Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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Citation Count: 0
Ameliorative Effects of Myrtus Communis L. Extract Involving the Inhibition of Oxidative Stress on High Fat Diet-Induced Testis Damage in Rats
(Taylor & Francis Ltd, 2024) Şener, Göksel; Koroglu, M. Kutay; Hersek, Irem; Ertas, Busra; Sen, Ali; Sener, Goksel; Ercan, Feriha; Eczacılık Meslek Bilimleri Bölümü
The possible protective effects of Myrtus communis L. (MC) extract on a high fat diet (HFD)-induced testicular injury in a rat model were investigated using histological and biochemical methods. Wistar albino rats were divided into three groups: a standard diet control group; a HFD group; and an HFD+MC group. The HFD and HFD+MC groups were fed with a HFD for 16 weeks. MC extract (100 mg/kg) was given orally five days a week to the rats in the HFD+MC group during the last four weeks of the experiment. Leptin, triglyceride, high-density lipoproteins, cholesterol, estrogen, testosterone, LH and FSH were analyzed in blood serum. Sperm parameters were evaluated from the epididymis. Testicular morphology, proliferative, apoptotic and NADPH oxidase-2 (NOX2)-positive cells were evaluated histologically. Testicular oxidative stress parameters were analyzed biochemically. In the HFD group, lipid and hormone profiles were changed, abnormal spermatozoa, degenerated seminiferous tubules with apoptotic and NOX2-positive cells were increased in number, and sperm motility and germinal proliferative cells decreased compared to the control group. Moreover, testicular malondialdehyde, 8-hydroxy-2-deoxyguanosine and myeloperoxidase levels increased, whereas glutathione and superoxide dismutase levels decreased in the HFD group compared to the control group. All these histological and biochemical features were ameliorated by MC treatment of HFD-fed rats. In conclusion, HFD caused alterations in sperm parameters and testicular morphology by increasing oxidative damage and apoptosis. MC extract may have potential protective effects by inhibiting oxidative damage.
Citation Count: 3
Analysis for Two-Dimensional Inverse Quasilinear Parabolic Problem by Fourier Method
(Taylor & Francis Ltd, 2021) Kanca, Fatma; Baglan, Irem; Bilgisayar Mühendisliği Bölümü
In this work, two-dimensional inverse quasi-linear parabolic problem with periodic boundary and integral overdetermination conditions is investigated. The formal solution is obtained by the Fourier approximation. Under some natural regularity and consistency conditions on the input data,the existence, uniqueness and continuously dependence upon the data of the solution are proved by iteration method. The inverse problem is first examined by linearization and then used implicit finite difference scheme for the numerical solution. Also predictor corrector method is considered in the numerical approach. Some results on the numerical solution with two examples are presented with figures and tables. The sensitivity of the scheme with respect to noisy overdetermination data is illustrated.
Citation Count: 21
Balance Training in Modern Dancers Proprioceptive-Neuromuscular Training Vs Kinesio Taping
(Science & Medicine inc, 2018) Tekin, Demet; Agopyan, Ani; Baltaci, Gul; Terapi ve Rehabilitasyon Bölümü
Kinesio tape and proprioceptive exercises are both used for increasing balance in dancers. The purposes of this study were to: a) determine the acute effect of kinesio tape (KT) application on the ankle joint on balance performance, b) investigate the effects of an 8-week proprioceptive-neuromuscular (PN) training program on balance performance, and c) compare their effects vs modern dance technique classes alone. Thirty-three trained, university-level modern dance students (9 male, 24 female) were divided randomly into three groups: kinesio tape (KT, n=11), proprioceptive-neuromuscular (PN, n=11), or control (n=11). Static (turn-out passe-opened eyes/releve and turn-out passe-closed eyes/flat foot), semi-dynamic (airplane), and dynamic balance (monopodalic-straight and -transverse in a turn-out passe-eyes opened/flat foot) tests were performed before and after the intervention. One day after pre-tests, KT mechanical correction technique was applied to the left ankle joint (supporting leg) in the KT group, and tests were repeated to determine the acute effect of KT. The PN group participated in an 8-week balance training program (2 days/wk, 60 min/day) involving exercises using stable and unstable surfaces. Significant improvements were observed for all static and dynamic balance tests in the PN group; semi-dynamic airplane and dynamic monopodalic-straight and transverse tests improved in the KT group; and only semi-dynamic airplane test scores changed significantly for the control group (p<0.05). Our findings suggest that with the exception of the semi-dynamic airplane test, both PN training and KT application were more effective at improving balance performance for modern dancers than modern dance technique classes alone.
