PubMed İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/8
Browse
Browsing PubMed İndeksli Yayınlar Koleksiyonu by WoS Q "Q3"
Now showing 1 - 20 of 33
- Results Per Page
- Sort Options
Article Citation Count: 1Comparison of in Vitro Antifungal Activity Methods Using Extract of Chitinase-Producing aeromonas Sp. Bhc02(Springer, 2023) Kızıltaş, Gülesme; Yilmaz, Gulesme; Tıbbi Hizmetler ve Teknikler BölümüBiological control to prevent fungal plant diseases offers an alternative approach to facilitate sustainable agriculture. Since the chitin in fungal cell walls is a target for biocontrol agents, chitinases are one of the important antifungal molecules. In this study, the aim was to investigate a new chitinase isolated from a fluvial soil bacterium and to show the antifungal activity of the characterized chitinase by comparing the three common methods. The bacterium with the highest chitinase activity was identified as Aeromonas sp. by 16 S rRNA sequence analysis. Following the determination of the optimum enzyme production time, the enzyme was partially purified, and the physicochemical parameters of the enzyme were investigated. In the antifungal studies, direct Aeromonas sp. BHC02 cells or partially purified chitinase were used. As a result, in the first method in which the Aeromonas sp. BHC02 cells were spread on the surface of petri dishes, no zone formation was observed around the test fungi spotted on the surface. However, zone formation was observed in the methods in which the antifungal activity was investigated using the partially purified chitinase enzyme. For example, in the second method, the enzyme was spread on the surface of PDA, and zone formation was observed only around Penicillum species among the test fungi spotted on the surface. In the third method, in which the necessary time was given for the formation of mycelium of the test fungi, it was observed that the growth of Fusarium solani, Alternaria alternata and Botrytis cinerea was inhibited by the partially purified chitinase. This study concludes that the results of the antifungal activities depend on the method used and all fungal chitins cannot be degraded with one strain's chitinase. Depending on the variety of chitin, some fungi can be more resistant.Article Citation Count: 0Comparison of Intraoperative Biliary Anastomosis Stenting Technique in Living-Donor Liver Transplantation: Review of 41 Patients(Turkiye Klinikleri, 2022) Dönmez, Ramazan; Balas, Ş.; Göktuğ, U.U.; Emek, E.; Tokat, Y.; Tıbbi Hizmetler ve Teknikler BölümüBackground/aim: Biliary fistula is one of the most important complications in liver transplantation. Complications can vary from simple local peritonitis to death, and various techniques have been described to prevent them. In this study, we compared two different stenting methods used in biliary tract anastomosis in living-donor liver transplantation. Material and methods: We retrospectively analyzed data from 41 living-donor liver transplantations that were performed due to end-stage liver failure between August 2019 and November 2020. Patients were grouped according to the stenting technique used in biliary anastomosis. Postoperative biliary tract complications were investigated. Results: Biliary fistulas were observed in 2 (7.4%) patients in the internal stent group, while 4 (28.5) fistulas were observed in the external stent group. Biliary tract stricture was observed in 2 (7.4%) patients in the internal stent group, but there was no statistical difference in complications. The preoperative MELD score (p = 0.038*) was found to be statistically significant in regard to developing complications. Conclusion: Our study did not show the effect of stenting methods used during biliary anastomosis on the development of complications. However, larger randomized controlled studies are needed. © TÜBİTAK.Article Citation Count: 0Does Working Style Affect the Occupational Balance and Life Satisfaction of Office Workers in Turkey? a Comparison Study(Ios Press, 2024) Aydöner, Selen; Aydoner, Selen; Altuntas, Onur; Bumin, Gonca; Ergoterapi BölümüBACKGROUND: The coronavirus outbreak (COVID-19) has caused various effects, changing people's lives and work styles. During this period, workplaces decided to work remotely, so people spent more time at home. Therefore, workers' personal and work lives were negatively affected. OBJECTIVE: This study planned to compare traditional and remote office workers' occupational balance and life satisfaction in Turkey during COVID-19. METHODS: Google Survey was used for data collection. Three hundred office workers (18-65 years old) from Turkey participated in the study. The occupational balance and life satisfaction levels of participants were assessed using the Occupational Balance Questionnaire (QB-Quest) and Personal Well-being Index-Adult (PWI-A). RESULTS: Data collected were