WoS İndeksli Yayınlar Koleksiyonu

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Citation - WoS: 7
Citation - Scopus: 8
Acute Changes in Electrophysiological Brain Dynamics in Elite Karate Players
(Springer international Publishing Ag, 2020) Duru, Adil Deniz; Balcioglu, Taylan Hayri; Ozcan Cakir, Canan Elif; Goksel Duru, Dilek
Regular physical exercise has enhanced effects on the human anatomy and functionality. Recently, an effect of a single set of exercise is shown to have positive effects on mood and on cognitive functioning. The aim of this study is to investigate the effect of a single bout of moderate exercise on the brain electrophysiological dynamics in resting-state condition and under the mental workload situation from elite-level athletes. For this purpose, electroencephalogram (EEG) is measured before and after the exercise sessions from 17 elite karate players who are members of the national karate team of Turkey. Blood lactate measurements are implemented to monitor the volunteers before EEG measurements. EEG data are analyzed using three metrics: conventional band power of each electrode, coherence metrics between electrodes for each band and source coherence values corresponding to each frequency band. Each metric is statistically analyzed between pre- and post-values, and results revealed that in all frequency bands, right parietal electrode had increased connection values which are thought to be related to ongoing sympathetic nervous system response observed during the recovery period. Another finding is the enhanced connectivity of frontal sources under the resting state as well as during the increased mental workload periods.
Advances and Strategies in Biosensor-Based Diagnostics for Parasitic Infections: A Comprehensive Scoping Review
(Springer, 2026) Aminizadeh, Selva; Alizadeh, Gita; Alizadeh, Zahra; Khalilzadeh, Balal; Abidin, Zurina Zainal; Marzi, Mahdi; Rafiei-Sefiddashti, Raheleh
Parasitic diseases are among the most widespread infections worldwide, causing millions of deaths and illnesses each year. So rapid and accurate diagnosis is essential, requiring highly sensitive and specific tests. Biosensors can provide significant advantages over traditional diagnostic methods because of their specificity, sensitivity, speed, simplicity, ease of use, repeatability, and capacity for early-stage disease detection. Recent advances in modern diagnostic tools for detecting parasitic infections use nanomaterials such as gold nanoparticles, carbon nanofibers, and carbon nanotubes. These developments have significantly lowered detection limits to the picogram and femtogram levels. This review will cover recent advancements in biosensor-based diagnostic techniques in parasitology.
Citation - WoS: 3
Citation - Scopus: 2
Age-Specific Seroprevalence of Hepatitis a Virus in Turkey Between 2000 and 2023: Systematic Review and Meta-Analysis
(Mdpi, 2024) Ciftci, Ihsan Hakki; Koroglu, Mehmet; Demiray, Tayfur; Terzi, Huseyin Agah; Kilbas, Elmas Pinar Kahraman
Background: Hepatitis A virus (HAV) is a leading cause of acute viral hepatitis and is primarily transmitted by the fecal-oral route. The clinical presentation and progression of the disease varies according to the age of the patient. Turkey is classified as a moderately endemic country, and HAV infection continues to be an important public health problem worldwide. Methods: In this study, a systematic meta-analysis was conducted to evaluate age-specific HAV seroprevalence rates in Turkey between 2000 and 2023. A comprehensive literature review identified 57 articles that met the inclusion criteria. The studies were assessed for quality, and seroprevalence rates were evaluated across four different age groups. Statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software (CMAVersion 3.0) and SPSS (SPSS Statistics 25.0). Results: HAV seroprevalence rates were found to be 73.18% in the 0 < 5 age group and 90.90% in the >35 age group. The overall seroprevalence estimated using a random effects model was 64.5% (95% CI: 58.3-70). High heterogeneity was observed among the studies, and the prevalence estimates changed when low-quality studies were excluded. Conclusions: This meta-analysis suggests that the increasing trend in HAV IgG seroprevalence in Turkey, especially among young populations, is likely due to the vaccination program initiated in 2012. Furthermore, the heterogeneity observed among regions highlights the importance of regional public health strategies. Future studies should focus on providing more detailed data to evaluate the long-term effects of vaccination and to explain regional differences in HAV seroprevalence.
