PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/8

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Citation Count: 1
Analysis of Substance Use and Mental Disorder Diagnoses in Adolescents With a History of Delinquency: a Cross-Sectional Study
(Springer, 2024) Dikeç, Gül; Dikec, Gul; Tas Soylu, Gulsenay; Bilac, Oznur; Uzunoglu, Gulcin; Ayakdas Dagli, Dilek; Hemşirelik Bölümü
This study aimed to evaluate substance use and comorbid mental disorders in delinquent adolescents presenting to a child and adolescent psychiatry outpatient clinic. This study included 47 adolescents aged 15-18 years and had a history of delinquency. Data were collected using the Addiction Profile Index Adolescent Form (API-A) and an information form. Results indicated that the adolescents' mean age is 16.11 +/- 1.05 years, 78.7% had committed crimes against property and 34.0% against the person, and 34.0% were also victims of crime. Mean API-A total scores indicated that their level of substance use was low. In addition, mean API-A total scores showed significant differences according to the adolescents' migration status, age, economic status, school attendance, mental disorder diagnosis, duration of mental disorder, and type of offense (p < 0.05). The benefit provided by timely and appropriate psychosocial interventions may have a key role in solving this problem for adolescents and improving their future as adults.
Citation Count: 5
Critical Thinking Among Clinical Nurses and Related Factors: a Survey Study in Public Hospitals
(Wiley, 2022) Harmancı Seren, Arzu Kader; Zuriguel-Perez, Esperanza; Seren, Arzu Kader Harmanci; Hemşirelik Bölümü
Aims and objectives The study investigated clinical nurses' critical thinking levels in public hospitals and related factors. Background Since health care environments have become more complex, the critical thinking skills of clinical nurses are more important in daily problem-solving and decision-making processes. However, little research was conducted on this topic among clinical nurses. Methods It was a cross-sectional study at five public hospitals between December 2018 and January 2019. The study followed the STROBE guideline. Data were collected from 559 nurses by a survey consisted of a data form and the Turkish version of the Nursing Critical Thinking in Clinical Practice Questionnaire. Results Nurses' mean critical thinking scores were moderate level. Total critical thinking scores of the clinical nurses significantly differed according to education, hospital type, shift work, professional category and role. There was a significant effect on the total critical thinking scores of the clinical nurses according to variables. Conclusion This study found that critical thinking levels of nurses' working in clinical settings in public hospitals were moderate level. Hospital type, shift work, professional and educational level and role were significantly associated with clinical nurses' critical thinking levels. Relevance to clinical practice This study provides evidence related to the levels of critical thinking of clinical nurses working in public hospitals. Since the critical thinking scores of the manager nurses, daytime working nurses' and nurses with bachelor's and master's degree education are higher, hospital managers may benefit from the study to implement effective strategies to improve the competence of critical thinking levels of nurses.
Citation Count: 25
The Dramatic Increase in Anti-Vaccine Discourses During the Covid-19 Pandemic: a Social Network Analysis of Twitter
(Taylor & Francis inc, 2022) Durmaz, Nihal; Hengirmen, Engin
Background/Aim The first case of COVID-19 in Turkey was officially recorded on March 11, 2020. Social media use increased worldwide, as well as in Turkey, during the pandemic, and conspiracy theories/fake news about medical complications of vaccines spread throughout the world. The aim of this study was to identify community interactions related to vaccines and to identify key influences/influencers before and after the pandemic using social network data from Twitter. Materials and methods Two datasets, including tweets about vaccinations before and after COVID-19 in Turkey, were collected. Social networks were created based on interactions (mentions) between Twitter users. Users and their influence were scored based on social network analysis and parameters that included in-degree and betweenness centrality. Results In the pre-COVID-19 network, media figures and authors who had anti-vaccine views were the most influential users. In the post-COVID-19 network, the Turkish minister of health, the was the most influential figure. The vaccine network was observed to be growing rapidly after COVID-19, and the physicians and authors who had opinions about mandatory vaccinations received a great deal of reaction. One-way communication between influencers and other users in the network was determined. Conclusions This study shows the effectiveness and usefulness of large social media data for understanding public opinion on public health and vaccination in Turkey. The current study was completed before the implementation of the COVID-19 vaccine in Turkey. We anticipated that social network analysis would help reduce the "infodemic" before administering the vaccine and would also help public health workers act more proactively in this regard.