analyzed statistically by the Independent Sample t-test. It was found that the remote office workers had lower levels of occupational balance (p = 0.02; r = -3.317) and life satisfaction (p = 0.01; r = -2.199) compared to the traditional office workers. CONCLUSION: Remote office workers were found to have lower occupational balance and life satisfaction than traditional office workers. In this period, when the way of working changes like COVID-19, it is crucial to determine office workers' occupational balance and life satisfaction and take precautions for their job performance and satisfaction.Article Citation Count: 1The Effect of a Video-Based Covid-19 Paediatric Patient Education on State Anxiety in Children With Suspected Covid-19 Admitted To Hospital(Elsevier Sci Ltd, 2023) Şancı, Yağmur; Celik, Serap; Yildiz, Suzan; Hemşirelik BölümüBackground: Anxiety causes the long-term psychological impacts on children during the pandemic.Objective: The aim of this study is to reduce anxiety in paediatric patients and increase their adherence to treatment through a video-based COVID-19 paediatric patient education.Methods: This quasi-experimental study with pretest-posttest single group was carried out in a research hospital's COVID-19 Paediatric Emergency Area in Turkey between May and August 2020. The sample consisted of 128 children aged between 4 and 12 years.Results: In the study, it was found that 50.8% of the children who came to the COVID-19 Paediatric Emergency Area due to suspicion of COVID-19 were boys and their mean age was 8.54 & PLUSMN; 2.62. 21.1% of the children were hospitalised before and 73.4% were afraid of the hospital. State stress scores of the participants before the patient education were higher in those, who didn't attend school between ages of 4-10, than those who went to school. State stress mean scores of the children from all age groups decreased significantly after the education.Conclusions: The video-based paediatric patient education decreases the children's hospital-related anxiety during the pandemic and increased their adherence to treatment.Review Citation Count: 0Effect of Everolimus on Prognosis of Neurofibromatosis Type 1 Lesions: a Systematic Review and Meta Analysis(Elsevier, 2024) Ibrahim, Ismail A.; Abdelkader, Rem Ehab; Nada, Ahmed Hosney; Younes, Siham; Hanen, George; Shahwan, Ghena; Nashwan, Abdulqadir J.Purpose: This study addresses the effectiveness of oral everolimus in treating various malignancies associated with Neurofibromatosis Type 1 (NF1). The purpose is to determine whether everolimus reduces lesion size in NF1 patients, considering the controversial findings from previous clinical trials. The scientific hypotheses and questions involve evaluating the impact of everolimus on NF1-associated lesions and understanding the variability in treatment outcomes. Methods: A systematic review and meta-analysis were conducted following PRISMA and Cochrane Collaboration guidelines. The study included four-phase II, single-arm, nonrandomized trials investigating the effect of oral everolimus on NF1-associated lesion size. The search covered multiple databases, and data extraction involved evaluating studies for inclusion criteria and assessing quality using the Cochrane Collaboration's Risk of Bias in Nonrandomized Studies tool. Statistical analysis utilized Open Meta(Analyst). Findings: The search yielded 388 studies, with 10 selected for full-text review and four included in the final analysis. The quality of the studies ranged from low to moderate. The meta-analysis indicated no observed heterogeneity (I2 = 0%), and the overall estimate suggested no significant reduction in NF1-associated lesion size with everolimus ( P = 0.069). Implications: The findings reveal a varied and inconsistent picture of everolimus efficacy in NF1 treatment. The study highlights the need for personalized approaches, considering individual genetic and clinical differences. The limitations, including small sample sizes and nonrandomized trials, call for larger, more standardized research efforts. The study emphasizes ongoing trials and the importance of future research in understanding predictors of everolimus response and optimizing treatment strategies for NF1 patients. Conclusion: While everolimus shows promise in reducing lesion size in a subset of NF1 patients, the study cannot draw conclusive results due to limitations in the included studies. Ongoing, adequately powered trials are crucial for advancing the evidence base and informing the potential role of everolimus in NF1 treatment. Others: There was no funding for this review and no conflicts of interest.Article Citation Count: 1Effects of Adding Respiratory Training To Osteopathic Manipulative Treatment on Exhaled Nitric Oxide Level and Cardiopulmonary Function in Patients With Pulmonary Arterial Hypertension(Excerpta Medica