Citation - WoS: 3
Citation - Scopus: 3
Analyzing Critical Success Factors of Sustainable Knowledge Management: an Interval-Valued Neutrosophic Approach
(Mdpi, 2024) Turan, Hakan; Bulak, Muhammet Enis; Buyukselcuk, Elif Caloglu
Knowledge management (KM) is a structured approach that includes the organized procedures of generating, capturing, arranging, storing, retrieving, distributing, and harnessing an organization's knowledge resources to attain its goals and improve its effectiveness. Encountering uncertainty and managing imprecise information are fundamental aspects of KM that cannot be avoided. In this context, sustainable KM aims to solve these issues and address prioritizing the long-term sustainability and efficiency of knowledge-related processes within an organization. The aim of this study is to structure a sustainable KM concept for organizations and identify the most common critical success factors (CSFs) with a novel analytical approach. In this context, the Interval-Valued Neutrosophic methodology, which is one of the multi-criteria decision methods (MCDMs), was adopted to evaluate and weight the determined CSFs. Four main headings-KM, environmental, economical, and social criteria-are evaluated along with their subfactors. Our findings show that KM is found to be the most important, and environmental factors followed KM. When the results are examined in terms of subfactors, cleaner production is found to be the most significant, with a global weight value of 11.13.
Citation - WoS: 1
Citation - Scopus: 1
Anti-Lipid Accumulation and Antioxidant Effects of the Root Extract From Rubus Discolor and Its Phytochemical Analysis
(Springer Science and Business Media Deutschland GmbH, 2025) Şekerler, T.; Gülmez, G.; Algül, K.F.; Göger, F.; Şenkardeş, İ.; Şen, A.; Şener, A.
Rubus species exhibit potent antioxidant properties due to their high phenolic compound content. In our study, phytochemical composition of the extract obtained from roots of Rubus discolor (RDE) was determined using LC-MS/MS. Subsequently, effect of this extract on lipid accumulation was investigated in HepG2 liver cells. For this purpose, HepG2 cells were treated with oleic acid to induce lipid accumulation. The effect of RDE on lipid accumulation was assessed using Oil-Red staining and measuring intracellular triglyceride, cholesterol levels. Melatonin was used as a positive control. Enzymes involved in lipid synthesis, including acetyl-CoA carboxylase (ACC1), fatty acid synthase (FAS), and transcription factor sterol regulatory element-binding protein 1 (SREBP-1c), as well as the antioxidant status, were evaluated by RT-PCR. As dose-dependent, RDE significantly reduced lipid accumulation and each concentrations (25, 50, 100 µg/mL) of RDE showed 78%, 48%, 38% ratio, respectively for Oil Red O staining. TG was found 1.92 ± 0.03, 1.76 ± 0.40, 1.22 ± 0.13, 1.41 ± 0.08 mg/mg protein for oleic acid and each concentrations (25, 50, 100 µg/mL) of RDE, respectively It significantly suppressed ACC1, FAS, and SREBP-1c (p < 0.001, p < 0.001, p < 0.01, respectively) at a dose of 50 µg/mL. The extract also exhibited in vitro strong antioxidant and good anti-inflammatory properties. Pedunculagin isomer, ellagic acid and ellagic acid pentoside compounds were found to be the main compounds of RDE with high total phenolic content. The results indicate that RDE has the potential to prevent lipid accumulation. These findings could provide a basis for further studies on the potential therapeutic effect of Rubus discolor in the treatment of NAFLD. © The Author(s) 2025.
