WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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Citation Count: 6
Acute Changes in Electrophysiological Brain Dynamics in Elite Karate Players
(Springer international Publishing Ag, 2020) Balcıoğlu, Taylan Hayri; Balcioglu, Taylan Hayri; Ozcan Cakir, Canan Elif; Goksel Duru, Dilek; Antrenörlük Eğitimi Bölümü
Regular physical exercise has enhanced effects on the human anatomy and functionality. Recently, an effect of a single set of exercise is shown to have positive effects on mood and on cognitive functioning. The aim of this study is to investigate the effect of a single bout of moderate exercise on the brain electrophysiological dynamics in resting-state condition and under the mental workload situation from elite-level athletes. For this purpose, electroencephalogram (EEG) is measured before and after the exercise sessions from 17 elite karate players who are members of the national karate team of Turkey. Blood lactate measurements are implemented to monitor the volunteers before EEG measurements. EEG data are analyzed using three metrics: conventional band power of each electrode, coherence metrics between electrodes for each band and source coherence values corresponding to each frequency band. Each metric is statistically analyzed between pre- and post-values, and results revealed that in all frequency bands, right parietal electrode had increased connection values which are thought to be related to ongoing sympathetic nervous system response observed during the recovery period. Another finding is the enhanced connectivity of frontal sources under the resting state as well as during the increased mental workload periods.
Citation Count: 1
Comparison of in Vitro Antifungal Activity Methods Using Extract of Chitinase-Producing aeromonas Sp. Bhc02
(Springer, 2023) Kızıltaş, Gülesme; Yilmaz, Gulesme; Tıbbi Hizmetler ve Teknikler Bölümü
Biological control to prevent fungal plant diseases offers an alternative approach to facilitate sustainable agriculture. Since the chitin in fungal cell walls is a target for biocontrol agents, chitinases are one of the important antifungal molecules. In this study, the aim was to investigate a new chitinase isolated from a fluvial soil bacterium and to show the antifungal activity of the characterized chitinase by comparing the three common methods. The bacterium with the highest chitinase activity was identified as Aeromonas sp. by 16 S rRNA sequence analysis. Following the determination of the optimum enzyme production time, the enzyme was partially purified, and the physicochemical parameters of the enzyme were investigated. In the antifungal studies, direct Aeromonas sp. BHC02 cells or partially purified chitinase were used. As a result, in the first method in which the Aeromonas sp. BHC02 cells were spread on the surface of petri dishes, no zone formation was observed around the test fungi spotted on the surface. However, zone formation was observed in the methods in which the antifungal activity was investigated using the partially purified chitinase enzyme. For example, in the second method, the enzyme was spread on the surface of PDA, and zone formation was observed only around Penicillum species among the test fungi spotted on the surface. In the third method, in which the necessary time was given for the formation of mycelium of the test fungi, it was observed that the growth of Fusarium solani, Alternaria alternata and Botrytis cinerea was inhibited by the partially purified chitinase. This study concludes that the results of the antifungal activities depend on the method used and all fungal chitins cannot be degraded with one strain's chitinase. Depending on the variety of chitin, some fungi can be more resistant.
Citation Count: 0
Comparison of Total Antioxidant Capacities and Phenolic Constituents of Grapes Cultivated in Turkey for Wine Production
(Taylor & Francis inc, 2024) Karaman Ersoy, Şeyda; Vural, Turkan; Baskan, Kevser Sozgen; Tutem, Esma; Temel Eczacılık Bilimleri Bölümü
Grapes are renowned for their health-promoting properties due to polyphenols, particularly anthocyanins in red grapes and flavonols in white grapes. This study evaluated the total antioxidant capacities (TAC) of specific grape varieties (Sultaniye, Chardonnay, Shiraz, Carignan, Alicante Bouschet, and Merlot) using the CUPRAC (CUPric Reducing Antioxidant Capacity) and ABTS/HRP (2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)/horseradish peroxidase) methods. Additionally, total phenolic, flavonoid, and anthocyanin contents were determined via Folin Ciocalteu, AlCl3/NaNO2, and pH differential methods. Primary phenolic compounds were identified with High-Performance Liquid Chromatography-Photodiode Array (HPLC-PDA). TAC values of the grape juices (mmol Trolox L-1) ranked as Alicante > Shiraz > Sultaniye > Carignan > Merlot > Chardonnay by CUPRAC, and Shiraz > Alicante > Merlot > Carignan >= Sultaniye > Chardonnay by ABTS/HRP and for skin extracts (mmol Trolox g(-1)), Carignan > Alicante > Shiraz > Merlot > Chardonnay > Sultaniye by CUPRAC, and Carignan > Shiraz > Alicante > Merlot > Chardonnay > Sultaniye by ABTS/HRP. The study demonstrated a strong correlation between phenolic composition and TAC values in grape samples, with anthocyanins as the predominant family contributing significantly to TAC. Varietal and intra-fruit differences in specific phenolic compounds were found to account for variations in observed TAC levels. Specifically, grape skin samples showed a more robust correlation between antioxidant capacity and total phenolic content (r = 0.986) than grape juices (r = 0.777). These findings underscore the considerable variation in antioxidant potential among grape varieties and emphasize the critical role of phenolic composition in the health-related benefits of grape consumption.
