WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

Browse

Now showing 1 - 20 of 64

The Acute Effects of Various Dynamic Stretching Exercises on Jump Performance and Range of Motion
(Universidad de Murcia, 2025) Savaan, Mustafa; Pmar, Yeliz; Pmar, Salih; Antrenörlük Eğitimi Bölümü
This study aimed to investigate the acute effects of different dynamic stretching (DS) protocols on vertical jump performance and range of motion (ROM). Thirty healthy male participants, with an average age of 23.48 years, body weight of 76.90 kg, and height of 181.87 cm, who had engaged in recreational exercise for at least two years, participated voluntarily. A "cross-controlled randomized" experimental design was utilized to assess four distinct DS protocols: a-DS at 100 bpm for 30", b-DS at 100 bpm for 75" s, c-DS at 150 bpm for 30", and d-DS at 150 bpm for 75". Acute ROM was measured using the Passive Straight Leg Raise Test (PSLR), while jump performance was assessed via countermovement jump (CMJ). Data were analyzed using repeated measures ANOVA and paired samples T-tests with significance set at p<.05. All four DS techniques significantly increased angles measured by PSLR following application (p <.05). CMJ values also showed significant improvements in both groups subjected to the shorter protocols lasting 30"at either tempo (p <.05). Consideration should be given to application duration and tempo when planning DS exercises, as structured warmup routines can enhance flexibility and optimize athletic performance.
An Analysis of Psychological Resilience Levels Among Judo Coaches According to Selected Demographic Factors
(Stowarzyszenie Idokan Polska-Idokan Poland Assoc, 2025) Besiktas, Murat Yalcin; Terekli, Mustafa Serdar; Beden Eğitimi ve Spor Bölümü; Antrenörlük Eğitimi Bölümü
Background. Psychological resilience is a crucial personal trait that enables individuals, especially those in high-stress professions like coaching, to adapt and thrive in the face of adversity. Understanding how resilience manifests among coaches can contribute to more effective support and development strategies in sports psychology. Problem and aim. This study aims to determine whether the psychological resilience levels of judo coaches differ according to demographic variables such as age, educational background, coaching certification level, years of coaching experience, profession, and perceived economic status. Material and methods. The sample included 284 active judo coaches (58 women and 226 men) from Istanbul, Kutahya, and Eskisehir. Data were collected using the "Psychological Resilience Scale for Adults" [Friborg et al. 2003; Basim, Cetin 2011] and a "Personal Information Form." Statistical analyses were conducted using SPSS 24.0, including independent samples t-tests, one-way ANOVA, and Eta squared analysis to assess the influence of demographic actors on resilience levels. Results. The findings indicated significant differences in psychological resilience levels based on gender, marital status, age, educational attainment, coaching experience, income level, and coaching certification level. Conclusions. The results suggest that psychological resilience among judo coaches is meaningfully influenced by various demographic characteristics. These findings underscore the importance of tailoring psychological support and development programs to the specific profiles of coaches.
Citation - WoS: 38
Appraising Systematic Reviews: a Comprehensive Guide To Ensuring Validity and Reliability
(Frontiers Media Sa, 2023) Shaheen, Nour; Shaheen, Ahmed; Ramadan, Alaa; Hefnawy, Mahmoud Tarek; Ramadan, Abdelraouf; Ibrahim, Ismail A.; Flouty, Oliver
Systematic reviews play a crucial role in evidence-based practices as they consolidate research findings to inform decision-making. However, it is essential to assess the quality of systematic reviews to prevent biased or inaccurate conclusions. This paper underscores the importance of adhering to recognized guidelines, such as the PRISMA statement and Cochrane Handbook. These recommendations advocate for systematic approaches and emphasize the documentation of critical components, including the search strategy and study selection. A thorough evaluation of methodologies, research quality, and overall evidence strength is essential during the appraisal process. Identifying potential sources of bias and review limitations, such as selective reporting or trial heterogeneity, is facilitated by tools like the Cochrane Risk of Bias and the AMSTAR 2 checklist. The assessment of included studies emphasizes formulating clear research questions and employing appropriate search strategies to construct robust reviews. Relevance and bias reduction are ensured through meticulous selection of inclusion and exclusion criteria. Accurate data synthesis, including appropriate data extraction and analysis, is necessary for drawing reliable conclusions. Meta-analysis, a statistical method for aggregating trial findings, improves the precision of treatment impact estimates. Systematic reviews should consider crucial factors such as addressing biases, disclosing conflicts of interest, and acknowledging review and methodological limitations. This paper aims to enhance the reliability of systematic reviews, ultimately improving decision-making in healthcare, public policy, and other domains. It provides academics, practitioners, and policymakers with a comprehensive understanding of the evaluation process, empowering them to make well-informed decisions based on robust data.
