Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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Acute Changes in Electrophysiological Brain Dynamics in Elite Karate Players
(Springer international Publishing Ag, 2020) Balcıoğlu, Taylan Hayri; Balcioglu, Taylan Hayri; Ozcan Cakir, Canan Elif; Goksel Duru, Dilek; Antrenörlük Eğitimi Bölümü
Regular physical exercise has enhanced effects on the human anatomy and functionality. Recently, an effect of a single set of exercise is shown to have positive effects on mood and on cognitive functioning. The aim of this study is to investigate the effect of a single bout of moderate exercise on the brain electrophysiological dynamics in resting-state condition and under the mental workload situation from elite-level athletes. For this purpose, electroencephalogram (EEG) is measured before and after the exercise sessions from 17 elite karate players who are members of the national karate team of Turkey. Blood lactate measurements are implemented to monitor the volunteers before EEG measurements. EEG data are analyzed using three metrics: conventional band power of each electrode, coherence metrics between electrodes for each band and source coherence values corresponding to each frequency band. Each metric is statistically analyzed between pre- and post-values, and results revealed that in all frequency bands, right parietal electrode had increased connection values which are thought to be related to ongoing sympathetic nervous system response observed during the recovery period. Another finding is the enhanced connectivity of frontal sources under the resting state as well as during the increased mental workload periods.
The Acute Effects of Various Dynamic Stretching Exercises on Jump Performance and Range of Motion
(Universidad de Murcia, 2025) Savaan, Mustafa; Pmar, Yeliz; Pmar, Salih
This study aimed to investigate the acute effects of different dynamic stretching (DS) protocols on vertical jump performance and range of motion (ROM). Thirty healthy male participants, with an average age of 23.48 years, body weight of 76.90 kg, and height of 181.87 cm, who had engaged in recreational exercise for at least two years, participated voluntarily. A "cross-controlled randomized" experimental design was utilized to assess four distinct DS protocols: a-DS at 100 bpm for 30", b-DS at 100 bpm for 75" s, c-DS at 150 bpm for 30", and d-DS at 150 bpm for 75". Acute ROM was measured using the Passive Straight Leg Raise Test (PSLR), while jump performance was assessed via countermovement jump (CMJ). Data were analyzed using repeated measures ANOVA and paired samples T-tests with significance set at p<.05. All four DS techniques significantly increased angles measured by PSLR following application (p <.05). CMJ values also showed significant improvements in both groups subjected to the shorter protocols lasting 30"at either tempo (p <.05). Consideration should be given to application duration and tempo when planning DS exercises, as structured warmup routines can enhance flexibility and optimize athletic performance.
Acute Serious Hepatitis of Unknown Cause in Children
(Galenos Publishing House, 2022) Kılbaş, E.P.K.; Altındiş, M.
On April 5, 2022, an increase in cases of acute hepatitis of unknown etiology was reported in previously healthy children under the age of 10 in the United Kingdom. Since there is no link between these patients, called acute non-HepA-E hepatitis, and viral hepatitis agents (hepatitis A, B, C, D, and E), the possible etiology, and pathogenesis of this emergency is being investigated. One of the alarming features of this epidemic is the high requirement for liver transplantation in a fraction of the cases. In cases other than hepatitis A, B, C, D, and E, a case definition is made by looking at a series of clinical pictures, including serum transaminase levels and age. As of August 26, 2022, 513 cases of acute hepatitis have been reported in Europe and 1,010 globally. Adenovirus was detected in 75% of cases tested in the UK, but data for other countries are still lacking. The role of other etiologic agents is still under investigation. The exact disease pathogenesis has not yet clear. Evidence of human-to-human transmission of the disease remains unclear. Epidemiological studies are critical in clarifying the uncertainties regarding the existence of links between the cases reported to date. Continuing the national and international surveillance activities of the countries in an organized manner is the most basic issue required for the elimination of the epidemic. Copyright © 2022 Tehran University of Medical Sciences.