Citation - WoS: 3
Citation - Scopus: 3
Antioxidants, Enzyme Inhibitory Activities, and Phytochemical Profiles of Seven Medicinal Plants Grown With Organic Farming Techniques
(Tubitak Scientific & Technological Research Council Turkey, 2023) Zor, Murat; Ozupek, Burcin; Pekacar, Sultan; Deliorman Orhan, Didem
In this study, the potential antihyperlipidemic, antidiabetic, and antiobesity effects of extracts obtained via infusion techniques from Artemisia absinthium L., Achillea millefolium L., Calendula officinalis L., Fumaria officinalis L., Mentha piperita L., Origanum onites L., and Urtica dioica L. grown with organic farming techniques were investigated using enzyme inhibition methods (alpha-glucosidase, pan-creatic cholesterol esterase, pancreatic lipase, and alpha-amylase). It is important that natural compounds or extracts to be used in the treat-ment of metabolic problems have antioxidant effects. The antioxidant effects of these species were tested in terms of ABTS and DPPH radical scavenging activity, ferric reducing power, and metal chelating capacity. Extracts (2 mg/mL) of M. piperita (91.43 +/- 0.90%) and O. onites (70.18 +/- 2.02%) showed potent inhibitory effects on the alpha-glucosidase enzyme. Among all species, only O. onites extract ex-erted an inhibitory effect on the cholesterol esterase enzyme close to that of reference compound simvastatin. While all extracts were effective in the tested antioxidant activity methods, it was determined that the M. piperita and O. onites extracts displayed particularly significantly strong activities in terms of ferric reducing power, ABTS radical scavenging effect, and metal chelating capacity. The total flavonoid and phenolic contents of all extracts were determined. The compositions of the most active extracts were analyzed for pheno-lic acids and flavonoids using RP-HPLC. The results of RP-HPLC analysis showed that the levels of ellagic acid (0.923 +/- 0.000 g/100 g extract) in the M. piperita extract and rosmarinic acid (0.813 +/- 0.003 g/100 g extract) in the O. onites extract were high. As a result, all species grown with organic farming techniques except U. dioica were found to have high antioxidant effects. In light of these findings, it was concluded that M. piperita and O. onites grown with organic farming techniques showed strong inhibitory effects in terms of the tested activities, especially for alpha-glucosidase and pancreatic cholesterol esterase, and that in vivo studies and activity-guided isolation studies should be conducted on these species in the future.
Assessment of Breastfeeding Self-Efficacy in Nursing Mothers Following Earthquakes: A Case Study of the Kahramanmaraş Earthquakes in Turkey
(Kashan Univ Medical Sciences, 2025) Dinmez, Sinem Guven; Karaman, Ozen Esra; Bakir, Emine
Background: Natural disasters disproportionately impact vulnerable populations, particularly mothers and infants. Research indicates that during such events, mothers often favor formula and supplementary feeding over breastfeeding. Self-efficacy is a critical determinant influencing breastfeeding practices in disaster contexts.
Objectives: This study aimed to examine the breastfeeding characteristics and self-efficacy of nursing mothers following the Kahramanmara & scedil; earthquakes.
Methods: This descriptive study was conducted at the Children's Polyclinic of Iskenderun State Hospital in Turkey from August 1 to August 31, 2023. A total of 54 mothers with infants aged 0-1 year at the time of the earthquake, who continued to breastfeed (providing breast milk for at least one feeding), were selected using a non-probability purposive sampling method. During the study period, all eligible mothers visiting the polyclinic who met the inclusion criteria were evaluated. Data were collected using a "Descriptive Data Form" and the "Breastfeeding Self-Efficacy Short Form Scale". Statistical analyses were performed using SPSS version 23, employing Independent Samples t-tests, Mann-Whitney U tests, and One-Way ANOVA for group comparisons. A P-value of less than 0.05 was considered statistically significant.
Results: The mean breastfeeding self-efficacy score among mothers was 58 +/- 5.87 (minimum 40; maximum 70). Mothers who exclusively breastfed their infants had significantly higher self-efficacy scores compared to those who introduced formula (P = 0.021) Among the mothers surveyed, 81.5% reported that their breastfeeding was affected by the earthquake; 41% cited issues related to privacy, while 27% faced challenges regarding shelter. Prior to the earthquake, 72% of infants were exclusively breastfed; however, this figure decreased as 81.5% of infants began receiving complementary foods alongside breast milk post-earthquake.
Conclusion: The findings indicate that mothers breastfeeding self-efficacy is at a moderate level. Additionally, mothers reported alterations in their breastfeeding practices compared to the pre-earthquake period. These results underscore the importance of promoting breastfeeding in disaster-affected areas and highlight the critical role of midwives in supporting these efforts.