Citation Count: 13
Design, Synthesis and Anticancer Activity Studies of Novel 4-Butylaminophenyl Hydrazide-Hydrazones as Apoptotic Inducers
(Pergamon-elsevier Science Ltd, 2022) Küçükgüzel, Şükriye Güniz; Baysal, Ozge Deniz Yesil; Basaran, Guzide Satir; Sezer, Gulay; Telci, Dilek; Kucukguzel, S. Guniz; Eczacılık Meslek Bilimleri Bölümü
In this study, a series of the novel Tetracaine derivatives bearing hydrazide-hydrazone moiety were designed, synthesized, and evaluated for anticancer activity. The structures of these compounds were characterized by spectral (H-1-C-13 NMR, FT-IR, and HR-MS analyses) methods. All synthesized compounds (2a-1) were screened for anticancer activity against human hepatocellular carcinoma (HepG2) and lung carcinoma (A549) cell lines. Against HepG2 and A549 cell lines, among the synthesized compounds, 4-(Butylamino)-N'-[(2,4-dichlorophenyl)methylidene]benzohydrazide (2i) demonstrated the most potent anticancer activity with IC50 values 28 and 7 mu M, respectively. Possible cytotoxic effects of compounds (2a-1) on both normal human lung fibroblast (MCR-5) and normal human dermal fibroblast (HDF) cell lines were assessed. Inhibition of anti-apoptotic protein Bax and Bcl-2 was investigated in HepG2 and A549 cells treated with compound 2i using qRT-PCR. Apoptosis was also detected by Annexin V studies. The flow cytometric analysis results showed that compound 2i treatment of HepG2 and A549 cells significantly increased apoptotic cell populations while decreasing viabilities in these carcinomas in a dose-dependent manner after 72 h of incubation. (C) 2022 Elsevier Ltd. All rights reserved.
Citation Count: 0
Does Working Style Affect the Occupational Balance and Life Satisfaction of Office Workers in Turkey? a Comparison Study
(Ios Press, 2024) Aydöner, Selen; Aydoner, Selen; Altuntas, Onur; Bumin, Gonca; Ergoterapi Bölümü
BACKGROUND: The coronavirus outbreak (COVID-19) has caused various effects, changing people's lives and work styles. During this period, workplaces decided to work remotely, so people spent more time at home. Therefore, workers' personal and work lives were negatively affected. OBJECTIVE: This study planned to compare traditional and remote office workers' occupational balance and life satisfaction in Turkey during COVID-19. METHODS: Google Survey was used for data collection. Three hundred office workers (18-65 years old) from Turkey participated in the study. The occupational balance and life satisfaction levels of participants were assessed using the Occupational Balance Questionnaire (QB-Quest) and Personal Well-being Index-Adult (PWI-A). RESULTS: Data collected were analyzed statistically by the Independent Sample t-test. It was found that the remote office workers had lower levels of occupational balance (p = 0.02; r = -3.317) and life satisfaction (p = 0.01; r = -2.199) compared to the traditional office workers. CONCLUSION: Remote office workers were found to have lower occupational balance and life satisfaction than traditional office workers. In this period, when the way of working changes like COVID-19, it is crucial to determine office workers' occupational balance and life satisfaction and take precautions for their job performance and satisfaction.