Adsorption Mechanisms, Kinetics and Photoactivities of Green Synthesized Hydroxyapatite Supported Zno and La-Zno Catalysts
(Pergamon-elsevier Science Ltd, 2024) Tuncel Turan, Duygu; Okte, A. Neren; Temel Eczacılık Bilimleri Bölümü
In this study, hydroxyapatite (HAP) is synthesized by a co-precipitation method from the waste eggshell, utilized as a support for ZnO (ZnO-HAP) and La-ZnO (La-ZnO-HAP) and employed to degrade methyl orange (MO) and methylene blue (MB) dyes under UV irradiation. Water vapor adsorption as relative humidity (84 % RH) on the HAP structure and the as-prepared catalysts are also examined. The characteristic ZnO and HAP reflections are detected in X-ray diffraction (XRD) analysis of ZnO-HAP, La-ZnO-HAP and humidified samples. ZnO and La-ZnO existence is also verified by scanning electron microscopy-energy dispersive X-ray (SEM-EDX) analysis, UV-Vis diffuse reflectance (UV-Vis DRS) spectra and X-ray photoelectron spectra (XPS). ZnO and La-ZnO loading on the HAP induce the formation of mesoporous structures with high surface areas. Dark adsorption capacities and photoactivities of the as-prepared samples are explored regarding electrostatic interactions, Lewis acid-base interactions and hydrogen bonding for both MO and MB. In particular, La-ZnO-HAP 500 degrees C and La-ZnO-HAP 500 degrees C (RH) exhibit improved adsorption abilities and photoactivities. The pseudo-second order model describes the kinetic behavior of all samples under dark conditions. Unhumidified samples follow Langmuir isotherm while Freundlich isotherm better fits humidified ones. Under irradiation, the Langmuir-Hinshelwood kinetic model describes the photoactivities of all samples. The four recycling tests confirm the stabilities of HAP 100 degrees C, HAP 500 degrees C, ZnO-HAP 500 degrees C and La-ZnO-HAP 500 degrees C. This study suggests that the ZnO or La-ZnO loaded HAP catalysts prepared in the presence and absence of humid conditions are considered promising materials for environmental remediation.
Advances in Ferritin Biosensors: Rapid and Cost-Effective Iron Level Assessment
(Field Crops Central Research Institute, 2025) Vonalioglu, Sena; Okur, Muhammed Daghan; Üstünsoy, Recep; Ertaş, Tahsin; Dinç, Bircan
Iron is an essential element crucial for oxygen transport in the bloodstream; however, deviations from its normal physiological levels can result in health complications. Iron deficiency is a widespread condition and a leading cause of anemia globally. Conversely, excessive iron accumulation can cause severe liver damage, such as cirrhosis, by exacerbating oxidative stress. Consequently, assessing iron status through biomarkers like ferritin, which is a protein that reflects the body’s iron stores, is critical for diagnosing iron-related disorders accurately. The ferritin test, which measures the concentration of ferritin protein in the blood, is a standard method for iron analysis. However, frequent hospital visits for such testing can be both time-intensive and expensive. This has driven significant interest in developing rapid and cost-effective methods for ferritin detection. To meet this demand, a variety of biosensors have been designed using diverse techniques to enable convenient ferritin analysis. Despite considerable advancements in biosensor technologies, a comprehensive classification and analysis of these devices remain lacking, leaving researchers without a unified understanding of their comparative strengths and limitations. This review addresses this gap by systematically categorizing ferritin biosensors based on their underlying mechanisms. The review explores electrochemical biosensors, such as those based on graphene, microfluidics, and ZnO–Mn3O4 nanocomposites, as well as electrical biosensors using quantum dots or gold nanorods. Additionally, optical biosensors, including photonic crystal sensors, surface plasmon resonance systems and magnesium sulfide nanosheets are discussed in detail. Unconventional and immunoassay-based biosensors, such as nanodiamond-based magnetic sensors and nanowire FETs, are also examined to highlight the breadth of detection strategies available. With the rising prevalence of iron-related disorders and the limitations of traditional diagnostic tools, this review underscores the critical need for portable, rapid, and cost-effective ferritin biosensing technologies, offering insights relevant to both clinical practice and future research. © 2025 Elsevier B.V., All rights reserved.
