Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

Browse

Now showing 1 - 20 of 78

19. Yüzyıl İstanbul Endüstri Mirasına Palimpsest Kavramı Üzerinden Ontolojik Değerlendirme
(Atatürk Üniversitesi, 2025) Ural, Ayşe Gülçin
Eski yazılı parşömen kağıtlarının silinip üzerine yeniden yazılar yazılması, ancak eski yazı izlerinin hala görünüyor olması hali palimpsest olarak tariflenmektedir. Mekân üzerinden bu kavramı incelemek gerekirse; yeniden işlevlendirilen yapılar içinden eski işlevin ve yapım biçiminin izlerini hala görebilmek şeklinde yorumlanabilmektedir. İstanbul gibi büyük tarihe sahip bir kentte, yeniden işlevlendirilmeye ihtiyaç duyan pek çok tarihi yapı bulunmaktadır. Bu yapılar içinde palimpsest kavramının daha net bir şekilde algılanabileceği yapı tipinin endüstri yapıları olduğu düşünülmüştür. Bu nedenle çalışma İstanbul, Avrupa ve Anadolu yakasında bulunan 19. yy. endüstri yapıları ile sınırlandırılmıştır. Çalışmanın amacı ise İstanbul’da bulunan 19. yy. endüstri yapılarının 2024 yılındaki durumlarına göre palimpsest kavramı üzerinden değerlendirme ve sorgulama yapmaktır. Çalışmada veri toplama yöntemi olarak nitel araştırma yöntemlerinden genel tarama modeli, belgesel tarama modeli ve tarihsel tarama modelinden faydalanılmıştır. Kavramsal zemini oluşturmak için genel tarama modeli ile palimpsest kavramına ve mekân ontolojisine dair inceleme yapılmıştır. Belgesel tarama yoluyla, tespit edilen yapıların çeşitli özelliklerine dair veri toplanmıştır. Tarihsel tarama ile ise yapıların yapım yılından itibaren geçirdiği süreç ve 2024 aralık ayında ne durumda olduğuna dair tespit yapmak istenmiştir. Toplanan teknik veriler ve görseller hermenötik yöntem ile değerlendirilmiştir. Çalışmanın sonucunda İstanbul’da bulunan 19. yy. endüstri yapıları içinde 11 adet Avrupa yakasında, 4 adet Anadolu yakasında palimpsest olarak değerlendirilebilecek yapı tespit edilmiştir. Araştırma; İstanbul’da bulunan 19. yy. endüstri yapılarının 2024 yılındaki durumlarını listelemek açısından ve bu yapıları mekânın ontolojisi üzerinden değerlendirilerek palimpsest kavramı ile yorumlamak açısından gerekli görülmüştür.
Citation - WoS: 1
Citation - Scopus: 1
A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhiza Glabra L. Varieties Root Extracts
(Marmara University, 2025) Sen, Ali; Servı, Hüseyın; Barak, Timur Hakan; Tekin, Fethullah; Şener, Azize; Marzi, Mahdi; Gülmez, Gizem
Plants are the significant global interest as alternative treatment sources with their biologically activecompounds. This study compares the chemical composition and the antioxidant, antidiabetic, and antimicrobialproperties of ethanol extracts of G. glabra L. two different varieties from different regions. The phytochemicalcompositions was determined using GC-MS. Additionaly, total phenolic (TPC), flavonoid (TFC) and triterpene (TTC)contents were determined. Glycyrrhizic acid contents were analysed by HPLC. G. glabra var. glandulifera (GF1) showedthe highest antioxidant activity. All extracts had strong antidiabetic effects, besides GF1 showing the highest effect. TheMIC values was determined against 8 bacterial and 1 yeast strain and values ranged from 2.500 to 0.500; 2.500 to 0.714;2.500 to 0.714 for G. glabra var. glabra (GB), GF1, G. glabra var. glandulifera (GF2) respectively. Phytochemical studies haveshown that TPC was 100.60±5.06, 127.90±0.30, 69.01±0.30 mg GAE /g extract; TFC was 80.07±0.15, 25.35±0.0, 16.58±0.31mg KE/g and TTC was 217.30±6.05,172.40±2.17, 126.30±4.50 mg OE/g extract for GB, GF1, GF2, respectively. GF1 inparticular has the highest glycyrrhizic acid content. This study will contribute to the creation of new treatment strategiesand potential therapeutic agents in addition to the use of G. glabra L. in traditional treatments. Our study is also apreliminary study for future studies.