Assessment of Breastfeeding Self-Efficacy in Nursing Mothers Following Earthquakes: A Case Study of the Kahramanmaraş Earthquakes in Turkey
(Kashan Univ Medical Sciences, 2025) Dinmez, Sinem Guven; Karaman, Ozen Esra; Bakir, Emine; Ebelik Bölümü
Background: Natural disasters disproportionately impact vulnerable populations, particularly mothers and infants. Research indicates that during such events, mothers often favor formula and supplementary feeding over breastfeeding. Self-efficacy is a critical determinant influencing breastfeeding practices in disaster contexts.
Objectives: This study aimed to examine the breastfeeding characteristics and self-efficacy of nursing mothers following the Kahramanmara & scedil; earthquakes.
Methods: This descriptive study was conducted at the Children's Polyclinic of Iskenderun State Hospital in Turkey from August 1 to August 31, 2023. A total of 54 mothers with infants aged 0-1 year at the time of the earthquake, who continued to breastfeed (providing breast milk for at least one feeding), were selected using a non-probability purposive sampling method. During the study period, all eligible mothers visiting the polyclinic who met the inclusion criteria were evaluated. Data were collected using a "Descriptive Data Form" and the "Breastfeeding Self-Efficacy Short Form Scale". Statistical analyses were performed using SPSS version 23, employing Independent Samples t-tests, Mann-Whitney U tests, and One-Way ANOVA for group comparisons. A P-value of less than 0.05 was considered statistically significant.
Results: The mean breastfeeding self-efficacy score among mothers was 58 +/- 5.87 (minimum 40; maximum 70). Mothers who exclusively breastfed their infants had significantly higher self-efficacy scores compared to those who introduced formula (P = 0.021) Among the mothers surveyed, 81.5% reported that their breastfeeding was affected by the earthquake; 41% cited issues related to privacy, while 27% faced challenges regarding shelter. Prior to the earthquake, 72% of infants were exclusively breastfed; however, this figure decreased as 81.5% of infants began receiving complementary foods alongside breast milk post-earthquake.
Conclusion: The findings indicate that mothers breastfeeding self-efficacy is at a moderate level. Additionally, mothers reported alterations in their breastfeeding practices compared to the pre-earthquake period. These results underscore the importance of promoting breastfeeding in disaster-affected areas and highlight the critical role of midwives in supporting these efforts.
