Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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Updating the Signal-To Level To Reduce Anti-Hepatitis C Virus False Positivity
(Kowsar Medical Institute, 2021) Oztürk, S.; Ağalar, C.
Background: Anti-hepatitis C virus (anti-HCV) is the only screening test being used in the diagnosis of hepatitis C. In this study, we examined anti-HCV positivity rates in our hospital. Objectives: The aim of administering the anti-HCV test was to distinguish patients with hepatitis C infection from false positivity in patients with reactive results. Methods: The anti-HCV tests were performed at Fatih Sultan Mehmet Training and Research Hospital in Istanbul, Turkey, between January 1, 2015 and December 31, 2019. The patients were evaluated retrospectively in terms of age, gender, anti-HCV titer, the clinic for which the examination was requested, the reason for the examination, and the history of hepatitis C. Results: In this study, 511 patients who had two negative polymerase chain reaction (PCR) results were evaluated as false positive cases and enrolled. The cut-off value was found to be 7.5 IU/ml, with the highest sensitivity of 94.4% and specificity of 94.5% (area under the curve [AUC]: 0.982). The lowest anti-HCV titer (5.2) was from patients without acute hepatitis, who were HCV-RNA positive and diagnosed with chronic hepatitis C. Conclusions: It may be more appropriate to report anti-HCV cut-off value of 0-5 as negative, 5-7.5 as borderline, and > 7.5 as positive. Working with a more acceptable cut-off level with a greater number of tests can help identify patients with asymptomatic HCV infection. Also, it can possibly reduce the cost due to a decrease in the number of PCR tests administered. © 2021, Author(s).
The Correlational Study of the Vertical Jump Test and Wingate Cycle Test as a Method To Assess Anaerobic Power in Road Cyclists
(Nevzat Demirci, 2023) Ulusoy, Y.; Koçak, F.
Road Cycling is an important sport that uses anaerobic and aerobic metabolism and especially sprinter cyclists have higher anaerobic capacity. The assessment of anaerobic power in cyclists often involves the use of the vertical jump and Wingate cycle tests. The lack of research in the field of cycling-specific tests to assess anaerobic performance has led to the improvement of existing research. The objective of this research was to investigate the correlation between the vertical jump test and the Wingate anaerobic cycling tests, both of which are often used to assess anaerobic power in road cyclists. A correlation study was conducted on 15 athletes of the Turkish national road cycling team in the 14-16 age group (15.107 ± 0.717 (SD)). The sample of the study was determined by using the convenient sampling method. On the first day, anthropometric measurements and the vertical jump test were conducted. The Wingate cycle ergometer test, lasting for a duration of 30 seconds, was administered to the participants on the second day. The computer application was used to determine the 30-second peak and average anaerobic power during the test. The results acquired from the study revealed a statistically significant positive relationship between the vertical jump performance and the peak power production measured during the Wingate cycle test (r=0.321, p<0.05). The findings indicate that vertical jump tests may serve as suitable field measurements of anaerobic power for road cyclists, as an alternative to the laboratory-based Wingate anaerobic test. © The Author(s) 2023.
Citation - WoS: 6
Citation - Scopus: 6
beta Vulgaris L. Var. Cicla Improves Memory Deficits in Intracerebroventricular Streptozotocin Injected Rats: Role on Neuroinflammation
(Marmara Univ, 2021) Ertas, Busra; Topal, Fadime; Gulhan, Rezzan; Yanardag, Refiye; Sacan, Ozlem; Sener, Goksel
Alzheimer's disease is a challenging disease for patients due to progressive loss of cognition and behavioral disorders. Disruption of cholinergic transmission and neuroinflammation are the most important mechanisms underlying cognitive damage. Beta vulgaris L. var. cicla (BV) has been reported to have various pharmacological effects associated with its rich antioxidant content. In addition, anti-cholinesterase and antiinflammatory activities of BV have been demonstrated in vitro. The aim of this study is to elucidate the therapeutic effect of BV against cognitive impairment, reduction in cholinergic transmission and neuroinflammation caused by intracerebroventricular (ICV) administration of streptozotocin (STZ). STZ was administered bilaterally at a dose of 3 mg/kg via ICV to rats, and BV treatment at a dose of 2 g/kg for 21 days was administered orally to STZ-induced animals. After behavioral tests, AChE activity, TNF-alpha and IL-1 beta levels were measured in hippocampus and cortex tissues excised from decapitated animals. Novel object recognition and passive avoidance test showed that the treatment of BV reverted the ICV-STZ induced memory dysfunctions in rats. Furthermore, increased AChE levels in the hippocampal and cortical tissues of STZ-induced rats were significantly reduced with 21 days of BV treatment. In conclusion, these results confirm that STZ administration caused cholinergic hypofunction, neuronal inflammation and cognitive dysfunction in rats, and BV therapy significantly inhibited these changes with its potential neuroprotective activity.