inc-elsevier Science inc, 2022) Naci, Baha; Demir, Rengin; Onder, Omer O.; Sinan, Umit Yasar; Kucukoglu, Mehmet Serdar; Fizyoterapi Ve Rehabilitasyon BölümüLimited research exists regarding nonpharmacologic management of pulmonary arterial hypertension (PAH), except for exercise training. The objective of this study was to investigate the effects of osteopathic manipulative treatment (OMT) alone and combined with respiratory training on fractional exhaled nitric oxide (FeNO), and cardiopulmonary function in patients with PAH. This single-blind, prospective, randomized controlled study included 54 patients with PAH who were randomly allocated to OMT, combined intervention, and control groups. The OMT group (n = 16) and combined intervention group (n = 16) received OMT and yoga respiratory training plus OMT, respectively, twice a week for 8 weeks. The control group (n = 16) received no intervention. All patients undertook an educational lecture. FeNO level, pulmonary function, 6-minute walk distance (6MWD), maximal inspiratory and expiratory pressures, and handgrip strength were assessed at baseline and 8 weeks. Combined intervention and OMT groups significantly improved all outcome measures after 8 weeks of treatment (p 0.01), except mean forced expiratory flow between 25% and 75% of forced vital capacity, which did not change in the OMT group (p 0.05). The control group showed significant deteriorations in 6MWD, inspiratory and peripheral muscle strength, and pulmonary function except peak expiratory flow at 8 weeks (p <0.05). The combined intervention group revealed significantly greater improvements of FeNO, 6MWD, respiratory and peripheral muscle strength, and pulmonary function except mean forced expiratory flow between 25% and 75% of forced vital capacity compared with the OMT group (p <0.05). All outcomes significantly improved in both intervention groups versus the control group (p <0.05). Our study demonstrated that adding respiratory training to OMT provided further benefit to FeNO level and cardiopulmonary function compared with OMT alone and that the OMT might be a useful and safe intervention for patients who cannot attend cardiac rehabilitation programs. (c) 2021 Elsevier Inc. All rights reserved. (Am J Cardiol 2022;162:184-190)Article Citation Count: 0Elastic Sac To Support Oral Feeding Performance of Preterm Infants: Crossover Randomized Controlled Study(Wiley, 2024) Genç, Canan; Goezen, Duygu; Narter, Fatma; Hemşirelik BölümüBackgroundSwaddling is recommended for preterm infants during feeding. Swaddling preterm infants with elastic cotton materials allows infants to easily stretch and move their extremities. This study aimed to assess the effect of bottlefeeding in a novel "elastic sac" on physiological parameters and feeding performance of preterm infants. MethodsA randomized controlled, crossover trial was conducted with total of 26 preterm infants at 26-36(+6) weeks of gestation. Infants randomly assigned to group 1 (n = 13) were bottlefed in an elastic sac (researcher-designed single-piece pouch made of soft, elastic cotton) for the first feeding and in normal clothes for the next feeding. Infants randomly assigned to group 2 (n = 13) were fed first in normal clothes and then in the elastic sac. The physiological parameters and feeding performance of the infants were assessed during each feeding. ResultsPreterm infants fed in the elastic sac had lower heart rate and higher oxygen saturation during and after feeding than infants fed in normal clothes (P < 0.05). Although all values were within clinically normal ranges, the findings suggest that feeding preterm infants in the elastic sac had a favorable effect on physiological parameters compared with feeding in normal clothes. There was no significant difference in the infants' feeding performance (P > 0.05). ConclusionA semielevated right lateral position and flexed body posture are recommended while feeding preterm infants, which can be easily maintained using the elastic sac. Feeding preterm infants in an elastic sac may support physiologic stability during oral feeding.Article Citation Count: 1An Evaluation of a Web-Based Crisis Management Training Program for Nurse Managers: the Case of the Covid-19 Crisis(Cambridge Univ Press, 2023) Harmancı Seren, Arzu Kader; Seren, Arzu Kader Harmanci; Bacaksiz, Feride Eskin; Gungor, Serkan; Bilgin, Osman; Baykal, Ulku; Hemşirelik BölümüObjective:The effective management of nursing services, the main power in patients' care and treatment in the front line of the fight against the COVID-19 pandemic, and nurse managers' effective leadership behaviors in the fight against the pandemic have been important key factors. It is thus critical to support nurse managers, strengthen them through training, and increase their competency so that they can successfully manage crises, disasters, or