Assessment of the Psychometric Properties of the Online Education Student Satisfaction Scale: a Methodological Study
(Springer Publishing Company, 2024) Harmancı Seren, A.K.; Alan, H.; Türkmen, E.; Gungor, S.; Baykal, Ü.; Hemşirelik Bölümü
Background and Purpose: Assessing student satisfaction is essential in evaluating the quality of education. The number of valid and reliable tools that measure students’ satisfaction with online education is limited. This methodological study aimed to assess the psychometric properties of the online education student satisfaction scale. Methods: Eleven academicians from the nursing field provided expert opinions on content validity. Separate 25 students evaluated the language clarity of the draft scale. The study sample included 525 third- and fourth-year nursing students. Finally, a group of 30 nursing students different from the sample participated in the test–retest. The study created an item pool based on the recent literature. The researchers calculated the items’ content validity rates and the scale’s content validity index by taking the experts’ opinions. In addition, item–total score correlation analysis, exploratory factor analysis, discrimination analysis, stability test, and internal consistency analysis were performed. Results: An item with a low-correlation value was excluded from the scale. The correlation coefficients of the remaining items were between.536 and.811. In the second round of exploratory factor analysis, a five-factor structure emerged that explained 72.1% of the total variance. In addition, item discrimination, stability, and internal consistency test results ensured that the scale was valid and reliable. Conclusions: The online education student satisfaction scale with five subdimensions containing 28 items is a valid and reliable tool. Researchers, educators, and managers may use it to evaluate students’ satisfaction with online education. © Copyright 2024 Springer Publishing Company, LLC.
Avatar: a Film at the Center of the Feminine Other
(Univ Pittsburgh, Univ Library System, 2025) Dereboyu, Pelin Guregen; Guzel, Ebru; Olaru, Gabriela Oana; Ayberk, Erhan
This study analyzes James Cameron's 2009 film Avatar from the perspective of the feminine other through deconstruction. In the movie, nature and the Na'vi people are depicted as feminine, while modern man and the science, technology, and military power he represents are portrayed as masculine. Although it critiques the colonialist structure of modernity, the film's narrative structure and character portrayals indicate that it reproduces the superiority of Western-centered ideology and the masculine mind. The study analyzes how the film's narrative and character representations implicitly support masculine centrism. The analysis reveals how nature and marginalized cultures are romanticized and presented in the film and how the notion that the feminine can only survive by adopting masculine traits is processed in the subtext. Grounded in a conceptual and theoretical framework, this research focuses on the sustainability of the patriarchal capitalist system and gender politics while critically examining how cinema reconstructs ideological structures through the narratives in the film.
Biopsychosocial-Based Exercise Model for Rheumatic Diseases Via Telerehabilitation: a Case Series With a One Year Follow Up
(Nova Southeastern Univ, 2025) Nacar, Nazli Elif; Karaca, Nur Banu; Bulut, Zeynep Irem; Sari, Erkin Oguz; Bulut, Senem
Purpose: This study aims to examine the sustainability of the biopsychosocial exercise performed by telerehabilitation on individuals with rheumatic disease, with and without supervision, and investigate the effect of the biopsychosocial-based exercise model on biopsychosocial status, general health status, and anxiety-depression levels of individuals. Method: Twenty patients with rheumatic diseases performed a biopsychosocial-based exercise model Cognitive Exercise Therapy Approach via telerehabilitation with physiotherapist-supervised and unsupervised exercises who continued for three sessions per week for 12 months. Outcome measures were Health Assessment Questionnaire, Hospital Anxiety and Depression Scale, and Cognitive Exercise Therapy Approach-Biopsychosocial Questionnaire. Patients were assessed at baseline, 3rd, 6th, 9th, and 12th months. Results: There was no significant difference by time for Health Assessment Questionnaire (p=0.512) and Hospital Anxiety and Depression Scale-anxiety and depression scores (p=0.162 and p=0.825, respectively) between the five measures at the one-year followup. Similarly, there is no significant difference in Cognitive Exercise Therapy Approach-Biopsychosocial Questionnaire score outcomes by time (p=0.184). Conclusion: In this study a group of rheumatic patients with face-to-face biopsychosocial exercise habits were able to maintain their exercise habits with realtime telerehabilitation with or without supervised during the 1-year follow-up period during the COVID-19 pandemic was shown. Although there was no improvement in the parameters during the pandemic period when social isolation and depression-anxiety disorders increased, the level of recovery which individuals had previously gained was not adversely affected and the healing properties were preserved with the help of telerehabilitation.