Acute Serious Hepatitis of Unknown Cause in Children
(Galenos Publishing House, 2022) Kılbaş, E.P.K.; Altındiş, M.
On April 5, 2022, an increase in cases of acute hepatitis of unknown etiology was reported in previously healthy children under the age of 10 in the United Kingdom. Since there is no link between these patients, called acute non-HepA-E hepatitis, and viral hepatitis agents (hepatitis A, B, C, D, and E), the possible etiology, and pathogenesis of this emergency is being investigated. One of the alarming features of this epidemic is the high requirement for liver transplantation in a fraction of the cases. In cases other than hepatitis A, B, C, D, and E, a case definition is made by looking at a series of clinical pictures, including serum transaminase levels and age. As of August 26, 2022, 513 cases of acute hepatitis have been reported in Europe and 1,010 globally. Adenovirus was detected in 75% of cases tested in the UK, but data for other countries are still lacking. The role of other etiologic agents is still under investigation. The exact disease pathogenesis has not yet clear. Evidence of human-to-human transmission of the disease remains unclear. Epidemiological studies are critical in clarifying the uncertainties regarding the existence of links between the cases reported to date. Continuing the national and international surveillance activities of the countries in an organized manner is the most basic issue required for the elimination of the epidemic. Copyright © 2022 Tehran University of Medical Sciences.
Citation - WoS: 11
Citation - Scopus: 9
Antibiotic Use and Influencing Factors Among Hospitalized Patients With Covid-19: a Multicenter Point-Prevalence Study From Turkey
(Galenos Publ House, 2022) Sencan, Irfan; Cag, Yasemin; Karabay, Oguz; Kurtaran, Behice; Guclu, Ertugrul; Ogutlu, Aziz; Agalar, Canan
Background: Broad-spectrum empirical antimicrobials arc frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective. and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age +/- standard deviation of the patients was 65.0 +/- 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (372%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005). presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein >10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p <0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings.
Citation - WoS: 3
Citation - Scopus: 3
Antioxidants, Enzyme Inhibitory Activities, and Phytochemical Profiles of Seven Medicinal Plants Grown With Organic Farming Techniques
(Tubitak Scientific & Technological Research Council Turkey, 2023) Zor, Murat; Ozupek, Burcin; Pekacar, Sultan; Deliorman Orhan, Didem
In this study, the potential antihyperlipidemic, antidiabetic, and antiobesity effects of extracts obtained via infusion techniques from Artemisia absinthium L., Achillea millefolium L., Calendula officinalis L., Fumaria officinalis L., Mentha piperita L., Origanum onites L., and Urtica dioica L. grown with organic farming techniques were investigated using enzyme inhibition methods (alpha-glucosidase, pan-creatic cholesterol esterase, pancreatic lipase, and alpha-amylase). It is important that natural compounds or extracts to be used in the treat-ment of metabolic problems have antioxidant effects. The antioxidant effects of these species were tested in terms of ABTS and DPPH radical scavenging activity, ferric reducing power, and metal chelating capacity. Extracts (2 mg/mL) of M. piperita (91.43 +/- 0.90%) and O. onites (70.18 +/- 2.02%) showed potent inhibitory effects on the alpha-glucosidase enzyme. Among all species, only O. onites extract ex-erted an inhibitory effect on the cholesterol esterase enzyme close to that of reference compound simvastatin. While all extracts were effective in the tested antioxidant activity methods, it was determined that the M. piperita and O. onites extracts displayed particularly significantly strong activities in terms of ferric reducing power, ABTS radical scavenging effect, and metal chelating capacity. The total flavonoid and phenolic contents of all extracts were determined. The compositions of the most active extracts were analyzed for pheno-lic acids and flavonoids using RP-HPLC. The results of RP-HPLC analysis showed that the levels of ellagic acid (0.923 +/- 0.000 g/100 g extract) in the M. piperita extract and rosmarinic acid (0.813 +/- 0.003 g/100 g extract) in the O. onites extract were high. As a result, all species grown with organic farming techniques except U. dioica were found to have high antioxidant effects. In light of these findings, it was concluded that M. piperita and O. onites grown with organic farming techniques showed strong inhibitory effects in terms of the tested activities, especially for alpha-glucosidase and pancreatic cholesterol esterase, and that in vivo studies and activity-guided isolation studies should be conducted on these species in the future.