Citation Count: 1
The Effect of a Video-Based Covid-19 Paediatric Patient Education on State Anxiety in Children With Suspected Covid-19 Admitted To Hospital
(Elsevier Sci Ltd, 2023) Şancı, Yağmur; Celik, Serap; Yildiz, Suzan; Hemşirelik Bölümü
Background: Anxiety causes the long-term psychological impacts on children during the pandemic.Objective: The aim of this study is to reduce anxiety in paediatric patients and increase their adherence to treatment through a video-based COVID-19 paediatric patient education.Methods: This quasi-experimental study with pretest-posttest single group was carried out in a research hospital's COVID-19 Paediatric Emergency Area in Turkey between May and August 2020. The sample consisted of 128 children aged between 4 and 12 years.Results: In the study, it was found that 50.8% of the children who came to the COVID-19 Paediatric Emergency Area due to suspicion of COVID-19 were boys and their mean age was 8.54 & PLUSMN; 2.62. 21.1% of the children were hospitalised before and 73.4% were afraid of the hospital. State stress scores of the participants before the patient education were higher in those, who didn't attend school between ages of 4-10, than those who went to school. State stress mean scores of the children from all age groups decreased significantly after the education.Conclusions: The video-based paediatric patient education decreases the children's hospital-related anxiety during the pandemic and increased their adherence to treatment.
Citation Count: 0
Effect of Everolimus on Prognosis of Neurofibromatosis Type 1 Lesions: a Systematic Review and Meta Analysis
(Elsevier, 2024) Ibrahim, Ismail A.; Abdelkader, Rem Ehab; Nada, Ahmed Hosney; Younes, Siham; Hanen, George; Shahwan, Ghena; Nashwan, Abdulqadir J.
Purpose: This study addresses the effectiveness of oral everolimus in treating various malignancies associated with Neurofibromatosis Type 1 (NF1). The purpose is to determine whether everolimus reduces lesion size in NF1 patients, considering the controversial findings from previous clinical trials. The scientific hypotheses and questions involve evaluating the impact of everolimus on NF1-associated lesions and understanding the variability in treatment outcomes. Methods: A systematic review and meta-analysis were conducted following PRISMA and Cochrane Collaboration guidelines. The study included four-phase II, single-arm, nonrandomized trials investigating the effect of oral everolimus on NF1-associated lesion size. The search covered multiple databases, and data extraction involved evaluating studies for inclusion criteria and assessing quality using the Cochrane Collaboration's Risk of Bias in Nonrandomized Studies tool. Statistical analysis utilized Open Meta(Analyst). Findings: The search yielded 388 studies, with 10 selected for full-text review and four included in the final analysis. The quality of the studies ranged from low to moderate. The meta-analysis indicated no observed heterogeneity (I2 = 0%), and the overall estimate suggested no significant reduction in NF1-associated lesion size with everolimus ( P = 0.069). Implications: The findings reveal a varied and inconsistent picture of everolimus efficacy in NF1 treatment. The study highlights the need for personalized approaches, considering individual genetic and clinical differences. The limitations, including small sample sizes and nonrandomized trials, call for larger, more standardized research efforts. The study emphasizes ongoing trials and the importance of future research in understanding predictors of everolimus response and optimizing treatment strategies for NF1 patients. Conclusion: While everolimus shows promise in reducing lesion size in a subset of NF1 patients, the study cannot draw conclusive results due to limitations in the included studies. Ongoing, adequately powered trials are crucial for advancing the evidence base and informing the potential role of everolimus in NF1 treatment. Others: There was no funding for this review and no conflicts of interest.
