TR-Dizin İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9
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Article Citation - Scopus: 6Myrtus Communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation(Istanbul University Press, 2022) Mustafaoglu, F.K.; Ertas, B.; Sen, A.; Akakin, D.; Sener, G.; Ercan, F.Objective: Obesity is associated with many diseases, including urinary system disorders such as chronic kidney disease and overactive bladder syndrome. Myrtus communis L. (MC) extract has been reported to have antioxidant and anti-inflammatory effects. The aim of this study was to investigate the protective effects of MC extract on high-fat diet (HFD)-induced kidney and bladder damage. Materials and Methods: Wistar albino male rats were divided into three experimental groups: control, HFD and HFD+MC. Experimental groups were fed a standard diet (control group) or HFD (HFD and HFD+MC groups) for 16 weeks. MC extract (100 mg/kg) was administered to the HFD+MC group orally during the last 4 weeks (5 days/week) of the experiment. High-density lipoprotein, total cholesterol, triglyceride and leptin levels were measured in blood serum. Tissue malondialdehyde (MDA), glutathione (GSH), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and myeloperoxidase (MPO) levels were evaluated biochemically. Kidney and bladder morphology, NADPH oxidase-2 (NOX-2) and nuclear factor-kappa B (NF-ҡB)-positive and apoptotic cells were evaluated histologically. Results: Lipid profiles altered and leptin levels increased in blood serum. MDA, 8-OHdG and MPO levels increased and GSH level decreased in kidney and bladder in the HFD group. Moreover, degenerated kidney and bladder morphology, increased NOX-2 and NF-ҡB-positive and apoptotic cells were observed in this group. All of these biochemical and histological parameters were ameliorated in the HFD+MC group. Conclusion: HFD-induced obesity causes kidney and bladder damage by oxidative and inflammatory processes. MC extract may reduce oxidative stress and inflammation and play a protective role in obesity-related kidney and bladder damage. © 2022 by the Author(s).Article Citation - WoS: 1Citation - Scopus: 2Determining the Effect of Urbanization on the Vegetation of Gurun District (sivas) Based on Biotope Mapping and Vegetation Analysis(Istanbul Univ-cerrahapasa, 2020) Bozkurt, Selvinaz Gulcin; Akkemik, Unal; Kose, NesibeUrbanization is one of the strongest negative effects on vegetational change within and around a city. In this study, it is aimed to determine the flora and vegetational changes within and around the city based on the identification and mapping of the biotopes which show differences in terms of ecologic factors met in Gurun district center and its vicinity and which are suitable for Corine biotope classification. First, 13 main biotope types are classified. In the biotopes, total 666 plant taxa were identified, 84 of which were endemic. Vegetation of the biotopes was determined, and then similarity levels of main biotopes are calculated according to the similarity coefficient method of Sorensen. Accordingly, while the similar areas are health facilities and agricultural areas the most different ones are parks and sports areas and drainage areas. The results emphasize the similarity levels of vegetation in biotopes and the negative effect of human intervention in the study area. As a result, with its rich natural structure, vegetation covers and endemism rate, the district of Gurun has significant natural biotopes and it is suggested that biotope classification should be considered in determining vegetation change and urban planning.