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Citation - WoS: 2
Citation - Scopus: 2
Adsorption Mechanisms, Kinetics and Photoactivities of Green Synthesized Hydroxyapatite Supported Zno and La-Zno Catalysts
(Pergamon-elsevier Science Ltd, 2024) Tuncel Turan, Duygu; Okte, A. Neren; Temel Eczacılık Bilimleri Bölümü
In this study, hydroxyapatite (HAP) is synthesized by a co-precipitation method from the waste eggshell, utilized as a support for ZnO (ZnO-HAP) and La-ZnO (La-ZnO-HAP) and employed to degrade methyl orange (MO) and methylene blue (MB) dyes under UV irradiation. Water vapor adsorption as relative humidity (84 % RH) on the HAP structure and the as-prepared catalysts are also examined. The characteristic ZnO and HAP reflections are detected in X-ray diffraction (XRD) analysis of ZnO-HAP, La-ZnO-HAP and humidified samples. ZnO and La-ZnO existence is also verified by scanning electron microscopy-energy dispersive X-ray (SEM-EDX) analysis, UV-Vis diffuse reflectance (UV-Vis DRS) spectra and X-ray photoelectron spectra (XPS). ZnO and La-ZnO loading on the HAP induce the formation of mesoporous structures with high surface areas. Dark adsorption capacities and photoactivities of the as-prepared samples are explored regarding electrostatic interactions, Lewis acid-base interactions and hydrogen bonding for both MO and MB. In particular, La-ZnO-HAP 500 degrees C and La-ZnO-HAP 500 degrees C (RH) exhibit improved adsorption abilities and photoactivities. The pseudo-second order model describes the kinetic behavior of all samples under dark conditions. Unhumidified samples follow Langmuir isotherm while Freundlich isotherm better fits humidified ones. Under irradiation, the Langmuir-Hinshelwood kinetic model describes the photoactivities of all samples. The four recycling tests confirm the stabilities of HAP 100 degrees C, HAP 500 degrees C, ZnO-HAP 500 degrees C and La-ZnO-HAP 500 degrees C. This study suggests that the ZnO or La-ZnO loaded HAP catalysts prepared in the presence and absence of humid conditions are considered promising materials for environmental remediation.
Citation - WoS: 1
Citation - Scopus: 1
Analysis of Substance Use and Mental Disorder Diagnoses in Adolescents With a History of Delinquency: a Cross-Sectional Study
(Springer, 2024) Dikeç, Gül; Dikec, Gul; Tas Soylu, Gulsenay; Bilac, Oznur; Uzunoglu, Gulcin; Ayakdas Dagli, Dilek; Hemşirelik Bölümü
This study aimed to evaluate substance use and comorbid mental disorders in delinquent adolescents presenting to a child and adolescent psychiatry outpatient clinic. This study included 47 adolescents aged 15-18 years and had a history of delinquency. Data were collected using the Addiction Profile Index Adolescent Form (API-A) and an information form. Results indicated that the adolescents' mean age is 16.11 +/- 1.05 years, 78.7% had committed crimes against property and 34.0% against the person, and 34.0% were also victims of crime. Mean API-A total scores indicated that their level of substance use was low. In addition, mean API-A total scores showed significant differences according to the adolescents' migration status, age, economic status, school attendance, mental disorder diagnosis, duration of mental disorder, and type of offense (p < 0.05). The benefit provided by timely and appropriate psychosocial interventions may have a key role in solving this problem for adolescents and improving their future as adults.
Citation - WoS: 9
Citation - Scopus: 8
Antibiotic Use and Influencing Factors Among Hospitalized Patients With Covid-19: a Multicenter Point-Prevalence Study From Turkey
(Galenos Publ House, 2022) Ağalar, Canan; Cag, Yasemin; Karabay, Oguz; Kurtaran, Behice; Guclu, Ertugrul; Ogutlu, Aziz; Agalar, Canan; Tıbbi Hizmetler ve Teknikler Bölümü
Background: Broad-spectrum empirical antimicrobials arc frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective. and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age +/- standard deviation of the patients was 65.0 +/- 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (372%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005). presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein >10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p <0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings.
