WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

Browse

Now showing 1 - 20 of 75

Citation Count: 2
Accentuated Eccentric Load Training: Traditional Set Versus Cluster Set
(Iermakov S S, 2022) Pınar, Salih; Pinar, Salih; Kaya, Selman; Antrenörlük Eğitimi Bölümü
Background and Study Aim Material and MethodsThis study aims to comparatively analyse the effects of cluster set (CS) and traditional set (TS) applications on strength and power outputs in accentuated eccentric load (AEL) training. Thirty-two amateur male football players with at least 2 years of strength training history participated in the study (Xage: 18,78 +/- 0,83 years, Xheight:166,73 +/- 8,61 cm., Xbody weight: 69,59 +/- 6,03 kg.). Participants were randomly divided into two groups: CS (n=16) and TS (n=16). In both groups, the same "AEL Training" was applied and different set models were used. Augmented eccentric load (AEL) training was performed with 3 sets of 8 repetitions, 50% concentric and 80% eccentric of 1 Repetition Maximum (1-RM) and with a fast lifting tempo. The sets were completed with 20 seconds of rest after every two repetitions in the AEL-CS group and without any rest between repetitions in the AEL-TS group, and the training sessions were performed twice a week for 4 weeks. Countermovement jump (CMJ), 50cm drop jump-reactive strenght index (DJ-RSI) test, 1-RM strenght test, 10-20-30m sprint test and Illinois Agility Test (IAT) were performed on the athletes before and after the training.ResultsWhen analysing the data obtained in this study, Skewness and Kurtosis values and Kolmogorov-Smirnov values were examined to determine homogeneity. In order to compare the pre-test and post-test averages between groups, ANOVA was used for Repeated Measures, and Sample T Test was used to compare the pre-test and post-test averages within groups. The statistical significance level was determined as p<0.05. When the groups were compared, the difference in the improvement rate averages was tested. At the end of the four-week study, drop jump-reactive strength index (DJ-RSI), countermovement jump (CMJ), Illinois Agility Test (IAT) 10-20-30m sprint values and 1-RM values were improved percentage-wise in both AEL-CS and AEL-TS groups. Between the groups, a significant difference was observed between DJ-RSI, CMJ, and 10-20-m Sprint Test results (p<0.05). When we compare the results within groups, it can be concluded that the AEL-CS group showed more improvement in terms of strength, change of direction (COD) skills and Sprint compared to the AEL-TS group.ConclusionsIn conclusion, it can be advised to use cluster set in accentuated eccentric load training in order to improve strength, Sprint and COD skills.
Citation Count: 0
Adaptation of Caregivers' Task Scale for Multiple Sclerosis To Turkish Society: Validity and Reliability Study
(Dokuz Eylul Univ inst Health Sciences, 2022) Eroğlu, Nermin; Tosun, Anil Tekeoglu; Hemşirelik Bölümü
Objectives: This study was planned and carried out methodologically to adapt the Caregiving Tasks in Multiple Sclerosis Scale (CTiMSS) to Turkish society. Methods: A methodological research. The study was conducted with caregivers of individuals with multiple sclerosis who presented to the neurology clinic of a university hospital between June 2019 and September 2020. The validity and reliability study of the Caregiving Tasks in Multiple Sclerosis Scale (CTiMSS) was performed with a total of 142 individuals, which is more than 5 times the number of items on the scale (24 items). Results: The validity of the CTiMSS was evaluated with language validity, construct validity (CFA), and content validity. The reliability coefficient of the internal consistency analysis (Cronbach's Alpha) was found to be extremely high (0.97). Item-total correlation of the scale was examined, and accordingly, no items were removed from the scale. The scale was administered to 30 patients at a two-week interval to analyze test-retest reliability and time-dependent invariance. Conclusion: The CTiMSS, which was adapted to Turkish society to evaluate the tasks of individuals providing care for individuals with multiple sclerosis, is a valid and reliable tool. We recommend that it should be administered to different groups and cultures to increase its evidence value. CTiMSS is an appropriate measurement tool to determine the duties of caregivers of individuals with multiple sclerosis.
