PubMed İndeksli Yayınlar Koleksiyonu

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Citation - WoS: 9
Citation - Scopus: 7
Investigation of Land Cover (lc)/Land Use (lu) Change Affecting Forest and Seminatural Ecosystems in Istanbul (turkey) Metropolitan Area Between 1990 and 2018
(Springer, 2023) Bozkurt, Selvinaz Gulcin; Kusak, Lutfiye; Akkemik, Unal
This study was conducted to examine the land cover (LC)/land use (LU) change affecting forest and seminatural ecosystems and the spatio-temporal development of urban expansion between 1990 and 2018 in the city of Istanbul, where urbanization is the most intense in Turkey. For this purpose, using Corine Land Cover (1990, 2000, 2006, 2012, and 2018) dataset, the land cover of the area was determined in 5 different classes (artificial surface, agriculture, forest, water bodies, water), maps were produced, and tabular data were created. The changes in LC/LU between 1990 and 2018 were determined according to the Puyravaud land cover change rate and hot spot analysis methods. According to our findings, we determined that urbanization in Istanbul expanded the most in the east-west direction, and the agricultural and forest areas gradually decreased by 3.02% and 6.66% respectively; urban areas increased at the same rate of 9.69%. It is predicted that this change will continue increasing until 2030 when the forecasting method is applied in the field. It has been determined that the most important reasons for this situation are local government policies, population growth, and economic development initiatives applied in the area. As a result, it has emerged that measures should be taken based on sustainability and naturalness approaches to design urban development plans and to protect natural areas on a large scale, in order to limit possible LC/LU conversion from natural structure to urbanization in the area.
Citation - WoS: 4
Citation - Scopus: 5
The Validity and Reliability of the Thanatophobia Scale-Turkish Form: a Psychometric Study Among Nurses
(Sage Publications inc, 2024) Cifcioglu, Zulfiye Yildiz; Seren, Arzu K. Harmanci
Purpose: To examine the validity and reliability of the Thanatophobia Scale-Turkish Form among nurses. Design and methods: This methodological study included 154 nurses. Content and construct validity, item analysis, confirmatory factor analysis, and internal consistency were used to evaluate the data. Findings: The content validity index of the scale was 0.91. Item-total score correlation values varied between 0.453 and 0.718. As a result of the confirmatory factor analyses, one factor was confirmed. Cronbach's alpha internal consistency coefficient was 0.854. Practice Implications: Thanatophobia Scale-Turkish Form is a valid and reliable tool used to evaluate the fear of death among nurses.
Citation - WoS: 11
Citation - Scopus: 11
Synthesis, Antimicrobial Evaluation, and Molecular Modeling Studies of New Thiosemicarbazide-Triazole Hybrid Derivatives of (s)-naproxen
(Wiley-v C H verlag Gmbh, 2022) Han, M. Ihsan; Ince, Ufuk; Gunduz, Miyase Gozde; Kucckguzel, S. Guniz
The discovery of new antimicrobial molecules is crucial for combating drug-resistant bacterial and fungal infections that pose a dangerous threat to human health. In the current research, we applied a molecular hybridization approach to synthesize original thiosemicarbazide-triazole derivatives starting from (S)-naproxen (7a-7k). After structural characterization using FT-IR, H-1-NMR, C-13-NMR, and HR-MS, the obtained compounds were screened for their antimicrobial activities against Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Candida albicans ATCC 10231 and their isolates, as well. Although all compounds were found to be moderate antimicrobial agents, in general, their antibacterial activities were better than antifungal effects. Among the tested compounds, 7j carrying nitrophenyl group on the thiosemicarbazide functionality represented the best MIC value against S. aureus isolate. Finally, molecular docking studies were performed in the active pocket of S. aureus flavohemoglobin to rationalize the obtained biological data.