Citation Count: 9
The Earthquakes in Turkey and Their Effects on Nursing and Community Health
(Wiley, 2023) Harmancı Seren, Arzu Kader; Dikeç, Gül; Hemşirelik Bölümü
BackgroundSevere damage was experienced in 10 provinces in Turkey, and the north of Syria, with the earthquakes that hit Kahramanmaras at midnight and afternoon on February 6, 2023. AimThe authors aimed to give brief information to the international nursing community about the situation related to earthquakes in the aspects of nurses. ConclusionThese earthquakes caused traumatic processes in the affected regions. Many people, including nurses and other healthcare professionals, died or were injured. The results demonstrated that the required preparedness had not been applied. Nurses went to these areas voluntarily or on assignment and cared for individuals with injured. The universities in the country passed to distance education because of the shortage of safe places for victims. This situation also negatively influenced nursing education and clinical practice by interrupting in-person education one more time after the COVID-19 pandemic. Implications for nursing and nursing policySince the outcomes show a need for well-organized health and nursing care, policymakers may consider getting nurses' contributions to the disaster preparedness and management policy-making processes.
Citation Count: 1
The Effect of an Educational Peer-Based Intervention Program on Sexual and Reproductive Health Behavior
(Wiley, 2024) Oğul, Zeynep; Sahin, Nevin Hotun; Ebelik Bölümü
IntroductionThe fact that adolescent people experience risky sexual behavior and have insufficient knowledge of sexual and reproductive health (SRH) indicates the need for SRH education. This study investigates the impact of peer-educated SRH programs on the knowledge and behaviors of adolescents.MethodThis study was conducted as a randomized controlled trial on 275 university students. The subjects were randomly assigned to the peer educators (n = 25), intervention (n = 125) and control (n = 125) groups using systematic random sampling. Peer educators provided face-to-face SRH education to the intervention group. The researcher provided the same education to the control group via the online conference method. SRH knowledge and behavior evaluated with scales before, after, and 3 and 6 months after the SRH education. The obtained data were analyzed using SPSS version 25 through statistical tests and analysis of covariance.ResultsThe female and male ratio of the participants was almost equal (49.4%, 50.6%). The mean age was found to be 20.42 +/- 1.14 years. The mean scores of the students in the intervention group increased from 21.20 +/- 0.14 to 35.20 +/- 0.07 for sexual health knowledge questionnaire (SHKQ), and from 130.56 +/- 0.55 to 147,90 +/- 0,25 for reproductive health scale (RHS) after the education. Compared with the control group, these increases in the mean scores of SHKQ and RHS were found to be statistically significant.ConclusionThe findings show the important role of the SRH peer education method on the effect of transferring knowledge about sexual behaviors. Health and education policy-makers are advised to implicate SRH peer education.
Citation Count: 0
The Effect of Formative Assessment on Students' Clinical Knowledge, Skills and Self-Efficacy Levels
(Elsevier Sci Ltd, 2024) Kökkız, Rukiye; Inangil, Demet; Turkoglu, Ilayda; Tıbbi Hizmetler ve Teknikler Bölümü
Aim: This research aims to examine the effect of using formative assessment methods in clinical education on students' knowledge, skills and self-efficacy levels. Background: Formative assessment is used as a method designed to identify areas where students fall short and provide feedback for improvement. Formative assessment and feedback represent fundamental characteristics of quality teaching in higher education and play a decisive role in learning in nursing education. Although educators observe students performing practical tasks during clinical education, evaluation is not made by a structured control list. Therefore, just as nursing students are evaluated with "Skill Checklists" in the OSCE exam, there is a need to evaluate nursing skills during patient care in the clinical field. Design: The study was designed as a pre-test post-test randomized controlled experimental study. Method: Before the research, both groups filled out the self-efficacy form. The experimental group received formative assessment throughout the course. At the end of the semester, all students were given a skills test and asked to fill out the self-efficacy form again. Finally, a knowledge test was administered to the entire class. Results: The average knowledge score of the experimental group is higher than the control group. It was determined that there was a statistical difference of 16.54 points in the average skill scores between the groups. Posttests showed significant differences in skills such as breathing-cough exercise, basic glycemic measurement, subcutaneous injection and blood collection skills. Conclusion: It was determined that the formative assessment method increased nursing students' knowledge, skills and self-efficacy levels regarding basic nursing skills.