Citation Count: 3
Analysis for Two-Dimensional Inverse Quasilinear Parabolic Problem by Fourier Method
(Taylor & Francis Ltd, 2021) Kanca, Fatma; Baglan, Irem; Bilgisayar Mühendisliği Bölümü
In this work, two-dimensional inverse quasi-linear parabolic problem with periodic boundary and integral overdetermination conditions is investigated. The formal solution is obtained by the Fourier approximation. Under some natural regularity and consistency conditions on the input data,the existence, uniqueness and continuously dependence upon the data of the solution are proved by iteration method. The inverse problem is first examined by linearization and then used implicit finite difference scheme for the numerical solution. Also predictor corrector method is considered in the numerical approach. Some results on the numerical solution with two examples are presented with figures and tables. The sensitivity of the scheme with respect to noisy overdetermination data is illustrated.
Citation Count: 0
Analysis of Selected Steroid Hormones in Sea of Marmara Sediment Samples by Lc-esi/Ms-ms
(Istanbul Univ, Fac Pharmacy, 2023) Yurdun, Türkan; Yurdun, Turkan; Eczacılık Meslek Bilimleri Bölümü
Background and Aims: Sediment is the general name given to the muddy structure located at the bottom of aquatic environments such as the sea. In our study, the amounts of steroid hormones were investigated in the sediment samples taken from the Marmara Sea. According to other studies, it has been determined that the excess of the hormone load in the sediments may be an indicator of human/animal sourced pollution, as well as the negative effects of the hormones mixed in the seas with the ecological cycle on the health of humans and animals.Methods: In our study, 31 selected human/animal, plant, natural and synthetic hormone-steroids were studied using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI/MS-MS). Methanol and QuEChERS were used as extraction methods. Sediment samples were taken from a total of 27 points selected for sampling at the Marmara Sea.Results: According to the results we found, the androgens: androsterone (24.50-1718.18 ng g-1), testosterone (86.30-1600.32 ng g-1); the estrogens: mestranol (33.73-228.32 ng g-1), equilin (53.44-1232.53 ng g-1); the progestagens; pregnenolone (37.50374.76 ng g-1), progesterone (39.96-405.60 ng g-1); levonorgestrel (325.25 and 937.93 ng g-1); the fecal sterols: cholestanone (57.57-1726.32 ng g-1), coprostanol + epicoprostanol (51.43-1370.33 ng g-1); and the plant sterol; campesterol (35.30-1859.90 ng g-1) were the compounds detected.Conclusion: Estrogens and progestogens are active components of birth control pills, and cholestanone and coprostanol + epicoprostanol are steroids that are indicative of human/animal pollution. Coprostanol + epicoprostanol and cholestanone, which are indicators of fecal pollution, were detected in all sediment samples. In our study, steroid hormones were detected for the first time in Sea of Marmara sediments and possible environmental risks were evaluated.
Citation Count: 1
An Analysis of the Gross Motor Skills of Children Aged 3-6 Years With Autism Spectrum Disorder in Comparison With Their Typically Developing Peers
(Sagamore Publishing Llc, 2023) Pınar, Salih; Ozer, Dilara; Pinar, Salih; Antrenörlük Eğitimi Bölümü
The aim of this study is to examine the motor skill levels of children aged 3-6 years with Autism spectrum dis-order (ASD) in comparison with their typically devel-oping (TD) peers and to reveal their needs for motor support programs. The research group consisted of 88 participants aged 3-6 years, including 43 children (40 boys and 3 girls) diagnosed with ASD attending spe-cial education and rehabilitation institutions, and 45 TD children (23 boys and 22 girls) receiving pre-school education in a private institution (ASD=57.4 months, +/- 9.32 - TD=59.06 months, +/- 8.61). The Peabody Devel-opmental Motor Scale-2 (PDMS-2) and the Turkish Ver-sion of the Gilliam Autism Rating Scale-2 (GARS-2-TV) were used as data-collection tools in the study. The Mann-Whitney U test was used for the two-group com-parisons of the parameters that did not exhibit normal distribution in the analysis of the data. The Spearman correlation analysis was applied to determine the relationship between the variables. The significance was evaluated at the p<0.05 level. As a result of the research, the balance, locomotor and manipula-tive skills and total gross motor scores of the children with ASD were found to be lower than those of the TD children (p<0.05). In addition, it was observed that there was a significant correlation between GARS-2 -TV scores and PDMS-2 scores of the children with ASD (p<0.05).
