WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhiza Glabra L. Varieties Root Extracts
(Marmara Univ, Fac Pharmacy, 2025) Gulmez, Gizem; Sen, Ali; Servi, Huseyin; Barak, Timur Hakan; Tekin, Fetullah; Marzi, Mahdi; Sener, Azize
Plants are the significant global interest as alternative treatment sources with their biologically active compounds. This study compares the chemical composition and the antioxidant, antidiabetic, and antimicrobial properties of ethanol extracts of G. glabra L. two different varieties from different regions. The phytochemical compositions was determined using GC-MS. Additionaly, total phenolic (TPC), flavonoid (TFC) and triterpene (TTC) contents were determined. Glycyrrhizic acid contents were analysed by HPLC. G. glabra var. glandulifera (GF1) showed the highest antioxidant activity. All extracts had strong antidiabetic effects, besides GF1 showing the highest effect. The MIC values was determined against 8 bacterial and 1 yeast strain and values ranged from 2.500 to 0.500; 2.500 to 0.714; 2.500 to 0.714 for G. glabra var. glabra (GB), GF1, G. glabra var. glandulifera (GF2) respectively. Phytochemical studies have shown that TPC was 100.60 +/- 5.06, 127.90 +/- 0.30, 69.01 +/- 0.30 mg GAE /g extract; TFC was 80.07 +/- 0.15, 25.35 +/- 0.0, 16.58 +/- 0.31 mg KE/g and TTC was 217.30 +/- 6.05,172.40 +/- 2.17, 126.30 +/- 4.50 mg OE/g extract for GB, GF1, GF2, respectively. GF1 in particular has the highest glycyrrhizic acid content. This study will contribute to the creation of new treatment strategies and potential therapeutic agents in addition to the use of G. glabra L. in traditional treatments. Our study is also a preliminary study for future studies.
Accelerated Planar Development of Convex Free-Form Mesh Patches Using a Variable Step-Size Energy Dissipation Approach
(Sciendo, 2025) Yavuz, Erdem; Yazici, Rifat
Free-form complex surfaces are prevalent in modern graphic applications. With the increasing prevalence of complex 3D surfaces enabled by advances in range scanning and 3D printing technologies, minimising parameterization times for large meshes has become crucial. This paper proposes an efficient approach for the planar development of convex free-form mesh patches using an improved energy-based technique with a variable step-size algorithm. Building upon the energy model of Wang et al., our study addresses the limitations of conventional energy dissipation algorithms, which employ fixed step sizes. The proposed variable step-size method, particularly suitable for convex or disk-shaped mesh surfaces, dynamically adjusts steps, significantly reducing energy dissipation iterations. Leveraging our previous geometric flattening method, we further enhance planar surface development using an advanced mass-spring-based approach. Here, we show that our method accelerates the mechanical flattening process while maintaining high accuracy, achieving a shape error of 0.400 and an area error of 0.147 after 36 iterations for the Surf1 patch, reducing the required iterations by nearly half compared to the fixed step-size method. This study contributes to advancing the field of surface parameterization and flattening, with potential applications in various industries.
Ameliorative Effects of Myrtus Communis L. Extract Involving the Inhibition of Oxidative Stress on High Fat Diet-Induced Testis Damage in Rats
(Taylor & Francis Ltd, 2024) Coskunlu, Busra; Koroglu, M. Kutay; Hersek, Irem; Ertas, Busra; Sen, Ali; Sener, Goksel; Ercan, Feriha
The possible protective effects of Myrtus communis L. (MC) extract on a high fat diet (HFD)-induced testicular injury in a rat model were investigated using histological and biochemical methods. Wistar albino rats were divided into three groups: a standard diet control group; a HFD group; and an HFD+MC group. The HFD and HFD+MC groups were fed with a HFD for 16 weeks. MC extract (100 mg/kg) was given orally five days a week to the rats in the HFD+MC group during the last four weeks of the experiment. Leptin, triglyceride, high-density lipoproteins, cholesterol, estrogen, testosterone, LH and FSH were analyzed in blood serum. Sperm parameters were evaluated from the epididymis. Testicular morphology, proliferative, apoptotic and NADPH oxidase-2 (NOX2)-positive cells were evaluated histologically. Testicular oxidative stress parameters were analyzed biochemically. In the HFD group, lipid and hormone profiles were changed, abnormal spermatozoa, degenerated seminiferous tubules with apoptotic and NOX2-positive cells were increased in number, and sperm motility and germinal proliferative cells decreased compared to the control group. Moreover, testicular malondialdehyde, 8-hydroxy-2-deoxyguanosine and myeloperoxidase levels increased, whereas glutathione and superoxide dismutase levels decreased in the HFD group compared to the control group. All these histological and biochemical features were ameliorated by MC treatment of HFD-fed rats. In conclusion, HFD caused alterations in sperm parameters and testicular morphology by increasing oxidative damage and apoptosis. MC extract may have potential protective effects by inhibiting oxidative damage.