pandemics. This study aims to assess the effect of a web-based training program on the knowledge levels of nurse managers who worked during the COVID-19 pandemic. Methods:This is a randomized controlled experimental study. The study population consisted of the members of the Nurse Managers Association. The intervention group had 30 participants, and the control group had 31 participants in the final. Results:There was no statistically significant difference between the intervention and control groups' mean number of correct pre-test responses (P = 0.843). However, the intervention group's mean number of correct post-test responses was statistically significantly higher than the control group's after the web-based training program (P < 0.001). Conclusions:Web-based training programs can effectively increase nurse managers' knowledge levels. Therefore, web-based training programs should be developed in ordinary times for the management of crisis situations.Article Citation Count: 0Evaluation of Telemedicine for Contraceptive Counseling Given To Pregnant Women During the Covid-19 Pandemic: a Randomized Controlled Trial(Taylor & Francis inc, 2024) Sağlam Aksüt, Rabia; Inam, Ozen; Hemşirelik BölümüIn this study, we aimed to evaluate the impact of telemedicine for contraceptive counseling on knowledge levels and satisfaction with Family Planning Services. We collected data from 77 third-trimester pregnant women using a personal information form, Family Planning Knowledge Questionnaire, and the Satisfaction with Family Planning Services Scale and compared the data using chi-square test, Fisher's exact chi-square test, t-test for independent and dependent groups and Mann-Whitney U analysis. The experimental group participants (n = 37) received two informative video visits for contraceptive counseling, while the women in the control group (n = 40) received routine face-to-face Family Planning Services at their primary health care center. Participants in the experimental group showed a greater increase in knowledge levels and higher satisfaction with Family Planning Services than those in the control group (p < 0.05). In conclusion, we determined that telemedicine for contraceptive counseling is a promising option even beyond the pandemic.Article Citation Count: 2The Factors Associated With School Readiness: Sensory Processing, Motor, and Visual Perceptual Skills, and Executive Functions in Kindergarten Children(Routledge Journals, Taylor & Francis Ltd, 2023) Aydöner, Selen; Bumin, Gonca; Ergoterapi BölümüMany developmental skills are related to children's school readiness in the early years, and these skills are essential for later achievement. Some of these skills include sensory processing, motor and visual perceptual skills, and executive functions. To date, limited research has examined these skills associated with school readiness. This study investigated the relationship between sensory processing, motor and visual perceptual skills, and executive functions, and school readiness in kindergarten children. A total of 138 kindergarten children administered the Sensory Profile, the Bruininks-Oseretsky Test 2- Brief Form, the Test of Visual Perceptual Skills-3, the Childhood Executive Functioning Inventory, and the Primary School Readiness Scale. The results showed that sensory processing, motor and visual perceptual skills, and executive functions were correlated with children's school readiness, and these skills were also highly predictive of children's school readiness (p < 0.05). It is necessary for future studies to consider these skills when assessing school readiness and to include strategies to develop these skills in intervention programs.Article Citation Count: 1Global Health Emergencies During the Pandemic and Their Solutions(Tubitak Scientific & Technological Research Council Turkey, 2021) Ağalar, Canan; Bulut, Dilek; Sencan, Ismail Hakki; Agalar, Canan; Tıbbi Hizmetler ve Teknikler BölümüIn this review, we evaluated health care problems, which were not common before pandemic outbreak but have been common issues after its appereance and approaches to control pandemic considering its influences on people. We revised current health care developing approaches under the light of experience obtained throughout the pandemic so far. The aim is to be prepared in advance for possible upcoming pandemics. As in Covid 19 pandemics, such long lasting and widely affecting situations, durability is also very important together with flexibility and quickness. To provide durability, we need global policies taking the health to its center as well as health system policies.Article Citation Count: 0A Guide To Facilitate the Creation of a Femoral Tunnel for Arthroscopic Ligamentum Teres Reconstruction: a Three-Dimensional Computed Tomography Study(Oxford Univ Press, 2024) Ismailoglu, Abdul