Citation Count: 5
Apocynin Ameliorates Testicular Toxicity in High-Fat Diet-Fed Rats by Regulating Oxidative Stress
(Marmara Univ, inst Health Sciences, 2023) Şener, Göksel; Koroglu, M. Kutay; Coskunlu, Busra; Ertas, Busra; Sener, Goksel; Ercan, Feriha; Eczacılık Meslek Bilimleri Bölümü
Objective: The purpose of this study was to examine the effects of apocynin (APC), an inhibitor of NADPH oxidase (NOX), on high-fat diet (HF)induced testis cytotoxicity.Methods: Wistar albino rats were divided into three groups as control, HF and HF+APC groups. Rats in HF and HF+APC groups were fed using HF for 16 weeks and in the last four weeks of this period vehicle solution or APC (25 mg/kg) was administered orally five days a week, respectively. Control group was fed with standart lab chow for 16 weeks. Cholesterol, triglyceride, high-density lipoproteins, leptin, estrogen, testosterone, LH and FSH were estimated in blood serum. Sperm parameters were analysed from the epididymis. Testicular malondialdehyde, 8-hydroxy-2deoxyguanosine, glutathione, superoxide dismutase and myeloperoxidase levels were estimated biochemically. Testicular morphology, proliferative, apoptotic and NOX2-positive cells were analysed histologically.Results: HF-induced obesity caused significant alterations in serum lipid and hormone profiles. Testicular malondialdehyde, 8-hydroxy-2deoxyguanosine, and myeloperoxidase levels increased, glutathione and superoxide dismutase levels decreased in this group. Moreover, altered sperm parameters, increased degenerated seminiferous tubules, apoptotic and NOX2 - positive cells and decreased proliferative cells were observed in the HF group. All these biochemical and histological alterations improved in the HF+APC group.Conclusion: HF-induced obesity causes altreations in lipid values, sperm parameters and testicular morphology by increasing oxidative stress through NOX2 activity. Apocynin might prevent testis damage via regulating oxidant/antioxidant balance.
Citation Count: 2
Assessment of the Effectiveness of Patient Education and Interviews in Improving Medication Adherence of Renal Transplant Recipients
(Springernature, 2022) Akıncı Akşit, Naile; Ozbas, Ayfer; Akinci, Serkan; Hemşirelik Bölümü
Background Non-compliance with immunosuppressive drugs has been reported as the most significant cause of graft loss. Since non-compliance with immunosuppressive drugs is preventable, certain approaches based on the risk factors and causes of non-compliance can help eliminate this problem. Aims The purpose of this study is to assess the effectiveness of patient education and interviews in improving medication adherence of renal-transplant recipients. Materials and methods This study was designed as a randomized controlled trial. Using the G*Power program, the sample size was calculated as 60 subjects, with 30 in both the intervention group and control group. Data collection tools included a patient information form, a pretest-posttest, a drug monitoring form for kidney transplant patients, the Immunosuppressive Therapy Adherence Scale, measurement of tacrolimus blood levels, and a training booklet. Results The mean knowledge score in the intervention group was 12.17 +/- 3.39 at baseline, and it increased to 20.73 +/- 1.57 after the intervention. The mean scores on the Immunosuppressant Therapy Adherence Scale were 11.67 +/- 0.55 and 10.70 +/- 0.99 in the intervention group and control group, respectively. There was a statistically significant difference between the pre- test and post-test means on the Immunosuppressant Therapy Adherence Scale in the intervention group. The mean Immunosuppressant Therapy Adherence Scale score was higher in the intervention group. In the measurement of tacrolimus blood levels, medication adherence was found the be higher in the intervention group. The difference between the groups was statistically significant. There was a positive correlation between the tacrolimus blood levels and the Immunosuppressant Therapy Adherence Scale scores in both groups. Conclusions To conclude, our results have demonstrated that patient education and interviews improve immunosuppressant medication adherence in renal transplant recipients. Using direct or indirect methods proved similar outcomes, suggesting that both evaluation methods are safe.