A Guide To Facilitate the Creation of a Femoral Tunnel for Arthroscopic Ligamentum Teres Reconstruction: a Three-Dimensional Computed Tomography Study
(Oxford Univ Press, 2024) Ismailoglu, Abdul Veli; Ismailoglu, Pelin; Zeynalov, Samir, I; Ozdogmus, Omer; Yildizhan, Saliha Elif; Bayramoglu, Alp; Kayaalp, Asim
The ideal femoral tunnel passing through the centre of the femoral neck targeted to the footprint of the ligamentum teres (LT) is established during the LT reconstruction surgery with the free-hand technique. We aimed to quantitatively determine the entry site and define the angular orientation of the ideal femoral tunnel with its relevance to the femoral valgus angle (FVA) and the femoral anteversion angle (FAA) to facilitate the creation of an ideal femoral tunnel during the LT reconstruction surgery. A total of 60 randomly selected CT images were obtained to reconstruct three-dimensional femur models. A virtual reamer representing the ideal femoral tunnel was placed in the femur models. The femur length, FVA, FAA, the femoral tunnel anterior angle, the femoral tunnel superior angle and the skin- and bony-entry sites were measured. The femoral tunnel angular orientation was strongly correlated with the FVA and the FAA. Mathematical formulas were defined by which entry site of the reamer and the anterior and superior angulation of the femoral tunnel could be estimated before the surgery. The mean skin-entry site was 67.3 mm distal and 0.1 mm anterior to the centre of the greater trochanter's superior border. The angular orientation of the femoral tunnel using FVA and FAA can be easily estimated using mathematical formulas before LT reconstruction surgery. The entry site and angular orientation of the femoral tunnel described in this study can be used to reduce dependency on the usage of fluoroscopy and the workload on the surgeon during the LT reconstruction surgery.
Citation - WoS: 1
Citation - Scopus: 2
Investigating Body Image and Self-Esteem in Kidney Transplant Patients: a Qualitative Study
(Wolters Kluwer Medknow Publications, 2024) Akinci, N.; Varisoglu, Y.
Background:Kidney transplantation is one of the life-saving therapies for patients with end-stage renal disease, which affects a person's psychological, social, and physical well-being. How transplanted patients perceive their illness and their body can affect their physical and psychological recovery.Aim:This qualitative study was designed to evaluate self-esteem and body image in kidney transplant patients.Methods:The study involved 16 female renal transplanted patients. Data were collected using a two-part interview form developed by the investigators in accordance with the literature. We used Lundman's method to transcribe the interviews and coded the data from the interviews. The results of the study were discussed using the themes. The first three interviews were entered into MAXQDA, and then, additional interviews were analyzed.Results:Six main themes and 15 subthemes were generated based on the thematic analysis of the interviews with participants about body image and self-esteem. Themes included body acceptance, changes in body image, deterioration of social relationships, changes in self-esteem, spousal concerns, and organ perceptions. This study collected detailed data on body image, self-esteem, social relationships, and spouse/partner relationships after kidney transplantation.Conclusion:The change in participants' body image and self-esteem after kidney transplantation caused having negative feelings regarding sexual life, relationships, and social life and feeling unfamiliar with the transplanted organ.
Citation - WoS: 1
Citation - Scopus: 1
Does Working Style Affect the Occupational Balance and Life Satisfaction of Office Workers in Turkey? a Comparison Study
(Ios Press, 2024) Degerli, Medine Nur Ozata; Aydoner, Selen; Altuntas, Onur; Bumin, Gonca
BACKGROUND: The coronavirus outbreak (COVID-19) has caused various effects, changing people's lives and work styles. During this period, workplaces decided to work remotely, so people spent more time at home. Therefore, workers' personal and work lives were negatively affected. OBJECTIVE: This study planned to compare traditional and remote office workers' occupational balance and life satisfaction in Turkey during COVID-19. METHODS: Google Survey was used for data collection. Three hundred office workers (18-65 years old) from Turkey participated in the study. The occupational balance and life satisfaction levels of participants were assessed using the Occupational Balance Questionnaire (QB-Quest) and Personal Well-being Index-Adult (PWI-A). RESULTS: Data collected were analyzed statistically by the Independent Sample t-test. It was found that the remote office workers had lower levels of occupational balance (p = 0.02; r = -3.317) and life satisfaction (p = 0.01; r = -2.199) compared to the traditional office workers. CONCLUSION: Remote office workers were found to have lower occupational balance and life satisfaction than traditional office workers. In this period, when the way of working changes like COVID-19, it is crucial to determine office workers' occupational balance and life satisfaction and take precautions for their job performance and satisfaction.
