Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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Citation - WoS: 16
Citation - Scopus: 39
How Do Mobile Wallets Improve Sustainability in Payment Services? a Comprehensive Literature Review
(Mdpi, 2022) Hopali, Egemen; Vayvay, Ozalp; Kalender, Zeynep Tugce; Turhan, Deniz; Aysuna, Ceyda
Easy access to the Internet, smartphones, and mobile-based banking change customer shopping intentions. As a crucial component of financial technology (Fintech), mobile wallets enable customers to shop via smartphones. Mobile wallets present a cashless transactional method, cost-efficient services, and traceable options that improve sustainability in payment services. Over the last decade, mobile wallet services have evolved and attracted considerable attention from customers and companies. Due to the need for a comprehensive mobile wallet literature survey, this article aims at filling this research gap by covering articles published between 2012 and 2022 over the Scopus, Web of Science, and Science Direct databases. A clear filtering policy was conducted to observe the related article topics. Thus, 128 articles that met the inclusion and exclusion criteria were analyzed. Moreover, the articles were initially classified into three main groups, which was performed via scanning and categorizing all studies in the last ten years from different databases. In addition, the literature was systematically reviewed, providing a better understanding of mobile wallets and contributing to the literature by researching how this service can be improved for payment services with a focus on sustainability. The conducted literature review revealed that mobile wallets could be promoted in terms of environmental traceability, customer lifetime value, and security.
Citation - WoS: 2
Citation - Scopus: 4
Seroprevalence of Torch Viral Agents in Pregnant Women in Turkey: Systematic Review and Meta-Analysis
(Mdpi, 2025) Kilbas, Elmas Pinar Kahraman; Ciftci, Ihsan Hakki; Kilbas, Imdat; Toptan, Hande
Rubella Virus, Cytomegalovirus (CMV), Herpes Simplex Virus-2 (HSV-2), Hepatitis B (HBV) and Hepatitis C virus (HCV) can cause serious fetal disease. The seropositivity rates of these agents vary among countries and geographic regions. This study aimed to analyze the prevalence rates and diagnostic methods used in studies investigating the seroprevalence of viral pathogens in the TORCH group among pregnant women in Turkey between 2005 and 2024. A systematic search was conducted using electronic databases between January 2005 and January 2024. A total of 60 studies meeting the inclusion criteria were included. Data quality control was assessed using the Joanna Briggs Institute guideline prevalence studies checklist. Heterogeneity was measured using the I-squared (I-2) statistic in the Comprehensive Meta Analysis (CMA) program. The average seropositivity rates for Rubella, CMV, HSV-2, HBV and HCV in Turkey were determined as 91.18%, 94.81%, 35.52%, 1.66% and 0.25%, respectively. When the diagnostic methods were examined, it was determined that ELISA and ECLIA methods were used most frequently. The seropositivity of the agents did not show statistically significant differences according to the year periods, geographical regions and age of the patients (p > 0.05). The highest prevalence rates of Rubella and HSV-2 in pregnant women were reported in the Mediterranean region, the highest prevalence rates of CMV and HCV in the Southeastern Anatolia region and the highest seroprevalence of Anti HBs in the Marmara region. The results of this study support the necessity of increasing public awareness in the control of fetal infection caused by TORCH viral agents, prenatal screening, vaccination for Rubella and HBV and compliance with hygiene conditions for agents such as CMV, HSV-2 and HCV. The results of this study highlight the need to increase public awareness on prenatal screening for the control of fetal infection caused by all TORCH viral agents, vaccination for Rubella and HBV and compliance with hygiene conditions for agents such as CMV, HSV-2 and HCV.
