TR-Dizin İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9
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Editorial Decreased Stuttering While Walking: Speech and Fmri Findings(Galenos Publ House, 2023) Oge-Dasdogen, Ozlem; Ulasoglu-Yildiz, Cigdem; Kurt, Elif; Demiralp, Tamer; Dasdogen, Ozlem Oge[No Abstract Available]Article Citation - WoS: 6Citation - Scopus: 6<i>beta Vulgaris</I> L. Var. Cicla Improves Memory Deficits in Intracerebroventricular Streptozotocin Injected Rats: Role on Neuroinflammation(Marmara Univ, 2021) Ertas, Busra; Topal, Fadime; Gulhan, Rezzan; Yanardag, Refiye; Sacan, Ozlem; Sener, Goksel; Aker, Rezzan GulhanAlzheimer's disease is a challenging disease for patients due to progressive loss of cognition and behavioral disorders. Disruption of cholinergic transmission and neuroinflammation are the most important mechanisms underlying cognitive damage. Beta vulgaris L. var. cicla (BV) has been reported to have various pharmacological effects associated with its rich antioxidant content. In addition, anti-cholinesterase and antiinflammatory activities of BV have been demonstrated in vitro. The aim of this study is to elucidate the therapeutic effect of BV against cognitive impairment, reduction in cholinergic transmission and neuroinflammation caused by intracerebroventricular (ICV) administration of streptozotocin (STZ). STZ was administered bilaterally at a dose of 3 mg/kg via ICV to rats, and BV treatment at a dose of 2 g/kg for 21 days was administered orally to STZ-induced animals. After behavioral tests, AChE activity, TNF-alpha and IL-1 beta levels were measured in hippocampus and cortex tissues excised from decapitated animals. Novel object recognition and passive avoidance test showed that the treatment of BV reverted the ICV-STZ induced memory dysfunctions in rats. Furthermore, increased AChE levels in the hippocampal and cortical tissues of STZ-induced rats were significantly reduced with 21 days of BV treatment. In conclusion, these results confirm that STZ administration caused cholinergic hypofunction, neuronal inflammation and cognitive dysfunction in rats, and BV therapy significantly inhibited these changes with its potential neuroprotective activity.Article Design and Implementation of a Low Cost and Portable Tactile Stimulator Br(Tubitak Scientific & Technological Research Council Turkey, 2022) Kazma, Coskun; Levent, Vecdi Emre; Cardak, Merve; Aydin, NizamettinWhen central nervous system has a problem, somatic area I and II respond to stimulation differently. Therefore, it is possible to identify some of the central nervous diseases when somatosensory on the fingertip is stimulated and responses are recorded and analyzed. We designed a system to stimulate the mechanoreceptors on fingertips. It is composed of a mechanical system for fingertip stimulation, an embedded controller, a control computer, and a software to control overall operation. During test, mechanoreceptors are stimulated according to the test protocols. Individuals' answers are recorded to be evaluated by the developed software. In this study, several design approaches for embedded controller were also examined and an FPGA based controller with the same functionality but higher performance was implemented. A test procedure was performed on 51 individuals at the department of pediatric psychiatry in a hospital, to investigate whether the sex has an effect on attention deficit and hyperactivity disorder.Article Evaluating the Styles of Coping With Stress of Individuals With Multiple Sclerosis During the Covid - 19 Pandemic(Marmara Univ, inst Health Sciences, 2022) Eroglu, Nermin; Tosun, AnilObjective: Multiple sclerosis (MS)is among the most influential environmental factors. Quarantine days during Covid-19 outbreak can cause conditions such as anxiety, isolation stress, financial and long-term economic stress, including health concerns.The descriptive study was planned and applied with the aim of examining the impacts of Covid-19 pandemic on the styles of coping with stress of individuals with multiple sclerosis. Methods: The study was carried out on 246 volunteer individuals during April2020-May2020 following the approval of the Turkey MS Association and the briefing provided to the individuals.The data were acquired via Personal Information Form and The Styles of Coping with Stress Scale. Results: The mean age of individuals with MS was 39.41 +/- 9.06 years. Statistically significant increase was found in the sub-dimensions of optimistic and helpless approach with gender, submissive approach with marital status, helpless and submissive approach with education status, helpless, submissive and seeking social support sub-dimensions with working status (p<0.0, p<0.05). Conclusion: It was determined that individuals with MS use the helpless approach and submissive approach most frequently in coping with stress during the Covid-19 pandemic.It was determined that those living with their families mostly use the optimistic approach and selfconfident approach.It is thought that MS associations will be effective in coping with stress in reducing symptoms and social and physical support through informative meetings, home visits, psychotherapies, yoga and organized trainings.