Citation - WoS: 1
Citation - Scopus: 1
Are Child and Parent Health Behaviors Associated With Childhood Obesity? a Descriptive and Methodological Study
(Elsevier Science inc, 2023) Öztürk, Gizem; Kolcu, Merve; Hemşirelik Bölümü
Purpose: This study was conducted to determine the relationship between child and parents' health behaviors and childhood obesity. In addition, an adaptation of the Turkish version of the Family Health Behavior Scale (FHBS) was performed in this study.Design and methods: This is a descriptive and methodological study. The research sample consisted of 358 parents who have a child between the ages of 5 and 12 studying in one of the seven state schools at the kindergarten, primary, and secondary school levels in Istanbul. Data were collected between February 2022 to May 2022 using the Parent and Child Descriptive Information Form, the Family Nutrition and Physical Activity (FNPA) Screening Tool, and the FHBS. IBM SPSS 25.0 (IBM, Armonk, NY, USA) and SPSS AMOS 21.0 software were used to analyze the data.Results: It was found that the confirmatory factor analysis result of FHBS confirmed the original structure of the scale, and Cronbach's Alpha coefficient was calculated as 0.80. A positive correlation was found between the parents' total scores of FNPA and FHBS (r:0.511, p < 0.001).Conclusions: It is recommended to evaluate the child and their parents holistically in preventing and managing childhood obesity. School health nurses should plan family-centered interventions to improve health behaviors and carry out these interventions with a multidisciplinary team. Moreover, it has been determined that FHBS is a valid and reliable measurement tool for the Turkish population.
Assessment of Cross-Cultural Adaptations and Patient-Reported Outcome Measures Relevant To Shoulder Disorders in Turkish: a Systematic Review Using the Cosmin Methodology
(Public Library Science, 2025) Isiklar, Cagdas; Sirma, Gamze Cagla; Turgut, Elif
Background There are many shoulder assessment outcome measures in the literature that have been studied for validity and reliability. However, there is no study examining the Turkish-adapted patient outcome measures (PROMs) on the shoulder according to the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) checklist. In addition, there is a small number of studies that carry out this examination on the shoulder internationally. Determining the most appropriate questionnaires for clinical use will also be an important guide in patient evaluation by filling the gap in both literature and clinical aspects.Objective Our aim in this study is to identify the valid and reliable Turkish scales used to evaluate shoulder pain and disability, to reveal how compatible these scales are with the aspects of study quality and psychometric quality according to COSMIN criteria list.Methods A systematic search was performed in the following electronic databases: MED-LINE, Web of Science (WOS), EMBASE, SCOPUS, and ULAKBIM were searched from inception to September 2024.Results A total of 2890 articles were found in the databases. Four articles were included additionally without a search. Then, after eliminating the duplicates, 2231 articles were included based on the title and abstract search. 63 articles were included in full-text review. After the full-text review, according to our criteria, 29 articles were included in the systematic review. According to the assessment by the COSMIN checklist, 28 articles received the final classification of "inadequate". Only 1 article (UCLA-Tr) received the final classification of "adequate".Conclusion There is a wide range of Turkish PROMs available for the shoulder, with only one fully meeting COSMIN methodology criteria. However, this does not imply that other PROMs lack clinical utility. Future studies should focus on refining PROMs by incorporating MCID and PASS scores and prioritizing their responsiveness to enhance their clinical relevance. Additionally, variations in PROM performance across different patient populations highlight the need for context-specific evaluations to ensure their applicability in diverse clinical settings.Trial registration PROSPERO registration number: CRD42022298425.
The Association of Exhaled Nitric Oxide Level With Respiratory Muscle Strength, Pulmonary Function, Exercise Capacity, Sleep Quality, Functional Status, and Health-Related Quality of Life in Patients With Pulmonary Arterial Hypertension
(Amer Thoracic Soc, 2025) Naci, B.; Demir, R.; Onder, O. O.; Sinan, U.; Kucukoglu, M.
A Bibliometric Analysis of Refugee Health Publications in the Nursing Field by Visual Mapping Method
(Cambridge Univ Press, 2024) Dikeç, Gül; Dikec, G.; Seren, A. K. H.; Hemşirelik Bölümü
[No Abstract Available]
Can Financial Transactions Reveal the Change in Social Fabric Triggered by Urban Regeneration?