Citation - WoS: 3
Citation - Scopus: 3
Seroprevalence of coxiella Burnetii in Human and Animal Populations in Tiirkiye: Meta-Analysis
(Kafkas Univ, veteriner Fakultesi dergisi, 2023) Kilbas, Imdat; Kahraman Kilbas, Elmas Pinar; Ciftci, Ihsan Hakki
This study aims to reveal Coxiella burnetii by examining the studies reporting Q fever seroprevalence in humans and animals in the last 25 years in Turkiye. In this study, based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), various databases were searched between January 1997 and October. 2022. A literature review was carried out using data analyses performed using the IBM SPSS Version 25.0 statistical package program and Comprehensive Meta-Analysis (CMA) program. Overall prevalence of C. burnetii in humans was 22.78% (95% CI: 16.43%-29.12%), overall prevalence in animals was 13.49% (95% CI: 10.04-16.93%) was detected. The mean prevalence of C. burnetii in sheep was 19.1%+/- 10.88, 10.46 +/- 6.39% in cattle, 15.21 +/- 10.01% in studies including cattle and sheep together, 11.17 +/- 10.74 in cattle, sheep and goats, and 12.4%+/- 1.15% in sheep and goats. As a result of this study, it was determined that the prevalence of Q fever in humans in Turkiye is high in those dealing with animals, women who had a miscarriage, and infertile individuals. Although it is known that this disease is seen in Turkiye, there are not enough case reports in the literature. Detailed studies on Q fever in humans and animals need to be conducted. Further studies are needed to evaluate Q fever risk factors and prevalence data together within the scope of One Health approach.
Introduction: General Information About Discrimination in Turkey
(Peter Lang AG, 2021) Akincilar Köseoğlu, N.; Apak, D.
[No abstract available]
A Multi-Parameter Evaluation of the Neuroprotective and Cognitive-Enhancing Effects of Origanum Onites L. (turkish Oregano) Essential Oil on Scopolamine-Induced Amnestic Rats (feb,10.1007/S11011-022-00933-6, 2022)
(Springer/plenum Publishers, 2022) Aykac, Asli; Terali, Kerem; Ozbeyli, Dilek; Ede, Seren; Albayrak, Omercan; Baser, Kemal Husnu Can; Sener, Goksel
[No Abstract Available]
Citation - WoS: 13
Citation - Scopus: 16
Managing Viral Emerging Infectious Diseases Via Current and Future Molecular Diagnostics
(Mdpi, 2023) Altindis, Mustafa; Kilbas, Elmas Pinar Kahraman
Emerging viral infectious diseases have been a constant threat to global public health in recent times. In managing these diseases, molecular diagnostics has played a critical role. Molecular diagnostics involves the use of various technologies to detect the genetic material of various pathogens, including viruses, in clinical samples. One of the most commonly used molecular diagnostics technologies for detecting viruses is polymerase chain reaction (PCR). PCR amplifies specific regions of the viral genetic material in a sample, making it easier to detect and identify viruses. PCR is particularly useful for detecting viruses that are present in low concentrations in clinical samples, such as blood or saliva. Another technology that is becoming increasingly popular for viral diagnostics is next-generation sequencing (NGS). NGS can sequence the entire genome of a virus present in a clinical sample, providing a wealth of information about the virus, including its genetic makeup, virulence factors, and potential to cause an outbreak. NGS can also help identify mutations and discover new pathogens that could affect the efficacy of antiviral drugs and vaccines. In addition to PCR and NGS, there are other molecular diagnostics technologies that are being developed to manage emerging viral infectious diseases. One of these is CRISPR-Cas, a genome editing technology that can be used to detect and cut specific regions of viral genetic material. CRISPR-Cas can be used to develop highly specific and sensitive viral diagnostic tests, as well as to develop new antiviral therapies. In conclusion, molecular diagnostics tools are critical for managing emerging viral infectious diseases. PCR and NGS are currently the most commonly used technologies for viral diagnostics, but new technologies such as CRISPR-Cas are emerging. These technologies can help identify viral outbreaks early, track the spread of viruses, and develop effective antiviral therapies and vaccines.