Aqueous Parsley (Petroselinum crispum) Extract Ameliorated Methotrexate-Induced Brain and Small Intestine Damage in Rats
(Ankara Univ, 2025) Saçan, Ozlem; Şener, Göksel; Yanardag, Refıye; Tunali-Akbay, Tugba; Sivas, Guzin Goksun; Karaoğlu, Sümeyye Yılmaz; Dursun, Ercan
Methotrexate (MTX) is a widely used antiarthritic and chemotherapeutic agent known to cause damage to various tissues. This study investigated the potential protective effects of parsley extract against MTX-induced brain and intestinal tissue damage. Sprague-Dawley rats were divided into control, control + parsley, MTX, and MTX + parsley. MTX (20 mg/kg, i.p.) was administered to the MTX and MTX + parsley groups. The control + parsley, and MTX + parsley groups were administered 2 g/kg parsley extract by oral gavage for five consecutive days. After the fifth day, brain and small intestinal tissues were taken. Total protein, nitric oxide, lipid peroxidation, glutathione levels, tissue factor, superoxide dismutase, and glutathione S-transferase activities were determined in these tissues. The protein profiles of the tissues were evaluated using SDS polyacrylamide gel electrophoresis. Parsley administration caused a decrease in lipid peroxidation levels in both tissues of the MTX group. On the other hand, glutathione level, glutathione-S-transferase, and superoxide dismutase activities were found to be increased. On the other hand, parsley decreased the nitric oxide level which was increased in the intestinal tissues of the MTX group. There was no significant change in brain nitric oxide level and tissue factor activity between groups. MTX and parsley administration altered protein expression, leading to the appearance or disappearance of specific bands in intestinal and brain tissues. In conclusion, parsley alleviated MTX-induced damage in brain and intestinal tissues by reducing lipid peroxidation and modulating antioxidant defenses.
Brain in Metabolic Syndrome Model: the Effect of Exercises and Caloric Restriction
(Marmara Univ, 2022) Alev-Tuzuner, Burcin; Genc-Kahraman, Nevin; Ipekci, Hazal; Ustundag, Unsal Veli; Tunali-Akbay, Tugba; Emekli-Alturfan, Ebru; Yarat, Aysen
Caloric restriction (CR) and exercise (EX) have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX and/or CR in metabolic syndrome (MeS) induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10% fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX and/or CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control (C) group. These parameters reduced significantly in the metabolic syndrome with caloric restriction (MeS+CR) group, and more significantly in the metabolic syndrome with exercise and caloric restriction group (MeS+EXCR), compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeS+CR group, and MeS+EXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeS+EXCR group.