Citation - WoS: 21
Citation - Scopus: 22
Assessment of the Quality and Reliability of Information on Nutrition After Bariatric Surgery on Youtube
(Springer, 2020) Batar, Nazli; Kermen, Seda; Sevdin, Sezen; Yildiz, Nida; Guclu, Duygu
Background YouTube (TM) is a platform that many people, including patients, use to access health information. Recent studies have revealed that videos on YouTube (TM) are misleading or that medical videos may not contain appropriate information. This study aimed to assess the quality and reliability of videos on nutrition after bariatric surgery. Materials and Methods The keywords "after bariatric surgery diet" and "weight loss surgery postop diet" were used, and the first 100 videos for each keyword on YouTube (TM) were analyzed by considering the source, duration, content, and the number of likes of the video. The popularity of the video was calculated using the video power index (VPI) and view rate. The educational quality of the videos was evaluated using the DISCERN score, the Journal of the American Medical Association (JAMA) score, the Global Quality Score (GQS), the usefulness score, and a novel postoperation nutrition score (PONS). Results One hundred fourteen patients were included in the study. The mean duration and number of views were 12.51 min and 87,558.46, respectively. The DISCERN score, JAMA score, GQS, and usefulness score of the physicians or dietician-based videos were significantly higher than those of the patient-based videos (p < 0.001). Positive correlations were found between the VPI and view ratio, as well as between the duration and number of likes. Additionally, the DISCERN score was significant correlated with the duration and number of likes. Significantly positive correlations were found between the usefulness score and duration, usefulness score and number of likes, and PONS and duration (p < 0.01). Conclusions Informational videos on nutrition after bariatric surgery on YouTube (TM) are of low quality. Although the videos uploaded by physicians and dieticians have higher quality, only a few are available. Additionally, patients prefer to watch low-quality videos.
Citation - WoS: 5
Citation - Scopus: 5
The Association of Demographic, Psychological, Social and Activity Factors With Foot Health in People With Plantar Heel Pain
(Wiley, 2024) Gulle, Halime; Morrissey, Dylan; Tayfur, Abdulhamit; Coskunsu, Dilber Karagozoglu; Miller, Stuart; Birn-Jeffery, Aleksandra V.; Prior, Trevor
Background: Plantar Heel Pain (PHP) can be a debilitating musculoskeletal condition from which only 50% recover within a year due to poor understanding of the mechanisms explaining severity and predicting outcomes specific to PHP. Objective: To explore associations between biopsychosocial variables and the severity of people with PHP. Secondly, to determine what combination of self-reported factors distinguishes people with PHP from other foot pain (OFP). Methods: We collected data from 235 participants, including 135 (%57) PHP (age 44 +/- 12 years, 66% female) and 99 OFP (%43) (age 38 +/- 11 years, 57% female) using 5 demographic, 13 biomedical, 8 psychological, 3 social and 8 activity-related factors. These were tested in linear and logistic regression models. Results: Quality of life (QoL) (beta = 0.35; p < 0.001), education (beta = -0.22; p = 0.003), gender (beta = -0.20; p = 0.007), morning pain duration (beta = -0.18; p = 0.01) and disease duration (beta = -0.15; p = 0.040) were significantly associated with severity of PHP. The second model, without QoL, showed that having sensitisation (beta = -0.18; p = 0.002) and a higher level of morning pain (beta = -0.20; p = 0.01) are associated with severity. The logistic regression results revealed that people with PHP tend to have a systemic disease (OR = 3.34; 1.53-7.76), express more kinesiophobia (OR = 1.02; 1.01-1.14), are less likely to have previous injuries (OR = 0.40; 0.19-0.81), worse morning pain (OR = 1.02; 1.01-1.03) and standing pain (OR = 2.60; 1.39-4.87) compared to people with OFP. Conclusions: People with PHP have higher associated levels of a range of psychological, social and activity related factors than people with OFP. The findings highlight the importance of considering psychosocial assessments alongside physical examination.
Avatar: a Film at the Center of the Feminine Other
(Univ Pittsburgh, Univ Library System, 2025) Dereboyu, Pelin Guregen; Guzel, Ebru; Olaru, Gabriela Oana; Ayberk, Erhan
This study analyzes James Cameron's 2009 film Avatar from the perspective of the feminine other through deconstruction. In the movie, nature and the Na'vi people are depicted as feminine, while modern man and the science, technology, and military power he represents are portrayed as masculine. Although it critiques the colonialist structure of modernity, the film's narrative structure and character portrayals indicate that it reproduces the superiority of Western-centered ideology and the masculine mind. The study analyzes how the film's narrative and character representations implicitly support masculine centrism. The analysis reveals how nature and marginalized cultures are romanticized and presented in the film and how the notion that the feminine can only survive by adopting masculine traits is processed in the subtext. Grounded in a conceptual and theoretical framework, this research focuses on the sustainability of the patriarchal capitalist system and gender politics while critically examining how cinema reconstructs ideological structures through the narratives in the film.