Comparison of HLA-G Levels for Cord Blood Derived-MSC and Wharton's Jelly Derived-MSC
(Walter de Gruyter GmbH, 2025) Abatay Sel, Figen; Erol Bozkurt, Ayse; Karatas, Sule; Suleymanoglu, Mediha; Yasa, Beril; Yasa, Cenk; Savran Oguz, Fatma
Objectives: A special group of stem cells with multipotent and immunomodulatory properties are mesenchymal stem cells (MSCs). Many modulatory factors are thought to mediate immunomodulatory properties of MSCs. One of these modulatory factors is thought to be HLA-G, one of human leukocyte antigens (HLA). This study aimed to compare HLA-G levels in both stimulated and unstimulated of peripheral blood mononuclear cell (PBMC) cultures with "cord blood-MSC" (CB-MSC) and "Wharton's jelly-MSC" (WJ-MSC) at different rates and different incubation periods. Methods: WJ-MSCs were obtained by explant method, and CB-MSCs using Ficoll-paque. They were characterized by flow cytometry. MSCs and PBMCs were directly co-cultured for 24 and 72 h at 1:5 and 1:10, respectively. After incubations, the media were collected and HLA-G levels were measured by ELISA. Results: In the unstimulated group, the highest HLA-G level was found in the PBMC:WJ-MSC-72-1:5 group, while the lowest HLA-G level was found in the PBMC:CB-MSC-72-1:5. When 24-1:5 and 72-1:5 groups were examined, the HLA-G level decreased significantly in CB-MSC groups compared to WJ-MSC, while it increased significantly in the 24-1:10 and 72-1:10 groups (p<0.05). In stimulated groups, the highest HLA-G level was observed in the PBMC:CB-MSC-24-1:5. Conclusions: Our study aimed to evaluate the immunomodulatory effect of MSCs via HLA-G molecule. HLA-G levels changed with different incubation times of two different MSC sources. In this study, we suggest that MSCs as a cell therapy, in particular for immune system-related disease, may be a preliminary in vitro approach to evaluate the immunomodulatory effect via HLA-G.
Citation - Scopus: 2
Platanus Orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage
(Marmara University, 2022) Ayaz Adakul, B.; Şen, A.; Şener, T.E.; Erdoğan, Ö.; Çevik, Ö.; Eker, P.; Şener, G.
The aim of this study is to determine whether Platanus orientalis (PO) which has anti-inflammatory, antioxidant and diuretic properties and used in the treatment of kidney stones as traditional folk medicine, will reduce or prevent the stone formation in the urinary system. To simulate the urolithiasis model 0.75% ethylene glycol (EG) and 1% ammonium chloride (AC) were applied to Sprague-Dawley rats. The rats were divided into four groups (n=8). The control group was given standard drinking water for 5 weeks. EG group received 0.75% EG in their drinking water containing 0.75% EG and 1% AC. PO extract (100 mg/kg) was given orally for 5 weeks to the preventive group and for last 2 weeks to the therapeutic group, respectively. At the end of experiment, 24-hour urine and kidney samples were obtained. In urine samples, calcium and citrate levels were decreased and oxalate level was increased in the EG group. In kidney samples myeloperoxidase, caspase-3, N-acetyl-β-glycosaminidase (NAG) activities, malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), tumor necrosis factor-α and interleukin-1β levels were increased while superoxide dismutase activity and glutathione levels were decreased in the EG group. These biochemical parameters returned to control levels in both PO treatment groups. Histological findings also correlate with these results. Our findings are suggested that PO treatments is effective in both preventive and therapeutic groups. © 2022 Marmara University Press.