(Elsevier Sci Ltd, 2024) Özbay Daş, Zühal; Dass, Zuhal Ozbay; Ozbay, Ayse Elif Ozsoy; Bozkaya, Burcin; Balcisoy, Selim; Ekonomi ve Finans Bölümü
In this study, we aimed to investigate the relationship between single-building scaled urban regeneration, driven by the Disaster Risk Transformation Law, and urban segregation in Maltepe district. Following stricter building codes, the district underwent significant demolition and construction between 2014 and 2015. We employ construction data and credit card transaction data to analyze the demographic changes. We find that urban regeneration due to building renewal may have diverse context-dependent effects on the demographic tapestry of communities, their culture and history. While some neighborhoods showed positive response to increased local amenities and resulted in reduced mobility outside their local area, leading to greater income segregation from the rest of the city, others behaved in the opposite direction. Similarly, the transformation process has attracted a more educated and higher-income inflow of residents in some neighborhoods compared to others. Herein, we employ new big data and mobility-driven metrics from computational social science such as diversity, loyalty and assortativity to reveal the link between urban regeneration and segregation. Our findings provide important clues and insights to urban planners for developing urban policies leading to neighborhood designs that are more connected to each other (hence reducing segregation) while still offering modern amenities expected by their residents.
Citation - WoS: 1
Citation - Scopus: 1
Can Manual Therapy Alter Muscle Stiffness in Patients With Spinal Accessory Nerve Injury
(Wiley, 2025) Simsek, Ferhat; Naci, Baha; Kilicoglu, Meltem Bozaci; Alkan, Zeynep; Topcuoglu, Osman Melih; Gormez, Aysegul; Okyar, Ali Fethi
Objective. Shoulder and neck dysfunctions resulting from spinal accessory nerve injury impair quality of life. This study aims to investigate the effects of manual therapy in combination with standard physiotherapy on the mechanical properties of muscle, neck and shoulder function, pain, and quality of life in head and neck cancer patients. Study Design. Prospective, randomized, controlled, double-blind clinical trial. Setting. Department of Otorhinolaryngology Head and Neck Surgery of a university hospital. Methods. A total of 26 participants were randomized into two groups. The control group (n = 11) received standard physiotherapy including therapeutic exercises, scar tissue massage, and education. The intervention group (n = 10) received manual therapy consisting of soft tissue, myofascial release, and mobilization techniques in combination with standard physiotherapy. Outcome measures were mechanical properties of muscle, neck and shoulder active range of motion, shoulder pain and disability, and quality of life. Results. Upper trapezius and sternocleidomastoid muscle stiffness increased significantly in the control group (P < .01), whereas a significant reduction was observed in the intervention group compared to the control group (P = .001). A reduction in muscle thickness was observed bilaterally in both groups (P < .01). Moreover, all participants showed improvements in neck and shoulder active range of motion, shoulder pain, and quality of life (P < .01). Conclusion. Manual therapy in addition to standard physiotherapy was more effective in improving neck and shoulder function, quality of life, and reducing muscle stiffness compared to standard physiotherapy alone. Therefore, clinicians should consider incorporating manual therapy into their treatment protocols to optimize patient outcomes.
