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Citation Count: 2
Accentuated Eccentric Load Training: Traditional Set Versus Cluster Set
(Iermakov S S, 2022) Pınar, Salih; Pinar, Salih; Kaya, Selman; Antrenörlük Eğitimi Bölümü
Background and Study Aim Material and MethodsThis study aims to comparatively analyse the effects of cluster set (CS) and traditional set (TS) applications on strength and power outputs in accentuated eccentric load (AEL) training. Thirty-two amateur male football players with at least 2 years of strength training history participated in the study (Xage: 18,78 +/- 0,83 years, Xheight:166,73 +/- 8,61 cm., Xbody weight: 69,59 +/- 6,03 kg.). Participants were randomly divided into two groups: CS (n=16) and TS (n=16). In both groups, the same "AEL Training" was applied and different set models were used. Augmented eccentric load (AEL) training was performed with 3 sets of 8 repetitions, 50% concentric and 80% eccentric of 1 Repetition Maximum (1-RM) and with a fast lifting tempo. The sets were completed with 20 seconds of rest after every two repetitions in the AEL-CS group and without any rest between repetitions in the AEL-TS group, and the training sessions were performed twice a week for 4 weeks. Countermovement jump (CMJ), 50cm drop jump-reactive strenght index (DJ-RSI) test, 1-RM strenght test, 10-20-30m sprint test and Illinois Agility Test (IAT) were performed on the athletes before and after the training.ResultsWhen analysing the data obtained in this study, Skewness and Kurtosis values and Kolmogorov-Smirnov values were examined to determine homogeneity. In order to compare the pre-test and post-test averages between groups, ANOVA was used for Repeated Measures, and Sample T Test was used to compare the pre-test and post-test averages within groups. The statistical significance level was determined as p<0.05. When the groups were compared, the difference in the improvement rate averages was tested. At the end of the four-week study, drop jump-reactive strength index (DJ-RSI), countermovement jump (CMJ), Illinois Agility Test (IAT) 10-20-30m sprint values and 1-RM values were improved percentage-wise in both AEL-CS and AEL-TS groups. Between the groups, a significant difference was observed between DJ-RSI, CMJ, and 10-20-m Sprint Test results (p<0.05). When we compare the results within groups, it can be concluded that the AEL-CS group showed more improvement in terms of strength, change of direction (COD) skills and Sprint compared to the AEL-TS group.ConclusionsIn conclusion, it can be advised to use cluster set in accentuated eccentric load training in order to improve strength, Sprint and COD skills.
Citation Count: 6
Acute Changes in Electrophysiological Brain Dynamics in Elite Karate Players
(Springer international Publishing Ag, 2020) Balcıoğlu, Taylan Hayri; Balcioglu, Taylan Hayri; Ozcan Cakir, Canan Elif; Goksel Duru, Dilek; Antrenörlük Eğitimi Bölümü
Regular physical exercise has enhanced effects on the human anatomy and functionality. Recently, an effect of a single set of exercise is shown to have positive effects on mood and on cognitive functioning. The aim of this study is to investigate the effect of a single bout of moderate exercise on the brain electrophysiological dynamics in resting-state condition and under the mental workload situation from elite-level athletes. For this purpose, electroencephalogram (EEG) is measured before and after the exercise sessions from 17 elite karate players who are members of the national karate team of Turkey. Blood lactate measurements are implemented to monitor the volunteers before EEG measurements. EEG data are analyzed using three metrics: conventional band power of each electrode, coherence metrics between electrodes for each band and source coherence values corresponding to each frequency band. Each metric is statistically analyzed between pre- and post-values, and results revealed that in all frequency bands, right parietal electrode had increased connection values which are thought to be related to ongoing sympathetic nervous system response observed during the recovery period. Another finding is the enhanced connectivity of frontal sources under the resting state as well as during the increased mental workload periods.
Citation Count: 0
Adaptation of Caregivers' Task Scale for Multiple Sclerosis To Turkish Society: Validity and Reliability Study
(Dokuz Eylul Univ inst Health Sciences, 2022) Eroğlu, Nermin; Tosun, Anil Tekeoglu; Hemşirelik Bölümü
Objectives: This study was planned and carried out methodologically to adapt the Caregiving Tasks in Multiple Sclerosis Scale (CTiMSS) to Turkish society. Methods: A methodological research. The study was conducted with caregivers of individuals with multiple sclerosis who presented to the neurology clinic of a university hospital between June 2019 and September 2020. The validity and reliability study of the Caregiving Tasks in Multiple Sclerosis Scale (CTiMSS) was performed with a total of 142 individuals, which is more than 5 times the number of items on the scale (24 items). Results: The validity of the CTiMSS was evaluated with language validity, construct validity (CFA), and content validity. The reliability coefficient of the internal consistency analysis (Cronbach's Alpha) was found to be extremely high (0.97). Item-total correlation of the scale was examined, and accordingly, no items were removed from the scale. The scale was administered to 30 patients at a two-week interval to analyze test-retest reliability and time-dependent invariance. Conclusion: The CTiMSS, which was adapted to Turkish society to evaluate the tasks of individuals providing care for individuals with multiple sclerosis, is a valid and reliable tool. We recommend that it should be administered to different groups and cultures to increase its evidence value. CTiMSS is an appropriate measurement tool to determine the duties of caregivers of individuals with multiple sclerosis.