Citation Count: 1
The Effects of Dietary Changes on Bone Markers in Postmenopausal Vertebral Osteopenia
(Churchill Livingstone, 2020) Garipağaoğlu Denizhan, Muazzez; Garipagaoglu, Muazzez; Bicer, H. Selcen; Kurtulus, Duygu; Ozturk, Mustafa; Gunes, F. Esra; Beslenme ve Diyetetik Bölümü
Background & aims: Nutrition is one of the most important environmental factors affecting the formation of osteopenia. The purpose of this study was to investigate the effects of dietary changes on bone formation and bone resorption markers of postmenopausal women with vertebral osteopenia. Methods: In this study, 108 women with postmenopausal vertebral osteopenia were included. Patients were observed for a month to identify their regular nutritional status. Before intervention, blood and urine samples were taken from all patients. Then, 2-day food consumption records were taken and the patients were divided into 4 groups. Different types of diets (opposite of their regular diets) were prepared for these groups (1: control, 2: reduced-carbohydrate, 3: reduced-protein, 4: reduced-sodium) and followed for 3 months. At the end of follow-ups, blood and urine samples were taken again and changes in osteocalcin (OC) and N-terminal telopeptide (NTX) levels were examined. Results: According to biochemical analysis, there was a significant decrease (p < 0,001) in OC levels in reduced protein group and an increase (p > 0,05) in reduced carbohydrate group. When NTX levels were assessed, a significant decrease (p < 0.001) in the reduced carbohydrate group and a significant increase in the reduced protein group (p < 0.05) were found. Conclusion: Our findings show that reduced carbohydrate diet protected whereas, reduced protein diet negatively affected bone health. Osteopenic individuals were thought to be able to improve bone health and their quality of life by early dietary intervention. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Citation Count: 1
Effects of Motor Intervention Program on Academic Skills, Motor Skills and Social Skills in Children With Autism Spectrum Disorder
(Springer/plenum Publishers, 2024) Pınar, Salih; Ozer, Dilara Fatos; Pinar, Salih; Antrenörlük Eğitimi Bölümü
The aim of this study was to examine the effect of motor intervention program (MIP) on autistic index, pre-academic skills, motor skills and social skills of children with Autism Spectrum Disorder (ASD). The research group consisted of a total of 34 participants between the ages of 3-6, 17 in the control group (CG) and 17 in the experimental group (EG). EG participated in the motor intervention program for 60 min a day, 2 days a week for 12 weeks. In the study, the Gilliam Autistic Disorder Rating Scale-2-Turkish Version (GARS-2 TV), Peabody Motor Development Scale-2 (PMDS-2), Pre-Academic Skills Evaluation Form (PASAF) and Social Skills Evaluation System Preschool Teacher Form (SSRS-PTF) were used. The increase in all subtests and total scores of PASAF and posttest scores obtained from PMDS-2 were found to be higher in favor of the experimental group (p < 0.05). The decrease in the stereotype and social interaction scores of GARS-2 TV and the change in the cooperation, self-control and externalization sub-dimensions of SSRS-PTF were found to be statistically significant in favor of the EG group (p < 0.05). In conclusion, it was found that MIP applied to autistic children was effective on the development of motor skills, academic skills and social skills and decreased the level of autistic index. This result shows that MIP is an effective practice that provides a favorable environment for autistic young children to develop multiple skills.
Citation Count: 1
The Effects of Rational Emotive Behavior Therapy and Motivational Interviewing on Emotions, Automatic Thoughts, and Perceived Performance of Elite Female Volleyball Players
(Elsevier, 2023) Urfa, O.; Asci, F. H.
Objectives: The aim of this study was to examine the effect of Rational Emotive Behavior Therapy intervention alone (REBT-A) or with motivational interviewing (REBT + MI) on the emotions, automatic thoughts, and perceived performance of elite female volleyball players. Design: and method: Single-case, staggered multiple-baseline AB and ABC designs were adapted in the study. Five female volleyball players participated in the study, of which three players participated in the REBT-A and two players participated in the REBT + MI. The athletes were competing in the national volleyball league (Mage = 28, SD = 5.52). All participants were elite athletes with at least ten years of sports experience. Three scores (T1, T2, T3) were calculated for the athletes' perceived performance, emotion, and automatic thoughts. T1 was the baseline score calculated before the sessions. T2 was calculated after the first two sessions (the first three sessions for REBT + MI) and T3 was calculated after the last three sessions. In the data analysis, percentage changes, effect size, and visual analyzes were used in the T1, T2, and T3 scores. Results: REBT-A and REBT + MI interventions increased perceived performance, positive emotions, and positive automatic thoughts, and decreased negative emotions and negative automatic thoughts. REBT + MI was more advantageous than REBT-A in increasing positive emotion, positive automatic thought, and perceived performance. Conclusions: As a result, REBT alone or with motivational interviewing has a positive effect on perceived performance, emotions, and automatic thoughts, but REBT + MI has greater potential to increase positive constructs.