Citation - WoS: 6
Citation - Scopus: 7
Respiratory Muscle Endurance in Obesity Hypoventilation Syndrome
(Daedalus Enterprises inc, 2022) Dusgun, Elif Sena; Aslan, Goksen Kuran; Abanoz, Ebru Seker; Kiyan, Esen
BACKGROUND: An increase in respiratory work load and resistance to respiration cause a decrease in respiratory muscle endurance (RME) in patients with obesity hypoventilation syndrome (OHS). We aimed to evaluate and compare RME in subjects with OHS and a control group using an incremental load test and compare the RME of subjects with OHS in whom noninvasive ventilation (NIV) was and was not used. METHODS: Forty subjects with OHS (divided according to body mass index [BMI] as group I: 30-40 kg/m(2); and group II: 6 40 kg/m(2)) and 20 subjects with obesity (control group: 30-40 kg/m(2)) were included in the study. RME was evaluated using the incremental load test, and respiratory muscle strength (RMS) was evaluated using mouth pressure measurements. The 6-min walk test, Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), EQ-5D Health-Related Quality of Life Questionnaire (EQ-5D), and the Obesity and Weight-Loss Quality of Life Instrument (OWLQOL) were performed. RESULTS: RME and RMS (%) in group I were lower than the control group (P=.001, P=.005, and P=.001, respectively). No significant difference was found between the 3 groups in terms of 6-min walk distance (6MWD) percentage predicted values (P=.98). RME in the NIV user group was higher than the non-user group (P 5.006). ESS, total PSQI, and FSS scores in the control group were less than group I (P=.01, P=.009, and P=.005, respectively) and group II (P 5.01, P <.001, and P <.001, respectively). The EQ-5D scores of the control group were higher than group II only (P=.005 and P=.005, respectively). There were no differences in OWLQOL between the groups (P=.053). CONCLUSIONS: RME was low in subjects with OHS but higher in those who used NIV. The incremental load test could be performed easily and safely in a clinic setting.
Citation - WoS: 5
Citation - Scopus: 5
Paricalcitol Protects Against Hydrogen Peroxide-Induced Injury in Endothelial Cells Through Suppression of Apoptosis
(Frontiers Media Sa, 2023) Koksal, Muhammet Murat; Sekerler, Turgut; Cevik, Ozge; Sener, Azize
The vascular endothelium is one of the main targets of oxidative stress which plays an important role in the pathophysiology of vascular damage. Recent studies show that vitamin D can positively regulate endothelial functions in various chronic diseases and in cases of increased oxidative stress. In our study, we investigated the restorative and protective potentials of paricalcitol which is frequently used in patients with chronic renal failure, a vitamin D analogue, in human umbilical vein endothelial cells (HUVEC) before and after H2O2-induced oxidative stress. Paricalcitol treatment after the oxidative stress induced by H2O2 increased cell viability in endothelial cells depending on the dose that was used. While paricalcitol (500 nM) decreased caspase-3 activity and mitochondrial membrane potential loss, it increased nitric oxide (NO) production and reduced glutathione (GSH) levels. Paricalcitol treatment before oxidative stress increased cell viability. It increased NO production and mitochondrial membrane potential while significantly reducing caspase-3 activity. While paricalcitol caused a significant inhibition of protein disulfide isomerase (PDI) reductase activity in healthy endothelial cells, it did not cause a significant change on the PDI reductase activity under oxidative stress conditions. Present study showed that paricalcitol has restorative and protective effects on endothelial cells against oxidative injury, but these effects occur at high concentrations of paricalcitol.