Veli; Ismailoglu, Pelin; Zeynalov, Samir, I; Ozdogmus, Omer; Yildizhan, Saliha Elif; Bayramoglu, Alp; Kayaalp, AsimThe ideal femoral tunnel passing through the centre of the femoral neck targeted to the footprint of the ligamentum teres (LT) is established during the LT reconstruction surgery with the free-hand technique. We aimed to quantitatively determine the entry site and define the angular orientation of the ideal femoral tunnel with its relevance to the femoral valgus angle (FVA) and the femoral anteversion angle (FAA) to facilitate the creation of an ideal femoral tunnel during the LT reconstruction surgery. A total of 60 randomly selected CT images were obtained to reconstruct three-dimensional femur models. A virtual reamer representing the ideal femoral tunnel was placed in the femur models. The femur length, FVA, FAA, the femoral tunnel anterior angle, the femoral tunnel superior angle and the skin- and bony-entry sites were measured. The femoral tunnel angular orientation was strongly correlated with the FVA and the FAA. Mathematical formulas were defined by which entry site of the reamer and the anterior and superior angulation of the femoral tunnel could be estimated before the surgery. The mean skin-entry site was 67.3 mm distal and 0.1 mm anterior to the centre of the greater trochanter's superior border. The angular orientation of the femoral tunnel using FVA and FAA can be easily estimated using mathematical formulas before LT reconstruction surgery. The entry site and angular orientation of the femoral tunnel described in this study can be used to reduce dependency on the usage of fluoroscopy and the workload on the surgeon during the LT reconstruction surgery.Article Citation Count: 2cotinus Coggygria Scop. Attenuates Acetic Acid-Induced Colitis in Rats by Regulation of Inflammatory Mediators(Springer, 2023) Şener, Göksel; Ertas, Busra; Cevik, Ozge; Yildirim, Aybeniz; Kayali, Damla Gokceoglu; Akakin, Dilek; Sener, Goksel; Eczacılık Meslek Bilimleri BölümüIn traditional medicine, many medicinal plants are used in the treatment of various diseases caused by inflammation. The objective of the present study is to elucidate for the first time the effects of Cotinus coggygria (CC) ethanol extract (CCE) on colonic structure and inflammation of acetic acid-induced ulcerative colitis in rats. Colonic damage was assessed using disease activity index score, enzyme-linked immunosorbent assay, and hematoxylin-eosin staining. Also, in vitro antioxidant activity of CCE was investigated by ABTS methods. Total phytochemical content of CCE was measured spectroscopically. Acetic acid caused colonic damage according to disease activity index and macroscopic scoring. CCE significantly reversed these damages. While the levels of proinflammatory cytokines TNF-alpha, IL-1beta, IL-6, and TGF-1beta increased in tissue with UC, IL-10 level decreased. CCE increased inflammatory cytokine levels to values close to the sham group. At the same time, while markers indicating disease severity such as VEGF, COX-2, PGE2, and 8-OHdG indicated the disease in the colitis group, these values returned to normal with CCE. Histological research results support biochemical analysis. CCE exhibited significant antioxidant against ABTS radical. Also, CCE was found to have a high content of total polyphenolic compounds. These findings provide evidence that CCE might be benefit as a promising novel therapy in the treatment of UC in humans due to high polyphenol content and justify the use of CC in folkloric medicine for treatment of inflamed diseases.Article Citation Count: 6Investigation of Land Cover (lc)/Land Use (lu) Change Affecting Forest and Seminatural Ecosystems in Istanbul (turkey) Metropolitan Area Between 1990 and 2018(Springer, 2023) Bozkurt, Selvinaz Gülçin; Kusak, Lutfiye; Akkemik, UnalThis study was conducted to examine the land cover (LC)/land use (LU) change affecting forest and seminatural ecosystems and the spatio-temporal development of urban expansion between 1990 and 2018 in the city of Istanbul, where urbanization is the most intense in Turkey. For this purpose, using Corine Land Cover (1990, 2000, 2006, 2012, and 2018) dataset, the land cover of the area was determined in 5 different classes (artificial surface, agriculture, forest, water bodies, water), maps were produced, and tabular data were created. The changes in LC/LU between 1990 and 2018 were determined according to the Puyravaud land cover change rate and hot spot analysis methods. According to our findings, we determined that urbanization in Istanbul expanded the most in the east-west direction, and the agricultural and forest areas gradually decreased by 3.02% and 6.66% respectively; urban areas increased at the same rate of 9.69%. It is predicted that this change will continue increasing until 2030 when the forecasting method is applied in the field. It has been determined that the most important reasons for this situation are local government policies, population growth, and economic development initiatives applied in the area. As a result, it has emerged that measures should be taken based on sustainability and naturalness approaches to design urban development plans and to protect natural areas on a large scale, in order to limit possible LC/LU conversion from natural structure to urbanization in the area.Article Citation Count: 3Is Shoulder Geometry Important for Rotator Cuff Tears?