Citation Count: 1
Chatgpt as a Solution To Emotional Loneliness: a New Tool for Interpersonal Communication
(Marmara Univ, Fac Communication, 2024) Sarioglu, Elif Basak; Guregen, Esra Pelin
Loneliness stands as one of the most pervasive and universal health issues in contemporary society. This study, conducted within the scope of emotional loneliness, delves into the nuances of loneliness, understanding its origin and how it manifests in individuals. In the research where students from the Faculty of Communication of a foundation university in Istanbul were chosen as the sample, the data collected through in-depth interviews, a qualitative data collection tool, were analyzed using content analysis method. This phenomenological research design aimed to assess participants' attitudes toward utilizing a chatbot (ChatGPT) as a tool to combat emotional loneliness. Despite their generally positive disposition and strong tendency to anthropomorphize, participants were found to approach the use of ChatGPT with caution. The majority harbored negative judgments about ChatGPT and technological tools meeting emotional and social needs. However, a significant portion believes that the widespread adoption of ChatGPT and similar tools for socialization is imminent in the near future. Concerns predominantly revolve around mistrust in artificial intelligence technologies' ability to meet emotional needs and the potential harms they could inflict on socio-cultural life, with ethical issues forming another major theme. Notably, when expressing their apprehensions, participants frequently referenced artificial intelligence representations in popular culture, such as films, series, and games.
Citation Count: 2
Data Mining the City: User Demands Through Social Media
(Konya Technical Univ, Fac Architecture & design, 2021) Levent, Vecdi Emre; Levent, Vecdi Emre; Bilgisayar Mühendisliği Bölümü
Purpose Information technologies are commonly used in architectural and urban design. The use of these technologies providing support at every stage of the design opens up different perspectives for designers and users. The aim of the study is to obtain user demands for green spaces of a specific district by mining data through social media and to detect the actual green spaces of the same district using applications developed for this purpose. User demands for design decisions and applications of green spaces and the current situation of the study area are evaluated. Design/Methodology/Approach The research is firstly realized through social media, and data obtained from Twitter is analysed in order to evaluate user demands for parks and green spaces of Atasehir district in Istanbul City. Secondly, all green areas in the same district are detected by using digital maps. Two applications are specifically designed for this research; Tweet Grabber is used for user sentiment analysis on social media and Map Grabber is processed for extraction of green spaces via maps. The total area of the green spaces is compared with the desired area of open and green spaces per user. Findings The user demands and thoughts obtained in the study about the green spaces of the district are compatible with the actual situation of green spaces. It is observed that the users are mostly dissatisfied with the adequacy of green spaces. Designers, politicians, municipalities and all stakeholders can benefit from the obtained user expectations and feedback. Interpreting user demands by mining data through social media enables user participation in design decisions. This research method can be supportive and adaptive in related issues of design for the cities, enabling user participation in architectural and urban design. Research Limitations/Implications Parks and green spaces of Atasehir district of Istanbul are taken as a case study. Twitter is chosen for mining of data in social media based on parameters such as keywords and location. Social/Practical Implications The impact and support of users in design decisions can be clearly demonstrated by advanced information technologies. Mining data through social media and developed applications will contribute to design decisions and policies for architectural and urban spaces. Originality/Value Tweet Grabber and Map Grabber applications are developed for this research in order to get text based and image based data. The research includes a unique case study for mining data through social media on a specific design issue and target location.
