Scopus İndeksli Yayınlar Koleksiyonu

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Citation - WoS: 22
Citation - Scopus: 31
Digital Transformation in Project-Based Manufacturing: Developing the Isa-95 Model for Vertical Integration
(Elsevier, 2022) Apiliogullari, Lutfi
The Smart Factory is the intelligent management of all business operations that aims to produce innovative products in the most efficient and faster way through the cyber-physical system (CPS). CPS integrates the cyber (IT) and the physical world (OT) through the hierarchical layers of ISA-95 model and forms the backbone of Industry 4.0. The CPS plays a crucial role in transforming data from interconnected systems, and it is a pre-requisite for the entire system to be able to interact. The ISA-95 model consists of components that can be used to determine how the interaction between domains vertically within the facility. However, the current ISA-95 Model does not include all the components that need to be integrated in vertical integration of all domains. The product domain is one of them. All IT and OT components need to be represented in the ISA-95 layers to achieve an ideal CPS structure. In this study, all components needed to achieve the ideal CPS structure have been identified in an expanded ISA-95 Model for project-based manufacturers. An extended ISA-95 model is proposed so that each manufacturing industry can use it in the digital transformation process by adding a product domain and connectivity layer to the Model. The Model was tested and confirmed, by conducting a case study which was based on implementing the vertical integration on it. This model helps businesses to develop more effective digital transformation strategies by defining where they should focus on or from where they should start the digital transformation processes.
Citation - WoS: 2
Citation - Scopus: 3
Effect of Pacifier and Pacifier With Dextrose in Reducing Pain During Orogastric Tube Insertion in Newborns: a Randomized Controlled Trial
(Springernature, 2024) Akkaya-Gul, Aysenur; Ozyazicioglu, Nurcan
OBJECTIVE: This study aimed to assess the efficacy of pacifier use, with and without 25% dextrose, in reducing pain during orogastric tube insertion in newborns. STUDY DESIGN: In a randomized controlled trial involving 60 newborns at a public hospital from April to December 2019,participants were divided into three groups: pacifier (n=20), pacifier with 25% dextrose (n=20), and control (n=20). A pacifier, with and without dextrose, was used for the experimental groups, while the control group performed a routine procedure. Neonatal infant pain scale, crying duration, heart rate (HR), and oxygen saturation (SpO2) were evaluated. RESULTS: Results indicated that the control group experienced significantly higher pain levels, elevated HRs, decreased SpO2, and prolonged crying. Conversely, the pacifier with 25% dextrose group showed a notable reduction in crying duration. CONCLUSION: A pacifier, with and without 25% dextrose, effectively reduces pain and improves physiological and behavioral parameters during orogastric tube insertion.
Does Prolotherapy Have an Effect on the Care of Pressure Injuries? a Pilot Study
(Elsevier Sci Ltd, 2025) Eroglu, Nermin; Kokkiz, Rukiye; Eroglu, Hatice Eda; Kocoglu, Hasan
Background: This study contributes to wound healing with prolotherapy in people with pressure injuries. The study was planned and conducted as a randomized controlled trial to determine the effect of prolotherapy on the care of pressure injuries. Methods: The study was carried out with patients with pressure injuries in the intensive care unit of a city hospital between April and June 2023. A power analysis was performed, and the sample size was calculated as 20 patients, including 10 in the intervention and 10 in the control group. The patients in the experimental group were given wound care with gelofusine as prolotherapy in the morning and evening for three days, and the injury site was covered with a sterile sponge and fixation tape. The patients in the control group were treated with saline in the morning and evening for three days. In both groups, the wound width, depth, and length were measured and evaluated prior to each intervention for three days. Results: In the study, a significant difference was found between the mean ages of the participants in the experimental and control groups (p < 0.05). The decrease in width measurements in the experimental group was found to be statistically significant compared to the previous measurements, while the increase in width measurements in the control group was significant compared to the previous measurements (p < 0.05). Depth measurements decreased statistically significantly in the experimental group, while they increased significantly in the control group compared to previous measurement values (p < 0.05). Conclusion: In conclusion, it was determined that the administration of gelofusine for pressure injuries as prolotherapy in the experimental group may be more effective in wound healing than saline treatment applied in the control group. Further studies are warranted.