(Wiley, 2021) Bülbül, Ahmet Murat; Birinci, Murat; Kuyucu, Ersin; Bulbul, Ahmet Murat; Fizyoterapi Ve Rehabilitasyon BölümüPurpose This study is aiming to evaluate some specific anatomic shoulder parameters such as the lateral acromial angle (LAA), acromial index (AI), coracohumeral distance (CHD) and critical shoulder angle (CSA) in rotator cuff tears. Methods A total of 100 cases consisting of 50 patients with rotator cuff tears and 50 patients without rotator cuff tears, who underwent shoulder MRI (mangnetic resonance imaging) examination in Istanbul Medipol University Orthopedics and Traumatology Department, participated in this study. In this retrospective study, CCA, LAA, AI and CSA were evaluated in MRI in order to shed light on the theories of rotator cuff tears. Results There was no significant difference (P > .05) in acromial index and coracohumeral distance in the patient group. Lateral acromial angle and critical shoulder angle were significantly different in the patient group compared to the control group (P < .05). There was a weak negative correlation between CSA and CHD. Conclusion In our study, we found that patients with smaller LAA and higher CSA values in MRI images are prone to have rotator cuff tears. Further studies are needed in order to evaluate whether this association has predictive value.Review Citation Count: 4Kidney Transplantation: a Possible Solution To Obstructive Sleep Apnea in Patients With End-Stage Kidney Disease(Springer Heidelberg, 2023) Kanbay, Mehmet; Ureche, Carina; Copur, Sidar; Covic, Alexandra M. M.; Tanriover, Cem; Esen, Bugra H. H.; Covic, AdrianIntroductionObstructive sleep apnea (OSA) is frequently reported among patients with chronic kidney disease resulting in considerable morbidity and mortality. OSA may cause repetitive stimulation of the sympathetic nervous system and elevations in pulmonary artery pressure leading to an elevated risk of cardiac and vascular complications in patients with chronic kidney disease. Furthermore, OSA is associated with progressive worsening of kidney injury and loss of renal function. MethodsIn this systematic review and meta-analysis, we evaluated the effect of renal transplantation on the progression of OSA in patients with end-stage kidney disease. ResultsThe meta-analysis included eight studies with a total of 401 patients. Findings showed that kidney transplantation does not lead to a statistically significant effect on the apnea-hypopnea index (MD 2.6 events/hr, 95% CI -3.2 to 8.3, p = 0.21), total sleep time (MD 14.7 min/night, 95% CI -8.4 to 37.8, p = 0.76), sleep efficiency (MD 2.5%, 95% CI -1.4 to 6.3, p = 0.57), slow wave sleep (MD 0.4% of total sleep time, 95% CI -7.5 to 8.4, p = 0.05), and rapid eye movement sleep (MD 0.6% of total sleep time, 95% CI -2.2 to 3.3, p = 0.98). There was no statistically significant effect of kidney transplantation on OSA in patients with chronic renal disease.Article Citation Count: 1Multidrug Resistance in Pathogens of Community-Acquired Urinary Tract Infections in Turkey: a Multicentre Prospective Observational Study(Tubitak Scientific & Technological Research Council Turkey, 2023) Sencan, Irfan; Karabay, Oguz; Altay, Fatma Aybala; Suzuk Yildiz, Serap; Simsek, Husniye; Gozukara, Melih Gaffar; Surme, SerkanBackground/aim: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options.Materials and methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed. Results: Of the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advanced age, and having two or more risk factors showed a statistically significant relation with MDR existence (p < 0.001, p: 0.014, p < 0.001, respectively) that increasing number of risk factors or degree of advancing in age directly affects the number of antibiotic groups detected to have resistance by pathogens. In total, MDR isolates corresponded to 36.1% of our CAUTI samples; MDR existence was 35.7% in E. coli isolates and 57.2% in Klebsiella spp. isolates. Our results did not show an association between resistance or MDR occurrence rates and NUTS regions.Conclusion: The necessity of urine culture in outpatient clinics should be taken into consideration, at least after evaluating risk factors for antibacterial resistance individually. Community-acquired UTIs should be followed up time-and region-dependently. Antibiotic stewardship programmes