Relationship of Handwriting Skills With Cognitive Functions and Sensory Processing in the Older Adults
(Routledge Journals, Taylor & Francis Ltd, 2025) Sirma, Gamze Cagla; Yucel, Hulya
Aims: Handwriting involves complex processes, including cognitive function and sensory processing. Cognitive function and sensory processing change with aging. However, the relationship between these parameters remains unclear. The aim of this study is to investigate the relationship between cognitive function and sensory processing with handwriting skills in the older adults. Methods: Fifty-six community-dwelling individuals aged 65-75 years completed a sociodemographic questionnaire, the Adolescent/Adult Sensory Profile, the Montreal Cognitive Assessment (MoCA), and handwriting tasks. Results: The mean age was 70.62 +/- 3.49 years. The strongest correlations were observed between MoCA and the handwriting subtest. Low registration, sensory sensitivity, and sensation avoiding were positively correlated with handwriting subtests. Moreover, the results showed that these skills were also predictive of older adults' handwriting skills (p < 0.05). Conclusions: It is crucial for occupational therapists and physiotherapists to integrate handwriting skill assessment into their clinical settings in terms of its relationship with cognitive and sensory processing.
Marketing Ethics and Ethical Issues Related To Marketing Communication
(Springer-verlag Singapore Pte Ltd, 2018) Sayil, Emine Mediha
[No Abstract Available]
Ensemble-Based Alzheimer's Disease Classification Using Features Extracted From Hog Descriptor and Pre-Trained Models
(Sakarya University, 2024) Muzoğlu, Nedim; Akbacak, Enver
Alzheimer's Disease is the most common type of dementia and is a progressive, neurodegenerative disease. The disease worsens over time, and the patient becomes bedridden, unable to move or understand what is happening around him. The main concern of medicine is to slow down the progression of the disease for which no treatment has yet been developed. Artificial intelligence studies have achieved significant success in detecting many diseases. In this study, an artificial intelligence-based approach that uses MR images of the early stage of Alzheimer's Disease to detect the disease at an early stage is presented. Initially, a new dataset was created through the application of the fuzzy technique, thereby expanding the feature space. Then, an ensemble learning-based hybrid deep learning model was developed to reduce the misclassification rate for all classes. The features derived from the inception module, residual modules, and histogram of oriented gradients descriptor are subjected to classification through bagging and boosting algorithms. The proposed model has surpassed many state-of-the-art studies by achieving a high success rate of 99.60% in detecting Alzheimer's disease in its early stages.
Citation - Scopus: 4
Gender-Stereotyped Barriers Against Women Football Players in Turkey: a Qualitative Perspective on the Eccles' Expectancy-Value Theory
(Pamukkale University, 2022) Elmas, S.; Aşçi, F.H.
This qualitative research aimed to investigate the experiences of women football players in Turkey in terms of Eccles' Expectancy-Value Theory from a gender stereotypes perspective. A phenomenological method was used to allow a deeper understanding of their experiences. The research group consisted of eight women from three different football league levels in Istanbul, TR. The data were analyzed via thematic and content analysis. The identified themes after content analysis are: (1) loving football; (2) instrumentality of football; (3) sociocultural barriers against women players; (4) multidimensional perceived costs. According to these findings, we can illustrate that the social, cultural, and institutional environment of the women players creates many problems, difficulties, and deprivations in their participation, which make it difficult for their expectancy for success, task values, and future plans in their sports. In order to make the experiences of female football players about gender-based stereotypes more understandable, it is recommended that more studies that deal with the qualitative method and Eccles' theory should be done in future studies. © 2022 The Author(s).