Citation Count: 0
Clinical Outcomes of Conservative Versus Surgical Treatment for Patients With Proximal Humeral Fracture Before Physiotherapy
(Acta Medica Belgica, 2024) Özdinçler, Arzu; Alpozgen, A. Zengin; Gungor, F.; Ozdincler, A. Razak; Altun, S.; Fizyoterapi Ve Rehabilitasyon Bölümü
Fear of movement, pain, and loss of shoulder function are the most common problems irrespective of their approach to management after proximal humeral fracture (PHF). However, it has been unclear whether there could be differences between both treatments in early clinical outcomes. It can help physiotherapists to guide in choosing treatment approaches. This study aimed to compare kinesiophobia, pain, range of motion (ROM), shoulder function, and Quality of life (QoL) in patients treated with either conservative (CT) versus surgical (ST) after PHF. In addition, it aimed to determine correlations between fear of movement and seconder outcome measures. This cross-sectional study enrolled the patients having 5-6 weeks (being permitted active movement) after being treated either CT or ST and receiving no physical therapy. Pain, passive and active ROMs, shoulder function, fear of movement, and QoL were evaluated. 42 patients were recruited. Kinesiophobia scores were similar (p=0.55) and moderate in both groups. There was a significant difference in degrees of shoulder active flexion, active and passive abduction in favor of the CT group (p=0.05, p=0.02, p=0.04, respectively). However, there was no difference between groups regarding the remaining clinical outcomes. Furthermore, kinesiophobia showed a moderate negative correlation with energy/fatigue, social functioning, and general health. These findings showed that patients treated surgically did not have more kinesiophobia, less function, and QoL before starting physiotherapy, despite having soft tissue damage and different types of fractures. However, surgically treated patients had significantly less range of motion.
Citation Count: 0
Comparative Cross-Sectional Study on Sexual Function of Couples During Pregnancy: Assisted Reproductive Techniques Versus Spontaneous Conceptions
(Womens Health & Action Research Centre, 2024) Dinmez, Sinem; Dinmez, Sinem; Torun, Sebahat D.; Osmanoglu, Usame O.; Ebelik Bölümü
This study aims to compare the sexual functions of couples undergoing assisted reproductive techniques (ART) with those conceiving spontaneously during pregnancy. A total of 102 couples participated in this cross-sectional study, with 68 couples in the spontaneous conception group and 34 couples in the ART group. Data collection was conducted face-to-face in the antenatal clinic using separate "Descriptive Information Form" for women and men, "Female Sexual Function Index (FSFI)" for women, and "Libido Scoring System (LSS)" for men. Descriptive statistical methods, Chi-square and Fisher exact tests, t-test, and Pearson correlation test were used for data analysis. It was observed that the mean FSFI total scores of women who conceived spontaneously and through ART during pregnancy were at a good level (>= 30), while the mean LSS scores of their partners were at a moderate level (5-7). No statistically significant distinction existed among the groups. Further research is advisable by adjusting the sample selection criteria, such as gravida, duration of ART treatment, and gestational age.
