Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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Citation Count: 0
Adsorption Mechanisms, Kinetics and Photoactivities of Green Synthesized Hydroxyapatite Supported Zno and La-Zno Catalysts
(Pergamon-elsevier Science Ltd, 2024) Tuncel Turan, Duygu; Okte, A. Neren; Temel Eczacılık Bilimleri Bölümü
In this study, hydroxyapatite (HAP) is synthesized by a co-precipitation method from the waste eggshell, utilized as a support for ZnO (ZnO-HAP) and La-ZnO (La-ZnO-HAP) and employed to degrade methyl orange (MO) and methylene blue (MB) dyes under UV irradiation. Water vapor adsorption as relative humidity (84 % RH) on the HAP structure and the as-prepared catalysts are also examined. The characteristic ZnO and HAP reflections are detected in X-ray diffraction (XRD) analysis of ZnO-HAP, La-ZnO-HAP and humidified samples. ZnO and La-ZnO existence is also verified by scanning electron microscopy-energy dispersive X-ray (SEM-EDX) analysis, UV-Vis diffuse reflectance (UV-Vis DRS) spectra and X-ray photoelectron spectra (XPS). ZnO and La-ZnO loading on the HAP induce the formation of mesoporous structures with high surface areas. Dark adsorption capacities and photoactivities of the as-prepared samples are explored regarding electrostatic interactions, Lewis acid-base interactions and hydrogen bonding for both MO and MB. In particular, La-ZnO-HAP 500 degrees C and La-ZnO-HAP 500 degrees C (RH) exhibit improved adsorption abilities and photoactivities. The pseudo-second order model describes the kinetic behavior of all samples under dark conditions. Unhumidified samples follow Langmuir isotherm while Freundlich isotherm better fits humidified ones. Under irradiation, the Langmuir-Hinshelwood kinetic model describes the photoactivities of all samples. The four recycling tests confirm the stabilities of HAP 100 degrees C, HAP 500 degrees C, ZnO-HAP 500 degrees C and La-ZnO-HAP 500 degrees C. This study suggests that the ZnO or La-ZnO loaded HAP catalysts prepared in the presence and absence of humid conditions are considered promising materials for environmental remediation.
Citation Count: 0
Age-Specific Seroprevalence of Hepatitis a Virus in Turkey Between 2000 and 2023: Systematic Review and Meta-Analysis
(Mdpi, 2024) Kahraman Kılbaş, Elmas Pınar; Koroglu, Mehmet; Demiray, Tayfur; Terzi, Huseyin Agah; Kilbas, Elmas Pinar Kahraman; Tıbbi Hizmetler ve Teknikler Bölümü
Background: Hepatitis A virus (HAV) is a leading cause of acute viral hepatitis and is primarily transmitted by the fecal-oral route. The clinical presentation and progression of the disease varies according to the age of the patient. Turkey is classified as a moderately endemic country, and HAV infection continues to be an important public health problem worldwide. Methods: In this study, a systematic meta-analysis was conducted to evaluate age-specific HAV seroprevalence rates in Turkey between 2000 and 2023. A comprehensive literature review identified 57 articles that met the inclusion criteria. The studies were assessed for quality, and seroprevalence rates were evaluated across four different age groups. Statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software (CMAVersion 3.0) and SPSS (SPSS Statistics 25.0). Results: HAV seroprevalence rates were found to be 73.18% in the 0 < 5 age group and 90.90% in the >35 age group. The overall seroprevalence estimated using a random effects model was 64.5% (95% CI: 58.3-70). High heterogeneity was observed among the studies, and the prevalence estimates changed when low-quality studies were excluded. Conclusions: This meta-analysis suggests that the increasing trend in HAV IgG seroprevalence in Turkey, especially among young populations, is likely due to the vaccination program initiated in 2012. Furthermore, the heterogeneity observed among regions highlights the importance of regional public health strategies. Future studies should focus on providing more detailed data to evaluate the long-term effects of vaccination and to explain regional differences in HAV seroprevalence.
