was 27.6±4.9 years, and the Body Mass Index (BMI) was 25.4±4.8 (overweight). The mean number of pregnancies was 1.13±0.3, and the gestational week was 8.19±1.8. Of the participants, 35 had subclinical hypothyroidism, 37 had thyroiditis, and 113 had normal thyroid functions. The study identified 36 women with normal/adequate vitamin D levels (≥20 ng/ml), 113 with vitamin D insufficiency (10–20 ng/ml), and 36 with vitamin D deficiency (<10 ng/ml). The correlation analysis revealed no significant relationship between the thyroid function tests and vitamin D levels of the pregnant women. It was determined that vitamin D levels do not affect thyroid gland function in the first trimester.Article Determination of the Factors Affecting the Health and Social Lives of Individuals With Type I Diabetes During the Covid-19 Pandemic Process: a Qualitative Study(2024) Eroğlu, Nermin; Kolac, NurcanAim: This study was carried out to determine the factors affecting the health and social lives of individuals with Type I diabetes. Materials and Methods: The sample of the study consisted of 14 individuals with Type I diabetes living in Istanbul province. The quantitative data of the study were collected using a personal information form, and the qualitative data were collected through two open-ended questions. Results: Content analysis was used to evaluate qualitative data. The mean age of the individuals with Type I diabetes was 36.1% (n=14) years. As a result of the content analysis, two main themes and eight sub-themes were determined. Accordingly, the themes were negative emotions towards the illness and fear of being unable to maintain health during the pandemic process. Conclusion: In this study, individuals with Type I diabetes were found to have negative thoughts and to experience anxiety and fear about their health due to the COVID-19 pandemic. During the pandemic process, they were particularly affected by the inability to exercise enough and the deprivation of social life. In line with these results, the study revealed that the mental and physical needs of individuals with Type I diabetes, which is a disadvantaged group during the pandemic process. In these cases, it is recommended to develop teams that will provide support for remote chronic disease monitoring of individuals with type 1 diabetes, to train health professionals, to provide multidisciplinary support to individuals by investing in these issues, and to create emergency action plans that include all elements.Article Citation - Scopus: 12Protective Effects of Petroselinum Crispum (parsley) Extract Against Methotrexate-Induced Hepatotoxicity(Istanbul University Press, 2021) Ertas, B.; Turan, F.B.; Ozbeyli, D.; Yanardag, R.; Sacan, O.; Sener, G.Objective: By inhibiting the synthesis of thymidine and purine, and thereby DNA synthesis, Methotrexate (MTX), suppresses the proliferation of cancer cells. It is thought that the side-effect mechanism is related to oxidant molecules derived from MTX metabolism. In this study, we examined whether the Petroselinum crispum extracts (PCr; parsley) of which the antioxidant properties have been previously shown, was protective against MTX induced liver damage. Materials and Methods: Sprague Dawley rats (female/male; 200-250 g) were used. MTX was injected intraperitoneally and PCr extract was given orally. A single dose of 20mg/kg MTX was administered to the groups that were to experience hepatotoxicity. Then, a physiological saline (MTX group) or PCr (2 g/kg, MTX + PCr group) treatment was applied for 5 days. The same treatments were applied to the other groups (control group, PCr group) for 5 days after a single dose saline injection. At the end of the study, the biochemical parameters were examined in the blood and liver tissues taken from animals sacrificed by decapitation. Results: MTX caused a significant increase in malondialdehyde and collagen levels and myeloperoxidase and caspase-3 activities, while glutathione levels were found to have decreased. PCr treatment showed protective efficacy by preventing these increases. Conclusion: It appears that the administration of PCr to MTX treated rats prevented the accumulation of lipid peroxides, inflamatory reactions and depletion of antioxidant glutathione, and thus protected liver tissues against oxidative stress. © 2021 European Journal of Biology. All rights reserved.