Citation Count: 0
Design and Implementation of a Low Cost and Portable Tactile Stimulator Br
(Tubitak Scientific & Technological Research Council Turkey, 2022) Levent, Vecdi Emre; Levent, Vecdi Emre; Cardak, Merve; Aydin, Nizamettin; Bilgisayar Mühendisliği Bölümü
When central nervous system has a problem, somatic area I and II respond to stimulation differently. Therefore, it is possible to identify some of the central nervous diseases when somatosensory on the fingertip is stimulated and responses are recorded and analyzed. We designed a system to stimulate the mechanoreceptors on fingertips. It is composed of a mechanical system for fingertip stimulation, an embedded controller, a control computer, and a software to control overall operation. During test, mechanoreceptors are stimulated according to the test protocols. Individuals' answers are recorded to be evaluated by the developed software. In this study, several design approaches for embedded controller were also examined and an FPGA based controller with the same functionality but higher performance was implemented. A test procedure was performed on 51 individuals at the department of pediatric psychiatry in a hospital, to investigate whether the sex has an effect on attention deficit and hyperactivity disorder.
Citation Count: 2
The Direct and Indirect Effects of Irrational Beliefs on Perceived Performance: The Mediation Role of Emotions and Automatic Thoughts
(Springer, 2023) Aşçı, Fevziye Hülya; Asci, Fevziye Hulya; Beden Eğitimi ve Spor Bölümü
The aim of this study was to examine the relationship between irrational beliefs and perceived performance and the atemporal mediator role of emotions and automatic thoughts in this relationship. A cross-sectional study design with a convenient sampling method was used in the study. Participants included 395 athletes from basketball, football, handball, and volleyball and consisted of 267 male (Mage = 20.73, SD = 2.37) and 128 female (Mage = 21.33, SD = 2.17) athletes who voluntarily participated in the study. Data was analyzed via a path analysis and irrational beliefs were shown to negatively predict positive emotions and positive automatic thoughts, but these beliefs positively predicted negative emotions and negative automatic thoughts. The direct effect of irrational beliefs on perceived performance was not significant, but its indirect effect on perceived performance through emotions and automatic thoughts was significant. Irrational beliefs negatively predict perceived performance through emotions and automatic thoughts. It is concluded that emotions and automatic thoughts play a significant role in the relationship between irrational beliefs and perceived performance.
Citation Count: 0
Does Neuromuscular Electrical Stimulation Have an Additive Effect on Disability, Pain and Abdominal and Lumbar Muscle Thickness in Chronic Low Back Pain? - a Randomized Controlled Double-Blind Study
(Georg Thieme verlag Kg, 2022) Karagözoğlu Coşkunsu, Dilber; Coskunsu, Dilber Karagozoglu; Turan, Zeynep; Taskiran, Ozden Ozyemisci; Fizyoterapi Ve Rehabilitasyon Bölümü
Zusammenfassung
Citation Count: 0
The Effect of 3d Modeling on Family Quality of Life, Surgical Success, and Patient Outcomes in Congenital Heart Diseases: Objectives and Design of a Randomized Controlled Trial
(Turkish J Pediatrics, 2024) Sumengen, Aylin Akca; Ismailoglu, Abdul Veli; Ismailoglu, Pelin; Gumus, Terman; Celiker, Alpay; Namlisesli, Deniz; Cakir, Gokce Naz
Background. Understanding the severity of the disease from the parents' perspective can lead to better patient outcomes, improving both the child's health -related quality of life and the family's quality of life. The implementation of 3 -dimensional (3D) modeling technology in care is critical from a translational science perspective. Aim. The purpose of this study is to determine the effect of 3D modeling on family quality of life, surgical success, and patient outcomes in congenital heart diseases. Additionally, we aim to identify challenges and potential solutions related to this innovative technology. Methods. The study is a two -group pretest -posttest randomized controlled trial protocol. The sample size is 15 in the experimental group and 15 in the control group. The experimental group's heart models will be made from their own computed tomography (CT) images and printed using a 3D printer. The experimental group will receive surgical simulation and preoperative parent education with their 3D heart model. The control group will receive the same parent education using the standard anatomical model. Both groups will complete the Sociodemographic Information Form, the Surgical Simulation Evaluation Form - Part I -II, and the Pediatric Quality of Life Inventory (PedsQL) Family Impacts Module. The primary outcome of the research is the average PedsQL Family Impacts Module score. Secondary outcome measurement includes surgical success and patient outcomes. Separate analyses will be conducted for each outcome and compared between the intervention and control groups. Conclusions. Anomalies that can be clearly understood by parents according to the actual size and dimensions of the child's heart will affect the preoperative preparation of the surgical procedure and the recovery rate in the postoperative period.
