PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/8

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Citation - WoS: 9
Citation - Scopus: 7
Investigation of Land Cover (lc)/Land Use (lu) Change Affecting Forest and Seminatural Ecosystems in Istanbul (turkey) Metropolitan Area Between 1990 and 2018
(Springer, 2023) Bozkurt, Selvinaz Gulcin; Kusak, Lutfiye; Akkemik, Unal
This study was conducted to examine the land cover (LC)/land use (LU) change affecting forest and seminatural ecosystems and the spatio-temporal development of urban expansion between 1990 and 2018 in the city of Istanbul, where urbanization is the most intense in Turkey. For this purpose, using Corine Land Cover (1990, 2000, 2006, 2012, and 2018) dataset, the land cover of the area was determined in 5 different classes (artificial surface, agriculture, forest, water bodies, water), maps were produced, and tabular data were created. The changes in LC/LU between 1990 and 2018 were determined according to the Puyravaud land cover change rate and hot spot analysis methods. According to our findings, we determined that urbanization in Istanbul expanded the most in the east-west direction, and the agricultural and forest areas gradually decreased by 3.02% and 6.66% respectively; urban areas increased at the same rate of 9.69%. It is predicted that this change will continue increasing until 2030 when the forecasting method is applied in the field. It has been determined that the most important reasons for this situation are local government policies, population growth, and economic development initiatives applied in the area. As a result, it has emerged that measures should be taken based on sustainability and naturalness approaches to design urban development plans and to protect natural areas on a large scale, in order to limit possible LC/LU conversion from natural structure to urbanization in the area.
Does Prolotherapy Have an Effect on the Care of Pressure Injuries? a Pilot Study
(Elsevier Sci Ltd, 2025) Eroglu, Nermin; Kokkiz, Rukiye; Eroglu, Hatice Eda; Kocoglu, Hasan
Background: This study contributes to wound healing with prolotherapy in people with pressure injuries. The study was planned and conducted as a randomized controlled trial to determine the effect of prolotherapy on the care of pressure injuries. Methods: The study was carried out with patients with pressure injuries in the intensive care unit of a city hospital between April and June 2023. A power analysis was performed, and the sample size was calculated as 20 patients, including 10 in the intervention and 10 in the control group. The patients in the experimental group were given wound care with gelofusine as prolotherapy in the morning and evening for three days, and the injury site was covered with a sterile sponge and fixation tape. The patients in the control group were treated with saline in the morning and evening for three days. In both groups, the wound width, depth, and length were measured and evaluated prior to each intervention for three days. Results: In the study, a significant difference was found between the mean ages of the participants in the experimental and control groups (p < 0.05). The decrease in width measurements in the experimental group was found to be statistically significant compared to the previous measurements, while the increase in width measurements in the control group was significant compared to the previous measurements (p < 0.05). Depth measurements decreased statistically significantly in the experimental group, while they increased significantly in the control group compared to previous measurement values (p < 0.05). Conclusion: In conclusion, it was determined that the administration of gelofusine for pressure injuries as prolotherapy in the experimental group may be more effective in wound healing than saline treatment applied in the control group. Further studies are warranted.
Citation - WoS: 3
Citation - Scopus: 1
Work-Related Musculoskeletal Disorders Among Occupational Therapists in Turkey: a Cross-Sectional Study
(Taylor & Francis inc, 2024) Bektas, Selen Aydoner; Degerli, Medine Nur Ozata; Altuntas, Onur; Bumin, Gonca
Work-related musculoskeletal disorders are a common cause of absentism and work disability. As work-related musculoskeletal disorders represent an increasingly important issue for occupational therapists, this study determined musculoskeletal disorders among occupational therapists in Turkey. A total of 238 occupational therapists participated and completed the Nordic Musculoskeletal Questionnaire. As a result, 73.1% of participants reported experiencing neck pain and 72.3% reported experiencing low back pain at 12 months. Statistically significant differences were found between participants with and without work-related musculoskeletal disorders regarding gender, experience, workplace type, treatment, and daily working hours (p < 0.05). Occupational therapists may experience work-related musculoskeletal disorders due to not practicing proper body mechanics or non-provision of transferring equipment.
Citation - WoS: 4
Citation - Scopus: 5
The Validity and Reliability of the Thanatophobia Scale-Turkish Form: a Psychometric Study Among Nurses
(Sage Publications inc, 2024) Cifcioglu, Zulfiye Yildiz; Seren, Arzu K. Harmanci
Purpose: To examine the validity and reliability of the Thanatophobia Scale-Turkish Form among nurses. Design and methods: This methodological study included 154 nurses. Content and construct validity, item analysis, confirmatory factor analysis, and internal consistency were used to evaluate the data. Findings: The content validity index of the scale was 0.91. Item-total score correlation values varied between 0.453 and 0.718. As a result of the confirmatory factor analyses, one factor was confirmed. Cronbach's alpha internal consistency coefficient was 0.854. Practice Implications: Thanatophobia Scale-Turkish Form is a valid and reliable tool used to evaluate the fear of death among nurses.