Citation - WoS: 3
Citation - Scopus: 3
An International Multicenter Mental Health Standardized Patient Simulation on Nursing Students? Beliefs Toward Mental Health Conditions
(Elsevier Science inc, 2023) San, Eda Ozkara; Dikec, Gul; Ata, Elvan E.
Background: Negative beliefs can be a barrier to provide quality nursing care for persons living with mental health conditions. This international SP simulation study explored nursing students' beliefs toward persons with mental health conditions in the United States (US) and Turkey before and after participating in a mental health standardized patient simulation. Methods: A quasi-experimental study design was used in two settings in two countries. Measures included a socio-demographic survey and the Beliefs toward Mental Illness scale. Results were analyzed using paired sample t-test, independent t-test, and chi-square tests. Results: Students in the US had significantly lessened negative attitudes toward persons with mental health conditions when compared to the Turkey group. Conclusion: SP simulation may offer opportunities to improve nursing students' beliefs toward persons with mental health conditions.
Psychometric Evaluation of the Person-Centred Climate Questionnaire - Staff Version
(BMC, 2025) Arici, Furkan Cihat; Harmanci Seren, Arzu Kader; Edvardsson, David
BackgroundValid and reliable instruments are needed to assess person-centredness that serve as quality care indicators. Person-Centred Climate Questionnaire - staff version is an interculturally used tool to evaluate person-centredness in clinical settings. This study aimed to examine the psychometrics of the tool in the Turkish language.MethodsThis was a methodological study involving a sample of 140 nurses. One of the researchers collected data using the Turkish version of the questionnaire-staff version in a private hospital in Istanbul. After performing the language validity steps, the researchers analysed the content validity ratios of the items and the questionnaire's content validity index, and they performed exploratory and confirmatory factor analysis to validate the construct. The internal consistency of the subdimensions and the questionnaire was determined utilising a Cronbach's Alpha test.ResultsThe content validity ratios of the items ranged from 0.84 to 1, and the correlation coefficients ranged from 0.50 to 0.69. The three-factor structure accounted for 70.40% of the total variance. The items' standardised factor loads were between 0.501 and 1.140. The Cronbach's alpha consistency value was 0.90.ConclusionThe staff version of the questionnaire is an adequately valid and reliable instrument in the Turkish language.
Design and Synthesis of Thiosemicarbazides and 1,2,4-Triazoles Derived From Ibuprofen as Potential Metap (Type II) Inhibitors
(Elsevier Ireland Ltd, 2025) Yilmaz, Ozgur; Biliz, Yagmur; Ayan, Sumeyra; Cevik, Ozge; Karahasanoglu, Mufide; Cotuker, Reyhan; Kucukguzel, S. Guniz
In the present study, a range of novel thiosemicarbazides 4a-i and 1,2,4-triazoles 5a-i derived from ibuprofen, were synthesized. Structural elucidation of these synthesized compounds was performed utilizing a variety of spectroscopic methods, including FTIR, 1H NMR, 13C NMR and HR-MS. The synthesized compounds were tested for cytotoxicity in five different cancer cell lines (cervical cancer (HeLa), human breast cancer (MCF-7), human gastric adenocarcinoma (MKN-45), human metastatic prostate cancer (PC3) and human glioblastoma (U87)). The compounds were compared with healthy cells (NIH-3T3) and the most effective compounds were determined by means of the selectivity index. Thiosemicarbazides derived form ibuprofen 4i and 4d showed anticancer activity, while 1,2,4-triazoles derived form ibuprofen 5b, 5c, 5d, 5e, 5h, 5g showed anticancer activity in HeLa, MCF-7, MKN-45, PC3 and U87 cells. To test the stability of the protein-drug complexes all 18 compounds 4a-i and 5a-i were docked into the active site of the MetAP2 enzyme In general, computational inhibition constants values were correlated with the experimental values. The dynamic behavior of MetAP2-inhibitor complexes was analyzed using all atoms Molecular Dynamic (MD) simulations for 200 ns duration. MD revealed that the drugs bind in the active center of MetAP2 with stable RMSD and RMSF. In conclusion, in-silico results and in-vitro studies suggests that thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen may be novel anticancer drug candidates for treating cervical, breast, prostate, gastric and glioblastoma. Compounds provided induction of apoptotic proteins in the cell by inhibiting MetAP2 enzyme. Furthermore, the potential antioxidant activities of the compounds were evaluated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Among the compounds tested, 4a, 4b, 4e, 4f, 4h, and 4i exhibited values closely resembling the DPPH activity of the standards.