Citation Count: 0
Adolesan Sporcularda Olumlu Beden İmgesi ile Mükemmeliyetçilik İlişkisinde Öz Şefkatin Aracılık Rolünün Spor Türüne Göre İncelenmesi
(2024) Güngören, Fatma Eda; Aşçı, F. Hülya
Bu çalışmanın amacı adolesan sporcularda olumlu beden imgesi ile mükemmeliyetçilik ilişkisinde öz şefkatin aracılık rolünün spor türüne göre incelenmesidir. Çalışmaya İstanbul ilindeki kulüplerde bireysel ve takım sporlarıyla uğraşan, en az 2 yıl spor deneyimi olan 381 (x̄yaş=15,95± 1,05) kız sporcu katılmıştır. Çalışmaya katılan sporculara Kişisel Bilgi Formu, Beden Değeri Ölçeği-2; Öz Şefkat Ölçeği-Kısa Formu ve Spora Özgü Çok Boyutlu Mükemmeliyetçilik Ölçeği uygulanmıştır. Verilerin analizi Process Macro eklentisi aracılığıyla IBM SPSS kullanılarak gerçekleştirilmiştir. Çalışmada aracılık ilişkisini incelemek amacıyla oluşturulan modelleme ‘Koşullu Süreç Modeli’ kullanılarak incelenmiştir. Analiz sonuçlarına göre, mükemmeliyetçiliğin kişisel standartlar (B=-0,16; p<0,00), hatalarla aşırı ilgilenme (B=-0,33; p<0,05), algılanan ebeveyn baskısı (B=-0,13; p<0,05) ve algılanan koç baskısı (B=-0,20; p<0,05) alt boyutları ile öz şefkat arasında negatif ilişki vardır. Mükemmeliyetçiliğin kişisel standartlar (B= 0,38; p<0,05) alt boyutu olumlu beden imgesi ile pozitif ilişkiliyken, hatalarla aşırı ilgilenme (B=0,04; p>0,05), algılanan ebeveyn baskısı (B=0,14; p> 0,05), ve algılanan koç baskısı (B=0,01; p> 0,05), olumlu beden imgesi arasındaki ilişki anlamlı bulunmamıştır ve tüm bu ilişkilerde spor türü düzenleyici role sahip değildir. Ayrıca, bulgular öz şefkatin; kişisel standartlar, hatalarla aşırı ilgilenme, algılanan ebeveyn baskısı ve algılanan koç baskısı ile olumlu beden imgesi arasındaki ilişkiye aracılık ettiğini, bu aracılık etkisinde spor türünün düzenleyici rolü olmadığını göstermiştir. Sonuç olarak, adolesan sporcuların mükemmeliyetçilik düzeyleri öz şefkatten etkilenerek onların, olumlu beden imgesi düzeylerini etkilemektedir ve bu etkiler sporcuların bireysel veya takım sporu ile uğraşmalarına göre değişmemektedir.
Citation Count: 0
Adsorption Mechanisms, Kinetics and Photoactivities of Green Synthesized Hydroxyapatite Supported Zno and La-Zno Catalysts
(Pergamon-elsevier Science Ltd, 2024) Tuncel Turan, Duygu; Okte, A. Neren; Temel Eczacılık Bilimleri Bölümü
In this study, hydroxyapatite (HAP) is synthesized by a co-precipitation method from the waste eggshell, utilized as a support for ZnO (ZnO-HAP) and La-ZnO (La-ZnO-HAP) and employed to degrade methyl orange (MO) and methylene blue (MB) dyes under UV irradiation. Water vapor adsorption as relative humidity (84 % RH) on the HAP structure and the as-prepared catalysts are also examined. The characteristic ZnO and HAP reflections are detected in X-ray diffraction (XRD) analysis of ZnO-HAP, La-ZnO-HAP and humidified samples. ZnO and La-ZnO existence is also verified by scanning electron microscopy-energy dispersive X-ray (SEM-EDX) analysis, UV-Vis diffuse reflectance (UV-Vis DRS) spectra and X-ray photoelectron spectra (XPS). ZnO and La-ZnO loading on the HAP induce the formation of mesoporous structures with high surface areas. Dark adsorption capacities and photoactivities of the as-prepared samples are explored regarding electrostatic interactions, Lewis acid-base interactions and hydrogen bonding for both MO and MB. In particular, La-ZnO-HAP 500 degrees C and La-ZnO-HAP 500 degrees C (RH) exhibit improved adsorption abilities and photoactivities. The pseudo-second order model describes the kinetic behavior of all samples under dark conditions. Unhumidified samples follow Langmuir isotherm while Freundlich isotherm better fits humidified ones. Under irradiation, the Langmuir-Hinshelwood kinetic model describes the photoactivities of all samples. The four recycling tests confirm the stabilities of HAP 100 degrees C, HAP 500 degrees C, ZnO-HAP 500 degrees C and La-ZnO-HAP 500 degrees C. This study suggests that the ZnO or La-ZnO loaded HAP catalysts prepared in the presence and absence of humid conditions are considered promising materials for environmental remediation.