Age-Specific Seroprevalence of Hepatitis a Virus in Turkey Between 2000 and 2023: Systematic Review and Meta-Analysis
(Mdpi, 2024) Kahraman Kılbaş, Elmas Pınar; Koroglu, Mehmet; Demiray, Tayfur; Terzi, Huseyin Agah; Kilbas, Elmas Pinar Kahraman; Tıbbi Hizmetler ve Teknikler Bölümü
Background: Hepatitis A virus (HAV) is a leading cause of acute viral hepatitis and is primarily transmitted by the fecal-oral route. The clinical presentation and progression of the disease varies according to the age of the patient. Turkey is classified as a moderately endemic country, and HAV infection continues to be an important public health problem worldwide. Methods: In this study, a systematic meta-analysis was conducted to evaluate age-specific HAV seroprevalence rates in Turkey between 2000 and 2023. A comprehensive literature review identified 57 articles that met the inclusion criteria. The studies were assessed for quality, and seroprevalence rates were evaluated across four different age groups. Statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software (CMAVersion 3.0) and SPSS (SPSS Statistics 25.0). Results: HAV seroprevalence rates were found to be 73.18% in the 0 < 5 age group and 90.90% in the >35 age group. The overall seroprevalence estimated using a random effects model was 64.5% (95% CI: 58.3-70). High heterogeneity was observed among the studies, and the prevalence estimates changed when low-quality studies were excluded. Conclusions: This meta-analysis suggests that the increasing trend in HAV IgG seroprevalence in Turkey, especially among young populations, is likely due to the vaccination program initiated in 2012. Furthermore, the heterogeneity observed among regions highlights the importance of regional public health strategies. Future studies should focus on providing more detailed data to evaluate the long-term effects of vaccination and to explain regional differences in HAV seroprevalence.
Ameliorative Effects of Myrtus Communis L. Extract Involving the Inhibition of Oxidative Stress on High Fat Diet-Induced Testis Damage in Rats
(Taylor & Francis Ltd, 2024) Şener, Göksel; Koroglu, M. Kutay; Hersek, Irem; Ertas, Busra; Sen, Ali; Sener, Goksel; Ercan, Feriha; Eczacılık Meslek Bilimleri Bölümü
The possible protective effects of Myrtus communis L. (MC) extract on a high fat diet (HFD)-induced testicular injury in a rat model were investigated using histological and biochemical methods. Wistar albino rats were divided into three groups: a standard diet control group; a HFD group; and an HFD+MC group. The HFD and HFD+MC groups were fed with a HFD for 16 weeks. MC extract (100 mg/kg) was given orally five days a week to the rats in the HFD+MC group during the last four weeks of the experiment. Leptin, triglyceride, high-density lipoproteins, cholesterol, estrogen, testosterone, LH and FSH were analyzed in blood serum. Sperm parameters were evaluated from the epididymis. Testicular morphology, proliferative, apoptotic and NADPH oxidase-2 (NOX2)-positive cells were evaluated histologically. Testicular oxidative stress parameters were analyzed biochemically. In the HFD group, lipid and hormone profiles were changed, abnormal spermatozoa, degenerated seminiferous tubules with apoptotic and NOX2-positive cells were increased in number, and sperm motility and germinal proliferative cells decreased compared to the control group. Moreover, testicular malondialdehyde, 8-hydroxy-2-deoxyguanosine and myeloperoxidase levels increased, whereas glutathione and superoxide dismutase levels decreased in the HFD group compared to the control group. All these histological and biochemical features were ameliorated by MC treatment of HFD-fed rats. In conclusion, HFD caused alterations in sperm parameters and testicular morphology by increasing oxidative damage and apoptosis. MC extract may have potential protective effects by inhibiting oxidative damage.
Analysis for Two-Dimensional Inverse Quasilinear Parabolic Problem by Fourier Method
(Taylor & Francis Ltd, 2021) Kanca, Fatma; Baglan, Irem; Bilgisayar Mühendisliği Bölümü
In this work, two-dimensional inverse quasi-linear parabolic problem with periodic boundary and integral overdetermination conditions is investigated. The formal solution is obtained by the Fourier approximation. Under some natural regularity and consistency conditions on the input data,the existence, uniqueness and continuously dependence upon the data of the solution are proved by iteration method. The inverse problem is first examined by linearization and then used implicit finite difference scheme for the numerical solution. Also predictor corrector method is considered in the numerical approach. Some results on the numerical solution with two examples are presented with figures and tables. The sensitivity of the scheme with respect to noisy overdetermination data is illustrated.