Investigation of Vocal Fatigue, Anxiety Level, and Perceived Communication Skills According To the Purpose of Mask Use During the Pandemic
(Elsevier Inc., 2025) Işık, E.E.; Paltura, C.; Develioğlu, Ö.N.
Objective: The use of face masks during COVID-19 causes communication difficulties. Determining the effects of face masks can provide precautions against possible voice problems. The aim of the study is to determine the difference between vocal fatigue and anxiety levels depending on the use of masks in basic and basic-professional activities. Materials and Methods: This study was conducted in a descriptive and cross-sectional design. Data were collected between March and May 2021. The study included 476 people aged 18-65 years. Participants were divided into two groups according to the purpose of mask use; “wearing masks only for essential activities” group (EA) and “wearing masks for essential-professional activities” group (EPA). Vocal Fatigue Index (VFI), Beck Anxiety Inventory (BAI), and Self-Assessment Questions were used in the study. All scales and subjective evaluation questions were transferred to Google Forms. The link was sent to participants living in Turkey with a letter of consent. Results: VFI-Factor 1, VFI-Factor 2, VFI-Factor 3, VFI Total, and BAI scores differed statistically significantly between the groups. VFI and BAI scores of the EPA group were found to be higher. There was a correlation between all factors of VFI and BAI scores. According to the results of regression analysis, it was found that the purpose of mask use and BAI score increased the VFI score. When the EPA group was masked, their results on respiratory control abilities, auditory perception, and speech intelligibility were shown to be lower. Conclusion: Regardless of the purpose of use, face masks have been found to reduce speech intelligibility, auditory feedback, and the ability to maintain breath control while speaking. The findings of our study suggest that longer mask use may increase the VFI score. © 2025 The Voice Foundation
Citation - WoS: 6
Citation - Scopus: 7
Nurses' Views on Change Management in Health Care Settings: a Qualitative Study
(Wiley-hindawi, 2022) Cakiroglu, Oya Celebi; Hobek, Goksu Ulutas; Seren, Arzu Kader Harmanci
Aim To discover nurses' views on change management processes in health care settings. Background Because 'change' is an inevitable fact of today's health care environments, developing change management competencies at all levels is a must to survive and compete for the organisations and professionals in the health care systems. Methods A descriptive qualitative approach was used. The sample consisted of 18 nurses reached by using snowball sampling. The data were collected through semi-structured interviews and analysed using the Colaizzi method in the NVivo12 program. Results The results of the study were collected under three main themes: 'general approaches and initial responses to change', 'factors affecting attitudes toward change' and 'strategic mistakes made by managers during the change process'. Conclusion The study showed that nurses show different reactions to change. Their attitudes towards change could be affected positively and negatively by the relevant factors. Nurses thought that managers were making strategic mistakes during the change process. Implications for nursing management Recognizing the approaches of nurses and managers towards change and increasing awareness of the mistakes during the change process may contribute to the achievement of the change processes in health care settings.
