TR-Dizin İndeksli Yayınlar Koleksiyonu
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Article Multipl Skleroz Öz Yönetim Ölçeğinin Türk Toplumuna Uyarlanması: Geçerlik ve Güvenirlik Çalışması(Dokuz Eylul University, 2025) Tosun, Anil; Eroglu, NermınGiriş: Multipl Skleroz (MS), fiziksel ve psikolojik hasara neden olan ve oldukça değişken prognoza sahip kronik, otoimmün bir hastalıktır. Bireylerin fiziksel olarak bağımlı hale gelmesine neden olan semptom tedavisi dışında öz bakım becerilerinin geliştirilmesi oldukça önemlidir. Amaç: Araştırma Multipl Skleroz Öz Yönetim Ölçeği (MS-ÖYÖ) Türk toplumuna uyarlanması amacıyla metodolojik olarak planlandı ve uygulandı. Yöntemler: Araştırma, Temmuz 2019-Mayıs 2020 tarihleri arasında bir üniversite hastanesinin nöroloji kliniğine başvuran multipl sklerozlu bireylerle gerçekleştirilmiştir. MSSM-R’nin geçerlik ve güvenirliği 169 katılımcı ile test edilmiştir. Yapı geçerliliği doğrulayıcı faktör analizi (AMOS) ile incelenmiş, test–tekrar test güvenilirliği eşleştirilmiş örneklem t-testleri ve Pearson korelasyon analizi ile değerlendirilmiş ve iç tutarlılık Cronbach’s alpha ile belirlenmiştir. Ayrıca madde analizleri de yapılmıştır. Bulgular: MS-ÖYÖ geçerliği dil geçerliği, yapı geçerliği (DFA) ve kapsam geçerliği ile değerlendirilmiştir. Güvenirliğinde iç tutarlılık analizi (Cronbach’s Alpha) .88 oldukça yüksek bulunmuştur, madde toplam korelasyonu incelenmiş ve herhangi bir maddenin ölçekten çıkarılmamasına karar verilmiştir ve zamana karşı değişmezliğin değerlendirilmesi için test tekrar test güvenilirliği için 30 hastaya iki hafta ara ile ölçek tekrar uygulanmıştır. Sonuç: Multipl Sklerozlu bireylerin öz yönetimlerinin değerlendirmesi amacıyla Türk toplumuna uyarlanan MS-ÖYÖ geçerli ve güvenilir bir araçtır.”Türkçeye uyarlanan MSSM-R, geçerli ve güvenilir bir araç olup, multipl sklerozlu bireylerin öz-yönetim müdahalelerini desteklemek için hem klinik uygulamada hem de araştırmalarda kullanılabilir.Article Citation - WoS: 1Citation - Scopus: 1A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhiza Glabra L. Varieties Root Extracts(Marmara University, 2025) Sen, Ali; Servı, Hüseyın; Barak, Timur Hakan; Tekin, Fethullah; Şener, Azize; Marzi, Mahdi; Gülmez, GizemPlants are the significant global interest as alternative treatment sources with their biologically activecompounds. This study compares the chemical composition and the antioxidant, antidiabetic, and antimicrobialproperties of ethanol extracts of G. glabra L. two different varieties from different regions. The phytochemicalcompositions was determined using GC-MS. Additionaly, total phenolic (TPC), flavonoid (TFC) and triterpene (TTC)contents were determined. Glycyrrhizic acid contents were analysed by HPLC. G. glabra var. glandulifera (GF1) showedthe highest antioxidant activity. All extracts had strong antidiabetic effects, besides GF1 showing the highest effect. TheMIC values was determined against 8 bacterial and 1 yeast strain and values ranged from 2.500 to 0.500; 2.500 to 0.714;2.500 to 0.714 for G. glabra var. glabra (GB), GF1, G. glabra var. glandulifera (GF2) respectively. Phytochemical studies haveshown that TPC was 100.60±5.06, 127.90±0.30, 69.01±0.30 mg GAE /g extract; TFC was 80.07±0.15, 25.35±0.0, 16.58±0.31mg KE/g and TTC was 217.30±6.05,172.40±2.17, 126.30±4.50 mg OE/g extract for GB, GF1, GF2, respectively. GF1 inparticular has the highest glycyrrhizic acid content. This study will contribute to the creation of new treatment strategiesand potential therapeutic agents in addition to the use of G. glabra L. in traditional treatments. Our study is also apreliminary study for future studies.Article The Current Face of Mosaic Art: Flacking Istanbul Examples(Bursa Uludag University, 2025) Ural, A.G.French artist Ememem is an anonymous artist who started producing his artworks in the city of Lyon in 2016. The unknown street artist brought a contemporary perspective to the art of mosaic by decorating or patching the sidewalks with mosaic art. The term ‘flacking’, which he developed to express the combination of various fields such as upcycling, street art, mosaic art, is becoming increasingly