Empowering a Mother of Children With Autism: a Case Report on the Impact of Tele-Occupational Performance Coaching on Parent-Child Relationships, Maternal Self-Efficacy, and Occupational Performance
(Routledge Journals, Taylor & Francis Ltd, 2025) Bektas, Selen Aydoner; Bumin, Gonca
This case report aimed at tele-occupational performance coaching to empower the mother of a child with autism spectrum disorder by enhancing occupational performance, parent-child relationships, and maternal self-efficacy. Over 8 weeks, the intervention addressed goals collaboratively identified by the mother, including self-care, productivity, and leisure-related tasks. Results revealed clinically significant improvements, with a two-point increase in Canadian Occupational Performance Measure scores for both performance and satisfaction. Significant score increases were also obtained on the Parent-Child Relationship Scale and the Early Intervention Parenting Self-Efficacy Scale. The findings underscore the effectiveness of tele-occupational performance coaching in enhancing family dynamics and parental capabilities while emphasizing the potential of telehealth as a scalable and accessible modality for delivering family-centered occupational therapy. Future research should expand on these findings by incorporating diverse populations and assessing long-term outcomes.
NADPH Oxidase-2 Inhibitor Apocynin Attenuates High-Fat Diet-Induced Kidney and Bladder Injury
(Marmara Univ, Fac Medicine, 2025) Kanpalta Mustafaoglu, Fatma; Ertas, Busra; Sener, Goksel; Ercan, Feriha
Objective: This study aimed to evaluate the effects of NADPH oxidase-2 (NOX-2) inhibitor apocynin (APC) on high-fat diet (HFD)induced renal and bladder injury. Materials and Methods: Wistar albino rats were divided into 4 groups: Control, HFD, HFD+dimetyl sulfoxide (DMSO), and HFD+APC. Rats in HFD, HFD+DMSO, and HFD+APC groups were fed with HFD for sixteen weeks. In the last 4 weeks of the experiment, either DMSO or APC (25 mg/kg, dissolved in DMSO) was applied to the HFD+DMSO or HFD+APC groups. Lipid profiles and leptin values were measured in blood serum. Renal and bladder oxidant/antioxidant parameters, histological changes in the tissues, NOX-2-, nuclear factor kappa B (NF-& kgreen;B)-immunopositive and apoptotic cells were evaluated. Results: At the end of the experiment, leptin, cholesterol, and triglyceride levels were higher and high-density lipoprotein levels were lower in the HFD and HFD+DMSO groups compared to controls. In these experimental groups, an increase in malondialdehyde, 8-hydroxy-deoxyguanosine and myeloperoxidase levels and a decrease in glutathione levels, as well as an increase in collagen, NOX-2-and NF & kgreen;-B-immunopositive and apoptotic cells were found. Also, a deterioration in kidney and bladder morphology was observed. All these biochemical and histopathological findings improved in the HFD+APC group. Conclusion: High-fed diet causes renal and bladder injury by increasing NOX-2 activity and inflammation via oxidative stress. APC might alleviate tissue injury by inhibiting oxidative stress.
Citation - WoS: 6
Citation - Scopus: 6
Myrtle Improves Renovascular Hypertension-Induced Oxidative Damage in Heart, Kidney, and Aortic Tissue
(Springer, 2022) Arslan, Sule; Ozcan, Ozan; Gurel-Gokmen, Begum; Cevikelli-Yakut, Zatiye Ayca; Saygi, Halil Ibrahim; Sen, Ali; Tunali-Akbay, Tugba
Renovascular hypertension is defined as the reduction in renal perfusion resulting in sustained hypertension. This study aims to investigate the possible effects of myrtle leaf extract (Myrtus communis L.) on, heart, kidney and aorta tissues in the experimental renovascular hypertension (RVH). 32 male Wistar Albino rats were divided into four groups as control, hypertension, hypertension+ramipril, and hypertension+myrtle leaf extract treatment groups. RVH model was induced by Goldblatt's 2-kidney 1-clip method. 12 weeks later than the treatment blood pressures were recorded and oxidant and antioxidant parameters, tissue factor activity, and histological analysis were determined in the kidney, heart, and aortic tissues. The blood pressure levels of the hypertension group significantly increased compared to the control group. Administration of myrtle leaf extract and ramipril significantly decreased the increased blood pressure. In the hypertension group, oxidative damage increased in the kidney, heart, and aorta tissues. In the histological evaluation of tissues in RVH, heart muscle fibres degenerated. Bowman capsule and glomeruli dilated and tubules damaged in the kidney. Myrtle leaf extract administration regenerated the damages and degenerations. The administration of myrtle leaf extract restored the impaired oxidant-antioxidant balance in the heart, kidney and aorta tissues of hypertensive rats. Myrtle leaf extract can be considered as an alternative antihypertensive treatment target in the prevention of oxidative stress-induced damage in renovascular hypertension.