The Effects of Diaphragmatic Breathing Exercises on Individuals with Premature Ejaculation: A Randomized Controlled Trial
(Oxford University Press, 2025) Erkut, Umit; Karagözoğlu Coşkunsu, Dilber; Erkut, Kubra; Özden, Ali Veysel
Background There are no standardized, evidence-based rehabilitation protocols for premature ejaculation (PE) which hinders effective management, the development of validated patient-reported outcomes, regulatory oversight, and the potential benefits of targeted interventions. Aim To investigate the effect of diaphragmatic breathing exercises (DBE) on PE. Methods Sixty-two participants with PE were randomly assigned to Group I (n = 31) or Group II (n = 31). Both groups received behavioral therapy (BT) and pelvic floor muscle training (PFMT) twice daily, three days a week, for eight weeks. Additionally, Group I recieved DBE twice daily, every day, for eight weeks. Intravaginal ejaculation latency time (IELT) was calculated with a stopwatch, at the end of the 8th week (post-treatment), and at 1-year follow-up. Pelvic floor muscle (PFM) strength and endurance were evaluated with ultrasound, and changes in the in the autonomic nerves system (ANS) parameters (including the root mean square of successive differences [RMSSD], proportion of NN50 [PNN50], low-frequency [LF] power, and high-frequency [HF] power) were evaluated with an Elite HRV device at pre-treatment and post-treatment by a blinded assessor. Outcomes Primary outcome measurements were IELT, PFM strength and endurance, and changes in ANS paramaters. Results The study was completed by 29 participants (mean age = 31.4 ± 6.5 years) in Group I and 30 (mean age = 31.3 ± 7.6 years) in Group II. At post-treatment, all outcome measures showed significant improvements in both groups (P <.001 for all). Compared to Gropu II, Group I showed significantly greater improvements in IELT(P=0.12), RMSDD (P<.001), PNN50 (P=.003), LF Power (P<.001), HF Power (P=.003), strength(P<.001), and endurance (P<.001). The median IELT increase from baseline to post-treatment was 283 seconds (range: 84-870; 900%) in Group I and 204 seconds (range: 44- 581; 690%) in Group II. While IELT declined significantly from post-treatment to 1-year follow-up in Group II, no statistically significant change was found in Group I. Clinical Implications The effect of DBE on the ANS may help regulate the ejaculatory reflex. Strengths and Limitations This is the first study to apply breathing exercises with BT and PFMT in men with PE. Limitations include the lack of exercise adherence records beyond 8 weeks and the estimation-based IELT measurement at baseline. Conclusion Adding DBE, to BT and PFMT, yields better results in IELT (at 8 weeks and 1 year) and inreases PFM strength and endurance of PFM (at 8 weeks) in men with PE. © 2025 Elsevier B.V., All rights reserved.
Citation - WoS: 1
Twenty-Year Course of Antifungal Resistance in Candida Albicans in Türkiye: A Systematic Review and Meta-Analysis
(MDPI, 2025) Kilbas, Imdat; Kahraman Kilbas, Elmas Pinar; Horhat, Florin George; Ciftci, Ihsan Hakki
This study aimed to systematically evaluate the resistance rates of Candida albicans to various antifungals based on studies conducted in Turkiye and published between 2005 and 2025 and to analyze the factors contributing to resistance. A systematic literature search was conducted using various keywords in electronic databases (PubMed, Embase, Web of Science, EBSCO, Scopus, Turk Medline and Google Scholar). A total of 42 studies were included in the meta-analysis according to the determined criteria. The quality of the studies was assessed using the Joanna Briggs Institute checklist, and the analyses were performed using appropriate statistical software. The highest resistance rates for fluconazole, itraconazole, and voriconazole were observed in the Aegean and Marmara regions. In the analyses performed with the random-effects model, heterogeneity was found to be high for itraconazole, fluconazole, posaconazole, voriconazole, and caspofungin, and the strongest explanatory variable of this heterogeneity was the geographical region variable. In our study, we determined that antifungal resistance in C. albicans strains in Turkiye is generally low; however, an increasing trend has been observed over the years, especially in amphotericin B resistance. Although the low resistance rates to major antifungal agents such as fluconazole, voriconazole and echinocandins are promising, regional differences and methodological heterogeneity necessitate the development of treatment strategies based on local data.