Analysis of Substance Use and Mental Disorder Diagnoses in Adolescents With a History of Delinquency: a Cross-Sectional Study
(Springer, 2024) Dikeç, Gül; Dikec, Gul; Tas Soylu, Gulsenay; Bilac, Oznur; Uzunoglu, Gulcin; Ayakdas Dagli, Dilek; Hemşirelik Bölümü
This study aimed to evaluate substance use and comorbid mental disorders in delinquent adolescents presenting to a child and adolescent psychiatry outpatient clinic. This study included 47 adolescents aged 15-18 years and had a history of delinquency. Data were collected using the Addiction Profile Index Adolescent Form (API-A) and an information form. Results indicated that the adolescents' mean age is 16.11 +/- 1.05 years, 78.7% had committed crimes against property and 34.0% against the person, and 34.0% were also victims of crime. Mean API-A total scores indicated that their level of substance use was low. In addition, mean API-A total scores showed significant differences according to the adolescents' migration status, age, economic status, school attendance, mental disorder diagnosis, duration of mental disorder, and type of offense (p < 0.05). The benefit provided by timely and appropriate psychosocial interventions may have a key role in solving this problem for adolescents and improving their future as adults.
Analyzing Critical Success Factors of Sustainable Knowledge Management: an Interval-Valued Neutrosophic Approach
(Mdpi, 2024) Çaloğlu Büyükselçuk, Elif; Bulak, Muhammet Enis; Buyukselcuk, Elif Caloglu; Endüstri Mühendisliği Bölümü
Knowledge management (KM) is a structured approach that includes the organized procedures of generating, capturing, arranging, storing, retrieving, distributing, and harnessing an organization's knowledge resources to attain its goals and improve its effectiveness. Encountering uncertainty and managing imprecise information are fundamental aspects of KM that cannot be avoided. In this context, sustainable KM aims to solve these issues and address prioritizing the long-term sustainability and efficiency of knowledge-related processes within an organization. The aim of this study is to structure a sustainable KM concept for organizations and identify the most common critical success factors (CSFs) with a novel analytical approach. In this context, the Interval-Valued Neutrosophic methodology, which is one of the multi-criteria decision methods (MCDMs), was adopted to evaluate and weight the determined CSFs. Four main headings-KM, environmental, economical, and social criteria-are evaluated along with their subfactors. Our findings show that KM is found to be the most important, and environmental factors followed KM. When the results are examined in terms of subfactors, cleaner production is found to be the most significant, with a global weight value of 11.13.
Anti-Lipid Accumulation and Antioxidant Effects of the Root Extract From Rubus Discolor and Its Phytochemical Analysis
(Springer Science and Business Media Deutschland GmbH, 2025) Şekerler, T.; Gülmez, G.; Algül, K.F.; Göger, F.; Şenkardeş, İ.; Şen, A.; Şener, A.
Rubus species exhibit potent antioxidant properties due to their high phenolic compound content. In our study, phytochemical composition of the extract obtained from roots of Rubus discolor (RDE) was determined using LC-MS/MS. Subsequently, effect of this extract on lipid accumulation was investigated in HepG2 liver cells. For this purpose, HepG2 cells were treated with oleic acid to induce lipid accumulation. The effect of RDE on lipid accumulation was assessed using Oil-Red staining and measuring intracellular triglyceride, cholesterol levels. Melatonin was used as a positive control. Enzymes involved in lipid synthesis, including acetyl-CoA carboxylase (ACC1), fatty acid synthase (FAS), and transcription factor sterol regulatory element-binding protein 1 (SREBP-1c), as well as the antioxidant status, were evaluated by RT-PCR. As dose-dependent, RDE significantly reduced lipid accumulation and each concentrations (25, 50, 100 µg/mL) of RDE showed 78%, 48%, 38% ratio, respectively for Oil Red O staining. TG was found 1.92 ± 0.03, 1.76 ± 0.40, 1.22 ± 0.13, 1.41 ± 0.08 mg/mg protein for oleic acid and each concentrations (25, 50, 100 µg/mL) of RDE, respectively It significantly suppressed ACC1, FAS, and SREBP-1c (p < 0.001, p < 0.001, p < 0.01, respectively) at a dose of 50 µg/mL. The extract also exhibited in vitro strong antioxidant and good anti-inflammatory properties. Pedunculagin isomer, ellagic acid and ellagic acid pentoside compounds were found to be the main compounds of RDE with high total phenolic content. The results indicate that RDE has the potential to prevent lipid accumulation. These findings could provide a basis for further studies on the potential therapeutic effect of Rubus discolor in the treatment of NAFLD. © The Author(s) 2025.