Citation - WoS: 16
Citation - Scopus: 23
Balance Training in Modern Dancers Proprioceptive-Neuromuscular Training Vs Kinesio Taping
(Science & Medicine inc, 2018) Tekin, Demet; Agopyan, Ani; Baltaci, Gul
Kinesio tape and proprioceptive exercises are both used for increasing balance in dancers. The purposes of this study were to: a) determine the acute effect of kinesio tape (KT) application on the ankle joint on balance performance, b) investigate the effects of an 8-week proprioceptive-neuromuscular (PN) training program on balance performance, and c) compare their effects vs modern dance technique classes alone. Thirty-three trained, university-level modern dance students (9 male, 24 female) were divided randomly into three groups: kinesio tape (KT, n=11), proprioceptive-neuromuscular (PN, n=11), or control (n=11). Static (turn-out passe-opened eyes/releve and turn-out passe-closed eyes/flat foot), semi-dynamic (airplane), and dynamic balance (monopodalic-straight and -transverse in a turn-out passe-eyes opened/flat foot) tests were performed before and after the intervention. One day after pre-tests, KT mechanical correction technique was applied to the left ankle joint (supporting leg) in the KT group, and tests were repeated to determine the acute effect of KT. The PN group participated in an 8-week balance training program (2 days/wk, 60 min/day) involving exercises using stable and unstable surfaces. Significant improvements were observed for all static and dynamic balance tests in the PN group; semi-dynamic airplane and dynamic monopodalic-straight and transverse tests improved in the KT group; and only semi-dynamic airplane test scores changed significantly for the control group (p<0.05). Our findings suggest that with the exception of the semi-dynamic airplane test, both PN training and KT application were more effective at improving balance performance for modern dancers than modern dance technique classes alone.
Citation - WoS: 2
Citation - Scopus: 2
Best Practice Recommendations for Dysphagia Management in Intensive Care Unit (icu): a Delphi Study From Multidisciplinary Experts in Turkey
(Springer, 2024) Umay, Ebru; Eyigor, Sibel; Demirag, Kubilay; Kaymak Karatas, Gulcin; Gundogdu, Ibrahim; Giray, Esra; Adiguzel, Emre
There is no study about all aspects of oropharyngoesophageal (OPE) dysphagia from diagnosis to follow-up in a multidisciplinary manner in the world. In order to close this gap, we aimed to create a recommendation study that can be used in clinical practice, addressing all aspects of dysphagia in the ICU in detail with the opinion of experienced multidisciplinary experts. This recommendation paper was generated by a multidisciplinary team, using the seven-step process and a three-modified Delphi round via e-mail. Firstly, 15 open-ended questions were created, and then detailed recommendations including general principles, management, diagnosis, rehabilitation, and follow-up were created with the answers from these questions, Each recommendation item was voted on by the experts as overall consensus (strong recommendation), approaching consensus (weak recommendation), and divergent consensus (not recommended).In the first Delphi round, a questionnaire consisting of 413 items evaluated with a scale of 0-10 was prepared from the opinions and suggestions given to 15 open-ended questions. In the second Delphi round, 55.4% were accepted and revised suggestions were created. At the end of the third Delphi round, the revised suggestion form was approved again and the final proposals containing 133 items were created. This study includes comprehensive and detailed recommendations, including a broad perspective from diagnosis to treatment and follow-up, as detailed as possible, for management of dysphagia in patients with both oropharyngeal- and esophageal-dysphagia in ICU.
Citation - WoS: 14
Citation - Scopus: 15
The Best Whey Protein Powder Selection Via Vikor Based on Circular Intuitionistic Fuzzy Sets
(Mdpi, 2023) Buyukselcuk, Elif Caloglu; Sari, Yigit Can
People try very hard to have a symmetrical, strong, and beautiful body. The human body needs high amino acids for muscle protein synthesis. Whey protein is a good choice that contains all amino acids, which increases muscle protein synthesis and improves body shape with resistance exercise. For this reason, those who do sports, especially professionals, prefer to use these products frequently. A large number of commercial whey protein powders are sold on the market, and to achieve maximum purpose, individuals want to use the best one. Intuitionistic fuzzy sets are used in order to minimize the negative effects of the uncertainty environment and ambiguous information encountered in the decision-making process on the solution. In this study, VIKOR, based on the circular intuitionistic fuzzy set, has been used to determine the best whey protein supplement. In line with the comprehensive literature review and expert opinions, the evaluation criteria affecting the selection process have been determined, and the solution of the problem has been focused.