Citation Count: 1
Design and Development of a New Tactile Stimulator
(Ieee, 2019) Levent, Vecdi Emre; Levent, Vecdi Emre; Aydin, Nizamettin; Bilgisayar Mühendisliği Bölümü
We have designed and implement a tactile stimulator to obtain information from the central nervous system. Our system consists of two main components. The first one is tactile stimulator, which was designed to stimulate index and middle finger tips, stimulating mechanoreceptors according to the test protocol. Second one is a personal computer running a desktop software for the implementation of test protocols. The flow is as follows; the subjects are asked the question of the test protocol through the personal computer. The parameters are then transmitted to the embedded board on the machine. The embedded board drives step motors to apply the relevant test parameters. The desktop software expects the individual to answer the question using the right or the left mouse button of the computer mouse. After answering the relevant question, the test proceeds to the next step. According to the test protocol, the stimulation process of the mechanoreceptors located at the index and middle finger tips must start and terminate at the same time. From this perspective, the embedded board with 3 18F46K22 PIC microcontrollers produces 2 square wave signals with different frequencies and amplitudes at the same time. The embedded system card developed with the PIC microcontroller is also developed with FPGA. The system has also been tested on 24 blue and white collar employees and a significant result has been obtained.
Citation Count: 0
Design Process and Digital Storytelling on the Axis of Similarities and Differences
(Anadolu Univ, 2023) Yıldırım Coruk, İpek; İç Mimarlık Ve Çevre Tasarımı Bölümü
The design process, which expresses the act of designing in line with a thought and the steps that make up the product resulting from this action, constitutes the essence of design education studio environments. The methods and thought approaches that can be followed in this process are always among the issues questioned. With the study, this issue is approached through digital stories. The fact that digital storytelling, which is a lot of research in terms of its contributions in education-related fields, hasn't yet taken place sufficiently in the field of design education constitutes the starting point of the study. So, the study created with qualitative research method aims to raise awareness of the space design education literature on digital storytelling. In order to gain this awareness, the similarities and differences of the digital storytelling and design process has analyzed. The study determined that the design process and digital storytelling intersect with aspects of making implicit information visible, occurring in line with a problem or starting point, and including similar process stages. However, differences exist between these two concepts. This result provides a theoretical framework for those who want to benefit from digital storytelling.
Citation Count: 0
Determining the Effects of Nasopharyngeal Suction With Negative and Positive Pressure: Randomised Controlled Trial
(Marmara Univ, inst Health Sciences, 2024) Kökkız, Rukiye; Okuroglu, Guelten Karahan; Ustun, Nuran; Tıbbi Hizmetler ve Teknikler Bölümü
Objective: The study aims to determine the effects of nasopharyngeal suction with negative and positive pressure on pain level, respiratory parameters, and mucosal irritation in infants. Methods: This study was conducted as a posttest randomized controlled experimental research. The data was collected at G & ouml;ztepe Training and Research Hospital between January and November 2020. While the positive pressure suction method was applied to the experimental group, the negative pressure suction method was applied to the control group. Results: It is determined that the pain level mean scores at the 1 st and 5 th minutes after the suction procedure are lower in the experimental group than in the control group (p=0.01). p =0.01). SpO2 values at the 1st, st , 5th, th , and 15th th minutes after the procedure are significantly higher in the experimental group than in the control group (p=0.01). p =0.01). There is no statistically significant difference in the respiratory rate values between experimental and control groups (p>0.05). p >0.05). Conclusion: It is determined that the post-procedure pain level is lower and the SpO2 value is higher in the experimental group (positive pressure suction) compared to the control group (negative pressure suction). Both methods do not cause mucosal irritation, as well.