Citation - WoS: 4
Bitter Melon (Momordica charantia) Fruit Extract Ameliorates Methotrexate-Induced Reproductive Toxicity in Male Rats
(Marmara University, 2021) Kanpalta, Fatma; Özbeyli, Dilek; Sen, Ali; Cevik, O. Dağdeviren; Şener, Göksel; Ercan, Feriha; Eczacılık Meslek Bilimleri Bölümü
Objective: Methotrexate (MTX) is a drug commonly used for the treatment of malign neoplastic and inflammatory diseases. Anti-oxidant and anti-inflammatory effects of bitter melon (BM) were reported. The aim of this study was to examine the effects of BM fruit extract on MTX-induced testicular and epididymal damage. Materials and Methods: Sprague Dawley male rats were divided into three groups (n=8) as control, MTX and MTX+BM. A single dose of MTX (20 mg/kg) was injected intraperitoneally to the MTX and MTX+BM groups. BM fruit extract (600 mg/kg) was applied to the MTX+BM group orally for 5 days. Testes were examined for general histopathology, proliferating and apoptotic cells. The epididymis samples were used for the evaluation of sperm morphology. Oxidative and inflammatory markers were analysed biochemically. Results: Increased abnormal spermatozoa, degenerated seminiferous tubules with increased apoptotic cells and decreased proliferative cells were observed in the MTX group. TNF-α, IL-1β, 8-hydroxy-2-deoxyguanosine and caspase-3 levels increased, superoxide dismutase and catalase levels decreased in both testis and epididymis samples. All these histological and biochemical parameters were ameliorated in the MTX+BM group. Conclusion: Methotrexate causes testis damage by decreasing spermatogenic cells and increasing apoptosis through oxidative stress and inflammation. BM extract improves testis and epididymis damage with its possible anti-oxidant and anti-inflammatory effects. © 2025 Elsevier B.V., All rights reserved.
Citation - WoS: 2
Citation - Scopus: 4
Comparison of Motorcyclists' Hand Grip Strength and Reaction Time
(Asoc Didactica Andalucia, 2022) Tekin, D.; Agopyan, A.; Terapi ve Rehabilitasyon Bölümü
The purpose of this study was to compare hand grip strength and reaction times in male motorcycle racers grouped according to different ages and the classes of motorcycle used and determine the relation between these characteristics. Sixty-five healthy male motorcycle racers were divided into four groups according to their age and the power of the motorcycles' engine: (Group-1 [G1] = 600CC/23-34 years; Group-2 [G2] = 600-CC/35-48 years; Group-3 [G3] = 1000-CC/23-34 years; Group-4 [G4] = 1000-CC/35-48 years). Then, Nelson's reaction time and maximal hand grip strength were measured for both hands. There were no significant differences between the groups' grip strength (p>0.05). It was found that G1's right-and left-hand reaction time was faster than that of G2, and G1's left-hand reaction time was faster than that of G3 (p<0.05). The right-hand visual reaction time was found to have a negative weak correlation with the left-hand absolute grip strength (r=-0.247, p=0.047), and there was a weak positive correlation between the left-hand visual reaction time and height (r=0.315, p=0.011). G1's right-hand visual reaction time was better than that of G2 (p < 0.001), and G1's visual left-hand reaction time was better than those of G2 (p < 0.034) and G3 (p < 0.011). Although the absolute and relative hand grip strength values did not differ according to the ages and the engine power of the motorcycle used, it was found that the simple reaction time increased with increasing age.
