PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/8

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Citation - WoS: 1
Citation - Scopus: 1
Effect of Everolimus on Prognosis of Neurofibromatosis Type 1 Lesions: a Systematic Review and Meta Analysis
(Elsevier, 2024) Ibrahim, Ismail A.; Abdelkader, Rem Ehab; Nada, Ahmed Hosney; Younes, Siham; Hanen, George; Shahwan, Ghena; Nashwan, Abdulqadir J.
Purpose: This study addresses the effectiveness of oral everolimus in treating various malignancies associated with Neurofibromatosis Type 1 (NF1). The purpose is to determine whether everolimus reduces lesion size in NF1 patients, considering the controversial findings from previous clinical trials. The scientific hypotheses and questions involve evaluating the impact of everolimus on NF1-associated lesions and understanding the variability in treatment outcomes. Methods: A systematic review and meta-analysis were conducted following PRISMA and Cochrane Collaboration guidelines. The study included four-phase II, single-arm, nonrandomized trials investigating the effect of oral everolimus on NF1-associated lesion size. The search covered multiple databases, and data extraction involved evaluating studies for inclusion criteria and assessing quality using the Cochrane Collaboration's Risk of Bias in Nonrandomized Studies tool. Statistical analysis utilized Open Meta(Analyst). Findings: The search yielded 388 studies, with 10 selected for full-text review and four included in the final analysis. The quality of the studies ranged from low to moderate. The meta-analysis indicated no observed heterogeneity (I2 = 0%), and the overall estimate suggested no significant reduction in NF1-associated lesion size with everolimus ( P = 0.069). Implications: The findings reveal a varied and inconsistent picture of everolimus efficacy in NF1 treatment. The study highlights the need for personalized approaches, considering individual genetic and clinical differences. The limitations, including small sample sizes and nonrandomized trials, call for larger, more standardized research efforts. The study emphasizes ongoing trials and the importance of future research in understanding predictors of everolimus response and optimizing treatment strategies for NF1 patients. Conclusion: While everolimus shows promise in reducing lesion size in a subset of NF1 patients, the study cannot draw conclusive results due to limitations in the included studies. Ongoing, adequately powered trials are crucial for advancing the evidence base and informing the potential role of everolimus in NF1 treatment. Others: There was no funding for this review and no conflicts of interest.
Citation - WoS: 5
Citation - Scopus: 5
The Effects of Rational Emotive Behavior Therapy and Motivational Interviewing on Emotions, Automatic Thoughts, and Perceived Performance of Elite Female Volleyball Players
(Elsevier, 2023) Urfa, O.; Asci, F. H.
Objectives: The aim of this study was to examine the effect of Rational Emotive Behavior Therapy intervention alone (REBT-A) or with motivational interviewing (REBT + MI) on the emotions, automatic thoughts, and perceived performance of elite female volleyball players. Design: and method: Single-case, staggered multiple-baseline AB and ABC designs were adapted in the study. Five female volleyball players participated in the study, of which three players participated in the REBT-A and two players participated in the REBT + MI. The athletes were competing in the national volleyball league (Mage = 28, SD = 5.52). All participants were elite athletes with at least ten years of sports experience. Three scores (T1, T2, T3) were calculated for the athletes' perceived performance, emotion, and automatic thoughts. T1 was the baseline score calculated before the sessions. T2 was calculated after the first two sessions (the first three sessions for REBT + MI) and T3 was calculated after the last three sessions. In the data analysis, percentage changes, effect size, and visual analyzes were used in the T1, T2, and T3 scores. Results: REBT-A and REBT + MI interventions increased perceived performance, positive emotions, and positive automatic thoughts, and decreased negative emotions and negative automatic thoughts. REBT + MI was more advantageous than REBT-A in increasing positive emotion, positive automatic thought, and perceived performance. Conclusions: As a result, REBT alone or with motivational interviewing has a positive effect on perceived performance, emotions, and automatic thoughts, but REBT + MI has greater potential to increase positive constructs.