Citation Count: 0
Analyzing Critical Success Factors of Sustainable Knowledge Management: an Interval-Valued Neutrosophic Approach
(Mdpi, 2024) Çaloğlu Büyükselçuk, Elif; Bulak, Muhammet Enis; Buyukselcuk, Elif Caloglu; Endüstri Mühendisliği Bölümü
Knowledge management (KM) is a structured approach that includes the organized procedures of generating, capturing, arranging, storing, retrieving, distributing, and harnessing an organization's knowledge resources to attain its goals and improve its effectiveness. Encountering uncertainty and managing imprecise information are fundamental aspects of KM that cannot be avoided. In this context, sustainable KM aims to solve these issues and address prioritizing the long-term sustainability and efficiency of knowledge-related processes within an organization. The aim of this study is to structure a sustainable KM concept for organizations and identify the most common critical success factors (CSFs) with a novel analytical approach. In this context, the Interval-Valued Neutrosophic methodology, which is one of the multi-criteria decision methods (MCDMs), was adopted to evaluate and weight the determined CSFs. Four main headings-KM, environmental, economical, and social criteria-are evaluated along with their subfactors. Our findings show that KM is found to be the most important, and environmental factors followed KM. When the results are examined in terms of subfactors, cleaner production is found to be the most significant, with a global weight value of 11.13.
Citation Count: 7
Antibiotic Use and Influencing Factors Among Hospitalized Patients With Covid-19: a Multicenter Point-Prevalence Study From Turkey
(Galenos Publ House, 2022) Ağalar, Canan; Cag, Yasemin; Karabay, Oguz; Kurtaran, Behice; Guclu, Ertugrul; Ogutlu, Aziz; Agalar, Canan; Tıbbi Hizmetler ve Teknikler Bölümü
Background: Broad-spectrum empirical antimicrobials arc frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective. and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age +/- standard deviation of the patients was 65.0 +/- 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (372%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005). presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein >10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p <0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings.
Citation Count: 7
The Antioxidant, Anti-Inflammatory, and Antiplatelet Effects of ribes Rubrum L. Fruit Extract in the Diabetic Rats
(Wiley, 2022) Şener, Azize; Sen, Ali; Sekerler, Turgut; Algul, Fatma Kader; Cilingir-Kaya, Ozlem Tugce; Sener, Azize; Temel Eczacılık Bilimleri Bölümü
The prothrombotic and inflammatory state plays a significant role in the occurrence of cardiovascular complications in type 2 diabetes mellitus. In this study, the antidiabetic, anti-inflammatory, and antiplatelet potentials of the extracts obtained from Ribes rubrum were investigated. The antidiabetic, anti-inflammatory, and antioxidant activities of the ethanol and water extracts of R. rubrum were evaluated by in vitro methods. The total phenolic and flavonoid contents were also determined. The experimental diabetes model in rats was induced with streptozotocin (STZ). After hyperglycemia occurred, the ethanol extracts of R. rubrum (RRE, at 100 mg/kg and 500 mg/kg doses) were administered to the treatment groups for 14 days. Blood glucose, lipid profile, plasma, and pancreas tumor necrosis factor-alpha (TNF-alpha) levels were determined and compared at the end of the experiments. P-selectin levels and mitochondrial membrane polarization (MMP) of platelets were also measured. In vitro study, the RRE showed potent anti-inflammatory activity. Administration of RRE (at 100 mg/kg doses) to diabetic rats lowered blood glucose level insignificantly. The results showed that there was an increment in levels of TNF-alpha in plasma and pancreas tissue of the diabetic group compared to the control group. R. rubrum extract regulated and normalized their levels in plasma and pancreatic tissue. RRE at both doses significantly decreased platelet P-selectin levels and prevented STZ-induced loss of MMP in platelets. The results of current research indicate that RRE extract has potent anti-platelet and anti-inflammatory effects and may be beneficial in preventing diabetic complications. Practical applications Hyperglycemia causes dyslipidemia, advanced oxidative stress, platelet activation, and inflammation in diabetes mellitus. Plants with various medicinal properties are of worldwide interest for the treatment of diseases due to their biological activities. In this study, the antidiabetic, anti-inflammatory, and antioxidant effects of extracts of Ribes rubrum (%100 ethanol, 50% ethanol, water) were evaluated by in vitro and in vivo methods. The diabetes model was induced with streptozotocin (STZ). The rats were divided into control, diabetic control, R. rubrum-100 mg/kg, and R. rubrum-500 mg/kg doses groups. Blood glucose levels, tumor necrosis factor-alpha (TNF-alpha), platelet P-selectin levels, mitochondrial membrane polarization of platelets were examined. The present study has shown that R. rubrum has anti-inflammatory and antiplatelet activity. R. rubrum may be beneficial in the prevention and treatment of DM complications due to its anti-inflammatory and antithrombotic effects.