Citation - WoS: 8
Citation - Scopus: 10
Defining and Modeling Risks in Service Supply Chains
(University of Cincinnati, 2021) Karadayi-Usta, S.; Serdarasan, S.; Endüstri Mühendisliği Bölümü
Risk management in supply chains is of growing importance and has been studied extensively in manufacturing supply chains. However, risk in service supply chains (SSCs) is largely neglected. Since SSCs are not immune to disruptions, there is a need to study and understand supply chain risks from a service perspective. This paper sets out to identify, define and examine risks in SSCs. Using a systematic literature review, the paper explicitly defines seven risk types associated with SSCs: financial, relationship, demand, operational, service delivery, Information technology (IT), and external risks. To gain a deeper understanding of these risks and their consequences, a structural model of the relationships among them was developed using ISM and MICMAC. This study helps us to identify and understand all the risks that need to be assessed in SSCs, which in turn would lead to enhanced risk management and business sustainability. © 2021 University of Cincinnati. All rights reserved.
Citation - WoS: 1
Citation - Scopus: 1
Design and Development of a New Tactile Stimulator
(Ieee, 2019) Kazma, Coskun; Levent, Vecdi Emre; Aydin, Nizamettin; Bilgisayar Mühendisliği Bölümü
We have designed and implement a tactile stimulator to obtain information from the central nervous system. Our system consists of two main components. The first one is tactile stimulator, which was designed to stimulate index and middle finger tips, stimulating mechanoreceptors according to the test protocol. Second one is a personal computer running a desktop software for the implementation of test protocols. The flow is as follows; the subjects are asked the question of the test protocol through the personal computer. The parameters are then transmitted to the embedded board on the machine. The embedded board drives step motors to apply the relevant test parameters. The desktop software expects the individual to answer the question using the right or the left mouse button of the computer mouse. After answering the relevant question, the test proceeds to the next step. According to the test protocol, the stimulation process of the mechanoreceptors located at the index and middle finger tips must start and terminate at the same time. From this perspective, the embedded board with 3 18F46K22 PIC microcontrollers produces 2 square wave signals with different frequencies and amplitudes at the same time. The embedded system card developed with the PIC microcontroller is also developed with FPGA. The system has also been tested on 24 blue and white collar employees and a significant result has been obtained.
Determination of Post-Earthquake Trauma Level and Investigation of the Relationship with Physical Activity Status
(Turkey Assoc Physiotherapists, 2025) Tosun, Anil; Yilmaz, Nergis; Luque, Demet Tekin De Las Penas; Fizyoterapi Ve Rehabilitasyon Bölümü
Purpose: This study aims to examine the relationship between trauma levels caused by the February 6, 2023, Pazarc & imath;k-Elbistan earthquakes and individuals' physical activity status. It also aims to assess the presence of post-earthquake pain and its relationship with trauma levels. Methods: The data were collected via Google Forms and completed by 388 voluntary participants (299 female, 89 male) aged 18-65 years. In the study, the "Sociodemographic Form" was used to determine the general characteristics, the "Scale for Determining the Level of Post-Earthquake Trauma" (PETLDS) was used to determine the level of trauma, and the "International Physical Activity Questionnaire Short Form" (IPAQ-SF) was used to determine the physical activity status. Results: A significant difference was found in PETLDS scores based on residence in the earthquake-affected region (p<0.001); individuals in the region had higher scores (57.66 +/- 19.87) than those outside (49.00 +/- 18.49). Spearman's correlation analysis showed a weak negative correlation without statistical significance between the "Cognitive Restructuring" subscale and IPAQ-SF scores in individuals from the earthquake zone (Spearman's rank correlation coefficient =-0.18, p=0.042). Additionally, those who experienced post-earthquake pain had higher PETLDS scores than those who did not (p=0.000). Conclusion: This study found a negative relationship between post-earthquake trauma levels and physical activity. While inactive individuals had higher trauma levels, minimally active individuals showed lower trauma levels. These findings suggest that increasing physical activity after an earthquake may be an effective strategy for reducing trauma levels. Further research, education, and project-based initiatives are needed in this field.