common and attracting the attention of local municipalities. The aim of this study is to discuss the art of flacking, which is a face of mosaic art, which is a very old branch of art, derived from current terms. In terms of scope, examples from Istanbul will be tried to be found and compared with foreign examples. French artist Ememem is an anonymous artist who started producing his artworks in the city of Lyon in 2016. The unknown street artist brought a contemporary perspective to the art of mosaic by decorating or patching the sidewalks with mosaic art. The term ‘flacking’, which he developed to express the combination of various fields such as upcycling, street art, mosaic art, is becoming increasingly common and attracting the attention of local municipalities. The aim of this study is to discuss the art of flacking, which is a face of mosaic art, which is a very old branch of art, derived from current terms. Examples from around the world show how mosaic art can be transformed into impressive and meaningful projects in public spaces. However, it has been seen that modern mosaic trials are still insufficient in our country. It has been determined that for the development of mosaic art, various courses, workshops, contemporary examples to be applied in public spaces and initiatives should be made in order not to lose this valuable art. © (2025), All Rights Reserved.Article Tsunami Awareness: A Case Study Of Hasköy, Beyoğlu, İstanbul(Afet ve Acil Durum Yönetimi Başkanlığı (AFAD), 2025) Taskin, H.; Gunaydin, D.H.; Yücel, G.An earthquake-triggered tsunami, originating from seismic activity in seas and oceans, poses a significant threat to coastal settlements within its impact zone. As part of risk reduction efforts, enhancing public awareness of tsunamis is crucial for mitigating potential disaster-related damages. Accordingly, this study emphasizes the importance of tsunami awareness initiatives by assessing the pre-disaster knowledge levels of the community. The study aims to measure the tsunami-related knowledge and awareness levels of residents in a settlement exposed to tsunami hazards. In this qualitative research, data were collected through semi-structured interviews conducted with business owners and employees in a purposively selected settlement. The study was carried out in the Piripaşa neighborhood of the Hasköy district in Istanbul’s Beyoğlu region, specifically within the coastal area parallel to the shoreline of the Golden Horn. Data were obtained from 22 active commercial enterprises out of 50 located along this coastal road. During the interviews, five key questions were posed to assess the respondents’ basic knowledge of tsunami awareness. The questionnaire also included images of tsunami evacuation route signs. The questions covered demographic characteristics, business activity sector, knowledge of tsunami hazards, awareness of the region’s tsunami risk, familiarity with tsunami evacuation procedures, and knowledge of relevant institutions and organizations involved in tsunami preparedness. The findings of the study indicate that the majority of the surveyed enterprises predominantly operate within the service sector. Furthermore, the results reveal a notably low level of awareness among participants regarding tsunami hazards, as well as limited knowledge of appropriate response behaviors during such events. While 50% of participants believe that the region is not at risk of tsunamis, 59% reported being aware of tsunami warning signs, which is a notable observation. Enhancing awareness of tsunami hazards and the region’s tsunami risk level is both essential and a priority. © (2025), (Afet ve Acil Durum Yonetimi Baskanligi (AFAD)). All right reserved.Article Relationship Between Resilience, Secondary Traumatic Stress and Work-Related Factors Among Mental Health Professionals(Kare Publ, 2025) Dikec, Gul; Tokatlıoglu, Tugba Sahın; Çetinkaya, Saadet; Yasar, SaadetObjectives: Resilience is the ability to maintain or rapidly recover mental health under stress. Mental health profes- sionals are often exposed to workplace stress through violence, emotional labor, restrictions, and traumatic