Citation Count: 6
Evaluation of the Use of Diverse Mental Health Simulation in Nursing Students' Learning Experience an International Multisite Study
(Lippincott Williams & Wilkins, 2021) Dikeç, Gül; Dikec, Gul; Ata, Elvan Emine; Sendir, Merdiye; Hemşirelik Bölümü
Background: Simulated patients (SPs) in mental health nursing education provide a unique approach to assist student development in complex assessment skills. Purpose: The purpose of this international multisite study was to evaluate the use of two diverse mental health SP simulation scenarios on nursing students' satisfaction and self-confidence in learning to care for patients with mental health disorders in the United States (n = 70) and Turkey (n = 90). Methods: A multisite cross-sectional study design was used. Outcome measures included the Student Satisfaction and Self-confidence in Learning Scale and the adapted Simulation Effectiveness Tool Modified. Results were analyzed using independent I tests. Results: While students in the United States reported higher perceived self-confidence and satisfaction in learning, both student populations found the intervention effective to their learning (P<.05). Conclusion: Using SPs in mental health education allow students to practice their assessment skills learned in classroom and transfer them to the clinical area.
Citation Count: 4
Gilaburu (viburnum Opulus L.) Fruit Extract Has Potential Therapeutic and Prophylactic Role in a Rat Model of Acetic Acid-Induced Oxidant Colonic Damage
(Elsevier Ireland Ltd, 2024) Şener, Göksel; Cam, Muhammet Emin; Yuksel, Meral; Akakin, Dilek; Taskin, Turgut; Emre, Gizem; Karakoyun, Berna; Eczacılık Meslek Bilimleri Bölümü
Ethnopharmacological relevance: Ulcerative colitis (UC) which has a global impact on the health care system with its recurrent and incompletely curable characteristics, affects the patients' quality of life. Gilaburu (GB; Viburnum opulus L.) is a fruit with rich polyphenol ingredient which is used ethnobotanically in T & uuml;rkiye for medicinal purposes (for example, to pass kidney stones, to treat stomach, heart, and liver diseases, hemorrhages, hypertension, ulcers, common cold, tuberculosis, rheumatic and menstrual pain, and diabetes). On the other hand, the effects of GB in the experimental UC model have not been studied.Aim of the study: This study aimed to explore the potential antioxidant and anti-inflammatory effects of GB fruit extract in improving acetic acid (AA)-induced UC.Materials and methods: Starting immediately after (AA + GB group) or 1 week before (GB + AA + GB group) the colitis induced by intrarectal AA (5%; v/v) administration, the rats orally received GB (100 mg/kg) once per day for 3 days. The control and AA groups were administered orally saline (1 ml), while the AA + SS group were administered sulfasalazine (SS; 100 mg/kg; orally) as a positive control once per day for 3 days. Distal colonic tissue specimens were obtained for the histological and biochemical [myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), chemiluminescence (CL), caspase-3, 8-hydroxy-2(')-deoxyguanosine (8-OHdG), matrix metalloproteinase (MMP)-9, transforming growth factor (TGF)-beta(1), smad-3 and cytokine (tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, IL-8, interferon (IFN)-gamma), measurements] evaluations on the 3(rd) day.Results: Elevated macroscopic and microscopic damage scores, high tissue wet weight values, increased tissue-associated MPO, MDA, CL, caspase-3, 8-OHdG, cytokines (TNF-alpha, IL-1 beta, IL-6, IL-8), MMP-9, TGF-beta(1), smad-3 levels, and decreased GSH values of the AA group were all reversed by GB treatments (AA + GB and GB + AA + GB groups) (p < 0.05-0.001). However, sulfasalazine treatment (AA + SS group) did not change the IL-8, 8-OHdG, MMP-9, and TGF-beta(1) measurements significantly.Conclusions: Gilaburu shows both anti-inflammatory and antioxidant effects against AA-induced colonic damage by suppressing neutrophil infiltration, regulating inflammatory mediators, inhibiting reactive species production, lipid peroxidation, and apoptosis, conserving endogenous antioxidant glutathione, and ameliorating oxidative DNA damage. Since the current ulcerative colitis drugs display limited benefits and adverse side effects, potential therapeutic and/or prophylactic role of gilaburu can be evaluated in ulcerative colitis.