Citation - WoS: 3
Citation - Scopus: 4
Analysis for Two-Dimensional Inverse Quasilinear Parabolic Problem by Fourier Method
(Taylor & Francis Ltd, 2021) Kanca, Fatma; Baglan, Irem
In this work, two-dimensional inverse quasi-linear parabolic problem with periodic boundary and integral overdetermination conditions is investigated. The formal solution is obtained by the Fourier approximation. Under some natural regularity and consistency conditions on the input data,the existence, uniqueness and continuously dependence upon the data of the solution are proved by iteration method. The inverse problem is first examined by linearization and then used implicit finite difference scheme for the numerical solution. Also predictor corrector method is considered in the numerical approach. Some results on the numerical solution with two examples are presented with figures and tables. The sensitivity of the scheme with respect to noisy overdetermination data is illustrated.
An Analysis of Psychological Resilience Levels Among Judo Coaches According to Selected Demographic Factors
(Idokan Poland Association, 2025) Beşiktaş, M.Y.; Terekli, M.S.
Background. Psychological resilience is a crucial personal trait that enables individuals, especially those in high-stress professions like coaching, to adapt and thrive in the face of adversity. Understanding how resilience manifests among coaches can contribute to more effective support and development strategies in sports psychology. Problem and aim. This study aims to determine whether the psychological resilience levels of judo coaches differ according to demographic variables such as age, educational background, coaching certification level, years of coaching experience, profession, and perceived economic status. Material and methods. The sample included 284 active judo coaches (58 women and 226 men) from Istanbul, Kutahya, and Eskisehir. Data were collected using the “Psychological Resilience Scale for Adults” [Friborg et al. 2003; Basim, Cetin 2011] and a “Personal Information Form.” Statistical analyses were conducted using SPSS 24.0, including independent samples t-tests, one-way ANOVA, and Eta squared analysis to assess the influence of demographic actors on resilience levels. Results. The findings indicated significant differences in psychological resilience levels based on gender, marital status, age, educational attainment, coaching experience, income level, and coaching certification level. Conclusions. The results suggest that psychological resilience among judo coaches is meaningfully influenced by various demographic characteristics. These findings underscore the importance of tailoring psychological support and development programs to the specific profiles of coaches. © Yoshin Academy
Citation - WoS: 16
Citation - Scopus: 23
Balance Training in Modern Dancers Proprioceptive-Neuromuscular Training Vs Kinesio Taping
(Science & Medicine inc, 2018) Tekin, Demet; Agopyan, Ani; Baltaci, Gul
Kinesio tape and proprioceptive exercises are both used for increasing balance in dancers. The purposes of this study were to: a) determine the acute effect of kinesio tape (KT) application on the ankle joint on balance performance, b) investigate the effects of an 8-week proprioceptive-neuromuscular (PN) training program on balance performance, and c) compare their effects vs modern dance technique classes alone. Thirty-three trained, university-level modern dance students (9 male, 24 female) were divided randomly into three groups: kinesio tape (KT, n=11), proprioceptive-neuromuscular (PN, n=11), or control (n=11). Static (turn-out passe-opened eyes/releve and turn-out passe-closed eyes/flat foot), semi-dynamic (airplane), and dynamic balance (monopodalic-straight and -transverse in a turn-out passe-eyes opened/flat foot) tests were performed before and after the intervention. One day after pre-tests, KT mechanical correction technique was applied to the left ankle joint (supporting leg) in the KT group, and tests were repeated to determine the acute effect of KT. The PN group participated in an 8-week balance training program (2 days/wk, 60 min/day) involving exercises using stable and unstable surfaces. Significant improvements were observed for all static and dynamic balance tests in the PN group; semi-dynamic airplane and dynamic monopodalic-straight and transverse tests improved in the KT group; and only semi-dynamic airplane test scores changed significantly for the control group (p<0.05). Our findings suggest that with the exception of the semi-dynamic airplane test, both PN training and KT application were more effective at improving balance performance for modern dancers than modern dance technique classes alone.