Citation Count: 0
Age-Specific Seroprevalence of Hepatitis a Virus in Turkey Between 2000 and 2023: Systematic Review and Meta-Analysis
(Mdpi, 2024) Kahraman Kılbaş, Elmas Pınar; Koroglu, Mehmet; Demiray, Tayfur; Terzi, Huseyin Agah; Kilbas, Elmas Pinar Kahraman; Tıbbi Hizmetler ve Teknikler Bölümü
Background: Hepatitis A virus (HAV) is a leading cause of acute viral hepatitis and is primarily transmitted by the fecal-oral route. The clinical presentation and progression of the disease varies according to the age of the patient. Turkey is classified as a moderately endemic country, and HAV infection continues to be an important public health problem worldwide. Methods: In this study, a systematic meta-analysis was conducted to evaluate age-specific HAV seroprevalence rates in Turkey between 2000 and 2023. A comprehensive literature review identified 57 articles that met the inclusion criteria. The studies were assessed for quality, and seroprevalence rates were evaluated across four different age groups. Statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software (CMAVersion 3.0) and SPSS (SPSS Statistics 25.0). Results: HAV seroprevalence rates were found to be 73.18% in the 0 < 5 age group and 90.90% in the >35 age group. The overall seroprevalence estimated using a random effects model was 64.5% (95% CI: 58.3-70). High heterogeneity was observed among the studies, and the prevalence estimates changed when low-quality studies were excluded. Conclusions: This meta-analysis suggests that the increasing trend in HAV IgG seroprevalence in Turkey, especially among young populations, is likely due to the vaccination program initiated in 2012. Furthermore, the heterogeneity observed among regions highlights the importance of regional public health strategies. Future studies should focus on providing more detailed data to evaluate the long-term effects of vaccination and to explain regional differences in HAV seroprevalence.
Citation Count: 0
Aktivist Reklamlara Yönelik Y ve Z Kuşağının Tutumunun Satın Alma Niyetine Etkisi
(2024) Ugur, Hülya; Tosun, Nurhan Zeynep
Tüketicilerin beklenti ve istekleri doğrultusunda markaların toplumsal konuları gündeme getirerek yeniden canlanması ve eşitlik, adalet gibi temel ve varoluşsal konuları içeren reklam mesajları, yeni bir reklam paradigmasının ortaya çıkmasına zemin hazırlamıştır. Aktivist reklamcılık olarak ifade edilen bu yaklaşım markaların reklam kampanyalarında hedef kitlelerine toplumsal ve sosyal konulara yönelik mesajlar iletmelerini içermektedir. Özellikle toplumsal ve sosyal konularda daha duyarlı olan ve markalardan farklılıklar bekleyen Y ve Z kuşakları için markaların aktivist bir duruş sergilemeleri büyük önem taşımaya başlamıştır. Bu doğrultuda bu çalışma, yeni bir reklamcılık akımına ışık tutan aktivist reklamlara yönelik tutumların satın alma niyeti üzerindeki etkisini değerlendirmeyi amaçlamaktadır. Bu kapsamda çalışmada reklama yönelik tutum oluşumu üzerinde önemli bir etkiye sahip olan (a) reklam değeri, (b) güvenilirlik (c) bilgilendiricilik, (d) aldatıcılık, (e) eğlendiricilik ve (f) rahatsız edicilik tutum değişkenlerinin aktivist reklama yönelik tutum ve satın alma niyeti üzerindeki etkisi de irdelenmiştir. Bu bağlamda çalışmada nicel araştırma yöntemlerinden biri olan anket tekniği kullanılarak 417'si Y kuşağı ve 417'si Z kuşağı olmak üzere 834 birey anket çalışmasıyla değerlendirilmiştir. Y ve Z kuşağı katılımcıları bağlamında aktivist reklamlara yönelik tutumların satın alma niyeti üzerindeki etkisi değerlendirildiğinde, regresyon analizinin bağımlı değişken (satın alma niyeti) ile bağımsız değişken (reklama yönelik tutum) arasındaki etkileşimi anlamlı bir şekilde ortaya konmuştur. Ayrıca reklama yönelik tutum oluşumunda önemli rol oynayan tutum değişkenleri boyutlarının aktivist reklama yönelik tutum ve satın alma niyeti üzerindeki etkisi değerlendirildiğinde, bağımlı değişkenler (tutum, satın alma niyeti) ile bağımsız değişkenler (reklam değeri, bilgilendiricilik, aldatıcılık, eğlendirici ve rahatsız edici, güvenilirlik) arasındaki etkileşimi açıklayan regresyon analizinin de anlamlı sonuçlar verdiği görülmektedir.