Determining the Injury Risk Levels of Kyorugi and Poomsae Taekwondo Athletes and Comparing Them With Selected Athletic Performance Parameters
(Stowarzyszenie Idokan Polska-Idokan Poland Assoc, 2025) Ergin, Ceren z.; Pinar, Yeliz; Sani, Fatih; Cumbur, Cansel; Ramazanoglu, Nusret; Antrenörlük Eğitimi Bölümü
Background. Different disciplines within the same sport can lead to varying injury risks and performance requirements due to differences in energy systems, techniques, and competition rules. Problem and aim. This study assesses and compares injury risk levels among taekwondo athletes in the kyorugi and poomsae disciplines alongside selected athletic performance parameters. Material and Method. The study included 10 women (22 +/- 2.37 years) and 10 men (22 +/- 1.25 years) from the kyorugi discipline, and 10 women (19.4 +/- 2.55 years) and 10 men (18.8 +/- 3.29 years) from poomsae. All participants had competed in licensed elite-level competitions for at least 4 years. Injury risk and performance were evaluated using the Y balance test (YBT), reactive strength index (RSI), and functional movement screen (FMS). Results. Significant differences were found between male kyorugi and poomsae athletes in rotary stability (p=0.042), dominant leg Y balance (p=0.012), and composite scores (p=0.012). For female athletes, differences in dominant leg Y balance (p=0.049), anterior reach (p=0.027), RSI (p=0.001), and jump height (p=0.001) were noted. Female poomsae athletes had RSI values below normative standards. According to the YBT, the male poomsae group had the lowest number of athletes at risk of injury, whereas the female kyorugi group had the highest. Conclusions. Generally, taekwondo athletes displayed low injury risks based on FMS and YBT values, with moderate to low RSI risk levels. Increased reactive strength may correlate with higher injury risk. Female poomsae athletes should work to improve RSI scores, while kyorugi athletes should focus on strategies to address asymmetry-related injuries.
Determining the Type 2 Diabetes Risks and Healthy Lifestyle Behaviors of First Year University Students
(Dokuz Eylul Univ inst Health Sciences, 2022) Eroglu, Nermin; Temiz, Gamze; Hemşirelik Bölümü
Introduction: The present study was planned and carried out as a descriptive and cross-sectional study for determining the Type 2 diabetes risks and healthy lifestyle behaviors of first year university students. Material and Methods: The study was carried with 185 students at a foundation university in Istanbul during the dates of November-December 2019. The data were acquired online via Student Information Form, Type 2 Diabetes Questionnaire (FINDRISK) and Healthy Lifestyle Behaviors Scale. Results: The mean age of the students in the study was 19.79 +/- 2.47 years, 53.5 % (n=99) were male, 29.7 % (n=55 previously graduated from another university, 62.1 % (n=115) were students and it was determined that 50.3 % (n=93) had diabetic relatives. It was observed when the diabetes risk status was examined for all participants that they are in the low risk group due to a FINDRISK total score of <7. Conclusion: The study results emphasize the importance of determining the risk for university students to be diabetic in the next decade, putting forth the individuals with high risk and moving onto the next stage for diagnosis. In addition, it has been determined that the level of knowledge of students may have a positive impact on their healthy lifestyle behaviors.
Determining the Type 2 Diabetes Risks and Healthy Lifestyle Behaviors of First Year University Students (Vol 6, Pg 420, 2022)
(Dokuz Eylul Univ inst Health Sciences, 2023) Eroglu, Nermin; Temiz, Gamze; Hemşirelik Bölümü
Citation - WoS: 1
Citation - Scopus: 1
Do We Learn To Internalize Stigma From Our Parents? Comparison of Internalized Stigmatization in Adolescents Diagnosed With Adhd and Their Parents
(Mdpi, 2022) Dikec, Gul; Bilac, Oznur; Kardelen, Cansin; Sapmaz, Sermin Yalin; Hemşirelik Bölümü
This study compared internalized stigmatization levels of adolescents diagnosed with attention deficit and hyperactivity disorder (ADHD) with those of their parents. The study's data were collected from 107 adolescents diagnosed with ADHD and their parents between July 2020 and March 2021. The adolescents were followed up in the child and adolescent psychiatry outpatient clinic of a university hospital in western Turkey. The information forms for adolescents and parents, the Internalized Stigma of Mental Illness Scale-Adolescent Form (ISMI-AF) and the Parental Internalized Stigma of Mental Illness Scale (PISMI), were used to collect the data. There was no statistically significant difference between the total scores of internalized stigma and subscale mean scores of the adolescents and their parents (p > 0.05); only the subscale scores for stereotype endorsement were found to be significantly different (p < 0.05). PISMI scores affected ISMI-AF scores, which can be interpreted as parents' perspectives and attitudes toward stigmatization affecting adolescents. For ADHD, whose frequency is increasing daily, intervention studies should be conducted to reduce adolescents' and parents' internalized stigma and to enhance the educational outcomes of adolescents.