Citation Count: 1
Effects of Adding Respiratory Training To Osteopathic Manipulative Treatment on Exhaled Nitric Oxide Level and Cardiopulmonary Function in Patients With Pulmonary Arterial Hypertension
(Excerpta Medica inc-elsevier Science inc, 2022) Naci, Baha; Demir, Rengin; Onder, Omer O.; Sinan, Umit Yasar; Kucukoglu, Mehmet Serdar; Fizyoterapi Ve Rehabilitasyon Bölümü
Limited research exists regarding nonpharmacologic management of pulmonary arterial hypertension (PAH), except for exercise training. The objective of this study was to investigate the effects of osteopathic manipulative treatment (OMT) alone and combined with respiratory training on fractional exhaled nitric oxide (FeNO), and cardiopulmonary function in patients with PAH. This single-blind, prospective, randomized controlled study included 54 patients with PAH who were randomly allocated to OMT, combined intervention, and control groups. The OMT group (n = 16) and combined intervention group (n = 16) received OMT and yoga respiratory training plus OMT, respectively, twice a week for 8 weeks. The control group (n = 16) received no intervention. All patients undertook an educational lecture. FeNO level, pulmonary function, 6-minute walk distance (6MWD), maximal inspiratory and expiratory pressures, and handgrip strength were assessed at baseline and 8 weeks. Combined intervention and OMT groups significantly improved all outcome measures after 8 weeks of treatment (p 0.01), except mean forced expiratory flow between 25% and 75% of forced vital capacity, which did not change in the OMT group (p 0.05). The control group showed significant deteriorations in 6MWD, inspiratory and peripheral muscle strength, and pulmonary function except peak expiratory flow at 8 weeks (p <0.05). The combined intervention group revealed significantly greater improvements of FeNO, 6MWD, respiratory and peripheral muscle strength, and pulmonary function except mean forced expiratory flow between 25% and 75% of forced vital capacity compared with the OMT group (p <0.05). All outcomes significantly improved in both intervention groups versus the control group (p <0.05). Our study demonstrated that adding respiratory training to OMT provided further benefit to FeNO level and cardiopulmonary function compared with OMT alone and that the OMT might be a useful and safe intervention for patients who cannot attend cardiac rehabilitation programs. (c) 2021 Elsevier Inc. All rights reserved. (Am J Cardiol 2022;162:184-190)
Citation Count: 0
An Efficient and Robust 3d Medical Image Classification Approach Based on 3d Cnn, Time-Distributed 2d Cnn-Blstm Models, and Mrmr Feature Selection
(Wiley, 2024) Akbacak, Enver; Muzoglu, Nedim; Bilgisayar Mühendisliği Bölümü
The advent of 3D medical imaging has been a turning point in the diagnosis of various diseases, as voxel information from adjacent slices helps radiologists better understand complex anatomical relationships. However, the interpretation of medical images by radiologists with different levels of expertise can vary and is also time-consuming. In the last decades, artificial intelligence-based computer-aided systems have provided fast and more reliable diagnostic insights with great potential for various clinical purposes. This paper proposes a significant deep learning based 3D medical image diagnosis method. The method classifies MedMNIST3D, which consists of six 3D biomedical datasets obtained from CT, MRA, and electron microscopy modalities. The proposed method concatenates 3D image features extracted from three independent networks, a 3D CNN, and two time-distributed ResNet BLSTM structures. The ultimate discriminative features are selected via the minimum redundancy maximum relevance (mRMR) feature selection method. Those features are then classified by a neural network model. Experiments adhere to the rules of the official splits and evaluation metrics of the MedMNIST3D datasets. The results reveal that the proposed approach outperforms similar studies in terms of accuracy and AUC.
Citation Count: 0
Elastic Sac To Support Oral Feeding Performance of Preterm Infants: Crossover Randomized Controlled Study
(Wiley, 2024) Genç, Canan; Goezen, Duygu; Narter, Fatma; Hemşirelik Bölümü
BackgroundSwaddling is recommended for preterm infants during feeding. Swaddling preterm infants with elastic cotton materials allows infants to easily stretch and move their extremities. This study aimed to assess the effect of bottlefeeding in a novel "elastic sac" on physiological parameters and feeding performance of preterm infants. MethodsA randomized controlled, crossover trial was conducted with total of 26 preterm infants at 26-36(+6) weeks of gestation. Infants randomly assigned to group 1 (n = 13) were bottlefed in an elastic sac (researcher-designed single-piece pouch made of soft, elastic cotton) for the first feeding and in normal clothes for the next feeding. Infants randomly assigned to group 2 (n = 13) were fed first in normal clothes and then in the elastic sac. The physiological parameters and feeding performance of the infants were assessed during each feeding. ResultsPreterm infants fed in the elastic sac had lower heart rate and higher oxygen saturation during and after feeding than infants fed in normal clothes (P < 0.05). Although all values were within clinically normal ranges, the findings suggest that feeding preterm infants in the elastic sac had a favorable effect on physiological parameters compared with feeding in normal clothes. There was no significant difference in the infants' feeding performance (P > 0.05). ConclusionA semielevated right lateral position and flexed body posture are recommended while feeding preterm infants, which can be easily maintained using the elastic sac. Feeding preterm infants in an elastic sac may support physiologic stability during oral feeding.