Citation Count: 0
Effect of Sexual Quality of Life on Self-Management Perceptions of Women With Type 2 Diabetes
(Wolters Kluwer Medknow Publications, 2024) Eroğlu, Nermin; Hemşirelik Bölümü
Background:The quality of sexual life of women with type 2 diabetes has an impact on their self-management perceptions.Aim:To evaluate the effect of quality of sexual life on self-care perceptions of women with type 2 diabetes mellitus (DM).Material and Methods:It was an online descriptive study of 127 women with type 2 DM. The questionnaire consisted of a patient information form, sexual quality of life scale-female, and diabetes self-management perception scale.Results:There was a significant relationship between diabetes self-management perception and sexual quality of life (P = 0.000). The individuals' diabetes self-management perception scores differed significantly according to their age (F = 3.12; P = 0.047), and the sexual quality of life scores differed significantly according to their treatment type (F = 4.01; P = 0.020).Conclusion:There is a relationship between quality of sexual life and self-management perceptions of women with type 2 DM. As the quality of sexual life increases, diabetes self-management perceptions increase. Age affects diabetes self-management perception, and the type of treatment used by individuals also affects their quality of sexual life.
Citation Count: 0
Effectiveness of Non-Invasive Vagal Nerve Stimulation in Parkinson's Disease: a Comprehensive Systematic Review And Meta-analysis
(Elsevier Sci Ltd, 2025) Abouelmagd, Moaz Elsayed; Yousef, Obai; Ibrahim, Ismail A.; Elshahat, Ahmed
Background: Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by movement impairments. Vagus nerve stimulation (VNS) is a non-invasive brain stimulation technique that has shown promise in treating various neurological conditions, including PD. This systematic review aimed to evaluate the existing evidence on the efficacy of nVNS in managing PD symptoms. Methods: A comprehensive literature search was conducted to identify relevant studies published up to July 2024. The included studies investigated the effect of nVNS on various PD motor symptoms. The quality of studies was assessed using the Cochrane Risk of Bias 2 (ROB-2) and NIH tool for RCTs, single-arm studies, and case series studies respectively. Statistical analysis was conducted using Review Manager version 5.4.1 with outcomes expressed as Mean differences (MD) with 95% confidence intervals (CI). Results: The systematic review included eight randomized controlled trials (RCTs), one single-arm study, and one case series, encompassing a total of 217 patients with PD. The review revealed that nVNS in increasing Freezing of Gait (FOG) in PD (p = 0.04). However, no significant differences were found in UPDRS-III (p = 0.19 and p = 0.89 for on and off-medication conditions, respectively), UPDRS-II (p = 0.9), UPDRS-I (p = 0.46), Time Up and Go (p = 0.61), stand time (p = 0.87), walking speed (p = 0.22), or step length measured in meters (p = 0.8). Interestingly, a significant improvement was observed in step length measured in centimetres (p = 0.0005). No study reported serious adverse effects associated with nVNS treatment. Conclusion: Our finding suggests a potential benefit of nVNS in reducing FOG in PD, but did not demonstrate a significant improvement in other motor symptoms. Larger, longer follow-up studies are needed to confirm the effect nVNS on PD management. PROSPERO number: CRD42024574822.