Dodder (Cuscuta sp.) Extract Prevents Cognitive Deficits in a Rat Model of Hepatic Encephalopathy
(Kare Publ, 2024) Cevik, Ozge; Sen, Ali; Şener, Göksel; Ercan, Feriha; Doğan, Ahmet; Özbeyli, Dilek; Hatipoğlu, Bilge Nur; Eczacılık Meslek Bilimleri Bölümü
OBJECTIVE: In our study, the protective effect of dodder plant extract against encephalopathy induced by cholestatic liver disease model was investigated. METHODS: Spraque Dawley rats were used in the study. For the cholestatic liver disease model, the bile duct ligation (BDL) was applied. The groups were determined as control, Cuscuta sp. (CUS), BDL and BDL + CUS. Double ligation was performed in the bile duct in the BDL groups. For the applications, saline (SF) was administered to the control and BDL groups for 28 days while 250 mg/ kg of Cuscuta sp. extract was given by oral gavage to the CUS and BDL + CUS groups. At the end of the experiment, cognitive eval- uations were made by applying new object recognition and Morris water maze tests. After these tests, blood-brain barrier (BBB) measurements were made in half of the groups. In the other half of the groups, brain tissue samples were taken by decapitation and transforming growth factor-beta (TGF-β), 8-hydroxydeoxyguanosine (8-OHdG) and sodium-potassium adenosine triphospha- tase (Na+/K+-ATPase) measurements were made in the tissues. Histological examinations of the tissues were also performed. RESULTS: Cognitive performance was low, and BBB permeability was found to be increased in the group with bile duct liga- tion. In addition, TGF-β and 8-OHdG levels were increased in tissues, while Na+/K+-ATPase enzyme activity was suppressed. Treatment with Cuscuta sp. increased cognitive performance and decreased BBB permeability. Other biochemical parameters examined were significantly (p<0.05–0.001) reversed and supported by histological findings. CONCLUSION: Our findings in the study suggest that dodder plant may be beneficial for the protection of cognitive perfor- mance and brain tissue in encephalopathy caused by cholestasis. Keywords: Cuscuta sp.; cholestasis; encephalopathy; fibrosis.
The Effect of Combined Core Training Intervention on Ball Throwing Velocity and Jump Performance in Competitive Young Female Handball Players
(Iermakov S.S., 2025) Akalp, Ugur; Pinar, Salih; Pinar, Yeliz; Antrenörlük Eğitimi Bölümü
Background and Study Aim Handball is a dynamic team sport that requires a combination of technical, tactical, and physical abilities. Among the key physical components, throwing velocity and vertical jump performance are essential for successful gameplay. These skills rely not only on upper and lower limb strength but also on core muscle function. The aim of this study is to investigate the impact of a combined core training intervention on ball throwing velocity and vertical jump performance in young competitive female handball players. Material and Methods A total of 28 young female handball players ((X) over bar = 17.21 +/- 0.74 years, 169 +/- 5 cm body height, 62.07 +/- 7.43 kg body weight) participated in the study. They were divided into an experimental group (EG = 14) and a control group (CG = 14). Both groups underwent a pretest to assess ball throwing velocity and vertical jump performance. After the initial measurements, the CG followed a standard training regimen. The EG completed an intervention program comprising six combined core exercises, performed three times per week for eight weeks. The same measurements were repeated after the program. A 2x2 repeated measures ANOVA was used to determine differences between EG and CG. The main effects of time (pretest and posttest), group, and the time*group interaction were evaluated. Results No changes were observed in the ball throwing velocity or jump performance of the CG between pretest and posttest. However, significant improvements were found in the EG for both ball throwing velocity and vertical jump performance (F = 47.467, p <.001, eta(2) =.646). Conclusions Designing core training programs in a sport-specific manner plays a significant role in developing athletes who require both general and specialized training.