Citation Count: 1
in Silico Design, Synthesis and Antitubercular Activity of Novel 2-Acylhydrazono as Enoyl-Acyl Carrier Protein Reductase Inhibitors
(Taylor & Francis inc, 2024) Küçükgüzel, İlkay; Kumari, Jyothi; Tamhaev, Rasoul; Mourey, Lionel; Lherbet, Christian; Sriram, Dharmarajan; Kucukguzel, Ilkay; Eczacılık Meslek Bilimleri Bölümü
Mycobacteria regulate the synthesis of mycolic acid through the fatty acid synthase system type 1 (FAS I) and the fatty acid synthase system type-2 (FAS-II). Because mammalian cells exclusively utilize the FAS-I enzyme system for fatty acid production, targeting the FAS-II enzyme system could serve as a specific approach for developing selective antimycobacterial drugs. Enoyl-acyl carrier protein reductase enzyme (MtInhA), part of the FAS-II enzyme system, contains the NADH cofactor in its active site and reduces the intermediate. Molecular docking studies were performed on an in-house database (similar to 2200 compounds). For this study, five different crystal structures of MtInhA (PDB Code: 4TZK, 4BQP, 4D0S, 4BGE, 4BII) were used due to rotamer difference, mutation and the presence of cofactors. Molecular dynamics simulations (250 ns) were performed for the novel 2-acylhydrazono-5-arylmethylene-4-thiazolidinones derivatives selected by molecular docking studies. Twenty-three compounds selected by in silico methods were synthesized. Antitubercular activity and MtInhA enzyme inhibition studies were performed for compounds whose structures were elucidated by IR,H-1-NMR,C-13-NMR, HSQC, HMBC, MS and elemental analysis. Communicated by Ramaswamy H. Sarma
Citation Count: 0
Inter-Rater Reliability in the Assessment of Consciousness in Patients Receiving Palliative Care in Intensive Care: a Prospective Cross Sectional Observational Study
(Wiley, 2024) Kuğu, Emre; Kavala, Arzu; Oz, Seda Degirmenci; Sezer, Esra; Kugu, Emre; Coskun, Zeynep; Tıbbi Hizmetler ve Teknikler Bölümü
BackgroundThe Glasgow Coma Scale (GCS) is one of the methods that has validity for evaluating the consciousness levels of patients in the literature and is accepted by health authorities.AimThe purpose of this study was to evaluate the inter-rater reliability of GCS in intensive care patients receiving palliative care.Study DesignA prospective cross sectional observational study. The study was conducted in a general intensive care unit with 20 beds with patients receiving palliative care. In the unit, 18 nurses worked in two shifts, day and night. Each patient's primary palliative care nurse and two additional researchers were given one minute to independently record the patient's GCS total and subscale scores. All observations were completed within 5 min as there could be significant changes in the patient's GCS score during observations.ResultsA total of 258 assessments were completed. For the GCS total scoring, a moderate agreement was found between palliative care nurses and the first researcher-observer (49.0%) and also between palliative care nurses and the second researcher-observer (47.7%). In addition, there was a substantial agreement between the first and second researchers (78.9%) and also between all observers (61.5%) (all p = .001).ConclusionsAlthough there was a near-perfect agreement between the two researcher-observers, we found only moderate agreement among all observers (palliative care nurses and two researcher-observers) in the evaluation of GCS total and subscale scores.Relevance to Clinical PracticeWe found that lack of knowledge and training on the standardized use of GCS is still a problem for palliative and intensive care units. Because of the diversity of patients requiring GCS assessment in palliative care units, refresher training programs and hands-on workshops on consciousness assessment should be organized regularly for more experienced nurses.