Citation - WoS: 26
Citation - Scopus: 37
An Integrative Approach To Relationship Marketing, Customer Value, and Customer Outcomes in the Retail Banking Industry: a Customer-Based Perspective From Turkey
(Routledge Journals, Taylor & Francis Ltd, 2019) Sayil, Emine Mediha; Akyol, Ayse; Simsek, Gulhayat Golbasi
Given how important it is to provide superior value to customers and to maintain customer loyalty for a sustainable competitive advantage, the aim of this paper is to examine the relationships among relationship marketing components of - trust, competency, commitment, communication, and conflict handling, - relationship investment, relationship quality, perceived customer value, satisfaction and loyalty in an integrated framework in the Turkish retail banking industry. Unlike previous studies, this research extends the literature by analysing affective as well as cognitive dimensions in the same model with a holistic view by simultaneously examining the direct and indirect effects of the related concepts. The distinctive nature of this study is its evaluation of customer satisfaction and loyalty from the perspective of actual consumers. The research model was tested using data collected from 685 retail banking customers by applying structural equation modelling. The findings show that relationship marketing induces loyalty through relationship quality, customer value, and satisfaction, which are mainly provided by trust, communication, and relationship investment. Furthermore, relationship investment and relationship quality are the most important factors in the development of customer value, satisfaction, and loyalty. The emotional value dimension, which captures the affective aspects of perceived value, has the strongest effect on both satisfaction and loyalty.
Citation - WoS: 2
Citation - Scopus: 3
Player Selection in Football by Integrated Swara-Vikor Methods Under Fuzzy Environment
(Cell Press, 2024) Buyukselcuk, Elif Caloglu; Badem, Eray
This study aims to provide an objective evaluation and selection of the most suitable players for the Turkish National Football Team by using multi-criteria decision-making methods, specifically Stepwise Weight Assessment Ratio Analysis (SWARA) and VIsekriterijumsko KOmpromisno Rangiranje (VIKOR) based on neutrosophic numbers. In the initial step of the study, the important criteria for player selection were determined, and a total of 21 and 26 criteria were identified for goalkeeper and players, respectively. Agility, reflexes and jumping ability are very important for goalkeeper whereas marking, passing ability, agility, dribbling, and footwork are the most important criteria for players. The performances of the players were evaluated due to these criteria and finally the Turkish National Football Team was established scientifically because of the best player selection. This decision-making process will be more beneficial in making more informed and effective decisions in the national team's player selection process. The success of the team can be improved by providing an objective and systematic player selection approach.
Citation - WoS: 4
Citation - Scopus: 5
Mapping the Vascular and Muscular Topography of the Glabellar Region: Implication for Improving Safety and Efficacy of the Glabellar Injections
(Springer, 2024) Ismailoglu, Abdul Veli; Ismailoglu, Pelin; Aktekin, Mustafa
Background Botulinum neurotoxin (BoNT) and filler injections into the highly vascularized glabellar region for aesthetical purposes are extremely common. Injections into the glabellar region without precise anatomical knowledge of its vascular and muscular topography may pose the risk of severe complications.Objectives We aimed to improve the safety and efficacy of the glabellar injections by mapping the regional muscles and vasculature in relation to the medial canthus and the defined reference lines.Methods Meticulous dissection was performed to reveal glabellar region muscles and arteries under surgical microscope, in 16 hemifaces of whom arteries are injected with red-dyed latex. Location of the angular artery (AA) along with its branches was noted in relation to glabellar muscles.Results The AA was always located superficial to the levator labii superioris alaeque nasi muscle (LLSAN) and then coursed toward the medial canthus to anastomose with the supratrochlear artery deep to the origin of the depressor supercilii (DS). The AA gave subcutaneously located central and paracentral branches coursing close to the mid-face line in 14 out of 16 hemifaces. Variable muscular connections were also present between the LLSAN, the DS and the procerus (P) muscles. No arteries were detected at the base of the medial eyebrow to which the DS, the P, and the frontalis (F) inserted.Conclusions This study provides a detailed map of muscular and vascular anatomy of the glabellar region to facilitate safe and efficient filler and BoNT injections without complications.No Level Assigned This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Citation - WoS: 11
Citation - Scopus: 13
Critical Thinking Among Clinical Nurses and Related Factors: a Survey Study in Public Hospitals