The Challenges Experienced by International Nursing Students in Nursing Education: a Qualitative Study
(Ataturk Univ, 2024) Elmali Simsek, Hulya; Karali, Ece; Arslan, Gunay
Objective: The study aimed to determine the challenges experienced by international nursing undergraduate students during their education period. Methods: A phenomenological research design was used. The study was conducted with 20 international nursing students enrolled in a foundation university in T & uuml;rkiye. Colaizzi's phenomenological data analysis method was employed in the study. Results: Based on the study's results, three main themes, 'Learning in a different environment', 'Challenges', 'Solution-Non Solution' and 'System difference, Language problems in clinical practice, Broad nursing curriculum, Facilitators, Language barrier, Feeling homesick, Racism and discrimination, Housing difficulties, Lack of funding, Instant solution, Failing to find a solution sub-themes themes were created. Conclusion: It has been observed that students experience different environments, uncertainties, and various challenges, and that these situations directly affect their education and success. To that end, both the institutions they receive education and the academicians must support the students in various ways.
Child And Adolescent Mindfulness Measure Turkish Validity And Reliability Study;
(Galenos Publishing House, 2024) Bilaç, Ö.; Dikeç, G.; Akyol, C.K.; Kale, M.K.; Sapmaz, Ş.Y.; Kandemir, H.; Aydemir, Ö.
Objectives: The number of studies on mindfulness in children and adolescents has rised in recent years, and it is crucial to evaluate the mindfulness-based interventions applied with standardized measurement tools. This aim of this study was to make the Turkish language validity and reliability of the Child and Adolescent Mindfulness Measure (CAMM), which can be used in children and adolescents about mindfulness, which has been very well-liked in recent years, and which has validity and reliability in many languages, and to bring it into our language for the ages of 9-18. Materials and Methods: The total sample of the current study consisted of 156 children and adolescents, 48 of whom were children and adolescents with any mental disorderdiagnosis according to Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5). One hundred eight of them did not have any mental disorders diagnosis according to DSM-5, who had only periodic problems or were brought for counseling. Results: In the reliability analysis of the scale, the Cronbach’s alpha coefficient was found to be 0.76 for the whole scale. In test-retest reliability two weeks apart, the two measurements have a strong correlation between the measurements (r=0.634 p<0.0001). Conclusion: In conclusion, our findings show that the Turkish version of the CAMM is a valid and reliable measurement tool for the 9-18 age group. © 2024, Galenos Publishing House. All rights reserved.
Comparison of Intraoperative Biliary Anastomosis Stenting Technique in Living-Donor Liver Transplantation: Review of 41 Patients
(Turkiye Klinikleri, 2022) Dönmez, R.; Balas, Ş.; Göktuğ, U.U.; Emek, E.; Tokat, Y.
Background/aim: Biliary fistula is one of the most important complications in liver transplantation. Complications can vary from simple local peritonitis to death, and various techniques have been described to prevent them. In this study, we compared two different stenting methods used in biliary tract anastomosis in living-donor liver transplantation. Material and methods: We retrospectively analyzed data from 41 living-donor liver transplantations that were performed due to end-stage liver failure between August 2019 and November 2020. Patients were grouped according to the stenting technique used in biliary anastomosis. Postoperative biliary tract complications were investigated. Results: Biliary fistulas were observed in 2 (7.4%) patients in the internal stent group, while 4 (28.5) fistulas were observed in the external stent group. Biliary tract stricture was observed in 2 (7.4%) patients in the internal stent group, but there was no statistical difference in complications. The preoperative MELD score (p = 0.038*) was found to be statistically significant in regard to developing complications. Conclusion: Our study did not show the effect of stenting methods used during biliary anastomosis on the development of complications. However, larger randomized controlled studies are needed. © TÜBİTAK.
Citation - Scopus: 3
Comparison of the Hidden Curriculum for Nursing Education of Two Different Universities in the East and West of Turkiye
(Inonu University, 2024) Elmali Şimşek, H.; Aksoy, M.