Citation Count: 11
Monkeypox Post-Covid Knowledge, Worrying, and Vaccine Adoption in the Arabic General Population
(Mdpi, 2023) Swed, Sarya; Bohsas, Haidara; Alibrahim, Hidar; Rakab, Amine; Hafez, Wael; Sawaf, Bisher; Sah, Ranjit
Background: The outbreak of monkeypox was declared a global public health emergency by the World Health Organization on 23 July 2022. There have been 60,000 cases reported worldwide, most of which are in places where monkeypox has never been seen due to the travel of people who have the virus. This research aims to evaluate the general Arabic population in regard to the monkeypox disease, fears, and vaccine adoption after the WHO proclaimed a monkeypox epidemic and to compare these attitudes to those of the COVID-19 pandemic. Methods: This cross-sectional study was performed in some Arabic countries (Syria, Egypt, Qatar, Yemen, Jordan, Sudan, Algeria, and Iraq) between 18 August and 7 September 2022. The inclusion criteria were the general public residing in Arabic nations and being older than 18. This questionnaire has 32 questions separated into three sections: sociodemographic variables, prior COVID-19 exposure, and COVID-19 vaccination history. The second portion assesses the knowledge and anxieties about monkeypox, while the third section includes the generalized anxiety disorder (GAD7) scale. Logistic regression analyses were performed to compute the adjusted odds ratios (aOR) and their confidence intervals (95%CI) using STATA (version 17.0). Results: A total of 3665 respondents from 17 Arabic countries were involved in this study. Almost two-thirds (n = 2427, 66.2%) of the participants expressed more worry about COVID-19 than monkeypox diseases. Regarding the major cause for concern about monkeypox, 39.5% of participants attributed their anxiety to the fear that they or a member of their family may contract the illness, while 38.4% were concerned about monkeypox becoming another worldwide pandemic. According to the GAD 7 score, 71.7% of the respondents showed very low anxiety toward monkeypox and 43.8% of the participants scored poor levels of knowledge about monkeypox disease. Participants with previous COVID-19 infection showed a 1.206 times greater acceptance to receive the monkeypox vaccine than those with no previous infection. A 3.097 times higher concern for monkeypox than COVID-19 was shown by the participants who perceived monkeypox as dangerous and virulent than those who did not. Participants who have a chronic disease (aOR: 1.32; 95%CI: 1.09-1.60); participants worried about monkeypox (aOR: 1.21; 95%CI: 1.04-1.40), and perceived monkeypox as a dangerous and virulent disease (aOR: 2.25; 95%CI: 1.92-2.65); and excellent knowledge level (aOR: 2.28; 95%CI: 1.79-2.90) have emerged as significant predictors. Conclusions: Our study reported that three-fourths of the participants were more concerned about COVID-19 than monkeypox disease. In addition, most of the participants have inadequate levels of knowledge regarding monkeypox disease. Hence, immediate action should be taken to address this problem. Consequently, learning about monkeypox and spreading information about its prevention is crucial.
Citation Count: 13
A Multinational Cross-Sectional Study on the Awareness and Concerns of Healthcare Providers Toward Monkeypox and the Promotion of the Monkeypox Vaccination
(Frontiers Media Sa, 2023) Swed, Sarya; Alibrahim, Hidar; Bohsas, Haidara; Jawish, Nagham; Rais, Mohammed Amir; Nasif, Mohamad Nour; Data Collection Grp
BackgroundThe aim of this study was to explore potential healthcare workers' (HCWs) concerns about the monkeypox virus in order to create practical solutions to manage this disease. MethodsOnline cross-sectional research was conducted in 11 Arabic countries (Egypt, Saudi Arabia, Yemen, Syria, Libya, Algeria, Tunisia, Iraq, Palestine, Jordan, and Sudan) from 2 August 2022 to 28 December 2022. ResultsApproximately 82% of respondents felt the need to acquire further information. The acceptability of the vaccine against monkeypox has been indicated by more than half of the participants (54.5%). Furthermore, we state that 45% of the participants are knowledgeable about the monkeypox virus, and 53.1% of the participants have never been affected with COVID-19 before are more worried about COVID-19 than about monkeypox. Participants diagnosed with COVID-19 were 0.63 times less likely to worry about monkeypox than those who were not diagnosed with COVID-19. A greater willingness to get the monkeypox vaccination was seen among the age group 21-30 years (42.4%) compared to the other age groups. ConclusionMost healthcare professionals have a moderate knowledge of the monkeypox virus. Furthermore, they demonstrated a low willingness to get the vaccination against the monkeypox virus.