stories. Secondary traumatic stress results from being affected by others’ traumatic experiences. Examining the relationship between resilience and secondary traumatic stress among mental health professionals is therefore essential. Methods: This descriptive study was conducted between February and April 2022. Data were collected using the Per- sonal Information Form, the Resilience Scale for Adults, and the Secondary Traumatic Stress Scale. Participants included 212 psychiatric and mental health nurses, 28 psychiatrists, 14 psychologists, and six social workers. Results: A significant positive relationship was found between resilience and secondary traumatic stress. The regres- sion model, including secondary traumatic stress, gender, educational status, willingness to work in mental health, job satisfaction, and unit of work, significantly predicted resilience. Conclusion: Secondary traumatic stress and work-related factors, such as willingness and satisfaction with working in mental health and the unit of work, were found to play an essential role in resilience. Institutional support and supervision may strengthen resilience, while reducing secondary traumatic stress can enhance motivation and well- being. Institutions are recommended to implement strategies that address these factors to improve both resilience and professional effectiveness.Article Evaluation of Dietary Habits and Related Parameters in a Group of Inpatients With Mental Disorders(Kare Publ, 2025) Dikec, Gul; Ata, Elvan Emıne; Özer, Duygu; Çalışkan, Mahinur Betül; Taliskan, Mahinur BetulObjectives: This study aimed to examine the dietary habits and related parameters of individuals with mental disorders. Methods: This study was descriptive and cross-sectional. The sample consisted of 94 individuals hospitalized in the psychiatric clinic of a hospital between June and December 2021. Data were collected using an information form cre- ated by the researchers. Results: Of the participants, 83% were male, and 25.5% had a chronic physical illness. The patients had a diagnosis of mental disorder for an average of 6.07 years. The most common side effect was an increase in appetite (36.4%). Additionally, 76.6% ate within 15 minutes, 93.6% consumed fish once a week or never, and 56.4% never exercised. In- dividuals who consumed home-cooked meals had lower BMI averages than those who consumed fast food. A weakly significant positive correlation was found between BMI and waist circumference averages and the duration of medica- tion use. Individuals with anxiety disorders had lower waist circumference, glucose, and LDL values compared to those with mood disorders. In contrast, individuals with psychotic disorders had significantly lower LDL levels than those diagnosed with mood disorders. Conclusion: Individuals with mental disorders were found to have inadequate and unbalanced nutrition, consuming diets rich in carbohydrates and low in protein, which negatively affected their parameters. Psychiatric nurses should evaluate the dietary habits of patients and provide counseling about healthy nutrition.Article Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin(Turkish Chemical Society, 2025) Başkan, Kevser Sözgen; Ersoy, Şeyda Karaman; Akyüz, Merve; Karaman Ersoy, Şeyda; Sözgen Başkan, KevserQuercetin (QUE) is the most active compound in the flavone family, commonly found in the leaves, fruits, and flowers of many plants. The separation of QUE from various plant matrices has been a key research area due to its antioxidant, anti-inflammatory, antiviral, and antitumor properties. In this study, the conditions for synthesizing MMIPs and their use in QUE recovery were examined. Iron (II) chloride tetrahydrate (FeCl2·4H2O) and iron (III) chloride hexahydrate (FeCl3·6H2O) were used to prepare magnetic nanoparticles, and Fe3O4 was synthesized. Tetraethyl orthosilicate (TEOS) was used to coat the resulting Fe3O4 surface with silica. [3-(methacryloxy)propyl] trimethoxysilane (γ-MPS) was used to functionalize the surface of the formed Fe3O4@TEOS structure. The synthesis was carried out using QUE as the template molecule; tetrahydrofuran (THF), ethanol (EtOH), and a solvent mixture of acetone and acetonitrile (ACN) (3:1, v/v) served as porogen solvents; acrylamide (AM), methacrylic acid (MAA), and 4-vinylpyridine (4-VP) were used as functional monomers; ethylene glycol dimethacrylate (EDMA) served as the cross-linker, and 2,2’-azobisisobutyronitrile (AIBN) was used as the initiator at different molar ratios (T:M:CrL, 1:4:20, 1:8:20, and 1:8:40). The recognition and selectivity properties of these polymers were evaluated based on absorbance values at 370 nm obtained through equilibrium assays, which used QUE solutions prepared in THF, ACN, and 50% (v/v) EtOH solvent mixtures at different ratios. It was established that the magnetic imprinted polymer prepared with a 50% (v/v) EtOH solvent mixture and molar ratios of 1:8:40 (QUE:4-VP:EDMA) exhibited the highest adsorption capacity and imprinting factor. Using the prepared QUE-MMIP, QUE was recovered with 33% efficiency from red onion peel extract.Article Measuring Shoulder Abduction Strength Using 2 Different Dynamometers: Comprehensive Intrarater and Interrater Reliability and Validity(Turkish Assoc Orthopaedics Traumatology, 2025) Atli, Ecenur; Topaloglu, Mahir; Hosbay, Zeynep; Ozdincler, Arzu RazakObjective: The purpose of this study is to investigate the intrarater and interrater reliability of handheld dynamometer (HHD) measurements in assessing isometric muscle strength of the shoulder abductors and to compare these results with those obtained using a fixed dynamometer (FD). Methods: The study involved 25 voluntary participants, all over the age of 18, asymptomatic (with no injuries in the upper extremity), and not engaged in overhead sports. The participants were evaluated twice by 2 different testers who were experienced in orthopedic rehabilitation, at 90 degrees of shoulder abduction in the scapular plane. On the first measurement day, Tester 1 performed measurements using both HHD and FD, while on the second measurement day, both testers used only the HHD. A 3-to 7-day interval separated the 2 measurement sessions. Paired-samples t-tests were used to evaluate the systematic bias between the testers. Spearman's rank correlation coefficient, intraclass correlation coefficient, standard error of measurement, and minimal detectable change were calculated. The statistical significance level was accepted as P < .05. Results: Data from 22 participants (15 women, 7 men; mean age: 23.00 +/- 3.19 years) were analyzed, as 3 individuals did not attend the final assessment. A strong correlation (r = 0.772) was found between Tester 1's HHD measurements and FD, while a similarly strong correlation (r = 0.748) was observed for Tester 2's HHD measurements. Excellent intrarater reliability (intraclass correlation coefficient [ICC]= 0.941) was found between Tester 1's measurements, and excellent interrater reliability (ICC= 0.889) was found between testers. Conclusion: Handheld dynamometer has demonstrated excellent interrater and intrarater reliability and high validity for assessing shoulder abductor muscle strength in research and clinical use. Since the muscle strength of testers using the HHD may influence the results, the FD may be a more appropriate option when the study population is stronger than the testers. Studies involving different clinical populations and testers with varying experience levels are needed to improve the relevance of the results. Level of Evidence: Level III, Diagnostic Study.Article Consensus Paper on Candida Auris by Türkiye EKMUD, ID-IRI, THSK of Ministry of Health of the Republic of Türkiye, KLIMUD, TMC, TARD, and TYBD(Tubitak Scientific & Technological Research Council Turkey, 2025) Agalar, Canan; Erdem, Hakan; Cag, Yasemin; Arda, Bilgin; Balik, Recep; Bastug, Aliye; Arikan Akdagli, Sevtap; Sarı, Nagehan Didem; Uzun, Omrum; Arikan-akdagli, Sevtap; Utku, Tughan; Kalkanci, AyseCandida auris is an emerging fungal pathogen that has become a critical global health concern due to its high antifungal resistance and potential to cause nosocomial outbreaks. Since its initial identification in Japan in 2009, C. auris has spread rapidly, posing significant treatment challenges across