Coach Candidates' and Coaches' Nutrition Knowledge Affects Dietary Recommendations Indirectly: Mediator Effects of Self-Efficacy
(Mdpi, 2025) Altinok, Oyku; Bas, Murat
Background/Objectives: The nutritional knowledge and behavior of athletes are considerably influenced by the dietary recommendations of their coaches, which, in turn, affect their health and performance. In the context of social cognitive theory, this study examines the impact of general and sports nutrition knowledge (GeSNK), nutrition self-efficacy (NSE), and nutrition counseling self-efficacy (NCSE) on the dietary recommendations (DRs) provided by coach candidates and coaches (CC&Cs). Additionally, it explores variations in GeSNK, NSE, and NCSE among CC&Cs based on their sports positions, genders, and types of sports. Methods: This study included 70 coach candidates and 102 coaches, with data collected via validated scales for GeSNK, NSE, and NCSE. Using the PROCESS macro, the serial multiple mediator model was applied, and group comparisons were conducted via the Mann-Whitney U test. Results: The results revealed that 36% of participants achieved adequate GeSNK scores, but only 6.4% abstained from providing DRs. Participants engaged in individual sports exhibited higher NSE and NCSE scores than those involved in team sports. Additionally, 22.7% of CC&Cs identified their former coaches as a primary source of nutrition information. The study findings revealed that GeSNK, NSE, and NCSE significantly influenced DRs, collectively accounting for 23% of the variance in DRs. The direct effect of NCSE on DRs was statistically significant, whereas the direct effects of GeSNK and NSE were not significant. GeSNK and NSE jointly explained only 41% of the variance in NCSE, suggesting that additional factors influencing NCSE and DRs remain unexplored. Conclusions: To address the issue of inadequate dietary recommendations stemming from insufficient information, it is crucial to identify and understand these additional factors affecting NCSE and DRs. Diversifying nutrition education programs to enhance the nutrition knowledge of CC&Cs is essential. Furthermore, fostering collaboration between CC&Cs and nutritionists can ensure that athletes receive accurate and comprehensive nutritional guidance.
Collagen Peptides and Saccharomyces Boulardii Cncm I-745 Attenuate Acetic Acid-Induced Colitis in Rats by Modulating Inflammation and Barrier Permeability
(Wiley, 2025) Altinok, Oyku; Bas, Murat; Dolanbay, Elif Gelenli; Kolgazi, Meltem; Mert, Tugay; Uslu, Unal
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent episodes of inflammation and tissue damage, with limited treatment options. This study aimed to investigate the effects of collagen peptides and Saccharomyces boulardii on acetic acid (AA)-induced colitis. Thirty-six male Sprague-Dawley rats were randomly divided into the following four groups: normal control (NC), colitis control (CC), collagen peptide (CP; 0.6 g/kg/day), and S. boulardii (SB; 250 mg/day). Colitis was induced by an intrarectal administration of AA in all groups except NC, and treatments were administered daily for 7 days. The therapeutic effects were evaluated by assessing the disease activity index (DAI), colon mass index, macroscopic and microscopic tissue damage, histopathological changes, zonula occludens (ZO)-1 protein expression, and myeloperoxidase (MPO) activity. The results showed that CP and SB treatments substantially alleviated DAI scores (p < 0.05) and reduced the colon mass index. Colon macroscopic and microscopic damages improved compared to the CC group (p < 0.01). Histologically, both treatments reduced inflammatory cell infiltration, crypt damage, and ulceration, with CP showing a slightly more pronounced effect. Immunohistochemical analysis revealed significant restoration of ZO-1 protein expression in the treated groups, indicating improvement in intestinal barrier integrity (p < 0.01). Furthermore, MPO activity was reduced in both CP and SB groups, significantly in the SB group (p < 0.01). These findings are consistent with previous studies that highlight the anti-inflammatory and barrier-enhancing effects of collagen peptides and probiotics in UC models.
Citation - WoS: 1
Citation - Scopus: 1
Combined Spectroscopic and Chromatographic Techniques Augmented With Chemometrics for the Authentication of Black Cumin ( Nigella Sativa L . ) Seed Oil
(Academic Press inc Elsevier Science, 2024) Karaman Ersoy, Şeyda; Ersoy, Seyda Karaman; Kaya, Elif Nilay; Senol, Onur; Apak, Resat; Temel Eczacılık Bilimleri Bölümü
Edible oils adulteration has a great concern because of its health and economical effects. Black cumin seed oils (BCSOs) are one of the most adulterated edible oils. In this case, the purpose of this research was to investigate authenticity of commercial BCSOs by spectroscopic and chromatographic techniques combined with orthogonal partial least square -discriminant analysis (OPLS-DA) and hierarchical cluster analysis (HCA). Sixteen commercial BCSO samples (100 % pure-certified and other BCSOs), potential blending oils (sunflower, corn, and soybean oils), and twenty-one synthetically adulterated BCSO samples blended with sunflower (SFO), corn (CO), and soybean (SBO) oils at levels of 5 %, 10 %, 15 %, 20 %, 30 %, 40 %, and 50 % (v/v) were analysed. Screening of potential fingerprinting markers such as thymohydroquinone (THQ), thymoquinone (TQ), carvacrol (CRV), tocopherol isomers ( alpha-, gamma -, and delta -), as well as total antioxidant capacity and phenolic content analysis were carried out utilizing spectrophotometric CUPRAC, ABTS, and Folin Ciocalteu ' s assays. Commercial pure and fraudulent BCSOs and synthetically adulterated samples were successfully classified in OPLS-DA graphs with 95 % confidence level. Even to five percent detection limit for SFO, CO and SBO adulteration were prominently monitored. In consequence, the proposed spectroscopic and chromatographic methods seem to be a practically applicable, sensitive and versatile protocol that can be used as an alternative fingerprinting procedure to determine adulteration of commercial BCSOs.