Citation Count: 0
A Novel Petox-Based Nanogel Targeting Prostate Cancer Cells for Drug Delivery
(Wiley-v C H verlag Gmbh, 2024) Gulyuz, Sevgi; Sessevmez, Melike; Ukuser, Gokcen; Khalily, Melek Parlak; Tiryaki, Selen; Sipahioglu, Tarik; Yilmaz, Ozgur
This study focuses on creating a specialized nanogel for targeted drug delivery in cancer treatment, specifically targeting prostate cancer. This nanogel (referred to as SGK 636/Peptide 563/PEtOx nanogel) is created using hydrophilic poly(2-ethyl-2-oxazoline) (PEtOx) through a combination of living/cationic ring-opening polymerization (CROP) and alkyne-azide cycloaddition (CuAAC) "click" chemical reactions. A fluorescent probe (BODIPY) is also conjugated with the nanogel to monitor drug delivery. The characterizations through 1H-NMR, and FT-IR, SEM, TEM, and DLS confirm the successful production of uniform, and spherical nanogels with controllable sizes (100 to 296 nm) and stability in physiological conditions. The biocompatibility of nanogels is evaluated using MTT cytotoxicity assays, revealing dose-dependent cytotoxicity. Drug-loaded nanogels exhibited significantly higher cytotoxicity against cancer cells in vitro compared to drug-free nanogels. Targeting efficiency is examined using both peptide-conjugated and peptide-free nanogels, with the intracellular uptake of peptide 563-conjugated nanogels by tumor cells being 60-fold higher than that of nanogels without the peptide. The findings suggest that the prepared nanogel holds great potential for various drug delivery applications due to its ease of synthesis, tunable functionality, non-toxicity, and enhanced intracellular uptake in the tumor region. This study emphisizes an innovative PEtOx-based nanogel tailored for targeted drug delivery in prostate cancer. Developed using click chemistry, a valuable technique for chemical synthesis, it exhibits consistent nanogel formation with customizable sizes. In vitro, drug-loaded nanogel exhibits potent cytotoxicity against cancer cells. Notably, peptide-conjugated nanogels significantly boost tumor cell uptake, showcasing promising promising potential for effective cancer drug delivey.image
Citation Count: 4
Nurses' Views on Change Management in Health Care Settings: a Qualitative Study
(Wiley-hindawi, 2022) Harmancı Seren, Arzu Kader; Hobek, Goksu Ulutas; Seren, Arzu Kader Harmanci; Hemşirelik Bölümü
Aim To discover nurses' views on change management processes in health care settings. Background Because 'change' is an inevitable fact of today's health care environments, developing change management competencies at all levels is a must to survive and compete for the organisations and professionals in the health care systems. Methods A descriptive qualitative approach was used. The sample consisted of 18 nurses reached by using snowball sampling. The data were collected through semi-structured interviews and analysed using the Colaizzi method in the NVivo12 program. Results The results of the study were collected under three main themes: 'general approaches and initial responses to change', 'factors affecting attitudes toward change' and 'strategic mistakes made by managers during the change process'. Conclusion The study showed that nurses show different reactions to change. Their attitudes towards change could be affected positively and negatively by the relevant factors. Nurses thought that managers were making strategic mistakes during the change process. Implications for nursing management Recognizing the approaches of nurses and managers towards change and increasing awareness of the mistakes during the change process may contribute to the achievement of the change processes in health care settings.