The present study aimed to determine and compare the hidden curriculum of two institutions that provide undergraduate nursing education in two different regions of Türkiye. The descriptive and cross-sectional research was conducted with 319 nursing students. Data were collected with the Introductory Information Form and Hidden Curriculum Evaluation Scale in Nursing Education (HCES-N). While the mean score of the HCES-N total score of the nursing students attending the university in the West of Türkiye was 163.31 ± 21.69. The HCES-N total mean score of the nursing students attending in the East of Türkiye was calculated as 145.50 ± 25.81. While the HCES-N total score, school atmosphere, and professional achievement scores of the nursing students attending the university in the West of Türkiye were statistically higher than the nursing students attending the university in the east, the student-teacher-school interaction score was statistically lower. It was determined that the perceptions of the students participating in the study towards the hidden curriculum were moderate, while the perceptions of the students studying in the West of Türkiye were better. In line with these results, it is important to improve the physical conditions of schools in improving the hidden curriculum. © 2024, Inonu University. All rights reserved.
The Correlation Between Vitamin D Levels and Thyroid Functions in Early Pregnancy
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Dinmez, Sinem; Özlem, Dülger; Oğul, Zeynep
Vitamin D deficiency (serum vitamin D <10 ng/ml) and thyroid dysfunctions are prevalent issues globally, particularly during pregnancy. Evidence suggests a potential link between thyroid function and vitamin D levels. This study aims to investigate the correlation between serum vitamin D levels and thyroid functions in wome n during the first trimester of pregnancy. The study was conducted retrospectively at a University Education and Research Hospital’s pregnancy clinic, covering data from August 2023 to March 2024. The sample group consisted of first -trimester pregnant women who attended routine pregnancy check-ups and had complete vitamin D levels and thyroid function tests (n=185). The sociodemographic data form and blood serum level assessment forms were used as data collection tools. The data were analyzed using descriptive statistics and correlation analysis. The average age of the pregnant women participating in our study was 27.6±4.9 years, and the Body Mass Index (BMI) was 25.4±4.8 (overweight). The mean number of pregnancies was 1.13±0.3, and the gestational week was 8.19±1.8. Of the participants, 35 had subclinical hypothyroidism, 37 had thyroiditis, and 113 had normal thyroid functions. The study identified 36 women with normal/adequate vitamin D levels (≥20 ng/ml), 113 with vitamin D insufficiency (10–20 ng/ml), and 36 with vitamin D deficiency (<10 ng/ml). The correlation analysis revealed no significant relationship between the thyroid function tests and vitamin D levels of the pregnant women. It was determined that vitamin D levels do not affect thyroid gland function in the first trimester.
Decreased Stuttering While Walking: Speech and Fmri Findings
(Galenos Publ House, 2023) Oge-Dasdogen, Ozlem; Ulasoglu-Yildiz, Cigdem; Kurt, Elif; Demiralp, Tamer
[No Abstract Available]
Design and Implementation of a Low Cost and Portable Tactile Stimulator Br
(Tubitak Scientific & Technological Research Council Turkey, 2022) Kazma, Coskun; Levent, Vecdi Emre; Cardak, Merve; Aydin, Nizamettin
When central nervous system has a problem, somatic area I and II respond to stimulation differently. Therefore, it is possible to identify some of the central nervous diseases when somatosensory on the fingertip is stimulated and responses are recorded and analyzed. We designed a system to stimulate the mechanoreceptors on fingertips. It is composed of a mechanical system for fingertip stimulation, an embedded controller, a control computer, and a software to control overall operation. During test, mechanoreceptors are stimulated according to the test protocols. Individuals' answers are recorded to be evaluated by the developed software. In this study, several design approaches for embedded controller were also examined and an FPGA based controller with the same functionality but higher performance was implemented. A test procedure was performed on 51 individuals at the department of pediatric psychiatry in a hospital, to investigate whether the sex has an effect on attention deficit and hyperactivity disorder.