Citation - WoS: 1
Citation - Scopus: 1
Nutrition Therapy in Pediatric Burns
(Bentham Science Publ Ltd, 2021) Kunduraci, Yasemin E.; Garipagaoglu, Muazzez
Background: Burns are defined as injuries resulting from exposure to thermal radiation, electrical or chemical exposure of the skin or organic tissues. It has high mortality and morbidity in low and middle-income countries. Objective/Methods: The objective of this study is to evaluate the present knowledge principles of nutritional therapy for pediatric burns from the dietician's perspective, taking into account the epidemiology and physiology of the burn. The purpose of burn treatment is to provide survival and tissue repair and to increase immunity. Therefore, besides fluid electrolyte replacement and surgical interventions, nutritional therapy is quite important. Nutrition principles should aim to reduce inflammation and meet hypermetabolic needs. Results: In the clinical practice of children suffering from burns, daily energy need is calculated by adding the recommended energy expenditure to the burn percentage, but the most accurate method is the use of indirect calorimetry. Protein requirement is around 1.5-3.0 g/kg/day. Carbohydrate intake should be 55-60% of total energy intake, while lipids should be less than 30%. Vitamin supplements in the form of a multivitamin are recommended in addition to vitamin A, vitamin C, and Zinc. In cases where oral intake is insufficient, enteral nutrition should be applied as soon as possible. When enteral feeding is contraindicated, parenteral nutrition is preferred. Conclusion: Evaluating the nutritional status of children and meeting macro and micronutrient needs accelerate wound healing, shorten hospital stay, and reduce mortality.
Preface
(IGI Global, 2025) Khan, Shad Ahmad; Koy, A.; Rani, C.; Kansra, P.; Kajla, T.
Citation - WoS: 3
Citation - Scopus: 2
A Systematic Review and Meta-Analysis for the Efficacy of Transcranial Direct Current Stimulation (tdcs) in Ocd Treatment: A Non-Pharmacological Approach To Clinical Interventions
(Pergamon-elsevier Science Ltd, 2024) Ibrahim, Ismail A.; Nada, Ahmed Hosney; Asar, Nada Khalid; Ibrahim, Rand; Farouk, Rawan Ahmed; Al-Qiami, Almonzer; Noorbakhsh, Seyed Ali
Obsessive-compulsive disorder (OCD) is a prevalent mental condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions), significantly disrupting daily functioning and social interactions. Transcranial direct current stimulation (tDCS) presents a promising non-invasive treatment modality aimed at alleviating symptoms. However, the evidence regarding its effectiveness remains inconclusive. This study seeks to address this gap by conducting a systematic review and meta-analysis of clinical trials, offering improved guidance for clinical intervention. A comprehensive search strategy was implemented across multiple databases, including PubMed, Cochrane CENTRAL, Embase, Scopus, and Web of Science. This search focused strictly on randomized controlled trials (RCTs) involving 147 patients. These trials evaluated the efficacy of tDCS in OCD patients. Subsequent data extraction, risk of bias assessment, and statistical analysis using Review Manager software revealed the potential efficacy of tDCS in reducing OCD symptoms. The meta-analysis not only fails to demonstrate significant superiority of active tDCS over sham tDCS but also suggests that sham tDCS may be more effective than active tDCS in reducing OCD symptoms. This finding diminishes the promise of tDCS as an effective treatment for OCD. Larger trials are warranted to further elucidate these findings.
Citation - WoS: 1
Citation - Scopus: 1
Effect of Everolimus on Prognosis of Neurofibromatosis Type 1 Lesions: a Systematic Review and Meta Analysis
(Elsevier, 2024) Ibrahim, Ismail A.; Abdelkader, Rem Ehab; Nada, Ahmed Hosney; Younes, Siham; Hanen, George; Shahwan, Ghena; Nashwan, Abdulqadir J.