Citation - WoS: 1
Citation - Scopus: 1
A Bibliometric Analysis of Nursing Research in the Field of Refugee Health Between 1980 and 2024
(John Wiley and Sons Inc., 2025) Öztürk, Gizem; Dikeç, Gül; Harmanci Seren, Arzu Kader
Aim: This study aimed to examine the bibliographic characteristics of publications on refugees in the nursing field. Design: A bibliometric analysis design was adopted for the study. Sample: Included the articles scanned in the Web of Science Core Collection database. The study excluded the other databases and gray literature. Measurements: The 2120 articles published between 1980 and 2024 that met the inclusion criteria were analyzed using Bibliometrix in RStudio, VOSviewer, and Microsoft Excel software. Results: The majority of publications were published in 2024. The United Kingdom, the United States, Canada, and Australia have the highest publications, citations, and international cooperation. Additionally, “mental health” is one of the most frequently used keywords in studies. Conclusions: The increased migration rates and the growing need for healthcare for refugees underscore the importance of investing in nursing research within this field. Nurses and researchers should establish partnerships and share best practices with leading countries. © 2025 Elsevier B.V., All rights reserved.
Citation - WoS: 1
Citation - Scopus: 2
Biological Activities of Etodolac-Based Hydrazone, Thiazolidinone and Triazole Derivatives on Breast Cancer Cell Lines MCF-7 and MDA-MB
(Wiley, 2025) Sevinc, Sevgi Kocyigit; Cikla-Suzgun, Pelin; Tiber, Pinar Mega; Kucukguzel, S. Guniz; Orun, Oya
In this study, several etodolac-based hydrazone, thiazolidinone, and triazole derivatives that we synthesized and characterized in our earlier research were tested against the hormone-responsive breast cell line MCF-7 and the triple-negative MDA-MB-231, as well as the murine origin fibroblast cell line L-929, at varying doses for their effects on cell viability and toxicity and for their inhibitory activity on cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) formation. Cell viability and apoptosis tests were utilized to assess the anti-cancer potential of etodolac and its derivatives after the cells were exposed to varied concentrations of synthesized compounds for three different time periods. ELISA and Western blot methods were used to detect protein levels. All synthesized compounds demonstrated higher anti-cancer activity at significantly lower doses compared to etodolac (half-maximal inhibitory concentration [IC50] of 0-50 mu M range in derivatives versus 0.5-1 mM range in etodolac). Except for SGK 242, which had a major toxic effect on all cells, the chemicals SGK 206 and SGK 217 had a twice-less impact on control murine L-929 fibroblasts. Similar to proliferation, low concentrations of SGK 206 and SGK 217 (25-50 mu M) significantly induced apoptosis in breast cancer cells but not in normal cells. Additionally, they inhibited COX-2 protein expression at 50 mu M, and SGK 206 inhibited PGE2 release more effectively than etodolac in cancer cells. The results of this study suggest that, in comparison to a healthy control group, the thiazolidinone derivative SGK 206 and the thiazolidinone derivative SGK 217 are more effective than etodolac when it comes to the breast cancer cell lines MCF-7 and MDA-MB-231. SGK 206 exhibits a low IC50 value, a distinct dose-response relationship, and strong apoptotic effects, particularly on MDA-MB-231 cells.
Burn Rehabilitation: Evaluation of Physiotherapists' Knowledge and Awareness Levels
(Elsevier Sci Ltd, 2025) Seyyah, Mine; Akkurt, Mustafa Ferit; Yilmaz, Nergis
Objective: The aim of this study was to evaluate the level of knowledge and awareness of physiotherapists working in Turkey about burn rehabilitation. Method: This was a cross-sectional study conducted between March and June 2025 and data were collected using Google Form. A total of 324 people were included in the study. The level of knowledge and awareness of the participants about burn rehabilitation was evaluated with 28 questions created by taking expert opinion. Results: While 25.6 % of participants had experience in burn rehabilitation, only 1.2 % frequently encountered burn patients. Although 60.5 % had taken courses on burn rehabilitation, only 15.1 % considered their knowledge sufficient. Correct response rates to key knowledge questions were 78.7 % for exercise applicability, 79.6 % for timing, 54.6 % for the most common burn type in Turkey, 35.8 % for edema management, and 13 % for pressure garment duration, revealing gaps in clinical knowledge. Additionally, 92.9 % believed early physiotherapy improves recovery, and 98.4 % reported positive effects on quality of life. Discussion: Our results indicate that although most physiotherapists had taken courses on burn rehabilitation, their knowledge remains insufficient, whereas their awareness is high, underscoring the need for targeted training and certification programs.