Antibiotic Use and Influencing Factors Among Hospitalized Patients With Covid-19: a Multicenter Point-Prevalence Study From Turkey
(Galenos Publ House, 2022) Ağalar, Canan; Cag, Yasemin; Karabay, Oguz; Kurtaran, Behice; Guclu, Ertugrul; Ogutlu, Aziz; Agalar, Canan; Tıbbi Hizmetler ve Teknikler Bölümü
Background: Broad-spectrum empirical antimicrobials arc frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective. and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age +/- standard deviation of the patients was 65.0 +/- 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (372%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005). presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein >10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p <0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings.
The Antioxidant, Anti-Inflammatory, and Antiplatelet Effects of ribes Rubrum L. Fruit Extract in the Diabetic Rats
(Wiley, 2022) Şener, Azize; Sen, Ali; Sekerler, Turgut; Algul, Fatma Kader; Cilingir-Kaya, Ozlem Tugce; Sener, Azize; Temel Eczacılık Bilimleri Bölümü
The prothrombotic and inflammatory state plays a significant role in the occurrence of cardiovascular complications in type 2 diabetes mellitus. In this study, the antidiabetic, anti-inflammatory, and antiplatelet potentials of the extracts obtained from Ribes rubrum were investigated. The antidiabetic, anti-inflammatory, and antioxidant activities of the ethanol and water extracts of R. rubrum were evaluated by in vitro methods. The total phenolic and flavonoid contents were also determined. The experimental diabetes model in rats was induced with streptozotocin (STZ). After hyperglycemia occurred, the ethanol extracts of R. rubrum (RRE, at 100 mg/kg and 500 mg/kg doses) were administered to the treatment groups for 14 days. Blood glucose, lipid profile, plasma, and pancreas tumor necrosis factor-alpha (TNF-alpha) levels were determined and compared at the end of the experiments. P-selectin levels and mitochondrial membrane polarization (MMP) of platelets were also measured. In vitro study, the RRE showed potent anti-inflammatory activity. Administration of RRE (at 100 mg/kg doses) to diabetic rats lowered blood glucose level insignificantly. The results showed that there was an increment in levels of TNF-alpha in plasma and pancreas tissue of the diabetic group compared to the control group. R. rubrum extract regulated and normalized their levels in plasma and pancreatic tissue. RRE at both doses significantly decreased platelet P-selectin levels and prevented STZ-induced loss of MMP in platelets. The results of current research indicate that RRE extract has potent anti-platelet and anti-inflammatory effects and may be beneficial in preventing diabetic complications. Practical applications Hyperglycemia causes dyslipidemia, advanced oxidative stress, platelet activation, and inflammation in diabetes mellitus. Plants with various medicinal properties are of worldwide interest for the treatment of diseases due to their biological activities. In this study, the antidiabetic, anti-inflammatory, and antioxidant effects of extracts of Ribes rubrum (%100 ethanol, 50% ethanol, water) were evaluated by in vitro and in vivo methods. The diabetes model was induced with streptozotocin (STZ). The rats were divided into control, diabetic control, R. rubrum-100 mg/kg, and R. rubrum-500 mg/kg doses groups. Blood glucose levels, tumor necrosis factor-alpha (TNF-alpha), platelet P-selectin levels, mitochondrial membrane polarization of platelets were examined. The present study has shown that R. rubrum has anti-inflammatory and antiplatelet activity. R. rubrum may be beneficial in the prevention and treatment of DM complications due to its anti-inflammatory and antithrombotic effects.