Bangladesh Journal of Pharmacology
(Bangladesh Pharmacological Soc, 2024) Kulabas, Necla; Guven, Cansu Tamniku; Duracik, Merve; Ozakpinar, Ozlem Bingol; Kucukguzel, Ilkay
[No Abstract Available]
Clinical Outcomes of Conservative Versus Surgical Treatment for Patients With Proximal Humeral Fracture Before Physiotherapy
(Acta Medica Belgica, 2024) Kus, G.; Alpozgen, A. Zengin; Gungor, F.; Ozdincler, A. Razak; Altun, S.
Fear of movement, pain, and loss of shoulder function are the most common problems irrespective of their approach to management after proximal humeral fracture (PHF). However, it has been unclear whether there could be differences between both treatments in early clinical outcomes. It can help physiotherapists to guide in choosing treatment approaches. This study aimed to compare kinesiophobia, pain, range of motion (ROM), shoulder function, and Quality of life (QoL) in patients treated with either conservative (CT) versus surgical (ST) after PHF. In addition, it aimed to determine correlations between fear of movement and seconder outcome measures. This cross-sectional study enrolled the patients having 5-6 weeks (being permitted active movement) after being treated either CT or ST and receiving no physical therapy. Pain, passive and active ROMs, shoulder function, fear of movement, and QoL were evaluated. 42 patients were recruited. Kinesiophobia scores were similar (p=0.55) and moderate in both groups. There was a significant difference in degrees of shoulder active flexion, active and passive abduction in favor of the CT group (p=0.05, p=0.02, p=0.04, respectively). However, there was no difference between groups regarding the remaining clinical outcomes. Furthermore, kinesiophobia showed a moderate negative correlation with energy/fatigue, social functioning, and general health. These findings showed that patients treated surgically did not have more kinesiophobia, less function, and QoL before starting physiotherapy, despite having soft tissue damage and different types of fractures. However, surgically treated patients had significantly less range of motion.
Comparative Cross-Sectional Study on Sexual Function of Couples During Pregnancy: Assisted Reproductive Techniques Versus Spontaneous Conceptions
(Womens Health & Action Research Centre, 2024) Dulger, Ozlem; Dinmez, Sinem; Torun, Sebahat D.; Osmanoglu, Usame O.
This study aims to compare the sexual functions of couples undergoing assisted reproductive techniques (ART) with those conceiving spontaneously during pregnancy. A total of 102 couples participated in this cross-sectional study, with 68 couples in the spontaneous conception group and 34 couples in the ART group. Data collection was conducted face-to-face in the antenatal clinic using separate "Descriptive Information Form" for women and men, "Female Sexual Function Index (FSFI)" for women, and "Libido Scoring System (LSS)" for men. Descriptive statistical methods, Chi-square and Fisher exact tests, t-test, and Pearson correlation test were used for data analysis. It was observed that the mean FSFI total scores of women who conceived spontaneously and through ART during pregnancy were at a good level (>= 30), while the mean LSS scores of their partners were at a moderate level (5-7). No statistically significant distinction existed among the groups. Further research is advisable by adjusting the sample selection criteria, such as gravida, duration of ART treatment, and gestational age.
Comparison of HLA-G Levels for Cord Blood Derived-MSC and Wharton's Jelly Derived-MSC
(Walter de Gruyter GmbH, 2025) Abatay Sel, Figen; Erol Bozkurt, Ayse; Karatas, Sule; Suleymanoglu, Mediha; Yasa, Beril; Yasa, Cenk; Savran Oguz, Fatma
Objectives: A special group of stem cells with multipotent and immunomodulatory properties are mesenchymal stem cells (MSCs). Many modulatory factors are thought to mediate immunomodulatory properties of MSCs. One of these modulatory factors is thought to be HLA-G, one of human leukocyte antigens (HLA). This study aimed to compare HLA-G levels in both stimulated and unstimulated of peripheral blood mononuclear cell (PBMC) cultures with "cord blood-MSC" (CB-MSC) and "Wharton's jelly-MSC" (WJ-MSC) at different rates and different incubation periods. Methods: WJ-MSCs were obtained by explant method, and CB-MSCs using Ficoll-paque. They were characterized by flow cytometry. MSCs and PBMCs were directly co-cultured for 24 and 72 h at 1:5 and 1:10, respectively. After incubations, the media were collected and HLA-G levels were measured by ELISA. Results: In the unstimulated group, the highest HLA-G level was found in the PBMC:WJ-MSC-72-1:5 group, while the lowest HLA-G level was found in the PBMC:CB-MSC-72-1:5. When 24-1:5 and 72-1:5 groups were examined, the HLA-G level decreased significantly in CB-MSC groups compared to WJ-MSC, while it increased significantly in the 24-1:10 and 72-1:10 groups (p<0.05). In stimulated groups, the highest HLA-G level was observed in the PBMC:CB-MSC-24-1:5. Conclusions: Our study aimed to evaluate the immunomodulatory effect of MSCs via HLA-G molecule. HLA-G levels changed with different incubation times of two different MSC sources. In this study, we suggest that MSCs as a cell therapy, in particular for immune system-related disease, may be a preliminary in vitro approach to evaluate the immunomodulatory effect via HLA-G.