(Wiley, 2022) Urhan, Eylul; Zuriguel-Perez, Esperanza; Seren, Arzu Kader Harmanci
Aims and objectives The study investigated clinical nurses' critical thinking levels in public hospitals and related factors. Background Since health care environments have become more complex, the critical thinking skills of clinical nurses are more important in daily problem-solving and decision-making processes. However, little research was conducted on this topic among clinical nurses. Methods It was a cross-sectional study at five public hospitals between December 2018 and January 2019. The study followed the STROBE guideline. Data were collected from 559 nurses by a survey consisted of a data form and the Turkish version of the Nursing Critical Thinking in Clinical Practice Questionnaire. Results Nurses' mean critical thinking scores were moderate level. Total critical thinking scores of the clinical nurses significantly differed according to education, hospital type, shift work, professional category and role. There was a significant effect on the total critical thinking scores of the clinical nurses according to variables. Conclusion This study found that critical thinking levels of nurses' working in clinical settings in public hospitals were moderate level. Hospital type, shift work, professional and educational level and role were significantly associated with clinical nurses' critical thinking levels. Relevance to clinical practice This study provides evidence related to the levels of critical thinking of clinical nurses working in public hospitals. Since the critical thinking scores of the manager nurses, daytime working nurses' and nurses with bachelor's and master's degree education are higher, hospital managers may benefit from the study to implement effective strategies to improve the competence of critical thinking levels of nurses.
Citation - WoS: 1
Citation - Scopus: 1
Psychometric Properties of the Quality Nursing Care Scale-Turkish Version: a Methodological Study
(Bmc, 2022) Karaca, Anita; Kaya, Leyla; Kaya, Gizem; Seren, Arzu Kader Harmanci
AimTo analyze the psychometric properties of the Quality Nursing Care Scale in Turkish Language. Background: The quality of health services and nursing care effectively improves safe patient outcomes and reduces costs in healthcare organizations. There is a need for valid and reliable tools in order to use for evaluating the quality of nursing care. Methods: The methodological and cross-sectional study included 225 nurses working in a research and training hospital. Content validity, construct validity, item analysis, and internal consistency analysis were used. Results: The content validity index of the scale was 0.96. The item-total score correlation values of the items were 0.72 and higher. The factor loads of the items ranged from 0.42 to 0.90. Different from the original scale, Turkish form consisted of three sub-dimensions. The fit indices were acceptable or very good. The Cronbach's alpha internal consistency coefficient was 0.99. Conclusion: The Quality Nursing Care Scale was valid and reliable with its three-factor structure in Turkish Language. It may be used for measuring the quality of care in the aspects of nurses.
Citation - WoS: 2
Evaluation of the Effectiveness of Resonant Voice Therapy in Patients with Functional Voice Disorder
(Mosby-Elsevier, 2025) Hacioglu, Habibe N.; Bengisu, Serkan
Objective. This study aims to determine the effectiveness of resonant voice therapy (RVT) in patients with functional voice disorder and to examine the subjective and objective voice changes after the therapy. Study Design. This study adopted an experimental research design with a pretest-posttest control group. Method. Thirty-four women participated in the study-17 in the experimental group and 17 in the control group. Voice hygiene training and RVT were applied to the experimental group. The Turkish version of the Voice Handicap Index (VHI-10) and GRBAS (Grade, Roughness, Breathiness, Asthenia, and Strain) scale were used for subjective voice assessment. Voice recordings were subjected to acoustic analysis on the PRAAT program. After an 8-week therapy program, the same process was repeated for post-test assessment. Results. In the voice analyses performed after RVT, which was applied to patients with functional voice disorders, the results of the acoustic analysis showed statistically significant differences in jitter, PPQ5, RAP, shimmer, APQ11, and NHR parameters. Subjective voice analysis indicated a statistically significant decrease in VHI-10 scores from 20.88 +/- 5.33-9.06 +/- 3.3 in the experimental group. The GRBAS score was 4.29 +/- 1.2 before the therapy and 1.71 +/- 1.1 after the therapy, which is a statistically significant decrease. The results point out that RVT has been effective in improving the objective and subjective parameters of patients with functional voice disorders. Conclusion. RVT applied to patients with functional voice disorders provides significant improvement in acoustic and perceptual voice parameters. The RVT is an effective therapy method in the treatment of patients with functional voice disorders and should be considered as a therapeutic option.