Citation Count: 0
Determining the Type 2 Diabetes Risks and Healthy Lifestyle Behaviors of First Year University Students (vol 6, Pg 420, 2022)
(Dokuz Eylul Univ inst Health Sciences, 2023) Eroğlu, Nermin; Temiz, Gamze; Hemşirelik Bölümü
[No Abstract Available]
Citation Count: 0
Digital Travel Memories: a Comparison of Physical and Online Travel Experiences in the Terms of Recollection
(Marmara Univ, Fac Communication, 2022) Kesen, Tolga Berkay; Eyrek Keskin, Aysun; Spor Yöneticiliği Bölümü; Yeni Medya ve İletişim Bölümü
The study aims to undertake a comparison of physical and online travel experiences in terms of their recollection and the differences between each experience. Digitalization of travel is explained as visiting a place virtually by means of digital devices instead of visiting it physically. In the first part of the research, in which both qualitative and quantitative research methods were used, the viewer comments written under two most-viewed walking tour videos on YouTube were examined by using sentiment and text analysis which are among the social network analysis methods. In the second of the research, focus groups study are conducted with qualitative and experimental design. The focus groups consist of participants who visited the two cities (selected as sample) either physically (control groups) or online (experimental group). In the sentiment analysis, it was concluded that the positive and neutral sentiment expressions were higher than negative expressions, and in the text analysis individuals approached the online walking tours as a travel experience., In the focus groups research, it was observed that the use of natural sounds, the high visual quality in the videos are effective on individual's recollection of their travel in the online travel experiences. The content of the memories of physical travel experiences is usually about human interactivity and social life. In both travel experiences, it was determined that the information obtained by the individuals about the place through the media strengthens the recall of the images of their travel experiences.
Citation Count: 2
Digitalization of Memories - an Analysis Relationship Between Autobiographical Memory and Digital Photography
(Univ Ss Cyril & Methodius Trnava, Fac Mass Media Communication, 2020) Eyrek Keskin, Aysun; Yeni Medya ve İletişim Bölümü
Photography has been used as a mnemonic since its early years. It has the power to move the past to the present by breaking down the structure of time. Presenting a static image, it records an image of a past time. Looking through family and childhood photo albums, the person embarks on a journey through the past in his/her memory. Following digitalization, the function of photography has been changed in accordance with the transformation of it from analogue to digital. Photography is not only a mnemonic but also contains the function of the enjoyment of individuals, creating self, self-presenting to others. In terms of storage, screening and sharing, digital photography is more convenient and accessible than analogue photography. For these reasons, people's interest in digital photography has been rising and it encourages taking/recording images at the moments that will create their memories in the years ahead. The aim of this paper is to examine the relationship between autobiographical memory (contains information about individual experiences, memories) and forgetting/remembering between digital photography. The nature of the subject required the use of both qualitative and theoretical analysis of the participants' social media usage. The research data was collected conducting semi-structured interviews with participants who shared their images about individual lives and memories on social media. In addition, benefiting from the observation technique, the participants were requested to look at both printed and digital photo albums and asked if they remember the corresponding memories. The theoretical insights are based on critical theory. The studies reveal that memories become digital and affect memory due to rising motivation to take and share pictures on the social media.