Citation Count: 1
Protective Effects Of Rubus Tereticaulis Leaves Ethanol Extract on Rats With Ulcerative Colitis and Bio-Guided Isolation of Its Active Compounds: a Combined in Silico, in Vitro and in Vivo Study
(Elsevier Ireland Ltd, 2023) Şener, Göksel; Ozbeyli, Dilek; Terali, Kerem; Goger, Fatih; Yildirim, Aybeniz; Ertas, Busra; Sener, Goksel; Eczacılık Meslek Bilimleri Bölümü
The aim of this study was to evaluate the therapeutic effect of active ethanol extract obtained from the leaves of Rubus tereticaulis (RTME) against colitis, and to purify major compounds from this extract by bioassay-directed isolation. Rats with colitis induced via intra-rectal acetic acid administration (5%, v/v) received RTME or sulfasalazine for three consecutive days. On day four, all rats were decapitated, and the colonic tissue samples were collected for macroscopic score, colon weight, reduced glutathione (GSH), myeloperoxidase (MPO), and malondialdehyde (MDA) analyses. The active compounds and chemical composition of RTME were determined by bio-guided isolation and LC-MS/MS, respectively. Compared to the colitis group, the rats treated with RTME displayed significantly lowered macroscopic scores and colon wet weights (p < 0.001). These effects were confirmed biochemically by a decrease in colonic MPO activity (p < 0.001), MDA levels (p < 0.001), and an increase in GSH levels (p < 0.001). Kaempferol-3-O-beta-D-glucuronide (RT1) and quercetin-3-O-beta-D-glucuronide (RT2) were found to be the major compounds of RTME, as evidenced by in vitro anti-inflammatory and antioxidant activity-guided isolation. Their anti-inflammatory/antioxidant activities were also predicted by docking simulations. Additionally, quinic acid, 5-caffeoylquinic acid, quercetin pentoside, quercetin glucoside, quercetin3-O-beta-D-glucuronide, kaempferol-3-O-beta-D-glucuronide, and kaempferol rutinoside were identified in RTME via using LC-MS/MS. RT2, along with other compounds, may be responsible for the observed protective action of RTME against colitis. This study represents the first report on the beneficial effects of RTME in an experimental model of colitis and highlights the potential future use of RTME as a natural alternative to alleviate colitis.
Citation Count: 0
Psychometric Properties of the Quality Nursing Care Scale-Turkish Version: a Methodological Study
(Bmc, 2022) Kaya, Gizem; Harmancı Seren, Arzu Kader; Kaya, Gizem; Seren, Arzu Kader Harmanci; Hemşirelik Bölümü
AimTo analyze the psychometric properties of the Quality Nursing Care Scale in Turkish Language. Background: The quality of health services and nursing care effectively improves safe patient outcomes and reduces costs in healthcare organizations. There is a need for valid and reliable tools in order to use for evaluating the quality of nursing care. Methods: The methodological and cross-sectional study included 225 nurses working in a research and training hospital. Content validity, construct validity, item analysis, and internal consistency analysis were used. Results: The content validity index of the scale was 0.96. The item-total score correlation values of the items were 0.72 and higher. The factor loads of the items ranged from 0.42 to 0.90. Different from the original scale, Turkish form consisted of three sub-dimensions. The fit indices were acceptable or very good. The Cronbach's alpha internal consistency coefficient was 0.99. Conclusion: The Quality Nursing Care Scale was valid and reliable with its three-factor structure in Turkish Language. It may be used for measuring the quality of care in the aspects of nurses.
Citation Count: 1
The Relationship Between Perceived Quality of Care and the Patient Safety Culture of Turkish Nurses
(Lippincott Williams & Wilkins, 2022) Harmancı Seren, Arzu Kader; Akin, Semiha; Harmanci Seren, Arzu Kader; Hemşirelik Bölümü
Background Evaluating nurses' perceived quality of care and safety culture is an essential part of the nursing practice and critical to improving the quality of nursing care. Purpose This study aimed to examine the relationship between perceived quality of care and Turkish nurses' patient safety culture. Methods This was a descriptive cross-sectional study. The data were collected from a foundation university hospital in Istanbul. The sample consisted of 116 nurses, and data were collected using the Caring Behaviors Inventory-24 and Patient Safety Culture Scale. The nurses were asked to complete the questionnaires. Results The mean age of participating nurses was 25.95 (SD = 6.72) years. The mean duration of professional experience of the participants was 6.37 (SD = 6.05) years. Most (72.4%) of the participants were women who had graduated from vocational high schools (52.6%) and were working in the neonatal intensive care unit (37.9%). The highest mean subdimension score on the Caring Behaviors Inventory-24 was 5.78 (SD = 0.43) for the knowledge and skills subdimension. The highest mean subdimension score on the Patient Safety Culture Scale was 3.55 (SD = 0.48) for the unexpected event and error reporting subdimension. Statistically significant correlations were found between Caring Behaviors Inventory-24 and Patient Safety Culture Scale scores (r = .553, p < .01), with the lowest correlation found between the employee behavior and knowledge and skills dimensions (r = .305, p = .001). The highest statistically significant correlation coefficients that were found were between the Patient Safety Culture Scale total scores and the connectedness dimension of the Caring Behaviors Inventory-24 (r = .58, p < .001). Conclusions/Implications for Practice Nurses perceive patient care positively and have a positive perception of safety culture. Evaluating the perceived quality of care and patient safety culture perceptions will help prevent adverse events related to patient care and improve the quality of care.

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