should be more widely and effectively administrated.Article Citation Count: 3Occupational Competence and Activities of Daily Living Performance in Bronchial Asthma Competence professionnelle et activites de la vie quotidienne Performance dans l'asthme bronchique(Sage Publications inc, 2021) Güzel, Hüsna; Saglam, Melda; Pekcetin, Serkan; Yagli, Naciye Vardar; Boyaci, Hasim; Terapi ve Rehabilitasyon BölümüBackground. Activity restriction is one of the most common symptoms reported by people living with bronchial asthma. Purpose. The study aimed to determine occupational competence and values in people living with bronchial asthma and compare with the occupational competence and activities of daily living (ADL) of healthy controls. Methods. Twenty individuals with asthma and 20 healthy controls were enrolled. Occupational competence and values were assessed using the Occupational Self-Assessment (OSA) questionnaire. Restriction of ADL was determined using the London Chest ADL Scale. Findings. Occupational competence was lower, and all London Chest ADL scores were significantly higher in asthma individuals compared to controls (p < .05). The most affected parameters reported by asthma individuals on the OSA were the ability to concentrate, perform physical tasks, work toward goals, and use abilities effectively. Implications. Evaluating occupational competence in people living with bronchial asthma is important to identify their occupational problem areas and provide appropriate interventions.Article Citation Count: 3Paricalcitol Protects Against Hydrogen Peroxide-Induced Injury in Endothelial Cells Through Suppression of Apoptosis(Frontiers Media Sa, 2023) Şener, Azize; Sekerler, Turgut; Cevik, Ozge; Sener, Azize; Temel Eczacılık Bilimleri BölümüThe vascular endothelium is one of the main targets of oxidative stress which plays an important role in the pathophysiology of vascular damage. Recent studies show that vitamin D can positively regulate endothelial functions in various chronic diseases and in cases of increased oxidative stress. In our study, we investigated the restorative and protective potentials of paricalcitol which is frequently used in patients with chronic renal failure, a vitamin D analogue, in human umbilical vein endothelial cells (HUVEC) before and after H2O2-induced oxidative stress. Paricalcitol treatment after the oxidative stress induced by H2O2 increased cell viability in endothelial cells depending on the dose that was used. While paricalcitol (500 nM) decreased caspase-3 activity and mitochondrial membrane potential loss, it increased nitric oxide (NO) production and reduced glutathione (GSH) levels. Paricalcitol treatment before oxidative stress increased cell viability. It increased NO production and mitochondrial membrane potential while significantly reducing caspase-3 activity. While paricalcitol caused a significant inhibition of protein disulfide isomerase (PDI) reductase activity in healthy endothelial cells, it did not cause a significant change on the PDI reductase activity under oxidative stress conditions. Present study showed that paricalcitol has restorative and protective effects on endothelial cells against oxidative injury, but these effects occur at high concentrations of paricalcitol.Article Citation Count: 0Petroselinum Crispum Extract Prevents Scopolamine-Induced Lens Damage in Rats(Wiley-v C H verlag Gmbh, 2023) Ede Pazarbaşı, Seren; Şener, Göksel; Sener, Goksel; Sacan, Ozlem; Yanardag, Refiye; Eczane Hizmetleri Bölümü; Eczacılık Meslek Bilimleri BölümüAlzheimer's disease (AD) is a neurodegenerative disease that occurs especially in advanced ages. It reduces the quality of life of both the patient and their relatives. In addition to its primary effects, AD causes metabolic defects and tissues are damaged due to these effects. Oxidative stress damages cells by disrupting antioxidant/oxidant balance in many tissues, especially due to AD. In individuals with AD and the elderly, lens tissue is damaged due to oxidative stress and may cause vision loss. Therefore, it is very important to investigate herbal products that both prevent/cure AD and reduce AD-related oxidative stress, as they may have fewer side effects. In this study, the protective effects of parsley (Petroselinum crispum) extract on lens tissues of an experimental AD model induced by scopolamine were examined and evaluated through biochemical parameters. The result of biochemical experiments and principal component analysis, was observed that parsley extract had a therapeutic effect by reducing oxidative stress in lens tissues of experimentally induced AD rats. It can be suggested that the phenolic and flavonoid-rich content of parsley extract may have caused the reduction of oxidative damage in lens tissues and can be used to protect lens tissue against oxidative stress due to AD disease.