Antioxidants, Enzyme Inhibitory Activities, and Phytochemical Profiles of Seven Medicinal Plants Grown With Organic Farming Techniques
(Tubitak Scientific & Technological Research Council Turkey, 2023) Zor, Murat; Ozupek, Burcin; Pekacar, Sultan; Deliorman Orhan, Didem; Eczacılık Meslek Bilimleri Bölümü
In this study, the potential antihyperlipidemic, antidiabetic, and antiobesity effects of extracts obtained via infusion techniques from Artemisia absinthium L., Achillea millefolium L., Calendula officinalis L., Fumaria officinalis L., Mentha piperita L., Origanum onites L., and Urtica dioica L. grown with organic farming techniques were investigated using enzyme inhibition methods (alpha-glucosidase, pan-creatic cholesterol esterase, pancreatic lipase, and alpha-amylase). It is important that natural compounds or extracts to be used in the treat-ment of metabolic problems have antioxidant effects. The antioxidant effects of these species were tested in terms of ABTS and DPPH radical scavenging activity, ferric reducing power, and metal chelating capacity. Extracts (2 mg/mL) of M. piperita (91.43 +/- 0.90%) and O. onites (70.18 +/- 2.02%) showed potent inhibitory effects on the alpha-glucosidase enzyme. Among all species, only O. onites extract ex-erted an inhibitory effect on the cholesterol esterase enzyme close to that of reference compound simvastatin. While all extracts were effective in the tested antioxidant activity methods, it was determined that the M. piperita and O. onites extracts displayed particularly significantly strong activities in terms of ferric reducing power, ABTS radical scavenging effect, and metal chelating capacity. The total flavonoid and phenolic contents of all extracts were determined. The compositions of the most active extracts were analyzed for pheno-lic acids and flavonoids using RP-HPLC. The results of RP-HPLC analysis showed that the levels of ellagic acid (0.923 +/- 0.000 g/100 g extract) in the M. piperita extract and rosmarinic acid (0.813 +/- 0.003 g/100 g extract) in the O. onites extract were high. As a result, all species grown with organic farming techniques except U. dioica were found to have high antioxidant effects. In light of these findings, it was concluded that M. piperita and O. onites grown with organic farming techniques showed strong inhibitory effects in terms of the tested activities, especially for alpha-glucosidase and pancreatic cholesterol esterase, and that in vivo studies and activity-guided isolation studies should be conducted on these species in the future.
Apocynin Exhibits an Ameliorative Effect on Endothelial Dysfunction/ Atherosclerosis-Related Factors in High-Fat Diet-Induced Obesity in Rats
(Marmara Univ, Fac Medicine, 2024) Şener, Göksel; Ertas, Busra; Kaya, Rumeysa Keles; Sevinc, Sevgi Kocyigit; Amuran, Gokce Gullu; Ercan, Feriha; Cetinel, Sule; Eczacılık Meslek Bilimleri Bölümü
Objective: The aim of this study was to reveal the effect of apocynin (APO) on the factors involved in obesity-related endothelial dysfunction (ED) and atherosclerosis (AS). Materials and Methods: Male Wistar albino rats were divided into control (CNT), high-fat diet (HFD) and HFD+APO groups. HFD and HFD+APO groups were fed HFD for sixteen weeks. APO (25 mg/kg) was administered to the HFD+APO group for the last four weeks. The effects of APO on: AS-related metabolic parameters (triglyceride, total cholesterol, high-density lipoprotein-cholesterol, insulin and leptin), oxidative stress (OS), [ malondialdehyde, glutathione, nicotinamide adenine dinucleotide phosphate (NADPH)oxidase-2, oxidised-low-density lipoprotein (ox-LDL) and 8-hydroxy-2-deoxyguanosine], low-density lipoprotein and ox-LDL uptake potential (activin receptor-like kinase-1 and lectin-like oxidized low-density lipoprotein receptor-1, respectively), tissue inflammation inducible-nitric oxide synthase, nitric oxide), programmed cell death (terminal deoxynucleotidyl-transferase-dUTP-nick-end (alpha-smooth muscle actin), histology and ultrastructure of thoracic aorta were evaluated. Results: In obesity, APO had an ameliorative effect on metabolic parameters, OS, inflammation, ED, programmed cell death and oxLDL uptake potential, but not on foam cell formation and LDL uptake potential. Conclusion: Apocynin may improve ED and AS in obesity by suppressing OS-linked factors involved in the early stage of AS.