Citation - WoS: 1
Citation - Scopus: 1
Carvacrol Improves Cognitive Dysfunction by Decreasing Amyloid-Β Accumulation and Regulating Neuroinflammation in Ovariectomized Renovascular Hypertensive Rats
(Springer, 2024) Bayraktar, Duygu; Ertas, Busra; Aydin, Yasemin; Sener, Goksel
Hypertension contributes to both the development and progression of brain damage and cognitive dysfunction in the postmenopausal period in women. Carvacrol (CAR), which can easily cross the blood-brain barrier, exhibits neuroprotective properties due to its antioxidant, anti-inflammatory, and anti-apoptotic effects. In the present study, we have examined the effect of CAR treatment on learning-memory impairment in a post-menopausal hypertensive rat model that was induced by ovariectomy following two-kidney, one-clip renovascular hypertension surgery. From the third week after the establishment of renovascular hypertension in ovariectomized rats, CAR (40 mg/kg) was administered once daily for consecutive 7 weeks by gastric gavage. Systolic blood pressure was estimated by the tail-cuff method once a week. At the end of the study, cognitive functions were evaluated with behavioral tests and also neurochemical changes were measured in serum, cortex, and hippocampus by ELISA test. Blood pressure was decreased with CAR treatment in hypertensive rats. Serum estrogen levels decreased in ovariectomized rats and did not change with CAR treatment. CAR demonstrated beneficial effects on learning and memory tests as determined by increased recognition index, the number of platforms crossed, and time spent in the target quadrant. Due to CAR treatment, there was a marked reduction in the hippocampal and cortex amyloid-beta, osteopontin, interleukin-6 and tumor necrosis factor-alpha levels, and acetylcholinesterase activity, while an increment in neprilysin and interleukin-10 levels was found. In conclusion, since CAR suppressed amyloid-beta deposition and neuroinflammation in ovariectomized-hypertensive rats, it is thought that it may be protective against memory disorders in postmenopausal hypertensive women.
Comparison of the Effect of Maternal Breast Milk Odor, Facilitated Tucking, and Nonnutritive Sucking Applied To Preterm Neonates During Heel Stick on Pain and Physiological Parameters: a Randomized Controlled Trial
(Mary Ann Liebert, inc, 2024) Akbari, Negarin; Mutlu, Birsen; Khoddam, Homeira
Background: Preterm infants in the neonatal intensive care unit (NICU) frequently undergo painful procedures, which can lead to both short-term and long-term complications, including potential mortality. Effective pain management is crucial in this context. Although numerous studies have explored non-pharmacological pain relief methods for preterm infants, no research has simultaneously compared the effects of maternal breast milk odor, facilitated tucking, and nonnutritive sucking. Aim: This study aims to comparatively investigate the efficacy of nonnutritive sucking, facilitated tucking, and maternal breast milk odor in reducing pain in preterm neonates during heel sticks. Methods: A randomized controlled trial was conducted in a tertiary-level NICU with 144 preterm neonates (gestational age 31-36 weeks) requiring heel sticks. The infants were randomly assigned to four groups: control, nonnutritive sucking, facilitated tucking, and maternal breast milk odor. Pain and physiological parameters were assessed through video recordings of the procedures and scored at 1-minute intervals using the Premature Infant Pain Profile and Data Evaluation Form. Data were collected at baseline and at 1, 2, and 3 minutes before, during, and after the heel stick. Results: The study found significant effects of the interventions on physiological parameters and pain (heart rate: F = 7.5, p < 0.001; oxygen saturation: F = 16.39, p < 0.001; respiratory rate: F = 6.56, p < 0.001; pain: F = 61.45, p < 0.001). Facilitated tucking resulted in significantly lower pain scores (6.61 +/- 1.44) compared with the control group (14.22 +/- 3.61), maternal breast milk odor (12.22 +/- 3.08), and nonnutritive sucking (10.41 +/- 1.71) (p < 0.001). Conclusions: All interventions demonstrated effectiveness in maintaining physiological stability and alleviating pain. Nevertheless, the intervention identified as most effective in reducing pain was facilitated tucking group.