Citation Count: 0
The Effect of Different Body Mass Index Levels on Static and Dynamic Postural Balance Performance in Adults
(Dokuz Eylul Univ inst Health Sciences, 2023) Uğur Canöz, Ekin; Selcuk, Halit; Canoz, Ekin Ugur; Kortelli, Onur Salman; Demirbuken, Ilksan; Polat, Mine Gulden; Terapi ve Rehabilitasyon Bölümü
Purpose: It was aimed to estimate the static and dynamic postural balance performance in adults with different Body Mass Index (BMI) levels. Material and Methods: The study was conducted in uskudar Diabetes and Obesity Treatment Center between September and October 2021. Participants were divided into 5 groups according to BMI scores: normal-weight, overweight, 1st degree obese, 2nd degree obese, and 3rd degree obese. In addition, participants' static and dynamic balance performance were assessed by the Limits of Stability (LOS) and modified Clinical Test of Sensory Integration of Balance (m-CTSIB) tests. Results: For LOS parameters, there was a significant difference between groups in reaction time scores only for the backward direction (p<0.05). The endpoint and maximum excursion measurements except for the backward and directional control measurements except for the back and right were significantly different between groups, with the worst scores for 3rd degree obese group (p<0.05). For the m-CTSIB test, there was a significant difference between groups in all parameters except the eyes open condition on foam surface (p<0.05). Conclusion: The 3rd degree obese individuals are the most affected subgroup in dynamic balance. We recommended that rehabilitation and fall prevention programs primarily focus on 3rd degree obese individuals.
Citation Count: 4
Effect of Flurbiprofen Derivative (sgk597) on Cell Proliferation and Apoptosis of Breast Cancer Cell Lines
(Istanbul Univ, Fac Pharmacy, 2022) Küçükgüzel, Şükriye Güniz; Sevinc, Sevgi Kocyigit; Orun, Oya; Yilmaz, Ozgur; Kucukguzel, S. Guniz; Tiber, Pinar Mega; Eczacılık Meslek Bilimleri Bölümü
Background and Aims: The incidence of breast cancer is increasing day by day, especially in women. The search for new drugs against breast cancer is the focus of attention in research. Breast cancer and prostate cancer have remarkable biological similarities. Therefore, the 4-(4-chlorophenyl)-3-(1-(2-fluoro-[1,1'-biphenyl]-4-yl)ethyl)-5-((4-fluorobenzyl)thio)-4H-1,2,4-triazole (SGK597) compound that is suppressing cell proliferation in prostate cancer, was studied in MCF-7 breast can-cer and MCF-10A mammary epithelial cell lines. Methods: The WST-8 method was used to determine cell viability and cytotoxicity of SGK597 in MCF-7 and MCF10-A cell lines. The JC-1 test was applied to determine changes in mitochondrial membrane potential. The protein expression levels of Bax, Bcl-2, and c-PARP associated with apoptosis were determined using Western blot analysis.Results: After 24 and 48 hours of incubation of SGK597, the IC50 values were 28.74 pM and 17.28 pM for MCF-7; 65.9 pM and 50.5 pM for MCF-10A, respectively. Mitochondrial membrane potential showed a tendency toward depolarization in MCF-7 cells as a result of increasing concentration of SGK597, while the same tendency was not seen for MCF-10A. As a result of western blot experiments, no increase in the Bax/Bcl-2 ratio and c-PARP expression level was observed, indicating no apoptosis.Conclusion: It was observed that the compound SGK597 suppressed MCF-7 cell proliferation. These results indicate that SGK597 may be a candidate compound for use as an anticancer agent. Keywords: Apoptosis, breast cancer, flurbiprofen, thioether, triazole
Citation Count: 2
Effect of Multileaf Collimator Leaf Position Error Determined by Picket Fence Test on Gamma Index Value in Patient-Specific Quality Assurance of Volumetric-Modulated Arc Therapy Plans
(Springernature, 2021) Şahin, Sevim; Inal, Serpil Yondem; Senol, Elif; Yilmaz, Berrin; Sahin, Sevim; Elektrik-elektronik Mühendisliği Bölümü
Aim The correlation between the MLC QA (IBA Dosimetry, Germany) results of the picket fence test created with intentional errors and the patient's quality assurance (QA) evaluation was investigated to assess the impact of multileaf collimator (MLC) positioning error on patient QA. Materials and methods The picket fence, including error-free and intentional MLC errors, defined in Bank In, Bank Out, and Bank Both were analyzed using MLC QA. The QA of 15 plans consisting of stereotactic radiosurgery (SRS), stereotactic body radiotherapy (SBRT), and conventionally fractionated volumetric-modulated arc therapy (VMAT) acquired with electronic portal imaging devices (EPID) was evaluated in the presence of error-free and MLC errors. The QA of plans were analyzed with 2%/2 mm and 3%/3 mm criteria. Results The passing rates of the picket fence test were 97%, 92%, 91%, and 87% for error-free and intentional errors. The criterion of 3%/3 mm wasn't able to detect an MLC error for either SRS/SBRT or conventionally fractionated VMAT. The criterion of 2%/2mm was more sensitive to detect MLC error for the conventionally fractionated VMAT than SRS/SBRT. While only two of SBRT plans had <90%, four of conventionally fractionated VMAT plans had a <90% passing rate. Conclusion We found that the systematic MLC positioning errors defined with picket fence have a smaller but measurable impact on SRS/SBRT than the VMAT plan for a conventionally fractionated and relatively complex plan such as head and neck and endometrium cases.