Purpose: This study addresses the effectiveness of oral everolimus in treating various malignancies associated with Neurofibromatosis Type 1 (NF1). The purpose is to determine whether everolimus reduces lesion size in NF1 patients, considering the controversial findings from previous clinical trials. The scientific hypotheses and questions involve evaluating the impact of everolimus on NF1-associated lesions and understanding the variability in treatment outcomes. Methods: A systematic review and meta-analysis were conducted following PRISMA and Cochrane Collaboration guidelines. The study included four-phase II, single-arm, nonrandomized trials investigating the effect of oral everolimus on NF1-associated lesion size. The search covered multiple databases, and data extraction involved evaluating studies for inclusion criteria and assessing quality using the Cochrane Collaboration's Risk of Bias in Nonrandomized Studies tool. Statistical analysis utilized Open Meta(Analyst). Findings: The search yielded 388 studies, with 10 selected for full-text review and four included in the final analysis. The quality of the studies ranged from low to moderate. The meta-analysis indicated no observed heterogeneity (I2 = 0%), and the overall estimate suggested no significant reduction in NF1-associated lesion size with everolimus ( P = 0.069). Implications: The findings reveal a varied and inconsistent picture of everolimus efficacy in NF1 treatment. The study highlights the need for personalized approaches, considering individual genetic and clinical differences. The limitations, including small sample sizes and nonrandomized trials, call for larger, more standardized research efforts. The study emphasizes ongoing trials and the importance of future research in understanding predictors of everolimus response and optimizing treatment strategies for NF1 patients. Conclusion: While everolimus shows promise in reducing lesion size in a subset of NF1 patients, the study cannot draw conclusive results due to limitations in the included studies. Ongoing, adequately powered trials are crucial for advancing the evidence base and informing the potential role of everolimus in NF1 treatment. Others: There was no funding for this review and no conflicts of interest.
Citation - WoS: 2
Citation - Scopus: 2
A Systematic Review and Meta-Analysis of Molecular Characteristics on Colistin Resistance of acinetobacter Baumannii
(Mdpi, 2024) Ciftci, Ihsan Hakki; Kilbas, Elmas Pinar Kahraman; Kilbas, Imdat
Background: This study aimed to determine the molecular epidemiology of colistin-resistant A. baumannii in the last ten years and the frequency of gene regions related to pathogenesis, to compare the methods used to detect genes, and to confirm colistin resistance. Methods: This meta-analysis study was conducted under Preferred Reporting Items for Systematic Reviews and Meta-Analysis Guidelines. In the meta-analysis, research articles published in English and Turkish in electronic databases between January 2012 and November 2023 were examined. International Business Machines (IBM) Statistical Package for the Social Sciences (SPSS) Statistics for Macbook (Version 25.0. Armonk, NY, USA) was used for statistical analysis. The Comprehensive Meta-Analysis (CMA) (Version 3.0. Biostat, NJ, USA) program was used for heterogeneity assessment in the articles included in the meta-analysis. Results: After evaluating the studies according to the elimination criteria, 18 original articles were included. Among colistin-resistant strains, blaOXA-51 positivity was 243 (19.61%), blaOXA-23 was 113 (9.12%), blaOXA-58 was 7 (0.56%), blaOXA-143 was 15 (1.21%), and blaOXA-72 was seen in two (0.16%) strains. The positivity rates of pmrA, pmrB, and pmrC were found to be 22 (1.77%), 26 (2.09%), and 6 (0.48%). The mcr-1 rate was found to be 91 (7.34%), the mcr-2 rate was 78 (6.29%), and the mcr-3 rate was 82 (6.61%). Conclusions: The colistin resistance rate in our study was found to be high. However, only some research articles report and/or investigate more than one resistance gene together. Additionally, it may be challenging to explain colistin resistance solely by expressing resistance genes without discussing accompanying components such as efflux pumps, virulence factors, etc.
Citation - WoS: 3
Citation - Scopus: 4
Oral Pharmabiotic Tablet Formulations
(Marmara Univ, 2024) Kandur, Buse; Ugurlu, Timucin; Rayaman, Erkan; Ahbaz, Sevinc S.