Radioprotective Effect of Resveratrol for Early and Late Ionizing Radiation-Induced Damages on Colon and Rectum in Rats
(Marmara Univ, 2023) Beceren, Ayfer; Aydemir, Sezgin; Atasoy, Beste Melek; Esin, A. K.; Ercan, Feriha; Sener, T. Emre; Sener, Goksel
Radiotherapy, which is routinely used to treat a wide range of oncological disorders, primarily affects the malignant tissue in the targeted area, but also have negative effects in the surrounding tissues. Pelvic radiotherapy causes early and late effects on the colon and rectum. Resveratrol (RVT) has been revealed to have a number of pharmacological effects in a variety of experimental models and clinical circumstances, therefore it has piqued the interest of scientists in recent years. In this study, we aimed to investigate the potential protective effects of resveratrol (RVT), a strong antioxidant, anti-inflammatory and anti-mutagenic agent, against toxicity of colonic and rectal tissues seen in the early and late stages after pelvic radiation. The treatment durations of the current study were designed as one week and ten weeks interval by following radiation exposure. Sprague Dawley rats were divided into 5 groups (8 animals/group) as the control, radiation-early effects (Rd-E), radiation-late effects (Rd-L), and RVT-treated Rd-E (Rd-E+RVT) and RVT-treated Rd-L (Rd-L+RVT) groups. Ionizing radiation was performed to the pelvic area that covers colon and rectum in single fraction of 20 Gy in a linear accelerator using with 6 MV photon energy. RVT was orally administered (10 mg/kg/day) immediately following the radiation exposure and continued daily for 1 and 10 weeks for early and late groups, respectively. Pelvic radiation caused a significant decrease in glutathione level, while malondialdehyde levels, myeloperoxidase activity and 8-hydroxydeoxyguanosine were increased in both Rd-E and Rd -L groups in the colon and rectum tissues. Additionally, light microscopic evaluations (H & E staining) revealed degeneration of epithelium and inflammatory cell infiltration in the colonic and rectal tissues in radiation groups. RVT treatment reversed all conducted biochemical parameters and ameliorated histomorphological changes following early and late effects of pelvic radiation in tissues. In conclusion, resveratrol may be a candidate as a radioprotector for normal tissues during and after radiotherapy.
Reading Basic Design Principles Through Modern Architectural Structures
(Nilay Ozsavas Ulucay, 2023) Yıldırım Coruk, İ.
Basic design principles are taught within the scope of basic design education in the first-year studios. Basic design education and its content have different dimensions from the education system the student previously received due to its structure and difficulty comprehending because it contains new literature for the student and often has abstract educational content. On the other hand, the students have difficulty perceiving the information acquired in this course and question how they can benefit from it in the following years and professional life. Therefore, the aim of the study is to analyze the basic design principles through modern architectural structures. In the study created by qualitative research method, the data were obtained by analyzing the principles mentioned in the determined examples. These examples were selected among the Bauhaus and later modern buildings by considering the role of the Bauhaus school, where the basic design principles emerged in the spread of modern architecture, and the scope of the study was created. As a result of the study, concrete uses and equivalents of basic design principles were revealed with the determined examples. Thus, data on how students will benefit from basic design principles have been revealed. © 2023, Nilay OZSAVAS ULUCAY. All rights reserved.