Citation Count: 0
Are Child and Parent Health Behaviors Associated With Childhood Obesity? a Descriptive and Methodological Study
(Elsevier Science inc, 2023) Öztürk, Gizem; Kolcu, Merve; Hemşirelik Bölümü
Purpose: This study was conducted to determine the relationship between child and parents' health behaviors and childhood obesity. In addition, an adaptation of the Turkish version of the Family Health Behavior Scale (FHBS) was performed in this study.Design and methods: This is a descriptive and methodological study. The research sample consisted of 358 parents who have a child between the ages of 5 and 12 studying in one of the seven state schools at the kindergarten, primary, and secondary school levels in Istanbul. Data were collected between February 2022 to May 2022 using the Parent and Child Descriptive Information Form, the Family Nutrition and Physical Activity (FNPA) Screening Tool, and the FHBS. IBM SPSS 25.0 (IBM, Armonk, NY, USA) and SPSS AMOS 21.0 software were used to analyze the data.Results: It was found that the confirmatory factor analysis result of FHBS confirmed the original structure of the scale, and Cronbach's Alpha coefficient was calculated as 0.80. A positive correlation was found between the parents' total scores of FNPA and FHBS (r:0.511, p < 0.001).Conclusions: It is recommended to evaluate the child and their parents holistically in preventing and managing childhood obesity. School health nurses should plan family-centered interventions to improve health behaviors and carry out these interventions with a multidisciplinary team. Moreover, it has been determined that FHBS is a valid and reliable measurement tool for the Turkish population.
Citation Count: 15
Assessment of the Quality and Reliability of Information on Nutrition After Bariatric Surgery on Youtube
(Springer, 2020) Sevdin, Sezen; Kermen, Seda; Sevdin, Sezen; Yildiz, Nida; Guclu, Duygu; Beslenme ve Diyetetik Bölümü
Background YouTube (TM) is a platform that many people, including patients, use to access health information. Recent studies have revealed that videos on YouTube (TM) are misleading or that medical videos may not contain appropriate information. This study aimed to assess the quality and reliability of videos on nutrition after bariatric surgery. Materials and Methods The keywords "after bariatric surgery diet" and "weight loss surgery postop diet" were used, and the first 100 videos for each keyword on YouTube (TM) were analyzed by considering the source, duration, content, and the number of likes of the video. The popularity of the video was calculated using the video power index (VPI) and view rate. The educational quality of the videos was evaluated using the DISCERN score, the Journal of the American Medical Association (JAMA) score, the Global Quality Score (GQS), the usefulness score, and a novel postoperation nutrition score (PONS). Results One hundred fourteen patients were included in the study. The mean duration and number of views were 12.51 min and 87,558.46, respectively. The DISCERN score, JAMA score, GQS, and usefulness score of the physicians or dietician-based videos were significantly higher than those of the patient-based videos (p < 0.001). Positive correlations were found between the VPI and view ratio, as well as between the duration and number of likes. Additionally, the DISCERN score was significant correlated with the duration and number of likes. Significantly positive correlations were found between the usefulness score and duration, usefulness score and number of likes, and PONS and duration (p < 0.01). Conclusions Informational videos on nutrition after bariatric surgery on YouTube (TM) are of low quality. Although the videos uploaded by physicians and dieticians have higher quality, only a few are available. Additionally, patients prefer to watch low-quality videos.