Design and Implementation of a Low Cost and Portable Tactile Stimulator Br
(Tubitak Scientific & Technological Research Council Turkey, 2022) Kazma, Coskun; Levent, Vecdi Emre; Cardak, Merve; Aydin, Nizamettin
When central nervous system has a problem, somatic area I and II respond to stimulation differently. Therefore, it is possible to identify some of the central nervous diseases when somatosensory on the fingertip is stimulated and responses are recorded and analyzed. We designed a system to stimulate the mechanoreceptors on fingertips. It is composed of a mechanical system for fingertip stimulation, an embedded controller, a control computer, and a software to control overall operation. During test, mechanoreceptors are stimulated according to the test protocols. Individuals' answers are recorded to be evaluated by the developed software. In this study, several design approaches for embedded controller were also examined and an FPGA based controller with the same functionality but higher performance was implemented. A test procedure was performed on 51 individuals at the department of pediatric psychiatry in a hospital, to investigate whether the sex has an effect on attention deficit and hyperactivity disorder.
Determination of Post-Earthquake Trauma Level and Investigation of the Relationship with Physical Activity Status
(Turkish Physiotherapy Association, 2025) Tosun, Anil; Yılmaz, Nergis; Luque, Demet Tekın De Las Penas
Amaç: Çalışmanın amacı; 06 Şubat 2023’te meydana gelen Pazarcık-Elbistan merkezli depremler sebebiyle kişilerde oluşan travma düzeyinin, kişinin fiziksel aktivite durumu ile ilişkisini incelemektir. Aynı zamanda, kişilerde deprem sonrası ağrı varlığının sorgulanması ve bu durumun travma düzeyi ile ilişkisini ortaya koymaktır. Yöntem: Veriler çevrimiçi olarak Google formları aracılığıyla toplandı, 18-65 yaş arası 388 gönüllü katılımcı (299 kadın, 89 erkek) çalışmaya dahil edildi. Katılımcıların genel özelliklerini belirlemek için “Sosyodemografik Bilgi Formu”, travma düzeyini değerlendirmek için “Deprem Sonrası Travma Düzeyini Belirleme Ölçeği” (DSTDBÖ) ve fiziksel aktivite durumlarını belirlemek için “Uluslararası Fiziksel Aktivite Anketi Kısa Formu” (IPAQ-KF) kullanıldı. Bulgular: Deprem bölgesinde bulunma durumuna göre DSTDBÖ genel puan ortalamaları arasında anlamlı fark saptandı (p<0,001). Deprem bölgesinde bulunan 126 kişinin DSTDBÖ genel puan ortalaması 57,66±19,87 iken, bölgede bulunmayan 262 kişinin ortalaması 49,00±18,49 olarak bulundu. Spearman korelasyon analiziyle deprem bölgesinde olan ve olmayan bireylerin IPAQ-KF toplam puanları, DSTDBÖ alt faktör ve toplam puanları arasındaki ilişki incelenmiş olup sadece “Bilişsel Yapılandırma” alt faktörü ile IPAQ-KF toplam puanları arasında anlamlı bir ilişkiyi yansıtmayan negatif zayıf ilişki bulundu (deprem bölgesinde olanlar için Spearman korelasyon katsayı değeri =-0,18, p=0,042). Ve deprem sonrası ağrı yaşayan bireylerin DSTDBÖ puanları, ağrı yaşamayanlardan daha yüksek olarak saptandı (p=0,000). Sonuç: Bu çalışma ile deprem sonrası travma düzeyinin, fiziksel aktivite ile negatif ilişki gösterdiği belirlendi. İnaktif bireyler daha yüksek travma düzeylerine sahipken, minimal aktif bireylerde travma düzeyleri daha düşük bulundu. Bu bulgular, deprem sonrası fiziksel aktivitenin artırılmasının travma düzeylerini azaltmada etkili bir strateji olabileceğini göstermektedir. Bu alanda daha fazla araştırma, eğitim ve proje çalışmalarının yapılması gerekmektedir.