Citation - WoS: 13
Citation - Scopus: 16
Managing Viral Emerging Infectious Diseases Via Current and Future Molecular Diagnostics
(Mdpi, 2023) Altindis, Mustafa; Kilbas, Elmas Pinar Kahraman
Emerging viral infectious diseases have been a constant threat to global public health in recent times. In managing these diseases, molecular diagnostics has played a critical role. Molecular diagnostics involves the use of various technologies to detect the genetic material of various pathogens, including viruses, in clinical samples. One of the most commonly used molecular diagnostics technologies for detecting viruses is polymerase chain reaction (PCR). PCR amplifies specific regions of the viral genetic material in a sample, making it easier to detect and identify viruses. PCR is particularly useful for detecting viruses that are present in low concentrations in clinical samples, such as blood or saliva. Another technology that is becoming increasingly popular for viral diagnostics is next-generation sequencing (NGS). NGS can sequence the entire genome of a virus present in a clinical sample, providing a wealth of information about the virus, including its genetic makeup, virulence factors, and potential to cause an outbreak. NGS can also help identify mutations and discover new pathogens that could affect the efficacy of antiviral drugs and vaccines. In addition to PCR and NGS, there are other molecular diagnostics technologies that are being developed to manage emerging viral infectious diseases. One of these is CRISPR-Cas, a genome editing technology that can be used to detect and cut specific regions of viral genetic material. CRISPR-Cas can be used to develop highly specific and sensitive viral diagnostic tests, as well as to develop new antiviral therapies. In conclusion, molecular diagnostics tools are critical for managing emerging viral infectious diseases. PCR and NGS are currently the most commonly used technologies for viral diagnostics, but new technologies such as CRISPR-Cas are emerging. These technologies can help identify viral outbreaks early, track the spread of viruses, and develop effective antiviral therapies and vaccines.
Citation - WoS: 6
Citation - Scopus: 6
The Potential Role of Boron in the Modulation of Gut Microbiota Composition: an in Vivo Pilot Study
(Mdpi, 2024) Senturk, Nermin Basak; Kasapoglu, Burcu; Sahin, Eray; Ozcan, Orhan; Ozansoy, Mehmet; Ozansoy, Muzaffer Beyza; Sahin, Fikrettin
Background/Objectives: The role of the gut microbiome in the development and progression of many diseases has received increased attention in recent years. Boron, a trace mineral found in dietary sources, has attracted interest due to its unique electron depletion and coordination characteristics in chemistry, as well as its potential role in modulating the gut microbiota. This study investigates the effects of inorganic boron derivatives on the gut microbiota of mice. Methods: For three weeks, boric acid (BA), sodium pentaborate pentahydrate (NaB), and sodium perborate tetrahydrate (SPT) were dissolved (200 mg/kg each) in drinking water and administered to wild-type BALB/c mice. The composition of the gut microbiota was analyzed to determine the impact of these treatments. Results: The administration of BA significantly altered the composition of the gut microbiota, resulting in a rise in advantageous species such as Barnesiella and Alistipes. Additionally, there was a decrease in some taxa associated with inflammation and illness, such as Clostridium XIVb and Bilophila. Notable increases in genera like Treponema and Catellicoccus were observed, suggesting the potential of boron compounds to enrich microbial communities with unique metabolic functions. Conclusions: These findings indicate that boron compounds may have the potential to influence gut microbiota composition positively, offering potential prebiotic effects. Further research with additional analyses is necessary to fully understand the interaction between boron and microbiota and to explore the possibility of their use as prebiotic agents in clinical settings.