Comparison of Intraoperative Biliary Anastomosis Stenting Technique in Living-Donor Liver Transplantation: Review of 41 Patients
(Turkiye Klinikleri, 2022) Dönmez, Ramazan; Balas, Ş.; Göktuğ, U.U.; Emek, E.; Tokat, Y.; Tıbbi Hizmetler ve Teknikler Bölümü
Background/aim: Biliary fistula is one of the most important complications in liver transplantation. Complications can vary from simple local peritonitis to death, and various techniques have been described to prevent them. In this study, we compared two different stenting methods used in biliary tract anastomosis in living-donor liver transplantation. Material and methods: We retrospectively analyzed data from 41 living-donor liver transplantations that were performed due to end-stage liver failure between August 2019 and November 2020. Patients were grouped according to the stenting technique used in biliary anastomosis. Postoperative biliary tract complications were investigated. Results: Biliary fistulas were observed in 2 (7.4%) patients in the internal stent group, while 4 (28.5) fistulas were observed in the external stent group. Biliary tract stricture was observed in 2 (7.4%) patients in the internal stent group, but there was no statistical difference in complications. The preoperative MELD score (p = 0.038*) was found to be statistically significant in regard to developing complications. Conclusion: Our study did not show the effect of stenting methods used during biliary anastomosis on the development of complications. However, larger randomized controlled studies are needed. © TÜBİTAK.
Citation - WoS: 1
Consumption and Preferences of Fruits and Vegetables in Turkish Adults
(Cambridge Univ Press, 2020) Garipağaoğlu Denizhan, Muazzez; Yousefirad, Neda; Akman, Cansu; Sezer, Fatma Elif; Ilktac, Havvanur Yoldas; Garipagaoglu, Muazzez; Ersoy, Gulgun; Beslenme ve Diyetetik Bölümü
[No Abstract Available]
Citation - WoS: 9
Citation - Scopus: 9
Critical Thinking Among Clinical Nurses and Related Factors: a Survey Study in Public Hospitals
(Wiley, 2022) Harmancı Seren, Arzu Kader; Zuriguel-Perez, Esperanza; Seren, Arzu Kader Harmanci; Hemşirelik Bölümü
Aims and objectives The study investigated clinical nurses' critical thinking levels in public hospitals and related factors. Background Since health care environments have become more complex, the critical thinking skills of clinical nurses are more important in daily problem-solving and decision-making processes. However, little research was conducted on this topic among clinical nurses. Methods It was a cross-sectional study at five public hospitals between December 2018 and January 2019. The study followed the STROBE guideline. Data were collected from 559 nurses by a survey consisted of a data form and the Turkish version of the Nursing Critical Thinking in Clinical Practice Questionnaire. Results Nurses' mean critical thinking scores were moderate level. Total critical thinking scores of the clinical nurses significantly differed according to education, hospital type, shift work, professional category and role. There was a significant effect on the total critical thinking scores of the clinical nurses according to variables. Conclusion This study found that critical thinking levels of nurses' working in clinical settings in public hospitals were moderate level. Hospital type, shift work, professional and educational level and role were significantly associated with clinical nurses' critical thinking levels. Relevance to clinical practice This study provides evidence related to the levels of critical thinking of clinical nurses working in public hospitals. Since the critical thinking scores of the manager nurses, daytime working nurses' and nurses with bachelor's and master's degree education are higher, hospital managers may benefit from the study to implement effective strategies to improve the competence of critical thinking levels of nurses.