Development and Psychometric Properties of the Home Programme Quality Evaluation Tool for Therapists, Clients and Caregivers: A Validity and Reliability Study
(MA Healthcare Ltd, 2025) Akyurek, Gokcen; Bektas, Selen Aydoner; Sipahi, Busra
Background/Aims Home programmes - where rehabilitation activities are carried out in the client's home - are frequently used in the rehabilitation process but there are no standardised measurements to assess preparation, delivery and quality. The aim of this study was to determine the validity and reliability of two different forms - one for therapists and one for client and caregivers - that were developed as part of the Home Programme Quality Evaluation tool. Methods Initially, two 38-item forms were created based on a comprehensive literature review and expert panel evaluation. These forms were piloted with 30 participants from each target group to assess grammatical clarity, comprehensibility and cultural appropriateness. Based on the pilot feedback, minor linguistic adjustments were made, and the refined 38-item forms were then administered to 179 physiotherapists, occupational therapists and speech and language therapists, and 185 clients/caregivers (100 clients, 85 caregivers) for psychometric analyses. Psychometric analyses were conducted to evaluate validity and reliability, including exploratory and confirmatory factor analyses (chi-square/degree of freedom ratio, Goodness-of-Fit Index, Tucker-Lewis Index, Comparative Fit Index, Incremental Fit Index, root mean square error of approximation, standardised root mean square residual and internal consistency (Cronbach's alpha) and test-retest reliability (intraclass correlation coefficient and Pearson correlation). Results Exploratory and confirmatory factor analyses supported a one-factor structure for both forms, resulting in the final 11-item therapist form and 8-item client/caregiver form. The Home Programme Quality Evaluation tool demonstrated a good model fit for both forms (therapist form: chi(2)/df=2.66, goodness-of-fit index=0.909, Tucker-Lewis Index=0.886, standardised root mean square residual=0.060; client/caregiver form: chi(2)/df=3.37, goodness-of-fit index=0.929, Tucker-Lewis Index=0.950, standardised root mean square residual=0.027). Cronbach's alpha was 0.868 for the therapist form and 0.932 for the client/caregiver form. Test-retest reliability revealed strong positive correlations (r=0.994, P<0.001; r=0.998, P<0.001) and excellent stability over time (intraclass correlation coefficient=0.998 and 0.990, respectively). Conclusions The Home Programme Quality Evaluation's therapist and client/caregiver forms were found to have strong validity and reliability. The therapist form can enable therapists to monitor themselves, while the client and caregiver form can help clients or caregivers provide feedback on the home programme. Future studies can explore its application across different clinical populations and rehabilitation settings to further refine and optimise home-based interventions. Implications for practice For allied health professionals, the Home Programme Quality Evaluation tool serves as a practical tool for improving home programme design and implementation. By systematically assessing home programme quality, therapists can identify areas for improvement, ensuring that programmes are clear, feasible and well-integrated into the daily life of clients and their caregivers. Integrating the Home Programme Quality Evaluation tool into routine clinical practice can contribute to more effective rehabilitation outcomes, promoting structured, high-quality home programmes that align with the needs and capabilities of both clients and caregivers.
Citation - WoS: 3
Citation - Scopus: 3
The Direct and Indirect Effects of Irrational Beliefs on Perceived Performance: The Mediation Role of Emotions and Automatic Thoughts
(Springer, 2023) Urfa, Osman; Asci, Fevziye Hulya
The aim of this study was to examine the relationship between irrational beliefs and perceived performance and the atemporal mediator role of emotions and automatic thoughts in this relationship. A cross-sectional study design with a convenient sampling method was used in the study. Participants included 395 athletes from basketball, football, handball, and volleyball and consisted of 267 male (Mage = 20.73, SD = 2.37) and 128 female (Mage = 21.33, SD = 2.17) athletes who voluntarily participated in the study. Data was analyzed via a path analysis and irrational beliefs were shown to negatively predict positive emotions and positive automatic thoughts, but these beliefs positively predicted negative emotions and negative automatic thoughts. The direct effect of irrational beliefs on perceived performance was not significant, but its indirect effect on perceived performance through emotions and automatic thoughts was significant. Irrational beliefs negatively predict perceived performance through emotions and automatic thoughts. It is concluded that emotions and automatic thoughts play a significant role in the relationship between irrational beliefs and perceived performance.