Citation Count: 0
Effect of Pilates Exercises on the Body Composition of Fasting Females
(Galenos Publ House, 2022) Sevdin, Sezen; Kermen, Seda; Sevdin, Sezen; Ersin, Aybuke; Guclu, Duygu; Beslenme ve Diyetetik Bölümü
Objective: This study aimed to evaluate the changes in the body composition of individuals who fasted and did Pilates at least twice a week during Ramadan versus those who fasted but did no Pilates. Methods: This was an experimental study conducted on 60 healthy women who were admitted to the Noi Pilates in Istanbul Turkey, which was a private Pilates studio. The study was carried out on 60 grown-up, healthy women between 18 and 65 years of age who fasted in Ramadan 2019, some of whom did Pilates and some who did not. The women involved in the study had been doing Pilates for 6 months prior to Ramadan and did Pilates at least 3 times a week during Ramadan. Results: Significant increases were observed in body mass index (BMI), triceps skin-fold thickness (SFT), muscle mass and fat percentage in the fasting and non-pilates group (p<0.05). Our study found the change in the percentage of triceps SFT and fat in women who did Pilates to be more than those who did not. BMI, muscle mass, waist circumference and hip circumference of women who did Pilates and who did not do Pilates during Ramadan did not differ compared to the first measurements, and neither of the two methods dominated in terms of these variables. Conclusion: While a long period of fasting in Ramadan leads people to inactivity, personalized exercise and nutrition programs planned by experts may result in weight loss, especially for obese and slightly overweight people.
Citation Count: 0
The Effect of Training on Stress and Coping With Stress in Patients Receiving Infertility Treatment
(Cukurova Univ, Fac Medicine, 2020) Eroğlu, Nermin; Temiz, Gamze; Hemşirelik Bölümü
Purpose: This study was planned and applied semi-experimentally to examine the effect of education given to patients receiving infertility treatment on stress and coping with stress. Materials and Methods: The study is semi-experimental. It was held between May 2017 and January 2018 with individuals who applied to a foundation hospital in Istanbul province for IVF treatment. The sample was made up of 40 infertile individuals. The data were collected by the researcher through face-to-face interview method. Training was given after pretesting. Post-test was performed one month after the training. Results: The pre-education stress scale of middle school graduates of infertile women was higher, this difference disappeared after education, and there was a statistically significant difference between the infertility stress and coping scale subscale mean scores. As the use of active ignoring, active struggling and passive ignoring coping methods of women, the use of the methods of coping with the infertility subscale scores increased, the infertility stress subscale scores increased.. Conclusion: In this study, the relationship between infertility and stress research was investigated and it was concluded that the treatment process and results are an important source of stress in patients. According to the results obtained, it is recommended to determine the stress level and methods of coping with stress, and provide training and counseling on patients who apply to the hospital for infertility treatment.

Browse

Browsing WoS İndeksli Yayınlar Koleksiyonu by Scopus Q "N/A"