Amatör Spor Kulüplerinin Gelir Modelleri Yönetiminin İncelenmesi
(2024) Açıkyol, Soner; Öğüt, Esin Esra Erturan
Bu çalışmanın amacı, amatör spor kulüplerinin gelir modelleri yönetiminin incelenmesidir. Araştırmanın temel sorusu 'amatör spor kulüplerinin gelir modelleri yönetimi nasıldır?' olup araştırma açımlayıcı betimsel türdedir. Araştırmanın evrenini Türkiye'deki spor kulüpleri, örneklemini ise Kocaeli'nde bulunan 21 amatör spor kulübü oluşturmaktadır. Araştırmaya yalnızca amatör spor kulüpleri dahil edilmiş olup profesyonel futbol kulüpleri dışlanma kapsamında tutulmuştur. Araştırmada örneklem belirleme yönetimi olarak amaçlı örneklem yöntemlerine başvurulmuştur. Örneklem yöntemlerinden kartopu örneklem yöntemi temel alınmış, buna ek olarak kolayda örneklem yöntemi tercih edilmiştir. Çalışmada veri toplama aracı olarak yarı-yapılandırılmış görüşme tekniği seçilmiştir. Görüşmelerde toplam 11 soruya ilaveten çeşitli sonda soruları sorularak görüşülen kişinin konuyu derinlemesine açıkladığından emin olunmuştur. Ardından kayıtlar aynı gün deşifre edilerek dijital görüşme metinleri oluşturulmuştur. Verilerin analizinde 'içerik analizi' tekniği kullanılmıştır. Araştırmada elde edilen bulgular incelendiğinde spor kulüplerinin üye geliri elde etme kapasiteleriyle sponsor ve bağış gibi gelirlerinin yetersiz olduğu, giderlerinin özel ve kamu kulüplerinde farklılık gösterdiği görülmüştür. Kulüplerin 7405 sayılı Kanun sonrası hukuki statüleri bakımından farklı biçimlendiği ancak işleyiş bakımından aynı olduğu saptanmıştır. Sonuç olarak amatör spor kulüplerinin gelir ve gider kaynakları yönetimine bakıldığında görüşmeciler tarafından yetersiz bulunduğu anlaşılmış, 7405 sayılı yasadan önceki işleyiş ile yasadan sonraki işleyiş arasında kulüpleri çok etkileyen bir durum olmadığı görülmüştür. Özellikle yasaya uygun olduğu halde gelir elde etmek üzere üyelik aidatı gibi önemli bir kalemin etkili biçimde kullanılmadığı anlaşılmaktadır. Araştırma bulgularından gelir elde etme güçlükleri yaşayan kulüplerin finansal kapasitelerinin kulüp temeline dayanan bir spor sistemi için yeterli olmadığı sonucuna varılabilir. Araştırmanın bulgularından ortaya çıkan sonuç ve alanyazın dikkate alınarak bazı öneriler ortaya konulmuştur. Araştırmanın sonuçlarına bağlı kalarak ortaya konulan bu önerilerin amatör spor kulüplerinin yasa sonrası gelir modelleri yönetimine ışık tutması beklenmektedir.
Citation Count: 0
Ameliorative Effects of Myrtus Communis L. Extract Involving the Inhibition of Oxidative Stress on High Fat Diet-Induced Testis Damage in Rats
(Taylor & Francis Ltd, 2024) Şener, Göksel; Koroglu, M. Kutay; Hersek, Irem; Ertas, Busra; Sen, Ali; Sener, Goksel; Ercan, Feriha; Eczacılık Meslek Bilimleri Bölümü
The possible protective effects of Myrtus communis L. (MC) extract on a high fat diet (HFD)-induced testicular injury in a rat model were investigated using histological and biochemical methods. Wistar albino rats were divided into three groups: a standard diet control group; a HFD group; and an HFD+MC group. The HFD and HFD+MC groups were fed with a HFD for 16 weeks. MC extract (100 mg/kg) was given orally five days a week to the rats in the HFD+MC group during the last four weeks of the experiment. Leptin, triglyceride, high-density lipoproteins, cholesterol, estrogen, testosterone, LH and FSH were analyzed in blood serum. Sperm parameters were evaluated from the epididymis. Testicular morphology, proliferative, apoptotic and NADPH oxidase-2 (NOX2)-positive cells were evaluated histologically. Testicular oxidative stress parameters were analyzed biochemically. In the HFD group, lipid and hormone profiles were changed, abnormal spermatozoa, degenerated seminiferous tubules with apoptotic and NOX2-positive cells were increased in number, and sperm motility and germinal proliferative cells decreased compared to the control group. Moreover, testicular malondialdehyde, 8-hydroxy-2-deoxyguanosine and myeloperoxidase levels increased, whereas glutathione and superoxide dismutase levels decreased in the HFD group compared to the control group. All these histological and biochemical features were ameliorated by MC treatment of HFD-fed rats. In conclusion, HFD caused alterations in sperm parameters and testicular morphology by increasing oxidative damage and apoptosis. MC extract may have potential protective effects by inhibiting oxidative damage.