The Effect of Neck Mobilization Vs. Combined Neck and Lumbar Mobilization on Pain and Range of Motion in People With Cervical Disc Herniation: a Randomized Controlled Study
(Elsevier, 2025) Ozdincler, Arzu; Aktas, Dogan; Reyhanioglu, Duygu Aktar; Ozturk, Basar; Fizyoterapi Ve Rehabilitasyon Bölümü
Background: To assess the effectiveness of Kaltenborn-Evjenth Orthopedic Manual Therapy (KEOMT) applied to cervical-only mobilization versus both lumbar and cervical regions on pain intensity and range of motion (ROM) in individuals with cervical disc herniation. Methods: Thirty-three participants were enrolled in the study. The patients were randomly assigned to two groups. Group A received cervical-only KEOMT, while Group B received combined lumbar and cervical KEOMT. Interventions were administered three times a week for four weeks. Pain was measured using the Visual Analog Scale (VAS), ROM was assessed for flexion and lateral flexion, and Neck Pain and Disability Index (NPDI) and Short-Form 36 Health Survey (SF-36) were used for evaluation. Results: In intra-group measurements, a statistically significant difference was observed in all parameters of pain, ROM, disability, and quality of life for the mobilization methods applied in both groups (p < 0.05). Group B demonstrated significantly greater improvements in ROM/flexion, pain, and disability outcomes compared to Group A in inter-group measurements (p < 0.05). Physical and emotional sub-groups of quality of life measures also favored Group B in intergroup analysis (p < 0.05). However, the power values for ROM and quality of life parameters were found to be low. Conclusions: The cervical plus lumbar KEOMT technique is more effective than cervical-only mobilization in improving pain and disability. However, low power values for ROM and quality of life suggest these results may lack clinical significance, warranting further research.
The Effect of Vitamin D and Paricalcitol on Protein Disulfide Isomerase
(Marmara University, 2025) Köksal, Muhammed Murat; Şekerler, Turgut; Şener, Azize Yaman; Temel Eczacılık Bilimleri Bölümü
Protein disulfide isomerase (PDI), a multifunctional protein plays an important role as oxidoreductase, isomerase and chaperone in the cell. Prior studies have identified PDI is highly expressed in many different cancer types and presented as a new potential target for cancer treatment. Here, we investigated vitamin D and its analogue paricalcitol in silico interaction of the human PDI and inhibition of PDI reductase activity in vitro. We observed a non-covalent mechanism where the main skeleton of the vitamin D3 and paricalcitol structure is located at the hydrophobic site in the b' domain of PDI and forms a hydrogen bond with a residue (Hisl38) in this domain. They also form multiple weak hydrophobic interactions with various chemical groups of the b' subunit. For the first time, we demonstrate that 1,25-dihydroxyvitamin D3 (1a,25(OH)2 vitamin D3) and paricalcitol inhibit the PDIreductase activity in vitro and their 1C50 values are 20.7911.43 nmol/L and 32.8213.15 nmol/L respectively. The two compounds can also block the denitrosation activity of PDI. © 2025 Elsevier B.V., All rights reserved.

Browse

Browsing WoS İndeksli Yayınlar Koleksiyonu by WoS Q "N/A"