Citation Count: 1
The Association of Demographic, Psychological, Social and Activity Factors With Foot Health in People With Plantar Heel Pain
(Wiley, 2024) Gulle, Halime; Morrissey, Dylan; Tayfur, Abdulhamit; Coskunsu, Dilber Karagozoglu; Miller, Stuart; Birn-Jeffery, Aleksandra V.; Prior, Trevor
Background: Plantar Heel Pain (PHP) can be a debilitating musculoskeletal condition from which only 50% recover within a year due to poor understanding of the mechanisms explaining severity and predicting outcomes specific to PHP. Objective: To explore associations between biopsychosocial variables and the severity of people with PHP. Secondly, to determine what combination of self-reported factors distinguishes people with PHP from other foot pain (OFP). Methods: We collected data from 235 participants, including 135 (%57) PHP (age 44 +/- 12 years, 66% female) and 99 OFP (%43) (age 38 +/- 11 years, 57% female) using 5 demographic, 13 biomedical, 8 psychological, 3 social and 8 activity-related factors. These were tested in linear and logistic regression models. Results: Quality of life (QoL) (beta = 0.35; p < 0.001), education (beta = -0.22; p = 0.003), gender (beta = -0.20; p = 0.007), morning pain duration (beta = -0.18; p = 0.01) and disease duration (beta = -0.15; p = 0.040) were significantly associated with severity of PHP. The second model, without QoL, showed that having sensitisation (beta = -0.18; p = 0.002) and a higher level of morning pain (beta = -0.20; p = 0.01) are associated with severity. The logistic regression results revealed that people with PHP tend to have a systemic disease (OR = 3.34; 1.53-7.76), express more kinesiophobia (OR = 1.02; 1.01-1.14), are less likely to have previous injuries (OR = 0.40; 0.19-0.81), worse morning pain (OR = 1.02; 1.01-1.03) and standing pain (OR = 2.60; 1.39-4.87) compared to people with OFP. Conclusions: People with PHP have higher associated levels of a range of psychological, social and activity related factors than people with OFP. The findings highlight the importance of considering psychosocial assessments alongside physical examination.
Citation Count: 2
Best Practice Recommendations for Dysphagia Management in Intensive Care Unit (icu): a Delphi Study From Multidisciplinary Experts in Turkey
(Springer, 2024) Umay, Ebru; Eyigor, Sibel; Demirag, Kubilay; Kaymak Karatas, Gulcin; Gundogdu, Ibrahim; Giray, Esra; Adiguzel, Emre
There is no study about all aspects of oropharyngoesophageal (OPE) dysphagia from diagnosis to follow-up in a multidisciplinary manner in the world. In order to close this gap, we aimed to create a recommendation study that can be used in clinical practice, addressing all aspects of dysphagia in the ICU in detail with the opinion of experienced multidisciplinary experts. This recommendation paper was generated by a multidisciplinary team, using the seven-step process and a three-modified Delphi round via e-mail. Firstly, 15 open-ended questions were created, and then detailed recommendations including general principles, management, diagnosis, rehabilitation, and follow-up were created with the answers from these questions, Each recommendation item was voted on by the experts as overall consensus (strong recommendation), approaching consensus (weak recommendation), and divergent consensus (not recommended).In the first Delphi round, a questionnaire consisting of 413 items evaluated with a scale of 0-10 was prepared from the opinions and suggestions given to 15 open-ended questions. In the second Delphi round, 55.4% were accepted and revised suggestions were created. At the end of the third Delphi round, the revised suggestion form was approved again and the final proposals containing 133 items were created. This study includes comprehensive and detailed recommendations, including a broad perspective from diagnosis to treatment and follow-up, as detailed as possible, for management of dysphagia in patients with both oropharyngeal- and esophageal-dysphagia in ICU.
Citation Count: 7
The Best Whey Protein Powder Selection Via Vikor Based on Circular Intuitionistic Fuzzy Sets
(Mdpi, 2023) Çaloğlu Büyükselçuk, Elif; Sari, Yigit Can; Endüstri Mühendisliği Bölümü
People try very hard to have a symmetrical, strong, and beautiful body. The human body needs high amino acids for muscle protein synthesis. Whey protein is a good choice that contains all amino acids, which increases muscle protein synthesis and improves body shape with resistance exercise. For this reason, those who do sports, especially professionals, prefer to use these products frequently. A large number of commercial whey protein powders are sold on the market, and to achieve maximum purpose, individuals want to use the best one. Intuitionistic fuzzy sets are used in order to minimize the negative effects of the uncertainty environment and ambiguous information encountered in the decision-making process on the solution. In this study, VIKOR, based on the circular intuitionistic fuzzy set, has been used to determine the best whey protein supplement. In line with the comprehensive literature review and expert opinions, the evaluation criteria affecting the selection process have been determined, and the solution of the problem has been focused.