Citation Count: 0
Effects of Balance and Strength Training for Ankle Proprioception in People With Chronic Ankle Instability: a Randomized Controlled Study
(Amer Podiatric Med Assoc, 2024) Yekdaneh, Ayşe Asena; Mutlu, Cigdem Yazici; Terapi ve Rehabilitasyon Bölümü
Background: After an ankle sprain, the ligament and joint capsule are damaged, and as a result, proprioceptive sense is damaged, causing a feeling of giving away in the ankle and resulting in recurrent sprains. Given the relevant studies, it has been seen that people with chronic ankle instability (CAI) commonly have deficits in joint position sense and reinjury risks. Joint position sense plays an important role in ankle control, thereby reducing the risk of injury. Therefore, this study aims to compare the effects of balance and strength training on ankle proprioception in people with CAI. Methods: This single-blind randomized controlled study included 29 volunteer participants (21 women and eight men) aged 18 to 30 years. Participants with a Cumberland ankle instability scale score less than or equal to 24 were randomly divided into two treatment groups: strength training (n = 14) and balance training (n = 15). Y balance test, joint position, and vibration sense were evaluated at the beginning and end of the treatment. "Hop to stabilization" exercises were applied to the balance group and resistive bands exercises to the strength group, which were performed for 6 weeks, 35 minutes per day, two times per week. Results: There was no significant difference between the two groups in the anterior, posterolateral, and posteromedial directions of the Y balance test (P = .89, P = .50, and P = .34, respectively), but the strength training group showed significant improvement in ankle proprioception (140 degrees) and vibration sense (fifth finger) (P < .001), and the post hoc Cohen's d effect size values were medium (.52) and small (.25), respectively. Conclusions: The findings of this study show that strengthening and balance exercises have similar effects on dynamic balance, but strengthening exercises are more effective in improving joint position and vibration sense. Given the positive effects of both exercise programs, it is recommended to implement the two interventions separately or together for CAI rehabilitation.
Citation Count: 0
Effects of Computer-Based Balance Exercises on Balance, Pain, Clinical Presentation and Nerve Function in Patients With Diabetic Peripheral Neuropathy: a Randomized Controlled Study
(International Society of Musculoskeletal and Neuronal Interactions, 2024) Reyhanıoglu, D.A.; Yıldırım, G.; Sengun, I.Ş.; Kara, B.
Objective:To evaluate the use of a computer-based biodex balance exercise system (BBS) on balance, neuropathic pain, clinical presentation and nerve function in patients with diabetic peripheral neuropathy (DPN). Methods: A total of 32 participants with DPN were randomly assigned in a 1:1 ratio to an intervention group (IG) or control group (CG). The IG performed exercises using the BBS twice weekly for 8 weeks, while CG were informed regarding diabetes self-management. At baseline and after study completion, participants underwent balance (postural stability and fall risk) and neuropathic pain assessment (DN4 questionnaire) and were screened using the Michigan Neuropathy Screening Instrument and nerve conduction test. Results: Among the baseline participants, 14 in the IG and 13 in the CG completed the study. Balance training improved postural stability (overall, p<0.001), fall risk (p<0.001), neuropathic pain (p=0.01) and symptoms (p<0.001), and clinical presentation (p=0.02), but not nerve function, within the IG. At follow-up, IG displayed significantly improved stability (p<0.001) and fall risk (p=0.02) and decreased neuropathic symptoms (p=0.01) compared to the CG. Conclusion: Computer-based balance exercises improve balance, pain, and clinical presentation of DPN, but not nerve function, in patients with DPN. ClinicalTrials.gov ID: NCT05255497. © 2024, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.