Citation - WoS: 16
Citation - Scopus: 23
Balance Training in Modern Dancers Proprioceptive-Neuromuscular Training Vs Kinesio Taping
(Science & Medicine inc, 2018) Tekin, Demet; Agopyan, Ani; Baltaci, Gul
Kinesio tape and proprioceptive exercises are both used for increasing balance in dancers. The purposes of this study were to: a) determine the acute effect of kinesio tape (KT) application on the ankle joint on balance performance, b) investigate the effects of an 8-week proprioceptive-neuromuscular (PN) training program on balance performance, and c) compare their effects vs modern dance technique classes alone. Thirty-three trained, university-level modern dance students (9 male, 24 female) were divided randomly into three groups: kinesio tape (KT, n=11), proprioceptive-neuromuscular (PN, n=11), or control (n=11). Static (turn-out passe-opened eyes/releve and turn-out passe-closed eyes/flat foot), semi-dynamic (airplane), and dynamic balance (monopodalic-straight and -transverse in a turn-out passe-eyes opened/flat foot) tests were performed before and after the intervention. One day after pre-tests, KT mechanical correction technique was applied to the left ankle joint (supporting leg) in the KT group, and tests were repeated to determine the acute effect of KT. The PN group participated in an 8-week balance training program (2 days/wk, 60 min/day) involving exercises using stable and unstable surfaces. Significant improvements were observed for all static and dynamic balance tests in the PN group; semi-dynamic airplane and dynamic monopodalic-straight and transverse tests improved in the KT group; and only semi-dynamic airplane test scores changed significantly for the control group (p<0.05). Our findings suggest that with the exception of the semi-dynamic airplane test, both PN training and KT application were more effective at improving balance performance for modern dancers than modern dance technique classes alone.
Citation - WoS: 17
Citation - Scopus: 20
Exercise Improves Testicular Morphology and Oxidative Stress Parameters in Rats With Testicular Damage Induced by a High-Fat Diet
(Wiley, 2022) Elmas, Merve Acikel; Ozakpinar, Ozlem Bingol; Kolgazi, Meltem; Sener, Goksel; Arbak, Serap; Ercan, Feriha
Obesity and male infertility are problems that affect population. Exercise is a nonpharmacological way to reduce the negative health effects of obesity. The purpose of this study was to examine the effects of exercise on hormone levels, blood-testis barrier, and inflammatory and oxidative biomarkers in rats that became obese due to a high-fat diet (HFD). Male rats received a standard diet (STD group) or a HFD (HFD group) for 18 weeks. During the final 6 weeks of the experiment, swimming exercises (1 h/5 days/week) were given to half of these animals (STD + EXC and HFD + EXC groups). Finally, blood and testicular tissues were analysed by biochemical and histological methods. Body weight, leptin, malondialdehyde, interleukin-6, TNF-alpha and myeloperoxidase levels, apoptotic cells and DNA fragmentation were increased, and testis weight, insulin, FSH, LH, testosterone, glutathione and superoxide dysmutase levels, proliferative cells, ZO-1, occludin, and gap junction protein Cx43 immunoreactivity were decreased in the HFD group. All these hormonal, morphological, oxidative and inflammatory biomarkers were enhanced in the HFD + EXC group. It is thought that exercise protected testicular cytotoxicity by regulating hormonal and oxidant/antioxidant balances and testicular function, inhibiting inflammation and apoptosis, as well as preserving blood-testis barrier.
Citation - Scopus: 1
Effect of Sexual Quality of Life on Self-Management Perceptions of Women With Type 2 Diabetes
(Wolters Kluwer Medknow Publications, 2024) Eroglu, N.
Background:The quality of sexual life of women with type 2 diabetes has an impact on their self-management perceptions.Aim:To evaluate the effect of quality of sexual life on self-care perceptions of women with type 2 diabetes mellitus (DM).Material and Methods:It was an online descriptive study of 127 women with type 2 DM. The questionnaire consisted of a patient information form, sexual quality of life scale-female, and diabetes self-management perception scale.Results:There was a significant relationship between diabetes self-management perception and sexual quality of life (P = 0.000). The individuals' diabetes self-management perception scores differed significantly according to their age (F = 3.12; P = 0.047), and the sexual quality of life scores differed significantly according to their treatment type (F = 4.01; P = 0.020).Conclusion:There is a relationship between quality of sexual life and self-management perceptions of women with type 2 DM. As the quality of sexual life increases, diabetes self-management perceptions increase. Age affects diabetes self-management perception, and the type of treatment used by individuals also affects their quality of sexual life.