Citation - WoS: 1
Citation - Scopus: 1
A New Perspective on Osas Cases With the Baveno Classification
(Taylor & Francis Ltd, 2024) Koseoglu, Handan Inonu; Aykun, Goekhan; Kanbay, Asiye; Pazarli, Ahmet Cemal; Yakar, Halil Ibrahim; Demir, Osman
Objective/Background: Since the apnea-hypopnea index (AHI), which is used in the diagnosis and grading of OSAS, does not adequately reflect the clinical perspective of the disease, the Baveno classification of OSA was developed, which allows multicomponent evaluation of OSAS patients. The aim of our study was to evaluate the application of the Baveno classification in clinical practice. Patients/Methods: A prospective study was performed on patients diagnosed with OSAS between January 2021 and June 2022. Patients were divided into 4 groups according to Baveno classification (Groups A-D) and three groups as mild, moderate, and severe OSAS according to AHI. Results: A total of 378 patients (70% male, mean age 48.68 +/- 11.81 years) were included in the study. The patients had mild (n: 75; 20%), moderate (n: 88; 23%), and severe (n: 215; 57%) OSAS. According to Baveno classification, patients were included in Groups A (n: 90; 24%), B (n: 105 (28%), C (n: 65; 17%), and D (n: 118; 31%). The mean AHIs of the Baveno groups were similar (p = 0.116). Oxygen desaturation index (ODI) was higher in Groups B and D compared to Group A. The duration of T90 desaturation was longer in Groups C and D compared to Groups A and B (p < 0.05). Conclusions: The Baveno classification divided our OSAS cases into equivalent groups. One out of every four patients with mild OSAS was in Group D. This data was noteworthy in that the Baveno classification allows for the identification of symptomatic and comorbid patients with mild OSAS according to AHI and for the application of more effective treatments to these patients. Patients with comorbidities experienced oxygen desaturation for a longer period of time at night, and oxygenation deteriorated in patients with prominent symptoms. Baveno classification was found to be a more reasonable and easily applicable approach in clinical practice.
Citation - WoS: 2
Citation - Scopus: 4
The Effects of Dietary Changes on Bone Markers in Postmenopausal Vertebral Osteopenia
(Churchill Livingstone, 2020) Islamoglu, A. Humeyra; Garipagaoglu, Muazzez; Bicer, H. Selcen; Kurtulus, Duygu; Ozturk, Mustafa; Gunes, F. Esra
Background & aims: Nutrition is one of the most important environmental factors affecting the formation of osteopenia. The purpose of this study was to investigate the effects of dietary changes on bone formation and bone resorption markers of postmenopausal women with vertebral osteopenia. Methods: In this study, 108 women with postmenopausal vertebral osteopenia were included. Patients were observed for a month to identify their regular nutritional status. Before intervention, blood and urine samples were taken from all patients. Then, 2-day food consumption records were taken and the patients were divided into 4 groups. Different types of diets (opposite of their regular diets) were prepared for these groups (1: control, 2: reduced-carbohydrate, 3: reduced-protein, 4: reduced-sodium) and followed for 3 months. At the end of follow-ups, blood and urine samples were taken again and changes in osteocalcin (OC) and N-terminal telopeptide (NTX) levels were examined. Results: According to biochemical analysis, there was a significant decrease (p < 0,001) in OC levels in reduced protein group and an increase (p > 0,05) in reduced carbohydrate group. When NTX levels were assessed, a significant decrease (p < 0.001) in the reduced carbohydrate group and a significant increase in the reduced protein group (p < 0.05) were found. Conclusion: Our findings show that reduced carbohydrate diet protected whereas, reduced protein diet negatively affected bone health. Osteopenic individuals were thought to be able to improve bone health and their quality of life by early dietary intervention. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

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