Citation Count: 0
Carvacrol Improves Cognitive Dysfunction by Decreasing Amyloid-Β Accumulation and Regulating Neuroinflammation in Ovariectomized Renovascular Hypertensive Rats
(Springer, 2024) Şener, Göksel; Ertas, Busra; Aydin, Yasemin; Sener, Goksel; Eczacılık Meslek Bilimleri Bölümü
Hypertension contributes to both the development and progression of brain damage and cognitive dysfunction in the postmenopausal period in women. Carvacrol (CAR), which can easily cross the blood-brain barrier, exhibits neuroprotective properties due to its antioxidant, anti-inflammatory, and anti-apoptotic effects. In the present study, we have examined the effect of CAR treatment on learning-memory impairment in a post-menopausal hypertensive rat model that was induced by ovariectomy following two-kidney, one-clip renovascular hypertension surgery. From the third week after the establishment of renovascular hypertension in ovariectomized rats, CAR (40 mg/kg) was administered once daily for consecutive 7 weeks by gastric gavage. Systolic blood pressure was estimated by the tail-cuff method once a week. At the end of the study, cognitive functions were evaluated with behavioral tests and also neurochemical changes were measured in serum, cortex, and hippocampus by ELISA test. Blood pressure was decreased with CAR treatment in hypertensive rats. Serum estrogen levels decreased in ovariectomized rats and did not change with CAR treatment. CAR demonstrated beneficial effects on learning and memory tests as determined by increased recognition index, the number of platforms crossed, and time spent in the target quadrant. Due to CAR treatment, there was a marked reduction in the hippocampal and cortex amyloid-beta, osteopontin, interleukin-6 and tumor necrosis factor-alpha levels, and acetylcholinesterase activity, while an increment in neprilysin and interleukin-10 levels was found. In conclusion, since CAR suppressed amyloid-beta deposition and neuroinflammation in ovariectomized-hypertensive rats, it is thought that it may be protective against memory disorders in postmenopausal hypertensive women.
Citation Count: 0
Combined Spectroscopic and Chromatographic Techniques Augmented With Chemometrics for the Authentication of Black Cumin ( Nigella Sativa L . ) Seed Oil
(Academic Press inc Elsevier Science, 2024) Karaman Ersoy, Şeyda; Ersoy, Seyda Karaman; Kaya, Elif Nilay; Senol, Onur; Apak, Resat; Temel Eczacılık Bilimleri Bölümü
Edible oils adulteration has a great concern because of its health and economical effects. Black cumin seed oils (BCSOs) are one of the most adulterated edible oils. In this case, the purpose of this research was to investigate authenticity of commercial BCSOs by spectroscopic and chromatographic techniques combined with orthogonal partial least square -discriminant analysis (OPLS-DA) and hierarchical cluster analysis (HCA). Sixteen commercial BCSO samples (100 % pure-certified and other BCSOs), potential blending oils (sunflower, corn, and soybean oils), and twenty-one synthetically adulterated BCSO samples blended with sunflower (SFO), corn (CO), and soybean (SBO) oils at levels of 5 %, 10 %, 15 %, 20 %, 30 %, 40 %, and 50 % (v/v) were analysed. Screening of potential fingerprinting markers such as thymohydroquinone (THQ), thymoquinone (TQ), carvacrol (CRV), tocopherol isomers ( alpha-, gamma -, and delta -), as well as total antioxidant capacity and phenolic content analysis were carried out utilizing spectrophotometric CUPRAC, ABTS, and Folin Ciocalteu ' s assays. Commercial pure and fraudulent BCSOs and synthetically adulterated samples were successfully classified in OPLS-DA graphs with 95 % confidence level. Even to five percent detection limit for SFO, CO and SBO adulteration were prominently monitored. In consequence, the proposed spectroscopic and chromatographic methods seem to be a practically applicable, sensitive and versatile protocol that can be used as an alternative fingerprinting procedure to determine adulteration of commercial BCSOs.