Citation - WoS: 4
Citation - Scopus: 4
A Cross-Sectional Survey Study on Homophobia Among Medical, Nursing, Pharmacy, and Other Health Sciences Students
(Routledge Journals, Taylor & Francis Ltd, 2023) Harmancı Seren, Arzu Kader; Bacaksiz, Feride Eskin; Cakir, Hanife; Yilmaz, Sevil; Sukut, Ozge; Turan, Suzan; Maghsoudi, Nurten; Hemşirelik Bölümü
Since the lesbian, gay, bisexual, transgender, and intersex (LGBTI) community may be exposed to violence, discrimination, stigma, exclusion, and maltreatment due to their sexual orientation while accessing healthcare services, understanding, and improving the attitudes of future's health care professionals toward LGBTI individuals seem essential. This descriptive and cross-sectional study aimed to investigate the homophobia among medical, nursing, pharmacy, and healthcare sciences students and examine the related factors. The study included 2,531 students from medicine, nursing, pharmacy, and other health sciences (midwifery, nutrition and dietetics, physiotherapy, management of healthcare facilities) disciplines. Homophobia was measured with the Hudson and Ricketts Homophobia Scale. After getting ethical and institutional approvals, data were collected and analyzed using descriptive and inferential statistical tests. Medical students had the lowest homophobia score, and their mean score was significantly lower than other students. There was a significant difference between students' scores according to years of study, age, sex, acquaintance with LGBTI individuals, providing healthcare services to an LGBTI person, and opinions on providing care. Although homophobia scores of nursing, pharmacy, and other health sciences students were lower than the medical students', policies and expansive content regarding LGBTI should be in place in all health science educational institutes, including medical schools, to prevent students from holding homophobic and prejudicial attitudes against LGBTI individuals.
Design and Synthesis of Thiosemicarbazides and 1,2,4-Triazoles Derived From Ibuprofen as Potential Metap (Type II) Inhibitors
(Elsevier Ireland Ltd, 2025) Yilmaz, Ozgur; Biliz, Yagmur; Ayan, Sumeyra; Cevik, Ozge; Karahasanoglu, Mufide; Cotuker, Reyhan; Kucukguzel, S. Guniz
In the present study, a range of novel thiosemicarbazides 4a-i and 1,2,4-triazoles 5a-i derived from ibuprofen, were synthesized. Structural elucidation of these synthesized compounds was performed utilizing a variety of spectroscopic methods, including FTIR, 1H NMR, 13C NMR and HR-MS. The synthesized compounds were tested for cytotoxicity in five different cancer cell lines (cervical cancer (HeLa), human breast cancer (MCF-7), human gastric adenocarcinoma (MKN-45), human metastatic prostate cancer (PC3) and human glioblastoma (U87)). The compounds were compared with healthy cells (NIH-3T3) and the most effective compounds were determined by means of the selectivity index. Thiosemicarbazides derived form ibuprofen 4i and 4d showed anticancer activity, while 1,2,4-triazoles derived form ibuprofen 5b, 5c, 5d, 5e, 5h, 5g showed anticancer activity in HeLa, MCF-7, MKN-45, PC3 and U87 cells. To test the stability of the protein-drug complexes all 18 compounds 4a-i and 5a-i were docked into the active site of the MetAP2 enzyme In general, computational inhibition constants values were correlated with the experimental values. The dynamic behavior of MetAP2-inhibitor complexes was analyzed using all atoms Molecular Dynamic (MD) simulations for 200 ns duration. MD revealed that the drugs bind in the active center of MetAP2 with stable RMSD and RMSF. In conclusion, in-silico results and in-vitro studies suggests that thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen may be novel anticancer drug candidates for treating cervical, breast, prostate, gastric and glioblastoma. Compounds provided induction of apoptotic proteins in the cell by inhibiting MetAP2 enzyme. Furthermore, the potential antioxidant activities of the compounds were evaluated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Among the compounds tested, 4a, 4b, 4e, 4f, 4h, and 4i exhibited values closely resembling the DPPH activity of the standards.