Does Neuromuscular Electrical Stimulation Have an Additive Effect on Disability, Pain and Abdominal and Lumbar Muscle Thickness in Chronic Low Back Pain? - a Randomized Controlled Double-Blind Study
(Georg Thieme verlag Kg, 2022) Atli, Ecenur; Coskunsu, Dilber Karagozoglu; Turan, Zeynep; Taskiran, Ozden Ozyemisci
Zusammenfassung
The Effect of 3d Modeling on Family Quality of Life, Surgical Success, and Patient Outcomes in Congenital Heart Diseases: Objectives and Design of a Randomized Controlled Trial
(Turkish J Pediatrics, 2024) Sumengen, Aylin Akca; Ismailoglu, Abdul Veli; Ismailoglu, Pelin; Gumus, Terman; Celiker, Alpay; Namlisesli, Deniz; Cakir, Gokce Naz
Background. Understanding the severity of the disease from the parents' perspective can lead to better patient outcomes, improving both the child's health -related quality of life and the family's quality of life. The implementation of 3 -dimensional (3D) modeling technology in care is critical from a translational science perspective. Aim. The purpose of this study is to determine the effect of 3D modeling on family quality of life, surgical success, and patient outcomes in congenital heart diseases. Additionally, we aim to identify challenges and potential solutions related to this innovative technology. Methods. The study is a two -group pretest -posttest randomized controlled trial protocol. The sample size is 15 in the experimental group and 15 in the control group. The experimental group's heart models will be made from their own computed tomography (CT) images and printed using a 3D printer. The experimental group will receive surgical simulation and preoperative parent education with their 3D heart model. The control group will receive the same parent education using the standard anatomical model. Both groups will complete the Sociodemographic Information Form, the Surgical Simulation Evaluation Form - Part I -II, and the Pediatric Quality of Life Inventory (PedsQL) Family Impacts Module. The primary outcome of the research is the average PedsQL Family Impacts Module score. Secondary outcome measurement includes surgical success and patient outcomes. Separate analyses will be conducted for each outcome and compared between the intervention and control groups. Conclusions. Anomalies that can be clearly understood by parents according to the actual size and dimensions of the child's heart will affect the preoperative preparation of the surgical procedure and the recovery rate in the postoperative period.
Citation - Scopus: 1
Effect of Sexual Quality of Life on Self-Management Perceptions of Women With Type 2 Diabetes
(Wolters Kluwer Medknow Publications, 2024) Eroglu, N.
Background:The quality of sexual life of women with type 2 diabetes has an impact on their self-management perceptions.Aim:To evaluate the effect of quality of sexual life on self-care perceptions of women with type 2 diabetes mellitus (DM).Material and Methods:It was an online descriptive study of 127 women with type 2 DM. The questionnaire consisted of a patient information form, sexual quality of life scale-female, and diabetes self-management perception scale.Results:There was a significant relationship between diabetes self-management perception and sexual quality of life (P = 0.000). The individuals' diabetes self-management perception scores differed significantly according to their age (F = 3.12; P = 0.047), and the sexual quality of life scores differed significantly according to their treatment type (F = 4.01; P = 0.020).Conclusion:There is a relationship between quality of sexual life and self-management perceptions of women with type 2 DM. As the quality of sexual life increases, diabetes self-management perceptions increase. Age affects diabetes self-management perception, and the type of treatment used by individuals also affects their quality of sexual life.
