TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9

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  • Article
    Determination of the Factors Affecting the Health and Social Lives of Individuals With Type I Diabetes During the Covid-19 Pandemic Process: a Qualitative Study
    (2024) Eroğlu, Nermin; Kolac, Nurcan
    Aim: This study was carried out to determine the factors affecting the health and social lives of individuals with Type I diabetes. Materials and Methods: The sample of the study consisted of 14 individuals with Type I diabetes living in Istanbul province. The quantitative data of the study were collected using a personal information form, and the qualitative data were collected through two open-ended questions. Results: Content analysis was used to evaluate qualitative data. The mean age of the individuals with Type I diabetes was 36.1% (n=14) years. As a result of the content analysis, two main themes and eight sub-themes were determined. Accordingly, the themes were negative emotions towards the illness and fear of being unable to maintain health during the pandemic process. Conclusion: In this study, individuals with Type I diabetes were found to have negative thoughts and to experience anxiety and fear about their health due to the COVID-19 pandemic. During the pandemic process, they were particularly affected by the inability to exercise enough and the deprivation of social life. In line with these results, the study revealed that the mental and physical needs of individuals with Type I diabetes, which is a disadvantaged group during the pandemic process. In these cases, it is recommended to develop teams that will provide support for remote chronic disease monitoring of individuals with type 1 diabetes, to train health professionals, to provide multidisciplinary support to individuals by investing in these issues, and to create emergency action plans that include all elements.
  • Article
    Citation - WoS: 2
    Analysis of Selected Steroid Hormones in Sea of Marmara Sediment Samples by Lc-esi/Ms-ms
    (Istanbul Univ, Fac Pharmacy, 2023) Aysel, Esra; Yurdun, Turkan
    Background and Aims: Sediment is the general name given to the muddy structure located at the bottom of aquatic environments such as the sea. In our study, the amounts of steroid hormones were investigated in the sediment samples taken from the Marmara Sea. According to other studies, it has been determined that the excess of the hormone load in the sediments may be an indicator of human/animal sourced pollution, as well as the negative effects of the hormones mixed in the seas with the ecological cycle on the health of humans and animals.Methods: In our study, 31 selected human/animal, plant, natural and synthetic hormone-steroids were studied using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI/MS-MS). Methanol and QuEChERS were used as extraction methods. Sediment samples were taken from a total of 27 points selected for sampling at the Marmara Sea.Results: According to the results we found, the androgens: androsterone (24.50-1718.18 ng g-1), testosterone (86.30-1600.32 ng g-1); the estrogens: mestranol (33.73-228.32 ng g-1), equilin (53.44-1232.53 ng g-1); the progestagens; pregnenolone (37.50374.76 ng g-1), progesterone (39.96-405.60 ng g-1); levonorgestrel (325.25 and 937.93 ng g-1); the fecal sterols: cholestanone (57.57-1726.32 ng g-1), coprostanol + epicoprostanol (51.43-1370.33 ng g-1); and the plant sterol; campesterol (35.30-1859.90 ng g-1) were the compounds detected.Conclusion: Estrogens and progestogens are active components of birth control pills, and cholestanone and coprostanol + epicoprostanol are steroids that are indicative of human/animal pollution. Coprostanol + epicoprostanol and cholestanone, which are indicators of fecal pollution, were detected in all sediment samples. In our study, steroid hormones were detected for the first time in Sea of Marmara sediments and possible environmental risks were evaluated.
  • Article
    Determining the Type 2 Diabetes Risks and Healthy Lifestyle Behaviors of First Year University Students
    (Dokuz Eylul Univ inst Health Sciences, 2022) Eroglu, Nermin; Temiz, Gamze
    Introduction: The present study was planned and carried out as a descriptive and cross-sectional study for determining the Type 2 diabetes risks and healthy lifestyle behaviors of first year university students. Material and Methods: The study was carried with 185 students at a foundation university in Istanbul during the dates of November-December 2019. The data were acquired online via Student Information Form, Type 2 Diabetes Questionnaire (FINDRISK) and Healthy Lifestyle Behaviors Scale. Results: The mean age of the students in the study was 19.79 +/- 2.47 years, 53.5 % (n=99) were male, 29.7 % (n=55 previously graduated from another university, 62.1 % (n=115) were students and it was determined that 50.3 % (n=93) had diabetic relatives. It was observed when the diabetes risk status was examined for all participants that they are in the low risk group due to a FINDRISK total score of <7. Conclusion: The study results emphasize the importance of determining the risk for university students to be diabetic in the next decade, putting forth the individuals with high risk and moving onto the next stage for diagnosis. In addition, it has been determined that the level of knowledge of students may have a positive impact on their healthy lifestyle behaviors.
  • Article
    The Effects of Chard Extract Against Streptozotocin-Induced Erectile Dysfunction in Rats
    (Istanbul Univ, Fac Pharmacy, 2024) Aydin, Mustafa; Sacan, Ozlem; Kabasakal, Levent; Cetinel, Sule; Kadihasanoglu, Mustafa; Kendirci, Muammer; Sener, Goksel; Sönmez, Yeşim İpçi; Yanardag, Refıye
    Background and Aims: To analyze the potential therapeutic effects of chard against streptozotocin (STZ) -induced erectile dysfunction (ED) and oxidative damage in the corpus cavernousum in rats. Materials and Methods: In this study, Sprague-Dawley rats (250-300g) were allocated into groups as follows: control, diabetic, diabetic + chard, and diabetic + insulin. In order to induce diabetes, rats were given 65 mg/kg intraperitoneal streptozotocin. Chard extract was given orally at a dose 2 g/kg for 45 days beginning on 15 th days. Sixty days after STZ injection, intracavernosal pressure (ICP) was measured and rats were decapitated. Blood samples were obtained for glucose, asymmetric dimethylarginine (ADMA)levels, and lactate dehydrogenase (LDH) activity while cavernous tissues were taken to analyze luminol and lucigenin chemiluminescence (CL), malondialdehyde and glutathione and along with histological analysis. Results: The results revealed that diabetes caused significant decreases in cavernosal tissue glutathione levels, while luminol and lucigenin CL, and malondialdehyde levels were significantly elevated. Plasma glucose, ADMA levels, and LDH activity were also found to be increased in diabetic group. On the other hand, both chard extract and insulin treatment reversed these biochemical parameters significantly. Furthermore, it was found that the ICP value examined for evaluating erectile functions were lower in the diabetic group, but increased in both treatment groups which were similar to the control values. Conclusion: According to our results, chard extract, similar to insulin, reduced diabetes -induced oxidative damage in cavernosal tissue and protected erectile functions. This effects may be attributed its hypoglycemic and antioxidant properties.