Citation Count: 0
Comparison of the Effect of Maternal Breast Milk Odor, Facilitated Tucking, and Nonnutritive Sucking Applied To Preterm Neonates During Heel Stick on Pain and Physiological Parameters: a Randomized Controlled Trial
(Mary Ann Liebert, inc, 2024) Akbarı, Negarın; Mutlu, Birsen; Khoddam, Homeira; Hemşirelik Bölümü
Background: Preterm infants in the neonatal intensive care unit (NICU) frequently undergo painful procedures, which can lead to both short-term and long-term complications, including potential mortality. Effective pain management is crucial in this context. Although numerous studies have explored non-pharmacological pain relief methods for preterm infants, no research has simultaneously compared the effects of maternal breast milk odor, facilitated tucking, and nonnutritive sucking. Aim: This study aims to comparatively investigate the efficacy of nonnutritive sucking, facilitated tucking, and maternal breast milk odor in reducing pain in preterm neonates during heel sticks. Methods: A randomized controlled trial was conducted in a tertiary-level NICU with 144 preterm neonates (gestational age 31-36 weeks) requiring heel sticks. The infants were randomly assigned to four groups: control, nonnutritive sucking, facilitated tucking, and maternal breast milk odor. Pain and physiological parameters were assessed through video recordings of the procedures and scored at 1-minute intervals using the Premature Infant Pain Profile and Data Evaluation Form. Data were collected at baseline and at 1, 2, and 3 minutes before, during, and after the heel stick. Results: The study found significant effects of the interventions on physiological parameters and pain (heart rate: F = 7.5, p < 0.001; oxygen saturation: F = 16.39, p < 0.001; respiratory rate: F = 6.56, p < 0.001; pain: F = 61.45, p < 0.001). Facilitated tucking resulted in significantly lower pain scores (6.61 +/- 1.44) compared with the control group (14.22 +/- 3.61), maternal breast milk odor (12.22 +/- 3.08), and nonnutritive sucking (10.41 +/- 1.71) (p < 0.001). Conclusions: All interventions demonstrated effectiveness in maintaining physiological stability and alleviating pain. Nevertheless, the intervention identified as most effective in reducing pain was facilitated tucking group.
Citation Count: 1
A Comprehensive Assessment of the Cholinergic-Supporting and Cognitive-Enhancing Effects of rosa Damascena Mill. (damask Rose) Essential Oil on Scopolamine-Induced Amnestic Rats
(Wiley, 2024) Şener, Göksel; Ozbeyli, Dilek; Yigit-Hanoglu, Duygu; Baser, Kemal Husnu Can; Sener, Goksel; Aykac, Asli; Eczacılık Meslek Bilimleri Bölümü
Introduction: Alzheimer's disease (AD) is a neurodegenerative condition characterized by gradual loss of cognitive abilities (dementia) and is a major public health problem. Here, we aimed at investigating the effects of Rosa damascena essential oil (RDEO) on learning and memory functions in a rat model of amnesia induced by scopolamine, as well as on changes in acetylcholinesterase (AChE) activity, M-1 muscarinic acetylcholine receptor (mAChR) expression, and brain-derived neurotrophic factor (BDNF) levels in the extracted brain tissues. Methods: The control, amnesia (scopolamine, 1 mg/kg/i.p.) and treatment (RDEO, 100 mu L/kg/p.o. or galantamine, 1.5 mg/kg/i.p.) groups were subjected to Morris water maze and new object recognition tests. AChE activity was assayed by ELISA, and M-1 mAChR and BDNF concentration changes were determined by western blotting. Also, using computational tools, human M-1 mAChR was modeled in an active conformation, and the major components of RDEO were docked onto this receptor. Results: According to our behavioral tests, RDEO was able to mitigate the learning and memory impairments caused by scopolamine in vivo. Our in vitro assays showed that the observed positive effects correlated well with a decrease in AChE activity and an increase in M-1 mAChR and BDNF levels in amnestic rat brains. We also demonstrated in an in silico setting that the major components of RDEO, specifically -citronellol, geraniol, and nerol, could be accommodated favorably within the allosteric binding pocket of active-state human M-1 mAChR and anchored here chiefly by hydrogen-bonding and alkyl-pi interactions. Conclusion: Our findings offer a solid experimental foundation for future RDEO-based medicinal product development for patients suffering from AD.
Citation Count: 0
Correlations Between the Screen Time of Children With Special Needs and Their Parent-Child Relationships, Home Participation, and Occupational Performance
(Taylor & Francis Ltd, 2024) Aydöner, Selen; Aydoner, Selen; Gundogmus, Ezginur; Gunal, Rumeysa; Ozan, Aysenur Demir; Ergoterapi Bölümü
This study aimed to examine the relationships between the screen time of children with special needs and of their parents with their home participation, occupational performance, and parent-child relationships according to sex and diagnosis. Parents of 150 children with special needs (age range, 4 to 6 years) such as autism spectrum disorder, cerebral palsy, and attention deficit hyperactivity disorder, as well as undiagnosed and developmentally risky children, were included. The Demographic Information Form, Screen Time Usage Form, Parent-Child Relationship Scale, Participation and Environment Measure for Children and Youth, and Short Child Occupational Profile were used for the data collection. There was a significant relationship between the screen time of girls and their parent-child relationships, home participation, and occupational performance. Moreover, we detected a relationship between the screen time of children with autism spectrum disorder and positive parent-child relationships, home participation, and occupational performance. Therapists should account for screen time in their interventions associated with parent-child relationships, home participation, and occupational performance.