Citation Count: 1
An Evaluation of a Web-Based Crisis Management Training Program for Nurse Managers: the Case of the Covid-19 Crisis
(Cambridge Univ Press, 2023) Harmancı Seren, Arzu Kader; Seren, Arzu Kader Harmanci; Bacaksiz, Feride Eskin; Gungor, Serkan; Bilgin, Osman; Baykal, Ulku; Hemşirelik Bölümü
Objective:The effective management of nursing services, the main power in patients' care and treatment in the front line of the fight against the COVID-19 pandemic, and nurse managers' effective leadership behaviors in the fight against the pandemic have been important key factors. It is thus critical to support nurse managers, strengthen them through training, and increase their competency so that they can successfully manage crises, disasters, or pandemics. This study aims to assess the effect of a web-based training program on the knowledge levels of nurse managers who worked during the COVID-19 pandemic. Methods:This is a randomized controlled experimental study. The study population consisted of the members of the Nurse Managers Association. The intervention group had 30 participants, and the control group had 31 participants in the final. Results:There was no statistically significant difference between the intervention and control groups' mean number of correct pre-test responses (P = 0.843). However, the intervention group's mean number of correct post-test responses was statistically significantly higher than the control group's after the web-based training program (P < 0.001). Conclusions:Web-based training programs can effectively increase nurse managers' knowledge levels. Therefore, web-based training programs should be developed in ordinary times for the management of crisis situations.
Citation Count: 0
Evaluation of Industrial Iot Service Providers With Topsis Based on Circular Intuitionistic Fuzzy Sets
(Tech Science Press, 2024) Çaloğlu Büyükselçuk, Elif; Endüstri Mühendisliği Bölümü
Industrial Internet of Things (IIoT) service providers have become increasingly important in the manufacturing industry due to their ability to gather and process vast amounts of data from connected devices, enabling manufacturers to improve operational efficiency, reduce costs, and enhance product quality. These platforms provide manufacturers with real-time visibility into their production processes and supply chains, allowing them to optimize operations and make informed decisions. In addition, IIoT service providers can help manufacturers create new revenue streams through the development of innovative products and services and enable them to leverage the benefits of emerging technologies such as Artificial Intelligence (AI) and machine learning. Overall, the implementation of IIoT platforms in the manufacturing industry is crucial for companies seeking to remain competitive and meet the ever-increasing demands of customers in the digital age. In this study, the evaluation criteria to be considered in the selection of IIoT service provider in small and medium-sized (SME) manufacturing enterprises will be determined and IIoT service providers alternatives will be evaluated using the technique for order preference by similarity to an ideal solution (TOPSIS) method based on circular intuitionistic fuzzy sets. Based on the assessments conducted in accordance with the literature review and expert consultations, a set of 8 selection criteria has been established. These criteria encompass industry expertise, customer support, flexibility and scalability, security, cost-effectiveness, reliability, data analytics, as well as compatibility and usability. Upon evaluating these criteria, it was observed that the security criterion holds the highest significance, succeeded by cost-effectiveness, data analytics, flexibility and scalability, reliability, and customer support criteria, in descending order of importance. Following the evaluation of seven distinct alternatives against these criteria, it was deduced that the A6 alternative, a German service provider, emerged as the most favorable option. The identical issue was addressed utilizing sensitivity analysis alongside various multi-criteria decision-making (MCDM) methods, and after comprehensive evaluation, the outcomes were assessed. Spearman's correlation coefficient was computed to ascertain the association between the rankings derived from solving the problem using diverse MCDM methods.
Citation Count: 0
Evaluation of Telemedicine for Contraceptive Counseling Given To Pregnant Women During the Covid-19 Pandemic: a Randomized Controlled Trial
(Taylor & Francis inc, 2024) Sağlam Aksüt, Rabia; Inam, Ozen; Hemşirelik Bölümü
In this study, we aimed to evaluate the impact of telemedicine for contraceptive counseling on knowledge levels and satisfaction with Family Planning Services. We collected data from 77 third-trimester pregnant women using a personal information form, Family Planning Knowledge Questionnaire, and the Satisfaction with Family Planning Services Scale and compared the data using chi-square test, Fisher's exact chi-square test, t-test for independent and dependent groups and Mann-Whitney U analysis. The experimental group participants (n = 37) received two informative video visits for contraceptive counseling, while the women in the control group (n = 40) received routine face-to-face Family Planning Services at their primary health care center. Participants in the experimental group showed a greater increase in knowledge levels and higher satisfaction with Family Planning Services than those in the control group (p < 0.05). In conclusion, we determined that telemedicine for contraceptive counseling is a promising option even beyond the pandemic.