Determination of Post-Earthquake Trauma Level and Investigation of the Relationship with Physical Activity Status
(Turkish Physiotherapy Association, 2025) Tosun, Anil; Yılmaz, Nergis; Luque, Demet Tekın De Las Penas
Amaç: Çalışmanın amacı; 06 Şubat 2023’te meydana gelen Pazarcık-Elbistan merkezli depremler sebebiyle kişilerde oluşan travma düzeyinin, kişinin fiziksel aktivite durumu ile ilişkisini incelemektir. Aynı zamanda, kişilerde deprem sonrası ağrı varlığının sorgulanması ve bu durumun travma düzeyi ile ilişkisini ortaya koymaktır. Yöntem: Veriler çevrimiçi olarak Google formları aracılığıyla toplandı, 18-65 yaş arası 388 gönüllü katılımcı (299 kadın, 89 erkek) çalışmaya dahil edildi. Katılımcıların genel özelliklerini belirlemek için “Sosyodemografik Bilgi Formu”, travma düzeyini değerlendirmek için “Deprem Sonrası Travma Düzeyini Belirleme Ölçeği” (DSTDBÖ) ve fiziksel aktivite durumlarını belirlemek için “Uluslararası Fiziksel Aktivite Anketi Kısa Formu” (IPAQ-KF) kullanıldı. Bulgular: Deprem bölgesinde bulunma durumuna göre DSTDBÖ genel puan ortalamaları arasında anlamlı fark saptandı (p<0,001). Deprem bölgesinde bulunan 126 kişinin DSTDBÖ genel puan ortalaması 57,66±19,87 iken, bölgede bulunmayan 262 kişinin ortalaması 49,00±18,49 olarak bulundu. Spearman korelasyon analiziyle deprem bölgesinde olan ve olmayan bireylerin IPAQ-KF toplam puanları, DSTDBÖ alt faktör ve toplam puanları arasındaki ilişki incelenmiş olup sadece “Bilişsel Yapılandırma” alt faktörü ile IPAQ-KF toplam puanları arasında anlamlı bir ilişkiyi yansıtmayan negatif zayıf ilişki bulundu (deprem bölgesinde olanlar için Spearman korelasyon katsayı değeri =-0,18, p=0,042). Ve deprem sonrası ağrı yaşayan bireylerin DSTDBÖ puanları, ağrı yaşamayanlardan daha yüksek olarak saptandı (p=0,000). Sonuç: Bu çalışma ile deprem sonrası travma düzeyinin, fiziksel aktivite ile negatif ilişki gösterdiği belirlendi. İnaktif bireyler daha yüksek travma düzeylerine sahipken, minimal aktif bireylerde travma düzeyleri daha düşük bulundu. Bu bulgular, deprem sonrası fiziksel aktivitenin artırılmasının travma düzeylerini azaltmada etkili bir strateji olabileceğini göstermektedir. Bu alanda daha fazla araştırma, eğitim ve proje çalışmalarının yapılması gerekmektedir.
Citation - WoS: 1
Citation - Scopus: 2
Determining the Effect of Urbanization on the Vegetation of Gurun District (sivas) Based on Biotope Mapping and Vegetation Analysis
(Istanbul Univ-cerrahapasa, 2020) Bozkurt, Selvinaz Gulcin; Akkemik, Unal; Kose, Nesibe
Urbanization is one of the strongest negative effects on vegetational change within and around a city. In this study, it is aimed to determine the flora and vegetational changes within and around the city based on the identification and mapping of the biotopes which show differences in terms of ecologic factors met in Gurun district center and its vicinity and which are suitable for Corine biotope classification. First, 13 main biotope types are classified. In the biotopes, total 666 plant taxa were identified, 84 of which were endemic. Vegetation of the biotopes was determined, and then similarity levels of main biotopes are calculated according to the similarity coefficient method of Sorensen. Accordingly, while the similar areas are health facilities and agricultural areas the most different ones are parks and sports areas and drainage areas. The results emphasize the similarity levels of vegetation in biotopes and the negative effect of human intervention in the study area. As a result, with its rich natural structure, vegetation covers and endemism rate, the district of Gurun has significant natural biotopes and it is suggested that biotope classification should be considered in determining vegetation change and urban planning.