Citation - WoS: 4
Citation - Scopus: 5
A Comprehensive Assessment of the Cholinergic-Supporting and Cognitive-Enhancing Effects of rosa Damascena Mill. (damask Rose) Essential Oil on Scopolamine-Induced Amnestic Rats
(Wiley, 2024) Terali, Kerem; Ozbeyli, Dilek; Yigit-Hanoglu, Duygu; Baser, Kemal Husnu Can; Sener, Goksel; Aykac, Asli
Introduction: Alzheimer's disease (AD) is a neurodegenerative condition characterized by gradual loss of cognitive abilities (dementia) and is a major public health problem. Here, we aimed at investigating the effects of Rosa damascena essential oil (RDEO) on learning and memory functions in a rat model of amnesia induced by scopolamine, as well as on changes in acetylcholinesterase (AChE) activity, M-1 muscarinic acetylcholine receptor (mAChR) expression, and brain-derived neurotrophic factor (BDNF) levels in the extracted brain tissues. Methods: The control, amnesia (scopolamine, 1 mg/kg/i.p.) and treatment (RDEO, 100 mu L/kg/p.o. or galantamine, 1.5 mg/kg/i.p.) groups were subjected to Morris water maze and new object recognition tests. AChE activity was assayed by ELISA, and M-1 mAChR and BDNF concentration changes were determined by western blotting. Also, using computational tools, human M-1 mAChR was modeled in an active conformation, and the major components of RDEO were docked onto this receptor. Results: According to our behavioral tests, RDEO was able to mitigate the learning and memory impairments caused by scopolamine in vivo. Our in vitro assays showed that the observed positive effects correlated well with a decrease in AChE activity and an increase in M-1 mAChR and BDNF levels in amnestic rat brains. We also demonstrated in an in silico setting that the major components of RDEO, specifically -citronellol, geraniol, and nerol, could be accommodated favorably within the allosteric binding pocket of active-state human M-1 mAChR and anchored here chiefly by hydrogen-bonding and alkyl-pi interactions. Conclusion: Our findings offer a solid experimental foundation for future RDEO-based medicinal product development for patients suffering from AD.
Consensus Paper on Candida Auris by Türkiye EKMUD, ID-IRI, THSK of Ministry of Health of the Republic of Türkiye, KLIMUD, TMC, TARD, and TYBD
(Tubitak Scientific & Technological Research Council Turkey, 2025) Agalar, Canan; Erdem, Hakan; Cag, Yasemin; Arda, Bilgin; Balik, Recep; Bastug, Aliye; Arikan Akdagli, Sevtap
Candida auris is an emerging fungal pathogen that has become a critical global health concern due to its high antifungal resistance and potential to cause nosocomial outbreaks. Since its initial identification in Japan in 2009, C. auris has spread rapidly, posing significant treatment challenges across various healthcare settings worldwide. The biofilm formation ability of C. auris enhances its resilience against disinfectants and antifungal agents, complicating infection control in healthcare environments. This consensus report was developed by a collaboration between several Turkish medical societies including the Turkish Society of Infectious Diseases and Clinical Microbiology Specialty (EKMUD), the Turkish Society of Anesthesiology and Reanimation (TARD), the Turkish Intensive Care Society (TYBD), the Infectious Diseases-International Research Initiative (ID-IRI), the Clinical Microbiology Specialist Society (KLIMUD), the Turkish Microbiology Society (TMC), and the Public Health Institution of T & uuml;rkiye (PHIT) under the Ministry of Health. The report provides a comprehensive overview of C. auris and its management, with a focus on the epidemiology, antifungal resistance mechanisms, recommendations for diagnostic and therapeutic challenges, infection control and prevention measures, and surveillance of C. auris. This consensus report aims to establish standardized diagnostic protocols, improve national surveillance systems, and promote effective infection control measures to mitigate C. auris-related health risks in T & uuml;rkiye. It also offers comprehensive national recommendations and addresses the need for interinstitutional collaboration, improve public health, and strengthen the healthcare response to this pathogen.

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