PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/8

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Citation - WoS: 8
Citation - Scopus: 10
Determination of Chemical Components of the Endemic Species allium Turcicum L. Plant Extract by Lc-ms/Ms and Evaluation of Medicinal Potentials
(Cell Press, 2024) Ipek, Polat; Atalar, Mehmet Nuri; Baran, Ayse; Baran, Mehmet Firat; Ommati, Mohammad Mehdi; Karadag, Musa; Khalilov, Rovshan
The Allium turcicum L. (Zuzubak) plant as a cultivated vegetable have various health benefits and consumed as a food. Due to the shortcoming evidence in literature and the importance of this plant in folk medicine, in the present study, for the first time, we evaluated the bioactive profile of components (using LC-MS/MS), cytotoxicity, anticancer, antioxidant, and antibacterial prospectives of Zuzubak methanol extract. Reported results show that the extract is rich in bioactive compounds and has anticancer activity with breast cancer cells (MCF-7), human prostate cancer cells (DU -145), and Human osteosarcoma cancer Cell lines of (IC50) in dose dependent manner in the concentration range of 31.25 mu g/mL and 2000 mu g/mL for 24 and 48 h. Western blotting results determined that the extract significantly suppressed the growth of U2OS, MCF-7, and DU -145 cancer cells by down expression of Ang-1 (angiogenic protein) and Beclin-1 (autophagy protein) and overexpression of Bax (a proapoptotic protein). The oxidative stress indices showed a reduction in RPE-1 and MCF-7 cells and an upsurge in U2OS and DU -145 cells. Additionally, the antimicrobial assay showed suppression of the growth of various pathogenic microorganisms in 4.00 - 8.00 mu g/concentrations of Zuzubak extract using the microdilution method. The phytochemicals identified showed promising anticancer, antioxidant effects, and antimicrobial properties, representing a valuable herbal source for drug development studies.
Citation - WoS: 1
Citation - Scopus: 1
On Clinical Nurses' Views About Diversities- a Qualitative Study
(Cell Press, 2024) Cakir, Hanife; Seren, Arzu Kader Harmanci
It is a must for nurses to provide healthcare to people from diverse cultures, ethnicities, religions, and genders. This descriptive qualitative study aimed to explore nurses' approaches to various people. The study collected data via semi-structured interviews and contacted 40 nurses through snowball sampling. Most nurses were between the ages of 25-40 and female, 22 of them had postgraduate degrees, and 18 had undergraduate degrees in nursing. Only 10 of them had received special training related to diversity. MaxQda software program was used for content analyses, and four basic themes were determined respectively, "Nurses' perceptions of diversity," "Nurses' perceptions of diversity towards patients," "Nurses' perceptions of diversity towards healthcare professionals," and "Nurses' perceptions of diverse towards the institution." Participant nurses mainly revealed that although legal and organizational procedures aimed to prevent discriminative attitudes in clinical environments, discriminatory attitudes of nurses and healthcare professionals toward diverse people still occurred.
Citation - WoS: 2
Citation - Scopus: 4
Player Selection in Football by Integrated Swara-Vikor Methods Under Fuzzy Environment
(Cell Press, 2024) Buyukselcuk, Elif Caloglu; Badem, Eray
This study aims to provide an objective evaluation and selection of the most suitable players for the Turkish National Football Team by using multi-criteria decision-making methods, specifically Stepwise Weight Assessment Ratio Analysis (SWARA) and VIsekriterijumsko KOmpromisno Rangiranje (VIKOR) based on neutrosophic numbers. In the initial step of the study, the important criteria for player selection were determined, and a total of 21 and 26 criteria were identified for goalkeeper and players, respectively. Agility, reflexes and jumping ability are very important for goalkeeper whereas marking, passing ability, agility, dribbling, and footwork are the most important criteria for players. The performances of the players were evaluated due to these criteria and finally the Turkish National Football Team was established scientifically because of the best player selection. This decision-making process will be more beneficial in making more informed and effective decisions in the national team's player selection process. The success of the team can be improved by providing an objective and systematic player selection approach.

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