various healthcare settings worldwide. The biofilm formation ability of C. auris enhances its resilience against disinfectants and antifungal agents, complicating infection control in healthcare environments. This consensus report was developed by a collaboration between several Turkish medical societies including the Turkish Society of Infectious Diseases and Clinical Microbiology Specialty (EKMUD), the Turkish Society of Anesthesiology and Reanimation (TARD), the Turkish Intensive Care Society (TYBD), the Infectious Diseases-International Research Initiative (ID-IRI), the Clinical Microbiology Specialist Society (KLIMUD), the Turkish Microbiology Society (TMC), and the Public Health Institution of T & uuml;rkiye (PHIT) under the Ministry of Health. The report provides a comprehensive overview of C. auris and its management, with a focus on the epidemiology, antifungal resistance mechanisms, recommendations for diagnostic and therapeutic challenges, infection control and prevention measures, and surveillance of C. auris. This consensus report aims to establish standardized diagnostic protocols, improve national surveillance systems, and promote effective infection control measures to mitigate C. auris-related health risks in T & uuml;rkiye. It also offers comprehensive national recommendations and addresses the need for interinstitutional collaboration, improve public health, and strengthen the healthcare response to this pathogen.Article Citation - WoS: 1Citation - Scopus: 1Synthesis, Characterization, and Antimicrobial Evaluation of Some Novel Hydrazinecarbothioamides(Galenos Publishing House, 2025) Güler, Emrah; Dinç, Harika Öykü; Dincel, Efe Doğukan; Güzeldemirci, Nuray Ulusoy; Başoğlu-ünal, Faika; Kuran, Ebru Dıdem; Başoğlu, Faika; Ulusoy Güzeldemirci, NurayObjectives: This study focused on synthesizing and characterizing novel thiosemicarbazide derivatives containing a 1,2,4-triazole moiety and evaluating their antimicrobial activity against several bacterial strains. The research aimed to identify key structural features that enhance antimicrobial efficacy through structure-activity relationship analysis and identify the minimum inhibitory concentration (MIC) of the most potent compounds to assess their potential for further development as antimicrobial agents. Materials and Methods: Nine novel thiosemicarbazide derivatives containing a 1,2,4-triazole moiety were synthesized by reacting 1,2,4-triazole derivatives with thiosemicarbazide precursors, and the products were characterized using infrared spectroscopy, proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR) spectroscopy, and elemental analysis. The antimicrobial activity of these compounds (5a-i) was tested against Klebsiella pneumoniae (K. pneumoniae), Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, and Pseudomonas aeruginosa (P. aeruginosa), using microdilution, disk diffusion, and broth microdilution methods. Dimethyl sulfoxide was used as a negative control, and Vancomycin and Meropenem were used as positive controls, with all results converted to µM for consistent analysis. Results: The synthesized thiosemicarbazide derivatives (5a-i) were confirmed to be structurally correct through Fourier-transform infrared spectroscopy, 1H-NMR, and 13C-NMR spectroscopy. Among the tested compounds, 5e (4-bromophenyl) and 5g (n-propyl) showed significant antimicrobial activity, with 5g exhibiting the strongest effects against S. aureus and P. aeruginosa. Other derivatives, such as 5b (4-NO2Ph), 5c (4-FPh), and 5d (4-ClPh), showed moderate activity, while no significant activity was observed against K. pneumoniae or E. faecalis. Conclusion: The study successfully synthesized a series of novel thiosemicarbazide derivatives with a 1,2,4-triazole moiety and evaluated their antimicrobial potential. Compounds 5e and 5g exhibited significant antibacterial activity, particularly against S. aureus and P. aeruginosa, with MIC values in the low micromolar range. These findings suggest that the compounds hold promise as potential antimicrobial agents, and further studies should focus on optimizing their efficacy and exploring their mechanism of action.