Citation - WoS: 4
Citation - Scopus: 6
Hepatoprotective Effects of Parsley (petroselinum Crispum) Extract in Rats With Bile Duct Ligation
(Elsevier, 2023) Ede, Seren; Özbeyli, Dilek; Erdogn, Omer; Cevik, Ozge; Kanpalta, Fatma; Ercan, Feriha; Senerg, Goksel
Background and study aims: This study aimed to investigate the possible protective effects of parsley extract (Petroselinum Crispum; PC) against oxidative liver damage caused by bile obstruction in rats. Material and methods: Bile duct ligation (BDL) method was used to induce liver injury in rats. The rats were divided into the three groups each consisting of 8 rats; Sham-operated control (C), bile duct ligated + saline treated (BDL), and BDL + PC treated groups. PC extract was given at a dose of 2 g/kg orally for 28 days. Aspartate amino transferase (AST), alanin amino transferase (ALT), and bilirubin levels were analyzed in sera. In order to determine free radicals in liver injury, luminol and lucigenin chemiluminescence tests used. Oxidative stress was evaluated through superoxide dismutase, glutathione, malondialdehyde, Na+/K+-ATPase and 8-hydroxy guanosine levels. Furthermore, inflammation marker myeloperoxidase, apoptosis marker caspase-3, and fibrosis markers TGF- beta and hydoxyproline were investigated. The liver tissues were also examined for histological evaluations.Results: While PC treatment decreased AST and ALT levels which increased with BDL, oxidant damage parameters also decreased with this treatment. Conclusion: The present study, which is the first research for PC extract on cholestasis induced liver damage, demonstrated that PC extract could be a potential therapeutic agent against liver fibrosis and need further studies.
Immediate Effects of Soft Tissue Mobilization and Percussive Massage on Balance in Young Adults With Pes Planus: a Single Blind, Randomized Controlled Pilot Study
(Elsevier, 2024) kethudaoglu, Mustafa Oguz; Ozdemir, Aysem Ecem; Saglam, Oznur Kaya; Caglar, Engin; Caglar, Meltem Meran; Demir, Gokhan; Duymaz, Tomris
Background: Presence of pes planus is known to effect balance. In this study, it was aimed to examine the immediate effects of IASTM and PMT on static and dynamic balance in young adults with pes planus. Method: The navicular drop test was used to diagnose pes planus. 51 individuals were included in the study and divided into three groups [IASTM (n:15), percussive massage (n:18) and control (n:18) groups] by simple randomization. Flamingo and Y Balance test was assessed before and immediately after intervention. Repeated Measures ANOVA test was used for the intergroup comparison, and the One -Way ANOVA test was used for the intragroup comparison, also post -hoc test with Tukey correction was performed. Results: There was no significant difference in static balance between the three groups (p > 0.05). There was a significant difference in dynamic balance between groups (p < 0.05). Only IASTM group had significant differences at before and after intervention of all directions except for posterolateral direction of Y Balance Test (p < 0.05). Conclusion: IASTM applied to the plantar fascia of individuals with pes planus have immediate effects on dynamic balance when compared to no intervention and percussive massage even within a small sample size.
Citation - Scopus: 1
Investigating the Impact of Various Insole Applications on Balance and Postural Stability in the Elderly
(Elsevier, 2025) Ozturk, Basar; Ozdincler, Arzu Razak; Kocyigit, Ahmet; Kaya, Begum Kara; Kisa, Eylul Pinar
Objectives: Aging leads to physical and cognitive declines, notably affecting balance and motor skills, making falls a prevalent health concern among the elderly. Falls, a significant health issue among the elderly, often stem from these impairments. This study aims to investigate the impact of different insole materials, specifically cork and silicone, on balance and postural stability in the elderly. Methods: A randomized controlled trial was conducted at the Istanbul Barinyurt Elderly Care Center with 24 participants, divided into two groups to test cork and silicone insoles. Balance parameters, plantar pressure, the Timed Up and Go (TUG) test, and the Five Times Sit-to-Stand Test were used as measures. Data analysis was performed using the Mann-Whitney U and Wilcoxon tests. Results: Post-intervention, the cork insole group showed significant improvements in balance, maximum plantar pressure, and functional mobility tests compared to the silicone insole group. While both insoles enhanced certain balance parameters and walking performance, cork insoles proved more effective in key outcomes. Additionally, maximum plantar pressure for the cork insoles group decreased significantly, indicating better pressure distribution and potentially enhanced balance. Conclusion: Cork insoles are superior to silicone insoles in improving balance and postural stability among the elderly. This study supports using cork insoles as part of fall prevention strategies, emphasizing the importance of material properties in orthopedic insole design. Future research should explore long-term effects and integrate insoles with other postural stability methods for comprehensive elderly care.