Citation - WoS: 2
Citation - Scopus: 2
Global Health Emergencies During the Pandemic and Their Solutions
(2021) Sencan, Irfan; Bulut, Dilek; Agalar, Canan; Sencan, Ismail Hakki
Abstract: In this review, we evaluated health care problems, which were not common before pandemic outbreak but have been common issues after its appereance and approaches to control pandemic considering its influences on people. We revised current health care developing approaches under the light of experience obtained throughout the pandemic so far. The aim is to be prepared in advance for possible upcoming pandemics. As in Covid 19 pandemics, such long lasting and widely affecting situations, durability is also very important together with flexibility and quickness. To provide durability, we need global policies taking the health to its center as well as health system policies.Key words: Covid-19, health system, emergency, crisis, vulnerability, durability
Citation - WoS: 2
Citation - Scopus: 2
Turkish Translation/Cultural Adaptation and Psychometric Analyses of the Affordances in the Home Environment for Motor Development-Infant Scale (ahemd-Is)
(Sage Publications inc, 2023) Apaydin, Umut; Eraslan, Rabia; Balikci, Aymen; Elbasan, Buelent
In this study we translated the Affordances in the Home Environment for Motor Development-Infant Scale (AHEMD-IS) into Turkish, adapted the instrument culturally, examined its psychometric properties within a Turkish population, and identified its limitations. We administered the AHEMD-IS to families of 65 premature or full-term Turkish infants and repeated this testing for 17 families after one-two weeks to establish test-retest reliability. We calculated the Intraclass Correlation Coefficient (ICC) and Cronbach alpha coefficient to assess reliability, and we evaluated test validity using the Spearman's correlation coefficient and correlations with the Bayley-III motor development score. The Cronbach Alpha coefficient of the questionnaire was 0.846, and, for test-retest reliability, the ICC score was 0.830. The Turkish AHEMD-IS total score was moderately correlated with the Bayley-III fine motor development score (r = 0.469, p < 0.001), the Bayley-III gross motor development score (r = 0.533, p < 0.001), and the Bayley-III total motor development score (r = 0.526, p < 0.001). The Turkish version of the AHEMD-IS was found to be valid and reliable for children born prematurely or at full-term. The use of this questionnaire in Turkey will facilitate the creation of a home environment that will support motor development in children between 3-18 months of age.
Citation - WoS: 2
Citation - Scopus: 1
Multidrug Resistance in Pathogens of Community-Acquired Urinary Tract Infections in Turkey: a Multicentre Prospective Observational Study
(Tubitak Scientific & Technological Research Council Turkey, 2023) Sencan, Irfan; Karabay, Oguz; Altay, Fatma Aybala; Suzuk Yildiz, Serap; Simsek, Husniye; Gozukara, Melih Gaffar; Surme, Serkan
Background/aim: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options.Materials and methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed. Results: Of the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advanced age, and having two or more risk factors showed a statistically significant relation with MDR existence (p < 0.001, p: 0.014, p < 0.001, respectively) that increasing number of risk factors or degree of advancing in age directly affects the number of antibiotic groups detected to have resistance by pathogens. In total, MDR isolates corresponded to 36.1% of our CAUTI samples; MDR existence was 35.7% in E. coli isolates and 57.2% in Klebsiella spp. isolates. Our results did not show an association between resistance or MDR occurrence rates and NUTS regions.Conclusion: The necessity of urine culture in outpatient clinics should be taken into consideration, at least after evaluating risk factors for antibacterial resistance individually. Community-acquired UTIs should be followed up time-and region-dependently. Antibiotic stewardship programmes should be more widely and effectively administrated.
The Effect of Simulation-Based Electroconvulsive Therapy Education on Perception and Knowledge of Nursing Students: a Semiexperimental Study
(Lippincott Williams and Wilkins, 2025) Dikeç, G.; Şan, E.Ö.
Objectives Despite the recognized benefits and safety of electroconvulsive therapy (ECT) for treating mental disorders, negative perceptions persist among both the public and mental health professionals. This stigma is often rooted in historical practices and media portrayals, despite modern advancements in the technique. This study aimed to assess the impact of simulation-based ECT education on nursing students' perceptions and knowledge regarding ECT before and after the procedure. Methods This study was planned to use a single-group pretest and posttest quasi-experimental design with a 3-month follow-up. Simulation-based ECT education involved 1 hour of theoretical instruction followed by hands-on learning using a high-fidelity mannequin. Final-year nursing students enrolled in a psychiatric and mental health nursing course were examined on their knowledge and perceptions of ECT before, immediately after, and 3 months following the intervention. Results Students reported statistically significant improvements in their perception and knowledge levels after participating in the simulation-based ECT education. The results were similar at the 3-month follow-up. Conclusions Simulation-based ECT education can be effectively integrated into both undergraduate and graduate nursing curricula to foster positive perceptions and enhance knowledge about ECT. Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.