Citation Count: 0
Evaluation of the Effect of Sociodemographic Characteristics of Patients With Prostate Cancer on Their Sexual Experiences and Self-Efficacy Sexual Experiences and Self-Efficacy of Individuals With Prostate Cancer
(Springer, 2023) Eroğlu, Nermin; Ozkan, Ilknur; Hemşirelik Bölümü
The study was planned as a descriptive study to evaluate the effects of sociodemographic characteristics of prostate cancer patients on their sexual experiences and self-efficacy. The sample of the study consisted of 69 patients with prostate cancer who were followed up for treatment in the outpatient clinic of an oncology hospital between December 2020 and March 2021 and met the inclusion criteria of the stud. Research data were collected by using the Patient Information Form, Arizona Sexual Experiences Scale (ASEX)-Male, and Sexual Self-Efficacy Scale (SSES). The mean age of prostate cancer patients was 67.1 & PLUSMN; 11.74 years, 95.7% (n = 66) were married, 37.7% (n = 66) were university graduates, and 75.4% (n = 52) were unemployed. Patients' mean scores were 19.29 & PLUSMN; 7.66 on the total Sexual Self-Efficacy Scale and 22.08 & PLUSMN; 4.92 on the total Arizona Sexual Experiences Scale. In the study, it was determined that the sexual experiences and sexual self-efficacy of prostate cancer patients differed according to their education level, employment status, and duration of treatment. In the study, it was determined that patients with prostate cancer experienced sexual dysfunction and had low self-efficacy. In line with these results, our recommendations are for health professionals to evaluate the sexual functions of patients with prostate cancer and their sexual self-efficacy, which is an important determinant of sexual life, during the diagnosis, treatment, and care process. In addition, the sociodemographic characteristics of the patients should be considered when planning interventions that increase sexual self-efficacy in the management of sexual problems.
Citation Count: 5
The Evolution of Unprocessed Food Inflation in Turkey: an Exploratory Study on Select Products
(Cambridge Univ Press, 2022) Demirkilic, Serkan; Ozertan, Gokhan; Tekguc, Hasan
Food price increases stem from economic, agricultural, and political factors. Understanding the dynamics behind the food price formation process and assessing how potential factors contribute to food price changes will significantly affect policies formulated to manage food price increases. High food inflation rates have been a chronic problem in Turkey over the last decade, with unprocessed food prices rising faster than general price levels. In this article, we use exploratory analyses based on economic principles rather than econometric analyses. First, our results indicate that exchange rates are strongly associated with domestic food prices due to dependence on imported inputs. Second, deep-dive analyses on select products show that global price movements and pass-through prices from producer to consumer are not solely responsible for price increases.
Citation Count: 2
The Factors Associated With School Readiness: Sensory Processing, Motor, and Visual Perceptual Skills, and Executive Functions in Kindergarten Children
(Routledge Journals, Taylor & Francis Ltd, 2023) Aydöner, Selen; Bumin, Gonca; Ergoterapi Bölümü
Many developmental skills are related to children's school readiness in the early years, and these skills are essential for later achievement. Some of these skills include sensory processing, motor and visual perceptual skills, and executive functions. To date, limited research has examined these skills associated with school readiness. This study investigated the relationship between sensory processing, motor and visual perceptual skills, and executive functions, and school readiness in kindergarten children. A total of 138 kindergarten children administered the Sensory Profile, the Bruininks-Oseretsky Test 2- Brief Form, the Test of Visual Perceptual Skills-3, the Childhood Executive Functioning Inventory, and the Primary School Readiness Scale. The results showed that sensory processing, motor and visual perceptual skills, and executive functions were correlated with children's school readiness, and these skills were also highly predictive of children's school readiness (p < 0.05). It is necessary for future studies to consider these skills when assessing school readiness and to include strategies to develop these skills in intervention programs.
Citation Count: 1
Global Health Emergencies During the Pandemic and Their Solutions
(Tubitak Scientific & Technological Research Council Turkey, 2021) Ağalar, Canan; Bulut, Dilek; Sencan, Ismail Hakki; Agalar, Canan; Tıbbi Hizmetler ve Teknikler Bölümü
In this review, we evaluated health care problems, which were not common before pandemic outbreak but have been common issues after its appereance and approaches to control pandemic considering its influences on people. We revised current health care developing approaches under the light of experience obtained throughout the pandemic so far. The aim is to be prepared in advance for possible upcoming pandemics. As in Covid 19 pandemics, such long lasting and widely affecting situations, durability is also very important together with flexibility and quickness. To provide durability, we need global policies taking the health to its center as well as health system policies.