Citation Count: 3
A Cross-Sectional Survey Study on Homophobia Among Medical, Nursing, Pharmacy, and Other Health Sciences Students
(Routledge Journals, Taylor & Francis Ltd, 2023) Harmancı Seren, Arzu Kader; Bacaksiz, Feride Eskin; Cakir, Hanife; Yilmaz, Sevil; Sukut, Ozge; Turan, Suzan; Maghsoudi, Nurten; Hemşirelik Bölümü
Since the lesbian, gay, bisexual, transgender, and intersex (LGBTI) community may be exposed to violence, discrimination, stigma, exclusion, and maltreatment due to their sexual orientation while accessing healthcare services, understanding, and improving the attitudes of future's health care professionals toward LGBTI individuals seem essential. This descriptive and cross-sectional study aimed to investigate the homophobia among medical, nursing, pharmacy, and healthcare sciences students and examine the related factors. The study included 2,531 students from medicine, nursing, pharmacy, and other health sciences (midwifery, nutrition and dietetics, physiotherapy, management of healthcare facilities) disciplines. Homophobia was measured with the Hudson and Ricketts Homophobia Scale. After getting ethical and institutional approvals, data were collected and analyzed using descriptive and inferential statistical tests. Medical students had the lowest homophobia score, and their mean score was significantly lower than other students. There was a significant difference between students' scores according to years of study, age, sex, acquaintance with LGBTI individuals, providing healthcare services to an LGBTI person, and opinions on providing care. Although homophobia scores of nursing, pharmacy, and other health sciences students were lower than the medical students', policies and expansive content regarding LGBTI should be in place in all health science educational institutes, including medical schools, to prevent students from holding homophobic and prejudicial attitudes against LGBTI individuals.
Citation Count: 6
Design, Synthesis, and in Vitro and in Vivo Anticancer Activity Studies of New (s)-naproxen Thiosemicarbazide/1,2,4-triazole Derivatives
(Royal Soc Chemistry, 2022) Küçükgüzel, Şükriye Güniz; Tunc, Cansu Umran; Atalay, Pinar; Erdogan, Omer; Unal, Gokhan; Bozkurt, Mehmet; Kucukguzel, S. Guniz; Eczacılık Meslek Bilimleri Bölümü
In this study, a series of novel (S)-Naproxen derivatives bearing a thiosemicarbazide/1,2,4-triazole moiety were designed, synthesized, and evaluated for anticancer activity. The structures of these compounds were characterized by spectral (H-1-C-13 NMR, FT-IR, and HR-MS analyses) methods. All of the synthesized compounds (3a-m, 4a-j) were screened for anticancer activity against human breast cancer cell line MDA-MB-231. Among them, (S)-4-(2,4-dichlorophenyl)-5-[1-(6-methoxynaphthalen-2-yl)ethyl]-4H-1,2,4-triazole-3-thione (4b) showed the most potent anticancer activity with a good selectivity (IC50= 9.89 +/- 2.4 mu M). Inhibition of anti-apoptotic protein Bcl-2 was investigated in MDA-MB-231 cells treated with compound 4b using Western Blotting. Apoptosis was also detected by AO/EB and JC-1 staining. Furthermore, activation of caspase-3 enzyme activity demonstrated apoptosis. The flow cytometric analysis results showed that compound 4b decreases the number of cells in the G2/M phase and increases the cells in the S phase in a dose-dependent manner. The anticancer activity of compound 4b was also investigated. In the Ehrlich acid tumor model, a well-validated in vivo ectopic breast cancer model, compound 4b had anticancer activity and reduced the tumor volume at both low (60 mg kg(-1)) and high (120 mg kg(-1)) doses in mice, according to our in vivo results.