Aqueous Parsley (Petroselinum Crispum) Extract Ameliorated Methotrexate-Induced Brain and Small Intestine Damage in Rats
(Ankara Univ, 2025) Dursun, Ercan; Karaoglu, Sumeyye Yilmaz; Sivas, Guzin Goksun; Tufan, Elif; Sacan, Ozlem; Yanardag, Refiye; Akbay, Tugba Tunali
Methotrexate (MTX) is a widely used antiarthritic and chemotherapeutic agent known to cause damage to various tissues. This study investigated the potential protective effects of parsley extract against MTX-induced brain and intestinal tissue damage. Sprague-Dawley rats were divided into control, control + parsley, MTX, and MTX + parsley. MTX (20 mg/kg, i.p.) was administered to the MTX and MTX + parsley groups. The control + parsley, and MTX + parsley groups were administered 2 g/kg parsley extract by oral gavage for five consecutive days. After the fifth day, brain and small intestinal tissues were taken. Total protein, nitric oxide, lipid peroxidation, glutathione levels, tissue factor, superoxide dismutase, and glutathione S-transferase activities were determined in these tissues. The protein profiles of the tissues were evaluated using SDS polyacrylamide gel electrophoresis. Parsley administration caused a decrease in lipid peroxidation levels in both tissues of the MTX group. On the other hand, glutathione level, glutathione-Stransferase, and superoxide dismutase activities were found to be increased. On the other hand, parsley decreased the nitric oxide level which was increased in the intestinal tissues of the MTX group. There was no significant change in brain nitric oxide level and tissue factor activity between groups. MTX and parsley administration altered protein expression, leading to the appearance or disappearance of specific bands in intestinal and brain tissues. In conclusion, parsley alleviated MTX-induced damage in brain and intestinal tissues by reducing lipid peroxidation and modulating antioxidant defenses.
Are Child and Parent Health Behaviors Associated With Childhood Obesity? a Descriptive and Methodological Study
(Elsevier Science inc, 2023) Öztürk, Gizem; Kolcu, Merve; Hemşirelik Bölümü
Purpose: This study was conducted to determine the relationship between child and parents' health behaviors and childhood obesity. In addition, an adaptation of the Turkish version of the Family Health Behavior Scale (FHBS) was performed in this study.Design and methods: This is a descriptive and methodological study. The research sample consisted of 358 parents who have a child between the ages of 5 and 12 studying in one of the seven state schools at the kindergarten, primary, and secondary school levels in Istanbul. Data were collected between February 2022 to May 2022 using the Parent and Child Descriptive Information Form, the Family Nutrition and Physical Activity (FNPA) Screening Tool, and the FHBS. IBM SPSS 25.0 (IBM, Armonk, NY, USA) and SPSS AMOS 21.0 software were used to analyze the data.Results: It was found that the confirmatory factor analysis result of FHBS confirmed the original structure of the scale, and Cronbach's Alpha coefficient was calculated as 0.80. A positive correlation was found between the parents' total scores of FNPA and FHBS (r:0.511, p < 0.001).Conclusions: It is recommended to evaluate the child and their parents holistically in preventing and managing childhood obesity. School health nurses should plan family-centered interventions to improve health behaviors and carry out these interventions with a multidisciplinary team. Moreover, it has been determined that FHBS is a valid and reliable measurement tool for the Turkish population.
Assessment of Breastfeeding Self-Efficacy in Nursing Mothers Following Earthquakes: A Case Study of the Kahramanmaraş Earthquakes in Turkey
(Kashan Univ Medical Sciences, 2025) Dinmez, Sinem Guven; Karaman, Ozen Esra; Bakir, Emine
Background: Natural disasters disproportionately impact vulnerable populations, particularly mothers and infants. Research indicates that during such events, mothers often favor formula and supplementary feeding over breastfeeding. Self-efficacy is a critical determinant influencing breastfeeding practices in disaster contexts.
Objectives: This study aimed to examine the breastfeeding characteristics and self-efficacy of nursing mothers following the Kahramanmara & scedil; earthquakes.
Methods: This descriptive study was conducted at the Children's Polyclinic of Iskenderun State Hospital in Turkey from August 1 to August 31, 2023. A total of 54 mothers with infants aged 0-1 year at the time of the earthquake, who continued to breastfeed (providing breast milk for at least one feeding), were selected using a non-probability purposive sampling method. During the study period, all eligible mothers visiting the polyclinic who met the inclusion criteria were evaluated. Data were collected using a "Descriptive Data Form" and the "Breastfeeding Self-Efficacy Short Form Scale". Statistical analyses were performed using SPSS version 23, employing Independent Samples t-tests, Mann-Whitney U tests, and One-Way ANOVA for group comparisons. A P-value of less than 0.05 was considered statistically significant.