Citation - Scopus: 1
Investigating the Impact of Various Insole Applications on Balance and Postural Stability in the Elderly
(Elsevier, 2025) Ozturk, Basar; Ozdincler, Arzu Razak; Kocyigit, Ahmet; Kaya, Begum Kara; Kisa, Eylul Pinar
Objectives: Aging leads to physical and cognitive declines, notably affecting balance and motor skills, making falls a prevalent health concern among the elderly. Falls, a significant health issue among the elderly, often stem from these impairments. This study aims to investigate the impact of different insole materials, specifically cork and silicone, on balance and postural stability in the elderly. Methods: A randomized controlled trial was conducted at the Istanbul Barinyurt Elderly Care Center with 24 participants, divided into two groups to test cork and silicone insoles. Balance parameters, plantar pressure, the Timed Up and Go (TUG) test, and the Five Times Sit-to-Stand Test were used as measures. Data analysis was performed using the Mann-Whitney U and Wilcoxon tests. Results: Post-intervention, the cork insole group showed significant improvements in balance, maximum plantar pressure, and functional mobility tests compared to the silicone insole group. While both insoles enhanced certain balance parameters and walking performance, cork insoles proved more effective in key outcomes. Additionally, maximum plantar pressure for the cork insoles group decreased significantly, indicating better pressure distribution and potentially enhanced balance. Conclusion: Cork insoles are superior to silicone insoles in improving balance and postural stability among the elderly. This study supports using cork insoles as part of fall prevention strategies, emphasizing the importance of material properties in orthopedic insole design. Future research should explore long-term effects and integrate insoles with other postural stability methods for comprehensive elderly care.
Citation - WoS: 4
Citation - Scopus: 5
Therapeutic Effects of Line Dancing in People With Multiple Sclerosis: an Evaluator-Blinded, Randomized Controlled Study
(Routledge Journals, Taylor & Francis Ltd, 2024) Basturk, Sultan; Ekici, Gamze; Kirteke, Fatos; Durak, Omer Faruk; Ekici, Berkay
BackgroundLine dancing is a popular form of exercise shown to affect balance and mood positively. However, few studies examine its effectiveness in multiple sclerosis (MS). The study aims to investigate the effects of line dancing on balance, mood, and health-related quality of life in MS.MethodsParticipants were randomized into the line dance (n =15) and the control groups (n =16). Outcomes were measured using the Berg Balance Scale, Hospital Anxiety and Depression Scale, and Multiple Sclerosis Quality of Life-54 (MSQoL-54) at baseline and post intervention.ResultsPost-intervention in the line dancing group, significant improvements were observed in balance, anxiety status, and health-related quality of life. When the groups were compared, significant differences were found in balance, anxiety, and the mental health composite of the MSQoL-54.ConclusionThis study recommends the use of line dancing as a therapeutic intervention in MS. Nevertheless, comparisons with different intervention approaches and follow-up studies are needed.
Citation - WoS: 7
Citation - Scopus: 5
Synthesis and Evaluation of Novel Metacetamol Derivatives With Hydrazone Moiety as Anticancer and Antimicrobial Agents
(Wiley-v C H verlag Gmbh, 2023) Senkardes, Sevil; Atlihan, Irem; Cayir, Elif; Tiber, Pinar Mega; Orun, Oya; Nigiz, Seyma; Kucukguzel, S. Guniz
By exploiting the wide biological potential of the hydrazone scaffold, a series of hydrazone derivatives were synthesized, starting from N-(3-hydroxyphenyl)acetamide (metacetamol). The structures of the compounds were determined using IR, H-1 and C-13-NMR, and mass spectroscopic methods. The obtained molecules (3 a-j) were evaluated for their anticancer potential against MDA-MB-231 and MCF-7 breast cancer cell lines. According to the CCK-8 assay, all tested compounds showed moderate to potent anticancer activity. Among them, N-(3-(2-(2-(4-nitrobenzylidene)hydrazinyl)-2-oxoethoxy)phenyl)acetamide (3 e) was found to be the most effective derivative with an IC50 value of 9.89 & mu;M against MDA-MB-231 cell lines. This compound was further tested for its potential effects on the apoptotic pathway. Molecular docking studies was also carried out for 3 e in the colchicine binding pocket of tubulin. Additionally, compound 3 e also demonstrated effective antifungal activity, particularly against Candida krusei (MIC=8 & mu;g/ml), indicating that nitro group at the 4(th) position of the phenyl ring was the most preferable substituent for both cytotoxic and antimicrobial activity. Our preliminary findings suggest that compound 3 e could be exploited as a leading structure for further anticancer and antifungal drug development.