Citation Count: 0
Effects of Peroperative Cold Ischemia Time and Anhepatic Phase in Adult Living Donor Liver Transplant Recipients: Operation Time That Is Not Affected by the Anhepatic Phase but Is Prolonged by Cold Ischemia Time
(Elsevier Science inc, 2024) Oral, Alihan; Topcu, Feyza Sonmez; Sahin, Emrah; Oral, Alihan; Civan, Hasret Ayyildiz; Poyrazoglu, Kursat Orhan; Unal, Bulent; Tıbbi Hizmetler ve Teknikler Bölümü
Objective. It was aimed to examine the overall role of cold ischemia time and anhepatic phase durations in terms of peroperative blood transfusion needs, hospital stay conditions and postoperative charges, and survival in recipients. Material and Methods. One hundred forty-eight adult living donor liver transplant recipients (18 years and older) were included in the study. Whether the anhepatic phase and cold ischemia duration have an effect on the rates of surgery time, blood product transfusion, total hospital and intensive care unit stay, postoperative biliary complications, hepatic vein thrombosis, portal vein thrombosis, early postoperative bleeding, sepsis, and primary graft dysfunction. Was analyzed statistically. In addition, the effect of the anhepatic phase and cold ischemia time on graft survival was statistically examined by creating an average of the patient follow-up period. Results. It was observed that the operation time increased statistically as the cold ischemia time increased (P P = .000). No statistically significant fi cant relationship was found between other fi nd- ings and cold ischemia time and anhepatic phase. Conclusion. Prolonged surgery time due to increased cold ischemia time may be an important fi nding in terms of peroperative and postoperative results of the graft.
Citation Count: 0
The Effects of Two Different Concurrent Training Programs on Specific Performance, Physiological and Biochemical Parameters in Soccer Players
(Sage Publications Ltd, 2024) Pınar, Salih; Pinar, Salih; Ciloglu, Figen; Antrenörlük Eğitimi Bölümü
The study examined the effects of two concurrent training models, one being an eight-week High-Intensity Interval Training (HIIT) and the other, High-Intensity Functional Training (HIFT) both with additional strength training (S), on physiological parameters (blood lactate concentration and heart rate), athlete's performance (maximal strength, explosive power, aerobic endurance, 20 m sprint), and biochemical outputs. The study involved a total of 21 young males playing with amateur soccer licenses for at least 2 years divided into three groups. One group received S + HIIT training, second group received S + HIFT training and the control group continued their soccer-specific training. Both the experimental and the control groups underwent pre- and post-tests and while only the experimental groups underwent an eight-week training program. Pre- and post-tests of the all the participants included measurements of body composition, adaptation studies, trial measurements, biochemical blood, aerobic endurance measurements, sprint tests, and strength measurements. The Mixed Design ANOVA analysis was utilized to examine the performance, physiological, and biochemical data of the participants before and after the experiment. Concurrent training models were effective in increasing athletic performance (VO2max, CMJ, 1RM bench press and Yo-Yo test) and physiological outcomes during recovery (HR, blood lactate, Borg Scale) compared to the control group with traditional training. There was no significant difference between the biochemical changes in the S + HIIT, S + HIFT and control groups during the trial period. In summary, both concurrent training (CT) models had positive effects on sports performance and physiological outcomes, but not on biochemical outcomes.
Citation Count: 0
Efficiency of Modulated and Dose Rate Altered Flattening Filter Free Beams in High Dose Per Fraction Radiotherapy Applications on the Survival of Prostate Cancer Cell Lines
(Novin Medical Radiation Institute, 2021) Öztürk, Ayşe; Şahin, Sevim; Güngör, G.; Karabey, A.U.; Şahin, S.; Duruksu, G.; Gündoğdu, Ö.; Mimarlık Bölümü; Elektrik-elektronik Mühendisliği Bölümü
Background: The radiobiological effect of high dose rate FFF beams on the DU-145 cells was investigated with SBRT plans which have >10 Gy. Methods and Materials: To compare the radiobiological effect on DU-145 cell line four experiments designed: (1) the constant dose rate of 6 MV and 6 MV FFF with increased dose per pulse (2) the effect of dose per pulse while increasing instantaneous dose rate for 6 MV and 6 MV FFF, (3) the effect of increased average dose rate for 6 MV FFF and (4) the effect of protracted treatment time and modulation of 6 MV FFF beams. The survival fraction was counted with WST. Results: FF and FFF for 6 MV with same dose rate and treatment time has no effect on cell survival. Significant differences was observed on survival which were irradiated with 6 MV 600 MU/min and 6 MV FFF 1400 MU/min (p=0.024). There was no difference between 6 MV FFF 600 MU/min and 6 MV FFF 1400 MU/min for 10 Gy. The significant survival difference obtained for 20 Gy. The survival percentages for both 10 Gy and 20 Gy with Cyberknife were obtained higher than FFF. Conclusion: Our in-vitro study presented here show that higher dose rate and reduced treatment time might become a crucial factor for SBRT especially which has >10 Gy fraction dose. © 2021 Novin Medical Radiation Institute. All rights reserved.