Results: The mean breastfeeding self-efficacy score among mothers was 58 +/- 5.87 (minimum 40; maximum 70). Mothers who exclusively breastfed their infants had significantly higher self-efficacy scores compared to those who introduced formula (P = 0.021) Among the mothers surveyed, 81.5% reported that their breastfeeding was affected by the earthquake; 41% cited issues related to privacy, while 27% faced challenges regarding shelter. Prior to the earthquake, 72% of infants were exclusively breastfed; however, this figure decreased as 81.5% of infants began receiving complementary foods alongside breast milk post-earthquake.
Conclusion: The findings indicate that mothers breastfeeding self-efficacy is at a moderate level. Additionally, mothers reported alterations in their breastfeeding practices compared to the pre-earthquake period. These results underscore the importance of promoting breastfeeding in disaster-affected areas and highlight the critical role of midwives in supporting these efforts.
Assessment of Cross-Cultural Adaptations and Patient-Reported Outcome Measures Relevant To Shoulder Disorders in Turkish: a Systematic Review Using the Cosmin Methodology
(Public Library Science, 2025) Isiklar, Cagdas; Sirma, Gamze Cagla; Turgut, Elif
Background There are many shoulder assessment outcome measures in the literature that have been studied for validity and reliability. However, there is no study examining the Turkish-adapted patient outcome measures (PROMs) on the shoulder according to the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) checklist. In addition, there is a small number of studies that carry out this examination on the shoulder internationally. Determining the most appropriate questionnaires for clinical use will also be an important guide in patient evaluation by filling the gap in both literature and clinical aspects.Objective Our aim in this study is to identify the valid and reliable Turkish scales used to evaluate shoulder pain and disability, to reveal how compatible these scales are with the aspects of study quality and psychometric quality according to COSMIN criteria list.Methods A systematic search was performed in the following electronic databases: MED-LINE, Web of Science (WOS), EMBASE, SCOPUS, and ULAKBIM were searched from inception to September 2024.Results A total of 2890 articles were found in the databases. Four articles were included additionally without a search. Then, after eliminating the duplicates, 2231 articles were included based on the title and abstract search. 63 articles were included in full-text review. After the full-text review, according to our criteria, 29 articles were included in the systematic review. According to the assessment by the COSMIN checklist, 28 articles received the final classification of "inadequate". Only 1 article (UCLA-Tr) received the final classification of "adequate".Conclusion There is a wide range of Turkish PROMs available for the shoulder, with only one fully meeting COSMIN methodology criteria. However, this does not imply that other PROMs lack clinical utility. Future studies should focus on refining PROMs by incorporating MCID and PASS scores and prioritizing their responsiveness to enhance their clinical relevance. Additionally, variations in PROM performance across different patient populations highlight the need for context-specific evaluations to ensure their applicability in diverse clinical settings.Trial registration PROSPERO registration number: CRD42022298425.
Assessment of the Psychometric Properties of the Online Education Student Satisfaction Scale: a Methodological Study
(Springer Publishing Company, 2024) Harmancı Seren, A.K.; Alan, H.; Türkmen, E.; Gungor, S.; Baykal, Ü.
Background and Purpose: Assessing student satisfaction is essential in evaluating the quality of education. The number of valid and reliable tools that measure students’ satisfaction with online education is limited. This methodological study aimed to assess the psychometric properties of the online education student satisfaction scale. Methods: Eleven academicians from the nursing field provided expert opinions on content validity. Separate 25 students evaluated the language clarity of the draft scale. The study sample included 525 third- and fourth-year nursing students. Finally, a group of 30 nursing students different from the sample participated in the test–retest. The study created an item pool based on the recent literature. The researchers calculated the items’ content validity rates and the scale’s content validity index by taking the experts’ opinions. In addition, item–total score correlation analysis, exploratory factor analysis, discrimination analysis, stability test, and internal consistency analysis were performed. Results: An item with a low-correlation value was excluded from the scale. The correlation coefficients of the remaining items were between.536 and.811. In the second round of exploratory factor analysis, a five-factor structure emerged that explained 72.1% of the total variance. In addition, item discrimination, stability, and internal consistency test results ensured that the scale was valid and reliable. Conclusions: The online education student satisfaction scale with five subdimensions containing 28 items is a valid and reliable tool. Researchers, educators, and managers may use it to evaluate students’ satisfaction with online education. © Copyright 2024 Springer Publishing Company, LLC.

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