Citation Count: 3
Analysis for Two-Dimensional Inverse Quasilinear Parabolic Problem by Fourier Method
(Taylor & Francis Ltd, 2021) Kanca, Fatma; Baglan, Irem; Bilgisayar Mühendisliği Bölümü
In this work, two-dimensional inverse quasi-linear parabolic problem with periodic boundary and integral overdetermination conditions is investigated. The formal solution is obtained by the Fourier approximation. Under some natural regularity and consistency conditions on the input data,the existence, uniqueness and continuously dependence upon the data of the solution are proved by iteration method. The inverse problem is first examined by linearization and then used implicit finite difference scheme for the numerical solution. Also predictor corrector method is considered in the numerical approach. Some results on the numerical solution with two examples are presented with figures and tables. The sensitivity of the scheme with respect to noisy overdetermination data is illustrated.
Citation Count: 0
Analysis of Selected Steroid Hormones in Sea of Marmara Sediment Samples by Lc-esi/Ms-ms
(Istanbul Univ, Fac Pharmacy, 2023) Yurdun, Türkan; Yurdun, Turkan; Eczacılık Meslek Bilimleri Bölümü
Background and Aims: Sediment is the general name given to the muddy structure located at the bottom of aquatic environments such as the sea. In our study, the amounts of steroid hormones were investigated in the sediment samples taken from the Marmara Sea. According to other studies, it has been determined that the excess of the hormone load in the sediments may be an indicator of human/animal sourced pollution, as well as the negative effects of the hormones mixed in the seas with the ecological cycle on the health of humans and animals.Methods: In our study, 31 selected human/animal, plant, natural and synthetic hormone-steroids were studied using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI/MS-MS). Methanol and QuEChERS were used as extraction methods. Sediment samples were taken from a total of 27 points selected for sampling at the Marmara Sea.Results: According to the results we found, the androgens: androsterone (24.50-1718.18 ng g-1), testosterone (86.30-1600.32 ng g-1); the estrogens: mestranol (33.73-228.32 ng g-1), equilin (53.44-1232.53 ng g-1); the progestagens; pregnenolone (37.50374.76 ng g-1), progesterone (39.96-405.60 ng g-1); levonorgestrel (325.25 and 937.93 ng g-1); the fecal sterols: cholestanone (57.57-1726.32 ng g-1), coprostanol + epicoprostanol (51.43-1370.33 ng g-1); and the plant sterol; campesterol (35.30-1859.90 ng g-1) were the compounds detected.Conclusion: Estrogens and progestogens are active components of birth control pills, and cholestanone and coprostanol + epicoprostanol are steroids that are indicative of human/animal pollution. Coprostanol + epicoprostanol and cholestanone, which are indicators of fecal pollution, were detected in all sediment samples. In our study, steroid hormones were detected for the first time in Sea of Marmara sediments and possible environmental risks were evaluated.
Citation Count: 1
Analysis of Substance Use and Mental Disorder Diagnoses in Adolescents With a History of Delinquency: a Cross-Sectional Study
(Springer, 2024) Dikeç, Gül; Dikec, Gul; Tas Soylu, Gulsenay; Bilac, Oznur; Uzunoglu, Gulcin; Ayakdas Dagli, Dilek; Hemşirelik Bölümü
This study aimed to evaluate substance use and comorbid mental disorders in delinquent adolescents presenting to a child and adolescent psychiatry outpatient clinic. This study included 47 adolescents aged 15-18 years and had a history of delinquency. Data were collected using the Addiction Profile Index Adolescent Form (API-A) and an information form. Results indicated that the adolescents' mean age is 16.11 +/- 1.05 years, 78.7% had committed crimes against property and 34.0% against the person, and 34.0% were also victims of crime. Mean API-A total scores indicated that their level of substance use was low. In addition, mean API-A total scores showed significant differences according to the adolescents' migration status, age, economic status, school attendance, mental disorder diagnosis, duration of mental disorder, and type of offense (p < 0.05). The benefit provided by timely and appropriate psychosocial interventions may have a key role in solving this problem for adolescents and improving their future as adults.