Citation Count: 1
Evaluation of Health-Related Knowledge, Attitudes, and Behaviors of Undergraduate Students by Cardiovascular Risk Factors
(Cambridge Univ Press, 2021) Aydin, Volkan; Vizdiklar, Caner; Akici, Ahmet; Akman, Mehmet; Yavuz, Dilek Gogas; Altikardes, Zehra Aysun; Fak, Ali Serdar
Aim: To determine the presence of cardiovascular (CV) risk (CVR) factors in university students and evaluate how these factors are affected from the knowledge, attitudes, and habits of the individuals regarding healthy lifestyle. Background: Starting from early ages, lifestyle habits such as lack of physical activity, unhealthy eating, and inappropriate drug use increase CV and metabolic risks of individuals. Methods: In April-May 2018, sociodemographic characteristics of 770 undergraduate students, in addition to their knowledge, attitudes, and habits regarding their nutrition and physical activity status were obtained through face-to-face questionnaires. CVR factors were determined according to blood pressure, blood glucose, total cholesterol levels, and anthropometric measurements. Collected data were compared by CVR factor presence (CV[+] or CV[-]) in students. Findings: The mean age of the participants was 22.3 +/- 2.6 years. 59.6% were female and 71.5% were students of non-health sciences. In total, 274 individuals (35.9%) belonged to CV(+) group (mean risk number: 1.3 +/- 0.5) with higher frequency in males (42.1% versus 31.6%, P < 0.05). The most common CVR factors were smoking (20.6%), high total cholesterol (7.5%), and hypertension/high blood pressure (6.0%). 15.5% of the participants regularly used at least one drug/non-pharmaceutical product. 11.3% complied the Mediterranean diet well. 21.9% of CV(+) stated consuming fast food at lunch compared to 14.3% of CV(-) (P < 0.05). 44.6% stated exercising below the CV-protective level. Conclusions: This study showed one-third of university students was at CVR, independent of their sociodemographic characteristics. Furthermore, the students appear to perform below expectations in terms of nutrition and physical activity. Extensive additional measures are needed to encourage young individuals for healthy nutritional and physical activity habits.
Citation Count: 0
Evaluation of Hydrazide-Hydrazone and 4-Thiazolidinone Derivatives of Etodolac as Potential Anticancer Agents in Leukemia Cells
(Bentham Science Publ Ltd, 2024) Küçükgüzel, Şükriye Güniz; Averbek, Sera; Sevinc, Sevgi Kocyigit; Kilinc, Olca; Suzgun, Pelin Cikla; Kucukguzel, S. Guniz; Orun, Oya; Eczacılık Meslek Bilimleri Bölümü
Background Nonsteroidal anti-inflammatory drugs (NSAIDs), which are commonly used for their anti-inflammatory and analgesic properties, have also been found to prevent cancer. (+/-)(R,S) Etodolac is an NSAID that belongs to the class of cyclooxygenase-2 inhibitors. Various derivatives of etodolac are synthesized to boost its anti-proliferative action and lessen its potential negative effects. In our earlier studies, some novel derivatives of etodolac exhibited stronger cytotoxic effects on prostate cell lines and had similar effects on leukemia cells in pre-screening experiments.Objective Using the K562 leukemia cell line as a model, we sought to investigate the anti-cancer properties of a hydrazide-hydrazone derivative (SGK-205) and a 4-thiazolidinone derivative of etodolac (SGK-216).Materials and Methods In the current investigation, SGK-205 and SGK-216 compounds were administered to K562 cells for 24 and 48 hours at concentrations of 10, 25, 50, 75 and 100 mu M. Cell viability was assessed using the MTT test, and apoptosis by Annexin V-PI staining and mitochondrial membrane potential assays, together with mRNA expressions of apoptotic proteins. The levels of the proteins, HER2 and COX2, were also examined to evaluate COX2 inhibitory capacity.Results In K562 cells, there was a definite dose-dependent response to SGK-205 and SGK-216 compounds. Results from MTT viability tests, together