Pharmabiotic is a unique and recent term used to describe formulations containing probiotics. Pharmabiotics are probiotics prepared in a pharmaceutical form used to treat diseases and disorders by making physicochemical changes in human health. Probiotics, prebiotics, and synbiotics are included in this scope, and enzobiotics, which are a rising class of supplements, should be evaluated in this context, as they are a subspecies of synbiotics. Pharmabiotics, unlike nutribiotics, do not necessarily contain live microorganisms. The best examples of these are paraprobiotics and postbiotics. Tablet formulations are suitable dosage forms for pharmabiotics due to their redundant superiority over other solid dosage forms. Tablets are frequently preferred because they can be produced at low cost, are easily transported, and modified, are suitable for large-scale production, and are more stable than other dosage forms. Considering the examples in the literature and the definition of pharmabiotic, several tablet formulations can be mentioned as pharmabiotics. They can be divided into conventional uncoated tablets, chewable tablets, and effervescent tablets. With recent studies, this classification has expanded, and buccal mucoadhesive tablets, ODTs (orally disintegrating tablets) and FDTs (fast disintegrating tablets), layered/multi-layered tablets, and tablets within tablets have also taken their place in the classification. This article focuses on oral tablet formulations that can be classified as pharmabiotics.
Citation - WoS: 13
Citation - Scopus: 9
Thioethers: an Overview
(Bentham Science Publ Ltd, 2022) Han, M. Ihsan; Kucukguzel, S. Guniz
Spreading rapidly in recent years, cancer has become one of the causes of the highest mortality rates after cardiovascular diseases. The reason for cancer development is still not clearly understood despite enormous research activities in this area. Scientists are now working on the biology of cancer, especially on the root cause of cancer development. The aim is to treat the cancer disease and thus cure the patients. The continuing efforts for the development of novel molecules as potential anti-cancer agents are essential for this purpose. The main aim of this review was to present a survey on the medicinal chemistry of thioethers and provide practical data on their cytotoxicities against various cancer cell lines. The research articles published between 2001-2020 were consulted to prepare this review article; however, patent literature has not been included. The thioether-containing heterocyclic compounds may emerge as a new class of potent and effective anti-cancer agents in the future.
Citation - WoS: 2
Citation - Scopus: 2
Effectiveness of Non-Invasive Vagal Nerve Stimulation in Parkinson's Disease: a Comprehensive Systematic Review And Meta-analysis
(Elsevier Sci Ltd, 2025) Abouelmagd, Moaz Elsayed; Yousef, Obai; Ibrahim, Ismail A.; Elshahat, Ahmed
Background: Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by movement impairments. Vagus nerve stimulation (VNS) is a non-invasive brain stimulation technique that has shown promise in treating various neurological conditions, including PD. This systematic review aimed to evaluate the existing evidence on the efficacy of nVNS in managing PD symptoms. Methods: A comprehensive literature search was conducted to identify relevant studies published up to July 2024. The included studies investigated the effect of nVNS on various PD motor symptoms. The quality of studies was assessed using the Cochrane Risk of Bias 2 (ROB-2) and NIH tool for RCTs, single-arm studies, and case series studies respectively. Statistical analysis was conducted using Review Manager version 5.4.1 with outcomes expressed as Mean differences (MD) with 95% confidence intervals (CI). Results: The systematic review included eight randomized controlled trials (RCTs), one single-arm study, and one case series, encompassing a total of 217 patients with PD. The review revealed that nVNS in increasing Freezing of Gait (FOG) in PD (p = 0.04). However, no significant differences were found in UPDRS-III (p = 0.19 and p = 0.89 for on and off-medication conditions, respectively), UPDRS-II (p = 0.9), UPDRS-I (p = 0.46), Time Up and Go (p = 0.61), stand time (p = 0.87), walking speed (p = 0.22), or step length measured in meters (p = 0.8). Interestingly, a significant improvement was observed in step length measured in centimetres (p = 0.0005). No study reported serious adverse effects associated with nVNS treatment. Conclusion: Our finding suggests a potential benefit of nVNS in reducing FOG in PD, but did not demonstrate a significant improvement in other motor symptoms. Larger, longer follow-up studies are needed to confirm the effect nVNS on PD management. PROSPERO number: CRD42024574822.
Corrigendum to “on Clinical Nurses’ Views About Diversities- A Qualitative Study”
(Elsevier Ltd, 2025) Cakir, H.; Harmanci Seren, A.K.