Citation - WoS: 2
Citation - Scopus: 2
Investigation of Physical Parameters Influencing Body Awareness in Adults With Obesity: an Observational, Controlled Study
(Elsevier, 2024) Eryildiz, Ezgi; Delibas, Elifnur; Kesgin, Ilayda Melek; Ozturk, Ipek Beyza; Huseyinsinoglu, Burcu Ersoz
Aim: The primary aim was to compare the body awareness (BA) level in adults with obesity and non-obese adults. The secondary aim was to investigate the physical parameters associated with BA and compare them between adults with obesity and non-obese adults. Method: Thirty-two adults with obesity and age and sex-matched 32 non-obese adults were included in the study. The outcome measures were the Body Awareness Questionnaire, International Physical Activity QuestionnaireShort Form and Functional Reach Test to detect BA, physical activity (PA), and dynamic balance level, respectively. Reaction time was assessed by the Nelson Foot Reaction Test and knee and trunk position error by inclinometer. Results: There was no significant difference between the obese and non-obese group in terms of BA score (p = 0.18) and PA level (p = 0.50). Lower dynamic balance was observed in the obese group (p = 0.003). Only the trunk position error was higher in the obese group in the measurement of joint position error (p = 0.010). There were no significant differences in the right and left feet reaction times between the groups (p = 0.68 and p = 0.23). There were no relationships between BA score and PA level (p = 0.93), dynamic balance (p = 0.82), joint position error (p = 0.14), and right (p = 0.33) and left (p = 0.25) reaction times. Conclusion: There was no significant difference in body awareness between the non-obese and the obese group and there was no association between body awareness and the physical parameters. However, adults with obesity had impaired balance and proprioception compared to non-obese ones.
Montelukast Attenuates Abdominal Aortic Aneurysm in Rats: Anti-Inflammatory and Antioxidant Effects
(Elsevier, 2026) Tekin, Gozde; Cevik, Ozge; Cetinel, Sule; Sener, Goksel; Kizilay, Mehmet
Objective: Oxidative stress and inflammation are widely recognized as central mechanisms in the pathogenesis of abdominal aortic aneurysm. This study sought to examine the potential protective properties of montelukast in a rat model of aortic aneurysm. Methods: Male Sprague-Dawley rats were randomly allocated into three experimental groups. Abdominal aortic aneurysm was induced using the calcium chloride (CaCl2) model, in which gauze soaked in 0.5 M CaCl2 was placed directly onto the adventitial surface of the infrarenal abdominal aorta for 15 minutes. After induction, the treatment group received daily intraperitoneal injections of montelukast (10 mg/kg) for 4 consecutive weeks. At the study end point, animals were euthanized, and infrarenal aortic tissues were harvested for biochemical and histological evaluations. Measured parameters included matrix metalloproteinase (MMP)-2 and MMP-9 expression, myeloperoxidase (MPO) activity, and 8-hydroxy-2 '-deoxyguanosine levels. Antioxidant capacity was assessed through superoxide dismutase (SOD) activity assays. Histopathological examinations were performed, and statistical analysis was conducted using GraphPad Prism v.5. Results: Exposure to CaCl2 triggered pronounced oxidative injury and inflammation, as evidenced by elevated 8-hydroxy-2 '-deoxyguanosine levels, increased MPO activity, reduced SOD activity, and upregulated MMP-2 and MMP-9 expression. Montelukast administration markedly attenuated these changes, normalizing oxidative and inflammatory markers while improving histopathological architecture. Conclusions: Montelukast effectively counteracted CaCl2-induced aortic damage. The protective effects of montelukast appear to be mediated through suppression of MMP activity, restoration of SOD levels, and reduction of MPO-driven oxidative injury. By mitigating both inflammatory and oxidative mechanisms, montelukast contributes to the preservation of aortic wall structure. Clinical Relevance: Abdominal aortic aneurysm remains a major vascular disorder without an effective pharmacological therapy to slow its progression. In this experimental study, montelukast, a leukotriene receptor antagonist widely used in asthma, attenuated abdominal aortic aneurysm formation in rats and was associated with increased superoxide dismutase activity, reduced myeloperoxidase levels, and suppressed matrix metalloproteinase activation. These combined antioxidant, anti-inflammatory, and matrix-stabilizing effects preserved aortic wall integrity. Given montelukast's established safety and clinical availability, these findings support its potential for future clinical investigation as a pharmacological approach to limit aneurysm progression. (JVS-Vascular Science 2026;7:100405.)

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