Citation - Scopus: 4
Dodder (Cuscuta Sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats
(Istanbul University Press, 2022) Albayrak, O.; Ozbeyli, D.; Sen, A.; Cevik, O.; Erdogan, O.; Ercan, F.; Sener, G.
Objective: The aim is to examine the possible protective effect of Cuscuta sp. extract against liver damage induced by biliary obstruction in rats. Materials and Methods: To induce biliary obstruction, the bile duct ligation (BDL) method was used. Sprague Dawley rats were allocated to 4 groups: Control (C), Cuscuta (CUS), bile duct ligation (BDL), and bile duct ligation + Cuscuta (BDL+CUS). Control and BDL rats were given physiological saline (SF), while CUS and BDL+CUS groups were administered 250 mg/ kg of Cuscuta extract by oral gavage. At the end of 28th day, the rats were decapitated, serum and tissue samples were collected, and aspartate aminotransferase (AST), alanine transaminase (ALT), and direct and total bilirubin (DB and TB) levels were determined in blood samples. In liver tissues, transforming growth factor-β (TGF-β), 8-hydroxyguanosine (8-OHdG), hydroxyproline, and sodium-potassium ATPase (Na+/K+-ATPase) levels were determined. Results: Serum samples of rats with cholestasis had high ALT, AST, DB, and TB levels, while TGF-β, 8-OHdG, and hydroxyproline concentrations were found to be significantly high in tissues. Hepatic Na+/K+-ATPase levels were decreased through biliary obstruction. Biochemical parameters were drastically reversed by Cuscuta care; also, this was supported histologically. Conclusion: Results showed that Cuscuta extract, through its antioxidant and anti-inflammatory properties, provided protection against oxidative injury by biliary obstruction. Also, these results confirm the traditional use of Cuscuta sp. as hepatoprotective. © Ankara Medical Journal.All rights reserved.
Dodder (Cuscuta sp.) Extract Prevents Cognitive Deficits in a Rat Model of Hepatic Encephalopathy
(Kare Publ, 2024) Cevik, Ozge; Sen, Ali; Şener, Göksel; Ercan, Feriha; Doğan, Ahmet; Özbeyli, Dilek; Hatipoğlu, Bilge Nur
OBJECTIVE: In our study, the protective effect of dodder plant extract against encephalopathy induced by cholestatic liver disease model was investigated. METHODS: Spraque Dawley rats were used in the study. For the cholestatic liver disease model, the bile duct ligation (BDL) was applied. The groups were determined as control, Cuscuta sp. (CUS), BDL and BDL + CUS. Double ligation was performed in the bile duct in the BDL groups. For the applications, saline (SF) was administered to the control and BDL groups for 28 days while 250 mg/ kg of Cuscuta sp. extract was given by oral gavage to the CUS and BDL + CUS groups. At the end of the experiment, cognitive eval- uations were made by applying new object recognition and Morris water maze tests. After these tests, blood-brain barrier (BBB) measurements were made in half of the groups. In the other half of the groups, brain tissue samples were taken by decapitation and transforming growth factor-beta (TGF-β), 8-hydroxydeoxyguanosine (8-OHdG) and sodium-potassium adenosine triphospha- tase (Na+/K+-ATPase) measurements were made in the tissues. Histological examinations of the tissues were also performed. RESULTS: Cognitive performance was low, and BBB permeability was found to be increased in the group with bile duct liga- tion. In addition, TGF-β and 8-OHdG levels were increased in tissues, while Na+/K+-ATPase enzyme activity was suppressed. Treatment with Cuscuta sp. increased cognitive performance and decreased BBB permeability. Other biochemical parameters examined were significantly (p<0.05–0.001) reversed and supported by histological findings. CONCLUSION: Our findings in the study suggest that dodder plant may be beneficial for the protection of cognitive perfor- mance and brain tissue in encephalopathy caused by cholestasis. Keywords: Cuscuta sp.; cholestasis; encephalopathy; fibrosis.