Citation - WoS: 10
Citation - Scopus: 11
The Deterioration in Credibility, Destabilization of Exchange Rate and the Rise in Exchange Rate Pass-Through in Turkey
(Elsevier, 2021) Alkan, Buket; Agaslan, Erkan; Alkan, Buket; Cicek, Serkan; Ekonomi ve Finans Bölümü
The early literature on inflation targeting (IT) regime argues that adopting an IT regime in itself reduces the exchange rate pass-through (ERPT). The basic logic behind this argument is that pursuing a credible and independent monetary policy will help to anchor the inflation expecta-tions and stabilize the exchange rate volatility. In this study, we investigate whether the ERPT has increased in the last decade in Turkey where the credibility of the Central Bank of the Republic of Turkey (CBRT) has deteriorated and the exchange rate uncertainty has increased due to the weakening of commitment to inflation after political pressures although the IT regime has been implementing. Employing the Phillips curve model and then applying a narrowing window analysis, we have found that the ERPT coefficient increased as the beginning of the sample ap-proaches towards the last observation, especially since 2011. To search for the reason behind this increase, we additionally employed a threshold regression method following the work of Murase (2013) which allows both possibility of non-linearity in the ERPT relationship and exogenously adding the threshold variable to the model. When the gap between inflation expectations and the inflation forecasts grows, then the credibility is considered to decrease and we found that the ERPT gets higher if the gap exceeds a certain threshold. Similarly, we have found evidence supporting that the ERPT coefficient was higher when the exchange rate uncertainty exceeded a certain threshold.
Citation - WoS: 6
Citation - Scopus: 7
Determination of Chemical Components of the Endemic Species allium Turcicum L. Plant Extract by Lc-ms/Ms and Evaluation of Medicinal Potentials
(Cell Press, 2024) Ipek, Polat; Atalar, Mehmet Nuri; Baran, Ayse; Baran, Mehmet Firat; Ommati, Mohammad Mehdi; Karadag, Musa; Khalilov, Rovshan
The Allium turcicum L. (Zuzubak) plant as a cultivated vegetable have various health benefits and consumed as a food. Due to the shortcoming evidence in literature and the importance of this plant in folk medicine, in the present study, for the first time, we evaluated the bioactive profile of components (using LC-MS/MS), cytotoxicity, anticancer, antioxidant, and antibacterial prospectives of Zuzubak methanol extract. Reported results show that the extract is rich in bioactive compounds and has anticancer activity with breast cancer cells (MCF-7), human prostate cancer cells (DU -145), and Human osteosarcoma cancer Cell lines of (IC50) in dose dependent manner in the concentration range of 31.25 mu g/mL and 2000 mu g/mL for 24 and 48 h. Western blotting results determined that the extract significantly suppressed the growth of U2OS, MCF-7, and DU -145 cancer cells by down expression of Ang-1 (angiogenic protein) and Beclin-1 (autophagy protein) and overexpression of Bax (a proapoptotic protein). The oxidative stress indices showed a reduction in RPE-1 and MCF-7 cells and an upsurge in U2OS and DU -145 cells. Additionally, the antimicrobial assay showed suppression of the growth of various pathogenic microorganisms in 4.00 - 8.00 mu g/concentrations of Zuzubak extract using the microdilution method. The phytochemicals identified showed promising anticancer, antioxidant effects, and antimicrobial properties, representing a valuable herbal source for drug development studies.
Citation - WoS: 1
Citation - Scopus: 2
Developing a Valid and Reliable Perceived Global Future Scale
(Wiley, 2022) Harmancı Seren, Arzu Kader; Seren, Arzu K. Harmanci; Hemşirelik Bölümü
Purpose To develop a valid and reliable data collection tool to define individuals' perceptions of the global future. Design and Methods This methodological study was carried out on 870 participants in Istanbul, a city with the country's highest and most diverse population. Findings Content validity, construct validity, item analyses, and stability of the draft tool were tested. The seven-factor scale structure was confirmed. Cronbach's alpha coefficient of the scale was .93. Practice Implications The Perceived Global Future Scale, consisting of 36 items and seven dimensions, was used. It is a valid and reliable tool to define perceptions of individuals on the global future.

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