Citation Count: 0
A Guide To Facilitate the Creation of a Femoral Tunnel for Arthroscopic Ligamentum Teres Reconstruction: a Three-Dimensional Computed Tomography Study
(Oxford Univ Press, 2024) Ismailoglu, Abdul Veli; Ismailoglu, Pelin; Zeynalov, Samir, I; Ozdogmus, Omer; Yildizhan, Saliha Elif; Bayramoglu, Alp; Kayaalp, Asim
The ideal femoral tunnel passing through the centre of the femoral neck targeted to the footprint of the ligamentum teres (LT) is established during the LT reconstruction surgery with the free-hand technique. We aimed to quantitatively determine the entry site and define the angular orientation of the ideal femoral tunnel with its relevance to the femoral valgus angle (FVA) and the femoral anteversion angle (FAA) to facilitate the creation of an ideal femoral tunnel during the LT reconstruction surgery. A total of 60 randomly selected CT images were obtained to reconstruct three-dimensional femur models. A virtual reamer representing the ideal femoral tunnel was placed in the femur models. The femur length, FVA, FAA, the femoral tunnel anterior angle, the femoral tunnel superior angle and the skin- and bony-entry sites were measured. The femoral tunnel angular orientation was strongly correlated with the FVA and the FAA. Mathematical formulas were defined by which entry site of the reamer and the anterior and superior angulation of the femoral tunnel could be estimated before the surgery. The mean skin-entry site was 67.3 mm distal and 0.1 mm anterior to the centre of the greater trochanter's superior border. The angular orientation of the femoral tunnel using FVA and FAA can be easily estimated using mathematical formulas before LT reconstruction surgery. The entry site and angular orientation of the femoral tunnel described in this study can be used to reduce dependency on the usage of fluoroscopy and the workload on the surgeon during the LT reconstruction surgery.
Citation Count: 2
cotinus Coggygria Scop. Attenuates Acetic Acid-Induced Colitis in Rats by Regulation of Inflammatory Mediators
(Springer, 2023) Şener, Göksel; Ertas, Busra; Cevik, Ozge; Yildirim, Aybeniz; Kayali, Damla Gokceoglu; Akakin, Dilek; Sener, Goksel; Eczacılık Meslek Bilimleri Bölümü
In traditional medicine, many medicinal plants are used in the treatment of various diseases caused by inflammation. The objective of the present study is to elucidate for the first time the effects of Cotinus coggygria (CC) ethanol extract (CCE) on colonic structure and inflammation of acetic acid-induced ulcerative colitis in rats. Colonic damage was assessed using disease activity index score, enzyme-linked immunosorbent assay, and hematoxylin-eosin staining. Also, in vitro antioxidant activity of CCE was investigated by ABTS methods. Total phytochemical content of CCE was measured spectroscopically. Acetic acid caused colonic damage according to disease activity index and macroscopic scoring. CCE significantly reversed these damages. While the levels of proinflammatory cytokines TNF-alpha, IL-1beta, IL-6, and TGF-1beta increased in tissue with UC, IL-10 level decreased. CCE increased inflammatory cytokine levels to values close to the sham group. At the same time, while markers indicating disease severity such as VEGF, COX-2, PGE2, and 8-OHdG indicated the disease in the colitis group, these values returned to normal with CCE. Histological research results support biochemical analysis. CCE exhibited significant antioxidant against ABTS radical. Also, CCE was found to have a high content of total polyphenolic compounds. These findings provide evidence that CCE might be benefit as a promising novel therapy in the treatment of UC in humans due to high polyphenol content and justify the use of CC in folkloric medicine for treatment of inflamed diseases.
Citation Count: 2
Identification Problem of a Leading Coefficient To the Time Derivative of Parabolic Equation With Nonlocal Boundary Conditions
(Springer international Publishing Ag, 2019) Kanca, Fatma; Mishra, Vishnu Narayan; Bilgisayar Mühendisliği Bölümü
In this study, the problem of determining the time-dependent leading coefficient to the time derivative of heat equation with nonlocal boundary and integral addition conditions is considered. The existence and uniqueness of a solution of the inverse problem under considerations are established. Some results on the numerical solution with an example are presented.

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