Citation Count: 1
An Analysis of the Gross Motor Skills of Children Aged 3-6 Years With Autism Spectrum Disorder in Comparison With Their Typically Developing Peers
(Sagamore Publishing Llc, 2023) Pınar, Salih; Ozer, Dilara; Pinar, Salih; Antrenörlük Eğitimi Bölümü
The aim of this study is to examine the motor skill levels of children aged 3-6 years with Autism spectrum dis-order (ASD) in comparison with their typically devel-oping (TD) peers and to reveal their needs for motor support programs. The research group consisted of 88 participants aged 3-6 years, including 43 children (40 boys and 3 girls) diagnosed with ASD attending spe-cial education and rehabilitation institutions, and 45 TD children (23 boys and 22 girls) receiving pre-school education in a private institution (ASD=57.4 months, +/- 9.32 - TD=59.06 months, +/- 8.61). The Peabody Devel-opmental Motor Scale-2 (PDMS-2) and the Turkish Ver-sion of the Gilliam Autism Rating Scale-2 (GARS-2-TV) were used as data-collection tools in the study. The Mann-Whitney U test was used for the two-group com-parisons of the parameters that did not exhibit normal distribution in the analysis of the data. The Spearman correlation analysis was applied to determine the relationship between the variables. The significance was evaluated at the p<0.05 level. As a result of the research, the balance, locomotor and manipula-tive skills and total gross motor scores of the children with ASD were found to be lower than those of the TD children (p<0.05). In addition, it was observed that there was a significant correlation between GARS-2 -TV scores and PDMS-2 scores of the children with ASD (p<0.05).
Citation Count: 0
Analyzing Critical Success Factors of Sustainable Knowledge Management: an Interval-Valued Neutrosophic Approach
(Mdpi, 2024) Çaloğlu Büyükselçuk, Elif; Bulak, Muhammet Enis; Buyukselcuk, Elif Caloglu; Endüstri Mühendisliği Bölümü
Knowledge management (KM) is a structured approach that includes the organized procedures of generating, capturing, arranging, storing, retrieving, distributing, and harnessing an organization's knowledge resources to attain its goals and improve its effectiveness. Encountering uncertainty and managing imprecise information are fundamental aspects of KM that cannot be avoided. In this context, sustainable KM aims to solve these issues and address prioritizing the long-term sustainability and efficiency of knowledge-related processes within an organization. The aim of this study is to structure a sustainable KM concept for organizations and identify the most common critical success factors (CSFs) with a novel analytical approach. In this context, the Interval-Valued Neutrosophic methodology, which is one of the multi-criteria decision methods (MCDMs), was adopted to evaluate and weight the determined CSFs. Four main headings-KM, environmental, economical, and social criteria-are evaluated along with their subfactors. Our findings show that KM is found to be the most important, and environmental factors followed KM. When the results are examined in terms of subfactors, cleaner production is found to be the most significant, with a global weight value of 11.13.
Citation Count: 7
Antibiotic Use and Influencing Factors Among Hospitalized Patients With Covid-19: a Multicenter Point-Prevalence Study From Turkey
(Galenos Publ House, 2022) Ağalar, Canan; Cag, Yasemin; Karabay, Oguz; Kurtaran, Behice; Guclu, Ertugrul; Ogutlu, Aziz; Agalar, Canan; Tıbbi Hizmetler ve Teknikler Bölümü
Background: Broad-spectrum empirical antimicrobials arc frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective. and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age +/- standard deviation of the patients was 65.0 +/- 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (372%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005). presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein >10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p <0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings.
Citation Count: 0
Antimicrobial Effect of Drinkable Lugol Solution
(2024) Tunç, Ayşe Karacalı; Sarıtaş, Büşra Merve; Marzi, Mahdi; Dursun, Feray; Kaya, Şevin
The death rates due to infection in patients receiving long-term antibiotic treatment and hospitalized patients are quite alarming. Treatment of multidrug-resistant strains of Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, which cause widespread nosocomial infection, has become a global problem. Alternative treatment methods are needed for these species, which use all their resistance mechanisms day by day. Recently, it has been seen that iodine (lugol) solution has been used in the treatment of many infections. Significant results are observed, especially for nosocomial and wound infections. The literature on the antimicrobial effect of Lugol solution is very limited. In order to scientifically support such treatments, we aimed to investigate the antimicrobial effect of lugol on resistant bacteria in a laboratory environment. In our laboratory, we have previously isolated Acinetobacter baumannii, Shigella sonneii, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus strains with known antibiotic resistance. For these isolates, the agar dilution method prepared with different concentrations of lugol and the Broth Microdilution Method were used. As a result of our study, it was observed that drinkable Lugol solution affects multidrug-resistant microorganisms at very low concentrations. Thus, Lugol's success in infection treatments will be scientifically supported.