with mitochondrial membrane potential measurements and Annexin V-PI staining, revealed that SGK-216 and SGK-205 significantly outperformed etodolac in terms of their apoptotic and anti-proliferative activities. The concentration range of 10-20 mu M for both chemicals was sufficient to start biological responses. Apoptosis was also investigated through the expressions of pro- and anti-apoptotic proteins. Additionally, gene expression research demonstrated SGK-205 to be a beneficial substitute to etodolac in lowering COX-2 and human epidermal growth factor receptor-2 (HER2) expression.Conclusion Our data indicated both derivatives to have higher anti-proliferative and apoptotic effects compared to etodolac. An overall assessment highlighting apoptotic induction potential, acceptable toxicity levels, a consistent dose-response relationship, and COX2 inhibitory actions, in particular, indicated SGK-205 as a viable novel therapeutic.
Citation Count: 4
Evaluation of Psychosocial Outcomes of Living Liver Donors in Liver Transplantation
(Aves, 2022) Harmancı Seren, Arzu Kader; Seren, Arzu Kader Harmanci; Karayurt, Ozgul; Kul, Gulay Aksu; Kilic, Murat; Bozoklar, Cemal Ata; Tokat, Yaman; Hemşirelik Bölümü
Background: The purpose of this study was to evaluate the risk factors affecting psychosocial outcomes of living liver donors after liver transplantations. Methods: This was a descriptive, cross-sectional study. The sample consisted of living liver donors followed by 2 liver transplantation centers in 2 private hospitals in 2 different provinces, between August 2017 and October 2019. All the living liver donors were contacted without a time frame after donation and all the participants were evaluated once. The Beck Depression Scale, SF-36, General Self-Efficacy Scale, and Perceived Available Support Scale were used to collect data. The t-test, Kruskal-Wallis test, Mann-Whitney U-test, and Pearson correlation analysis were used for data analysis. Results: The mean age of the patients was 34.31 +/- 8.22 years. There was a positive, weak correlation between age and physical function. Gender, marital status, financial status, and education levels significantly affected physical components, social function, vitality, depression, and self-efficacy scores. High depression levels negatively affected the physical component, self-efficacy, and social support scores of the living liver donors. High self-efficacy positively affected social support. Conclusion: The study revealed that gender, marital status, employment status, and education levels were associated with psychosocial outcomes. The financial status was the main factor affecting each psychosocial variable. Financial status needs to be assessed in detail before and after the operation.
Citation Count: 0
Evaluation of Renal Functions of Inpatients With Mental Disorders
(Slack inc, 2024) Dikeç, Gül; Dikec, Gul; Ata, Elvan Emine; Ozer, Duygu; Hemşirelik Bölümü
The current study aimed to investigate the renal functions of inpatients with mental disorders. Data for this retrospective and descriptive study were collected from January 2021 to April 2021 from the records of patients who were hospitalized in the psychiatry clinic of a training and research hospital between 2018 and 2020. The study sample comprised hospital records of 376 patients. A significant negative relationship was determined between patients'glomerular filtration rate (GFR) and glucose level, duration of mental disorder, number of hospitalizations, and duration of medication use (p < 0.05). According to the analysis of patients' renal functions, mean GFR was statistically significantly lower in women with physical chronic diseases and diagnosed with personality disorders. Psychiatric-mental health nurses should evaluate and monitor renal functions of individuals with mental disorders and take precautions before kidney diseases develop.

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