Citation - WoS: 5
Citation - Scopus: 7
Bitter Melon (Momordica charantia) Fruit Extract Ameliorates Methotrexate-Induced Reproductive Toxicity in Male Rats
(Marmara University, 2021) Kanpalta, Fatma; Özbeyli, Dilek; Sen, Ali; Cevik, O. Dağdeviren; Şener, Göksel; Ercan, Feriha
Objective: Methotrexate (MTX) is a drug commonly used for the treatment of malign neoplastic and inflammatory diseases. Anti-oxidant and anti-inflammatory effects of bitter melon (BM) were reported. The aim of this study was to examine the effects of BM fruit extract on MTX-induced testicular and epididymal damage. Materials and Methods: Sprague Dawley male rats were divided into three groups (n=8) as control, MTX and MTX+BM. A single dose of MTX (20 mg/kg) was injected intraperitoneally to the MTX and MTX+BM groups. BM fruit extract (600 mg/kg) was applied to the MTX+BM group orally for 5 days. Testes were examined for general histopathology, proliferating and apoptotic cells. The epididymis samples were used for the evaluation of sperm morphology. Oxidative and inflammatory markers were analysed biochemically. Results: Increased abnormal spermatozoa, degenerated seminiferous tubules with increased apoptotic cells and decreased proliferative cells were observed in the MTX group. TNF-α, IL-1β, 8-hydroxy-2-deoxyguanosine and caspase-3 levels increased, superoxide dismutase and catalase levels decreased in both testis and epididymis samples. All these histological and biochemical parameters were ameliorated in the MTX+BM group. Conclusion: Methotrexate causes testis damage by decreasing spermatogenic cells and increasing apoptosis through oxidative stress and inflammation. BM extract improves testis and epididymis damage with its possible anti-oxidant and anti-inflammatory effects. © 2025 Elsevier B.V., All rights reserved.
Citation - Scopus: 1
Management of Diversities in the Context of Healthcare Professionals’ Attitudes Towards Diversities
(Association of Executive Nurses, 2021) Çakır, H.; Harmancı Seren, A.K.
People belonging to different cultures, ethnic origins, geographic regions, speak different languages and live together more and more in the world. This change has also found its counterpart in management practices, and diversity management approaches have begun to be included in the literature. In the light of the existing national and international literature, the study aimed to examine health professionals’ attitudes towards diversities and the factors affecting their attitudes. Considering the lack of literature in this field, the data compiled in this study are aimed to be useful in practices related to the management of diversities in the field of nursing. The study aims to provide a professional perspective on diversity and awareness of changing management paradigms for the manager nurses. © 2021 SHYD.
Citation - WoS: 13
Citation - Scopus: 13
Types of Bread Preferred by Adult Individuals and Bread's Place in Daily Nutrition
(Mattioli 1885, 2021) Ilktac, Havvanur Yoldas; Sadik, Merve; Garipagaoglu, Muazzez
Bread, one of the most consumed food by humankind throughout history, has a global importance in nutrition. The common belief in recent years that bread is fattening and is harmful to health causes bread to be excluded from daily nutrition. This study aims to determine the individuals' bread preferences and the contribution of the bread consumed to daily nutrition. It was carried out in Turkey with 1766 volunteer participants aged between 18-65 years. The data were collected with a questionnaire form applied by face-to-face interview method. In order to determine the nutritional status, 2-day food consumption records were kept. The body mass index average of individuals was 26.4 +/- 8.25 kg/m(2). The waist circumference averages of male and female participants were found as 97.8 +/- 12.97 cm, 91.1 +/- 16.13 cm, respectively. It was found that the most consumed bread was white bread (87.3%), followed by whole-grain bread (40.8%). It has been found that the consumption of whole grain bread is higher in women compared to men. Female participants' whole-grain bread consumption was found to be higher than male participants, while male participants' cornbread consumption was higher than female participants (p<0.00 and p=0.026). It was found that male participants consume 182.3 +/- 105.07 g of bread per day, while females 124.5 +/- 78.11 g. It was observed that bread constitutes 27.1% of total daily energy intake in male participants, while 22.1% in females and this difference was found statistically significant (p<0.001). These results reveal that bread is the main ingredient in nutrition for Turkish society. The type of bread, which makes up the majority of carbohydrates, is as important as the amount. It is thought that training on healthy consumption of bread at the national level, and national and public service announcements and government-backed activities can positively change the bread consumption habits of individuals.