Citation Count: 7
The Antioxidant, Anti-Inflammatory, and Antiplatelet Effects of ribes Rubrum L. Fruit Extract in the Diabetic Rats
(Wiley, 2022) Şener, Azize; Sen, Ali; Sekerler, Turgut; Algul, Fatma Kader; Cilingir-Kaya, Ozlem Tugce; Sener, Azize; Temel Eczacılık Bilimleri Bölümü
The prothrombotic and inflammatory state plays a significant role in the occurrence of cardiovascular complications in type 2 diabetes mellitus. In this study, the antidiabetic, anti-inflammatory, and antiplatelet potentials of the extracts obtained from Ribes rubrum were investigated. The antidiabetic, anti-inflammatory, and antioxidant activities of the ethanol and water extracts of R. rubrum were evaluated by in vitro methods. The total phenolic and flavonoid contents were also determined. The experimental diabetes model in rats was induced with streptozotocin (STZ). After hyperglycemia occurred, the ethanol extracts of R. rubrum (RRE, at 100 mg/kg and 500 mg/kg doses) were administered to the treatment groups for 14 days. Blood glucose, lipid profile, plasma, and pancreas tumor necrosis factor-alpha (TNF-alpha) levels were determined and compared at the end of the experiments. P-selectin levels and mitochondrial membrane polarization (MMP) of platelets were also measured. In vitro study, the RRE showed potent anti-inflammatory activity. Administration of RRE (at 100 mg/kg doses) to diabetic rats lowered blood glucose level insignificantly. The results showed that there was an increment in levels of TNF-alpha in plasma and pancreas tissue of the diabetic group compared to the control group. R. rubrum extract regulated and normalized their levels in plasma and pancreatic tissue. RRE at both doses significantly decreased platelet P-selectin levels and prevented STZ-induced loss of MMP in platelets. The results of current research indicate that RRE extract has potent anti-platelet and anti-inflammatory effects and may be beneficial in preventing diabetic complications. Practical applications Hyperglycemia causes dyslipidemia, advanced oxidative stress, platelet activation, and inflammation in diabetes mellitus. Plants with various medicinal properties are of worldwide interest for the treatment of diseases due to their biological activities. In this study, the antidiabetic, anti-inflammatory, and antioxidant effects of extracts of Ribes rubrum (%100 ethanol, 50% ethanol, water) were evaluated by in vitro and in vivo methods. The diabetes model was induced with streptozotocin (STZ). The rats were divided into control, diabetic control, R. rubrum-100 mg/kg, and R. rubrum-500 mg/kg doses groups. Blood glucose levels, tumor necrosis factor-alpha (TNF-alpha), platelet P-selectin levels, mitochondrial membrane polarization of platelets were examined. The present study has shown that R. rubrum has anti-inflammatory and antiplatelet activity. R. rubrum may be beneficial in the prevention and treatment of DM complications due to its anti-inflammatory and antithrombotic effects.
Citation Count: 0
Antioxidants, Enzyme Inhibitory Activities, and Phytochemical Profiles of Seven Medicinal Plants Grown With Organic Farming Techniques
(Tubitak Scientific & Technological Research Council Turkey, 2023) Zor, Murat; Ozupek, Burcin; Pekacar, Sultan; Deliorman Orhan, Didem; Eczacılık Meslek Bilimleri Bölümü
In this study, the potential antihyperlipidemic, antidiabetic, and antiobesity effects of extracts obtained via infusion techniques from Artemisia absinthium L., Achillea millefolium L., Calendula officinalis L., Fumaria officinalis L., Mentha piperita L., Origanum onites L., and Urtica dioica L. grown with organic farming techniques were investigated using enzyme inhibition methods (alpha-glucosidase, pan-creatic cholesterol esterase, pancreatic lipase, and alpha-amylase). It is important that natural compounds or extracts to be used in the treat-ment of metabolic problems have antioxidant effects. The antioxidant effects of these species were tested in terms of ABTS and DPPH radical scavenging activity, ferric reducing power, and metal chelating capacity. Extracts (2 mg/mL) of M. piperita (91.43 +/- 0.90%) and O. onites (70.18 +/- 2.02%) showed potent inhibitory effects on the alpha-glucosidase enzyme. Among all species, only O. onites extract ex-erted an inhibitory effect on the cholesterol esterase enzyme close to that of reference compound simvastatin. While all extracts were effective in the tested antioxidant activity methods, it was determined that the M. piperita and O. onites extracts displayed particularly significantly strong activities in terms of ferric reducing power, ABTS radical scavenging effect, and metal chelating capacity. The total flavonoid and phenolic contents of all extracts were determined. The compositions of the most active extracts were analyzed for pheno-lic acids and flavonoids using RP-HPLC. The results of RP-HPLC analysis showed that the levels of ellagic acid (0.923 +/- 0.000 g/100 g extract) in the M. piperita extract and rosmarinic acid (0.813 +/- 0.003 g/100 g extract) in the O. onites extract were high. As a result, all species grown with organic farming techniques except U. dioica were found to have high antioxidant effects. In light of these findings, it was concluded that M. piperita and O. onites grown with organic farming techniques showed strong inhibitory effects in terms of the tested activities, especially for alpha-glucosidase and pancreatic cholesterol esterase, and that in vivo studies and activity-guided isolation studies should be conducted on these species in the future.