In the original published version of this article, there were unwanted reference links in 2.3. Sample and setting and new references [1], [2] and [3] has been added in the revised version removing the older reference [1]. The original manuscript showed the Introduction, 2.3. Sample and setting and reference [1] as below: Until the beginning of the 20. century, nearly all civilized societies were controlled by upper-class white men. As a result, diverse people from the leading culture were marginalized based on ethnicity, race, religion, language, sex, or sexual orientation. The “Diversity management" concept first emerged in the United States of America (USA) to manage personal and cultural differences among employees. Later, globalization became a worldwide concept parallel with the internationalization of businesses, employees, and clients [1]. Snowball sampling was applied. Inclusion criteria were working in a hospital in Istanbul for at least one year [1], three years or more of professional experience [2], bachelor's or upper degrees in nursing education [3] and working as a staff or a manager nurse [4]. [1] J.L. Bronstein, D.I. Bolnick, “Her joyous enthusiasm for her life-work …”: early women authors in the American naturalist, Am. Nat. 192 (6) (2018) 655–663. The corrected version of Introduction with relevant references and 2.3. Sample and setting are as below: Until the beginning of the 20. century, nearly all civilized societies were controlled by upper-class white men [1]. As a result, diverse people from the leading culture were marginalized based on ethnicity, race, religion, language, sex, or sexual orientation [2]. The “Diversity management” concept first emerged in the United States of America (USA) to manage personal and cultural differences among employees. Later, globalization became a worldwide concept parallel with the internationalization of businesses, employees, and clients [3]. Snowball sampling was applied. Inclusion criteria were: 1. working in a hospital in Istanbul for at least one year, 2. three years or more of professional experience, 3. bachelor's or upper degrees in nursing education 4. and working as a staff or a manager nurse. [1] Judy, R. W., & d'Amico, C. (1997). Workforce 2020: Work and workers in the 21st century. Hudson Institute, Herman Kahn Center, PO Box 26–919, Indianapolis, IN 46226; tele. [2] Penaluna, B. E., Arismendi, I., Moffitt, C. M., & Penney, Z. L. (2017). Nine proposed action areas to enhance diversity and inclusion in the American Fisheries Society. Fisheries, 42(8), 399–402. [3] Hiranandani, V. (2012). Diversity management in the Canadian workplace: Towards an antiracism approach. Urban Studies Research, 2012(1), 385806. The authors apologize for the errors. © 2025 The Author(s)
Citation - WoS: 7
Citation - Scopus: 6
The Impact of Interaction Between Verteporfin and Yes-Associated Protein 1/Transcriptional Coactivator With Pdz-Binding Motif-Tea Domain Pathway on the Progression of Isocitrate Dehydrogenase Wild-Type Glioblastoma
(Sage Publications Ltd, 2023) Osama, Mahmoud; Essibayi, Muhammed Amir; Osama, Mona; Ibrahim, Ismail A.; Mostafa, Mostafa Nasr; Eksi, Murat Sakir
Verteporfin and 5-ALA are used for visualizing malignant tissue components in different body tumors and as photodynamic therapy in treating isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM). Additionally, verteporfin interferes with Yes-associated protein 1 (YAP)/Transcriptional coactivator with PDZ-binding motif - TEA domain (TAZ-TEAD) pathway, thus inhibiting the downstream effect of these oncogenes and reducing the malignant properties of GBM. Animal studies have shown verteporfin to be successful in increasing survival rates, which have led to the conduction of phase 1 and 2 clinical trials to further investigate its efficacy in treating GBM. In this article, we aimed to review the novel mechanism of verteporfin's action, the impact of its interaction with YAP/TAZ-TEAD, its effect on glioblastoma stem cells, and its role in inducing ferroptosis.
Citation - WoS: 1
Citation - Scopus: 1
Effectiveness of Postoperative Cephalosporins in Reducing Urinary Tract Infections and Other Parameters Following Transurethral Resection of the Prostate: a Systematic Review and Meta-Analysis
(Mosby-elsevier, 2025) Hafez, Wael; Al-Obeidat, Feras; Rashid, Asrar; Venkatachalapathi, Arun Kumar; Massaod, Amr; Albaha, Ziad; Cherrez-Ojeda, Ivan
[No Abstract Available]
Citation - WoS: 7
Citation - Scopus: 7
Recent Progress on Apoptotic Activity of Triazoles
(Bentham Science Publ Ltd, 2021) Cikla-Suzgun, P.; Kucukguzel, S. G.