Citation Count: 4
Determination of Chemical Components of the Endemic Species allium Turcicum L. Plant Extract by Lc-ms/Ms and Evaluation of Medicinal Potentials
(Cell Press, 2024) Ipek, Polat; Atalar, Mehmet Nuri; Baran, Ayse; Baran, Mehmet Firat; Ommati, Mohammad Mehdi; Karadag, Musa; Khalilov, Rovshan
The Allium turcicum L. (Zuzubak) plant as a cultivated vegetable have various health benefits and consumed as a food. Due to the shortcoming evidence in literature and the importance of this plant in folk medicine, in the present study, for the first time, we evaluated the bioactive profile of components (using LC-MS/MS), cytotoxicity, anticancer, antioxidant, and antibacterial prospectives of Zuzubak methanol extract. Reported results show that the extract is rich in bioactive compounds and has anticancer activity with breast cancer cells (MCF-7), human prostate cancer cells (DU -145), and Human osteosarcoma cancer Cell lines of (IC50) in dose dependent manner in the concentration range of 31.25 mu g/mL and 2000 mu g/mL for 24 and 48 h. Western blotting results determined that the extract significantly suppressed the growth of U2OS, MCF-7, and DU -145 cancer cells by down expression of Ang-1 (angiogenic protein) and Beclin-1 (autophagy protein) and overexpression of Bax (a proapoptotic protein). The oxidative stress indices showed a reduction in RPE-1 and MCF-7 cells and an upsurge in U2OS and DU -145 cells. Additionally, the antimicrobial assay showed suppression of the growth of various pathogenic microorganisms in 4.00 - 8.00 mu g/concentrations of Zuzubak extract using the microdilution method. The phytochemicals identified showed promising anticancer, antioxidant effects, and antimicrobial properties, representing a valuable herbal source for drug development studies.
Citation Count: 1
Developing a Valid and Reliable Perceived Global Future Scale
(Wiley, 2022) Harmancı Seren, Arzu Kader; Seren, Arzu K. Harmanci; Hemşirelik Bölümü
Purpose To develop a valid and reliable data collection tool to define individuals' perceptions of the global future. Design and Methods This methodological study was carried out on 870 participants in Istanbul, a city with the country's highest and most diverse population. Findings Content validity, construct validity, item analyses, and stability of the draft tool were tested. The seven-factor scale structure was confirmed. Cronbach's alpha coefficient of the scale was .93. Practice Implications The Perceived Global Future Scale, consisting of 36 items and seven dimensions, was used. It is a valid and reliable tool to define perceptions of individuals on the global future.
Citation Count: 0
Development of the Medical Adherence Scale in Adolescents Using Psychotropic Medication and Evaluation of Validity and Reliability in Turkish Population
(Elsevier Science inc, 2024) Dikeç, Gül; Bilac, Oznur; Sonkaya, Hilal Isleyen; Aydemir, Omer; Hemşirelik Bölümü
Purpose: Although treatment non -adherence is relatively high among adolescents, there is a need for standardized measurement tools that measure adherence to treatment in adolescents. This study aimed to develop a new measurement tool to assess the adherence to treatment of adolescents with mental disorders who use psychotropic medication. Methods: The data of this methodologically designed study were collected between 01.04.2022 and 01.07.2023 in the Department of Child and Adolescent Psychiatry of a university hospital in the Aegean Region of Turkey. The Medication Adherence Reporting Scale and Adolescent Medical Adherence Scale draft form were used for data collection. The scale items were formed from the themes, sub -themes, and statements in the qualitative study that the researchers had conducted with adolescents with mental disorders and their parents, clinicians' experiences, and systematic reviews and meta -synthesis in the literature. The study sample consisted of 95 adolescents with mental disorders. Exploratory factor analysis was performed with Varimax rotation to determine the factorial construct validity of the scale. Internal consistency analyses were performed in reliability analyses, and Cronbach's alpha coeff icient was used. Results: The mean age of the adolescents was 14.18 years (1.81); 50.5% were male, and 96.8% were attending school. When the mental disorder diagnoses were analyzed, 65.3% of the adolescents were being followed up with Attention De ficit and Hyperactivity Disorder diagnoses, and 58.8% were using stimulants. The 12 -item form of the Adolescent Medical Adherence Scale was found to have a three -factor structure with item -total correlation values ranging between 0.26 and 0.66, and these factors were named functionality, responsibility in treatment, and medication adherence. Factor loadings ranged between 0.44 and 0.86, and the items explained 62.98% of the total variance. The internal consistency coef ficients of the scale were between 0.69 and 0.83 for the subscales and 0.82 for the total scale. Conclusion: Based on the analysis and results used in this study, the Adolescent Medical Adherence Scale is a valid and reliable new measurement tool. Practice implications: This tool can be used in clinical settings to evaluate adolescents' treatment adherence and prognosis. Clinical studies conducted with adolescents can also determine adherence to treatment and affecting factors. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

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