Citation Count: 5
Apocynin Ameliorates Testicular Toxicity in High-Fat Diet-Fed Rats by Regulating Oxidative Stress
(Marmara Univ, inst Health Sciences, 2023) Şener, Göksel; Koroglu, M. Kutay; Coskunlu, Busra; Ertas, Busra; Sener, Goksel; Ercan, Feriha; Eczacılık Meslek Bilimleri Bölümü
Objective: The purpose of this study was to examine the effects of apocynin (APC), an inhibitor of NADPH oxidase (NOX), on high-fat diet (HF)induced testis cytotoxicity.Methods: Wistar albino rats were divided into three groups as control, HF and HF+APC groups. Rats in HF and HF+APC groups were fed using HF for 16 weeks and in the last four weeks of this period vehicle solution or APC (25 mg/kg) was administered orally five days a week, respectively. Control group was fed with standart lab chow for 16 weeks. Cholesterol, triglyceride, high-density lipoproteins, leptin, estrogen, testosterone, LH and FSH were estimated in blood serum. Sperm parameters were analysed from the epididymis. Testicular malondialdehyde, 8-hydroxy-2deoxyguanosine, glutathione, superoxide dismutase and myeloperoxidase levels were estimated biochemically. Testicular morphology, proliferative, apoptotic and NOX2-positive cells were analysed histologically.Results: HF-induced obesity caused significant alterations in serum lipid and hormone profiles. Testicular malondialdehyde, 8-hydroxy-2deoxyguanosine, and myeloperoxidase levels increased, glutathione and superoxide dismutase levels decreased in this group. Moreover, altered sperm parameters, increased degenerated seminiferous tubules, apoptotic and NOX2 - positive cells and decreased proliferative cells were observed in the HF group. All these biochemical and histological alterations improved in the HF+APC group.Conclusion: HF-induced obesity causes altreations in lipid values, sperm parameters and testicular morphology by increasing oxidative stress through NOX2 activity. Apocynin might prevent testis damage via regulating oxidant/antioxidant balance.
Citation Count: 0
Apocynin Exhibits an Ameliorative Effect on Endothelial Dysfunction/ Atherosclerosis-Related Factors in High-Fat Diet-Induced Obesity in Rats
(Marmara Univ, Fac Medicine, 2024) Şener, Göksel; Ertas, Busra; Kaya, Rumeysa Keles; Sevinc, Sevgi Kocyigit; Amuran, Gokce Gullu; Ercan, Feriha; Cetinel, Sule; Eczacılık Meslek Bilimleri Bölümü
Objective: The aim of this study was to reveal the effect of apocynin (APO) on the factors involved in obesity-related endothelial dysfunction (ED) and atherosclerosis (AS). Materials and Methods: Male Wistar albino rats were divided into control (CNT), high-fat diet (HFD) and HFD+APO groups. HFD and HFD+APO groups were fed HFD for sixteen weeks. APO (25 mg/kg) was administered to the HFD+APO group for the last four weeks. The effects of APO on: AS-related metabolic parameters (triglyceride, total cholesterol, high-density lipoprotein-cholesterol, insulin and leptin), oxidative stress (OS), [ malondialdehyde, glutathione, nicotinamide adenine dinucleotide phosphate (NADPH)oxidase-2, oxidised-low-density lipoprotein (ox-LDL) and 8-hydroxy-2-deoxyguanosine], low-density lipoprotein and ox-LDL uptake potential (activin receptor-like kinase-1 and lectin-like oxidized low-density lipoprotein receptor-1, respectively), tissue inflammation inducible-nitric oxide synthase, nitric oxide), programmed cell death (terminal deoxynucleotidyl-transferase-dUTP-nick-end (alpha-smooth muscle actin), histology and ultrastructure of thoracic aorta were evaluated. Results: In obesity, APO had an ameliorative effect on metabolic parameters, OS, inflammation, ED, programmed cell death and oxLDL uptake potential, but not on foam cell formation and LDL uptake potential. Conclusion: Apocynin may improve ED and AS in obesity by suppressing OS-linked factors involved in the early stage of AS.

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