Apoptosis is often called programmed cell death and is defined as a self-directed cell destruction process. It is different from necrosis due to the activation of caspases during this process. Apoptosis is directly related to cancer progression and plays a vital role in carcinogenesis; all cytotoxic drugs and radiation therapy programs initiate apoptosis in tumor cells. Today, studies show that heterocyclic compounds that contain triazole functionality have anticancer activities; triazoles are 5 membered rings, which contain two carbon and three nitrogen atoms. Therefore, many researchers have synthesized these small active compounds as target structures and evaluated their apoptotic activities. The present review describes recent medicinal aspects of triazoles as anticancer agents that have been reported during the past few years. We hope that the bioactivity of triazole derivatives will be beneficial for the rational design of a new generation of small molecule drugs.
Citation - WoS: 6
Citation - Scopus: 7
Molecular Epidemiology of Carbapenem-Resistant Acinetobacter Baumannii Isolates in Turkiye: Systematic Review
(Kare Publ, 2023) Kilbas, Elmas Pinar Kahraman; Kilbas, Imdat; Ciftci, Ihsan Hakki
The World Health Organization has designated carbapenem-resistant Acinetobacter baumannii (CRAB) as a "critical" pathogen on the global priority list of antibiotic-resistant bacteria. This study aims to discuss the molecular epidemiology of CRAB isolates in Turkiye in the last 12 years and the prevalence of gene regions associated with resistance or pathogenesis using a systematic review method. Our study consists of a literature search, determination of eligibility and exclusion criteria, qualitative analysis of studies, data extraction, and statistical analysis. All studies were analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Guidelines. The incidence rates of blaOXA-23, blaOXA-23-like, blaOXA-24/40, blaOXA-24/40-like, blaOXA-51, blaOXA-51-like, blaOXA-58, and blaOXA-58-like genes in CRAB strains were 76.4%, 68.6%, 1.2%, 3.4%, 97.0%, 98.6%, 8.4%, and 17.1%, respectively. It was determined that the prevalence of the blaOXA-23 and blaOXA-58 gene regions showed a statistically significant change over the years. Due to the high prevalence of A. baumannii strains carrying the blaOXA-23 variant, it is necessary to follow its geographical distribution and transposon and plasmid movements. Based on available data, molecular surveillance of CRAB strains should be standardized. In addition, sterilization and disinfection processes applied within the scope of an effective struggle against CRAB strains that can remain live on surfaces for a long time should be reviewed frequently.
Citation - WoS: 1
Update on the First Year of Covid-19
(Galenos Publ House, 2021) Kahraman Kilbas, Elmas Pinar; AltindIS, Mustafa; Yilancioglu, Kaan; TekIn, Ishak Ozel; Buran, Duran; Ozkan, Secil; Ilhan, Mustafa Necmi
The current outbreak of the Coronavirus, severe acute respiratory syndrome Coronavirus-2, which originated in the Wuhan province of the People's Republic of China became a pandemic. Although the clinical findings of the infection vary in adults, the most common symptoms are fever, dry cough, and shortness of breath. The diagnosis of the Coronavirus disease-2019 (COVID-19) is made by clinical symptoms, laboratory tests, and radiological methods. Many drugs such as antivirals, antibiotics, and corticosteroids are used in the treatment of COVID-19. For the successful control of the pandemic, prevention strategies are the key. There is strong consensus that, in addition to wearing masks, hand hygiene, and social distancing, an effective COVID-19 vaccine is probably the most effective approach to sustainably control the pandemic. In this article, current information about the pathogenesis, epidemiology, risk groups, diagnosis, treatment, prevention strategies, and vaccination of the disease in the first year of the COVID-19 pandemic are discussed.

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