The Effect of Vitamin D and Paricalcitol on Protein Disulfide Isomerase
(Marmara University, 2025) Koksal, Murat; Şekerler, Turgut; Şener, Azize
Protein disulfide isomerase (PDI), a multifunctional protein plays an important role as oxidoreductase, isomerase and chaperone in the cell. Prior studies have identified PDI is highly expressed in many different cancer types and presented as a new potential target for cancer treatment. Here, we investigated vitamin D and its analogue paricalcitol in silico interaction of the human PDI and inhibition of PDI reductase activity in vitro. We observed a non-covalent mechanism where the main skeleton of the vitamin D3 ans paricalcitol sturcture is located at the hydrophobic site in the b' domain of PDI and forms a hydrogen bond with a residue (His138) in tihs domain. They also form multiple weak hydrophobic interactions with various chemical groups of the b' subunit. For the first time, we demonstrate that 1,25-dihydroxyvitamin D3 (1a,25(OH)2 vitamin D3) and paricalcitol inhibit the PDI reductase activity in vitro and their IC50 values are 20.79±1.43 nmol/L and 32.83±3.15 nmol/L respectively. The two compounds can also block the denistrosation activity of PDI.
Citation - WoS: 2
The Effectiveness of Blood Flow Restriction Training on Upper Extremity Muscle Strength: a Systematic Review
(Georg Thieme verlag Kg, 2024) Yazgan, Elif Aleyna; Atli, Ecenur; Ozdincler, Arzu Razak
Objective This systematic review aims to investigate the effect of blood flow restriction training (BFRT) on upper extremity muscle strength in pathological conditions of the upper extremity musculoskeletal system or in healthy individuals. Materials and Methods This study was conducted in accordance with the PRISMA guideline statement. The randomized controlled studies which published from January 2000 to May 2022 were searched in the PubMed, Web of Science, MEDLINE, Scopus, and Cochrane Library databases. Inclusion criteria were healthy clinical population or musculoskeletal pathology related to the upper extremity, participants aged 18 and above, application of blood flow restriction to the arm, a randomized controlled study design, and publication in English. Additionally, the presentation of upper extremity muscle strength as an outcome measurement was required. The quality of the studies was evaluated using The Physiotherapy Evidence Database (PEDro) scale. Articles that were non-randomized, inaccessible in full text, and scored 4 or below on the PEDro scale were excluded. Results Five studies were included with 219 participants. The included studies had PEDro scores ranging from 5 to 8, with an average score of 6.4. This review demonstrated a positive or neutral effect of BFRT on grip strength and shoulder strength. Conclusion Although some studies have reported positive effects of BFRT on upper extremity muscle strength, there is no conclusive evidence regarding the protocol to be used for increasing upper extremity muscle strength.
Citation - WoS: 2
Citation - Scopus: 2
Effectiveness of Non-Invasive Vagal Nerve Stimulation in Parkinson's Disease: a Comprehensive Systematic Review And Meta-analysis
(Elsevier Sci Ltd, 2025) Abouelmagd, Moaz Elsayed; Yousef, Obai; Ibrahim, Ismail A.; Elshahat, Ahmed
Background: Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by movement impairments. Vagus nerve stimulation (VNS) is a non-invasive brain stimulation technique that has shown promise in treating various neurological conditions, including PD. This systematic review aimed to evaluate the existing evidence on the efficacy of nVNS in managing PD symptoms. Methods: A comprehensive literature search was conducted to identify relevant studies published up to July 2024. The included studies investigated the effect of nVNS on various PD motor symptoms. The quality of studies was assessed using the Cochrane Risk of Bias 2 (ROB-2) and NIH tool for RCTs, single-arm studies, and case series studies respectively. Statistical analysis was conducted using Review Manager version 5.4.1 with outcomes expressed as Mean differences (MD) with 95% confidence intervals (CI). Results: The systematic review included eight randomized controlled trials (RCTs), one single-arm study, and one case series, encompassing a total of 217 patients with PD. The review revealed that nVNS in increasing Freezing of Gait (FOG) in PD (p = 0.04). However, no significant differences were found in UPDRS-III (p = 0.19 and p = 0.89 for on and off-medication conditions, respectively), UPDRS-II (p = 0.9), UPDRS-I (p = 0.46), Time Up and Go (p = 0.61), stand time (p = 0.87), walking speed (p = 0.22), or step length measured in meters (p = 0.8). Interestingly, a significant improvement was observed in step length measured in centimetres (p = 0.0005). No study reported serious adverse effects associated with nVNS treatment. Conclusion: Our finding suggests a potential benefit of nVNS in reducing FOG in PD, but did not demonstrate a significant improvement in other motor symptoms. Larger, longer follow-up studies are needed to confirm the effect nVNS on PD management. PROSPERO number: CRD42024574822.

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