Citation - WoS: 1
Citation - Scopus: 2
Apocynin Exhibits an Ameliorative Effect on Endothelial Dysfunction/ Atherosclerosis-Related Factors in High-Fat Diet-Induced Obesity in Rats
(Marmara Univ, Fac Medicine, 2024) Ayci, Nurdan Bulbul; Ertas, Busra; Kaya, Rumeysa Keles; Sevinc, Sevgi Kocyigit; Amuran, Gokce Gullu; Ercan, Feriha; Cetinel, Sule
Objective: The aim of this study was to reveal the effect of apocynin (APO) on the factors involved in obesity-related endothelial dysfunction (ED) and atherosclerosis (AS). Materials and Methods: Male Wistar albino rats were divided into control (CNT), high-fat diet (HFD) and HFD+APO groups. HFD and HFD+APO groups were fed HFD for sixteen weeks. APO (25 mg/kg) was administered to the HFD+APO group for the last four weeks. The effects of APO on: AS-related metabolic parameters (triglyceride, total cholesterol, high-density lipoprotein-cholesterol, insulin and leptin), oxidative stress (OS), [ malondialdehyde, glutathione, nicotinamide adenine dinucleotide phosphate (NADPH)oxidase-2, oxidised-low-density lipoprotein (ox-LDL) and 8-hydroxy-2-deoxyguanosine], low-density lipoprotein and ox-LDL uptake potential (activin receptor-like kinase-1 and lectin-like oxidized low-density lipoprotein receptor-1, respectively), tissue inflammation inducible-nitric oxide synthase, nitric oxide), programmed cell death (terminal deoxynucleotidyl-transferase-dUTP-nick-end (alpha-smooth muscle actin), histology and ultrastructure of thoracic aorta were evaluated. Results: In obesity, APO had an ameliorative effect on metabolic parameters, OS, inflammation, ED, programmed cell death and oxLDL uptake potential, but not on foam cell formation and LDL uptake potential. Conclusion: Apocynin may improve ED and AS in obesity by suppressing OS-linked factors involved in the early stage of AS.
Citation - Scopus: 2
Event Graphs: Syntax, Semantics, and Implementation
(Institute of Electrical and Electronics Engineers Inc., 2023) Gunal, M.M.; Ismail Osais, Y.; Wagner, G.
This tutorial aims to introduce Event Graphs (EGs), invented 40 years ago by Lee Schruben to allow eventbased modeling of discrete dynamic systems. Their simplicity and naturalness in causality modelling and simulation modelling made EGs popular in research and practice. In a simulation, an event causes state changes in a system as well as other events to happen in the future. EGs provide a parsimonious diagram representation for the Event Scheduling paradigm of Discrete Event Simulation. We first introduce their visual syntax and informal semantics, and then present a recent extension by adding objects to EGs. Our tutorial also includes an introduction to the formal semantics of EGs and a Python implementation for executing EGs. © 2023 IEEE.
Development and Psychometric Properties of the Self-Efficacy Scale for Symptom Management and Self-Care in Patients with Cardiac Surgery
(Springer Publishing Co, 2025) Aksut, Rabia Saglam; Capik, Canturk; Elmas, Tugce Bozkurt
Background and Purpose: Evaluating self-efficacy for symptom management and self-care is crucial for ensuring follow-up care after cardiac surgery. As there is not yet a validated measurement tool for this evaluation, the aim of this study was to develop the Self-Efficacy Scale for Symptom Management and Self-Care (SESMSC: Cardiac Surgery) in patients with cardiac surgery and to examine its psychometric properties. Methods: The Symptom Management Theory and Bandura's Self-Efficacy Theory were used as the theoretical background for scale development. A multiphase design was utilized. The initial development phase consisted of item generation and expert panel review. The second phase comprised a three-step validation process: (a) face and content analysis (CFA) for construct validity, and (c) Cronbach's alpha, test-retest, and item- total correlation analysis to assess internal consistency reliability. The sample (n = 401) was randomly divided into two subsamples for EFA and CFA (EFA group: n = 201; CFA group: n = 200). Results: EFA suggested a 20-item, two-factor structure with factor loadings of .342-.782. The two subscales of the scale were labeled symptom management self-efficacy and self-efficacy for ch's alpha, test-retest, and item-total correlation results demonstrated acceptable internal consistency reliability. Implications for Practice: The SESMSC: Cardiac Surgery may be a useful tool to evaluate self-efficacy for symptom management and self-care after cardiac surgery. Further evaluation in independent samples is needed to investigate its psychometric properties and usefulness in clinical practice.

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