The Effect of 3d Modeling on Family Quality of Life, Surgical Success, and Patient Outcomes in Congenital Heart Diseases: Objectives and Design of a Randomized Controlled Trial
(Turkish J Pediatrics, 2024) Sumengen, Aylin Akca; Ismailoglu, Abdul Veli; Ismailoglu, Pelin; Gumus, Terman; Celiker, Alpay; Namlisesli, Deniz; Cakir, Gokce Naz
Background. Understanding the severity of the disease from the parents' perspective can lead to better patient outcomes, improving both the child's health -related quality of life and the family's quality of life. The implementation of 3 -dimensional (3D) modeling technology in care is critical from a translational science perspective. Aim. The purpose of this study is to determine the effect of 3D modeling on family quality of life, surgical success, and patient outcomes in congenital heart diseases. Additionally, we aim to identify challenges and potential solutions related to this innovative technology. Methods. The study is a two -group pretest -posttest randomized controlled trial protocol. The sample size is 15 in the experimental group and 15 in the control group. The experimental group's heart models will be made from their own computed tomography (CT) images and printed using a 3D printer. The experimental group will receive surgical simulation and preoperative parent education with their 3D heart model. The control group will receive the same parent education using the standard anatomical model. Both groups will complete the Sociodemographic Information Form, the Surgical Simulation Evaluation Form - Part I -II, and the Pediatric Quality of Life Inventory (PedsQL) Family Impacts Module. The primary outcome of the research is the average PedsQL Family Impacts Module score. Secondary outcome measurement includes surgical success and patient outcomes. Separate analyses will be conducted for each outcome and compared between the intervention and control groups. Conclusions. Anomalies that can be clearly understood by parents according to the actual size and dimensions of the child's heart will affect the preoperative preparation of the surgical procedure and the recovery rate in the postoperative period.
Citation - WoS: 10
Citation - Scopus: 11
The Effect of cotinus Coggygria L. Ethanol Extract in the Treatment of Burn Wounds
(Marmara Univ, 2022) Erta, Busra; Okuyan, Betul; Sen, Ali; Ercan, Feriha; Onel, Huseyin; Goger, Fatih; Sener, Goksel
The overall aim of the present research is to evaluate for the first time the curative effect of Cotinus coggygria leaves on burn injury in an experimental burn model along with its anti-inflammatory and antioxidant activity potential. Also, phenolic compounds of C. coggygria were characterised by LC-MS/MS. Wistar albino rats weighing 200-250 g were exposed to 90 degrees C bath for 10 s to induce burn injury, involving 30% of the total body surface area. In the treatment groups, 5% C. coggygria ethanol extract was applied topically as a cream immediately after the burn. Blood and skin tissue samples were taken after decapitation at the 4th and 48th hours following the burn procedure. Interleukin 1-beta (IL-1 beta) and tumour necrosis factor (TNF-alpha) were determined in serum samples, and hydroxyproline, prostoglandin E2 (PGE2), and myeloperoxidase (MPO) activity and 8-hydroxy-2'-deoxy-guanosine (8-OHdG) levels were determined in skin tissue samples. Increased levels of serum cytokines were decreased with C. coggygria treatment in both periods. MPO activity, prostaglandine (PGE2), and 8-OhdG levels increased, while hydroxyproline levels decreased due to burn damage. On the other hand, these parameters were returned to its normal levels with C. coggygria treatment. In addition, the tissue histology of animals treated with C. coggygria showed a complete epithelialization with increased collagenation. As a result, C. coggygria may be an alternative treatment approach for burns-induced skin damage and wounds.

Browse

Browsing Scopus İndeksli Yayınlar Koleksiyonu by Publication Index "TR-Dizin"