In Silico Evaluation of H1-Antihistamine as Potential Inhibitors of SARS-CoV RNA-Dependent RNA Polymerase: Repurposing Study of COVID-19 Therapy
(Turkish Pharmacists Association, 2024) Küçükgüzel, İlkay; Kulabaş, Necla; Hamdan, Mazın
Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), from the family Coronaviridae, is the seventh known coronavirus to infect humans and cause acute respiratory syndrome. Although vaccination efforts have been conducted against this virus, which emerged in Wuhan, China, in December 2019 and has spread rapidly around the world, the lack of an Food and Drug Administration-approved antiviral agent has made drug repurposing an important approach for emergency response during the COVID-19 pandemic. The aim of this study was to investigate the potential of H1-antihistamines as antiviral agents against SARS-CoV-2 RNA-dependent RNA polymerase enzyme. Materials and Methods: Using molecular docking techniques, we explored the interactions between H1-antihistamines and RNA-dependent RNA polymerase (RdRp), a key enzyme involved in viral replication. The three-dimensional structure of 37 H1-antihistamine molecules was drawn and their energies were minimized using Spartan 0.4. Subsequently, we conducted a docking study with Autodock Vina to assess the binding affinity of these molecules to the target site. The docking scores and conformations were then visualized using Discovery Studio. Results: The results examined showed that the docking scores of the H1-antihistamines were between 5.0 and 8.3 kcal/mol. These findings suggested that among all the analyzed drugs, bilastine, fexofenadine, montelukast, zafirlukast, mizolastine, and rupatadine might bind with the best binding energy (< -7.0 kcal/mol) and inhibit RdRp, potentially halting the replication of the virus. Conclusion: This study highlights the potential of H1-antihistamines in combating COVID-19 and underscores the value of computational approaches in rapid drug discovery and repurposing efforts. Finally, experimental studies are required to measure the potency of H1-antihistamines before their clinical use against COVID-19 as RdRp inhibitors.
Citation - WoS: 2
Citation - Scopus: 1
Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cells in the Treatment of Type 1 and Type 2 Diabetes Mellitus: a Systematic Review and Meta-Analysis
(Routledge Journals, Taylor & Francis Ltd, 2025) Nada, Ahmed Hosney; Ibrahim, Ismail A.; Oteri, Vittorio; Shalabi, Laila; Asar, Nada Khalid; Aqeilan, Saja Rami; Hafez, Wael
Introduction Many patients struggle to control glucose without side effects. Due to their immunomodulatory and regenerative properties, mesenchymal stem cells (MSCs) might treat Diabetes Mellitus (DM). The authors employed this meta-analysis to evaluate the efficacy and safety of umbilical cord MSCs (UCMSCs) for DM management. Methods The PubMed, Cochrane, WOS, Embase, and Scopus databases were searched for randomized controlled trials (RCTs) investigating the effects of UCMSCs on DM (Types 1, 2) till January 2024. Patient demographics, interventions, and outcomes, including glycated hemoglobin (HbA1c%), C-peptide levels, and insulin requirements, were extracted. A comprehensive meta-analysis software was used. Results Eight CTs of 334 patients (172 experimental and 162 controls) were included. UMSCs treatment substantially lowered HbA1c levels (MD = -1.06, 95% CI [-1.27, -0.85], p < 0.00001) with consistent outcomes (i(2) = 0%, p = 0.43). Fasting C-peptide levels were heterogeneous but favored placebo (MD = 0.35, 95% CI [0.15, 0.56], p = 0.0007). In T1D patients, daily insulin requirements decreased considerably (MD = -0.24, 95% CI [-0.29, -0.18], p < 0.00001), with heterogeneity addressed by sensitivity analysis. Conclusion UMSCs therapy reduced HbA1c and insulin requirements, and increased C-peptide levels. Multicenter clinical trials are required to confirm the long-term efficacy and safety of UMSC therapy.

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