Effects of an Adapted Dance Exercise Program on Trunk Control, Balance and Functional Mobility in Children and Adolescents with Cerebral Palsy: Randomized Controlled Study
(Taylor & Francis inc, 2025) Yekdaneh, Asena; Arman, Nilay
Aims: The study aimed to investigate whether an 8-week adapted dance exercise program (ADEP), delivered in addition to conventional physiotherapy, would improve trunk control, balance, functional mobility, and quality of life (QoL) in children and adolescents with cerebral palsy (CP) compared with conventional physiotherapy alone. Methods: Thirty participants with CP (Gross Motor Function Classification System Level I - II) were randomly assigned to the ADEP group (n = 15) or the control group (n = 15). Both groups received conventional physiotherapy, while the ADEP group additionally performed physiotherapist-choreographed dance exercises accompanied by music, twice a week for 8 weeks. Outcomes included the Trunk Control Measurement Scale (TCMS) for trunk control, the Pediatric Balance Scale (PBS) for balance, the Timed Up and Go (TUG) for functional mobility, and the Pediatric Outcomes Data Collection Instrument (PODCI) for QoL. Results: The ADEP group showed significantly greater improvements than the control group in TCMS-Total (Delta = 10.53 vs 3.50, p < .001), TCMS-selective motor control (Delta = 6.00 vs 1.42, p < .001), TCMS-dynamic sitting balance (Delta = 7.53 vs 2.28, p < .001), and PODCI-Global scores (Delta = 4.61 vs -1.71, p < .001). Both groups improved in PBS and TUG, but between-group differences were not significant. Effect sizes indicated large improvements in trunk control in favor of the ADEP group. Conclusions: An 8-week ADEP program, when combined with conventional physiotherapy, produced clinically meaningful gains in trunk control and QoL in children and adolescents with CP. These findings support the use of dance-based rehabilitation as a feasible and engaging adjunct to physiotherapy.
Citation - WoS: 3
Citation - Scopus: 3
Effect of Home Care After Cardiac Surgery
(Managed Care & Healthcare Communications Llc, 2023) Aksut, Rabia Saglam; Kilic, Dilek
OBJECTIVES: Home care that maintains continuity of health care services after cardiac surgery is considered a complementary component of clinical care. We estimated that effective home care given with a multidisciplinary approach would contribute to decreasing symptoms and readmissions to the hospital after cardiac surgery.STUDY DESIGN: This experimental study with a 6-week follow-up period and a 2-group repeated measures design with pretest, posttest, and interval tests was conducted in a public hospital in Turkey in 2016.METHODS: We identified the self-efficacy levels, symptoms, and readmissions to the hospital of 60 patients (30 in the experimental group and 30 in the control group) throughout the data collection process, and we estimated the effect of home care on self-efficacy, symptom management, and hospital readmissions by comparing the data of patients in the experimental and control groups. Each patient in the experimental group received 7 home visits along with 24/7 telephone counseling services throughout the first 6 weeks after discharge, and patients were provided physical care, training, and counseling services during these home visits with the collaboration of their physician.RESULTS: Home care resulted in better self-efficacy and fewer symptoms in the experimental group (P < .05), and it also reduced readmissions to the hospital in the experimental group (23.3%) compared with the control group (46.7%).CONCLUSIONS: This study's findings suggest that home care, with a focus on continuity of care, decreases symptoms and readmissions to the hospital and improves the self-efficacy of patients after cardiac surgery.
Citation - WoS: 4
Citation - Scopus: 6
Hepatoprotective Effects of Parsley (petroselinum Crispum) Extract in Rats With Bile Duct Ligation
(Elsevier, 2023) Ede, Seren; Özbeyli, Dilek; Erdogn, Omer; Cevik, Ozge; Kanpalta, Fatma; Ercan, Feriha; Senerg, Goksel
Background and study aims: This study aimed to investigate the possible protective effects of parsley extract (Petroselinum Crispum; PC) against oxidative liver damage caused by bile obstruction in rats. Material and methods: Bile duct ligation (BDL) method was used to induce liver injury in rats. The rats were divided into the three groups each consisting of 8 rats; Sham-operated control (C), bile duct ligated + saline treated (BDL), and BDL + PC treated groups. PC extract was given at a dose of 2 g/kg orally for 28 days. Aspartate amino transferase (AST), alanin amino transferase (ALT), and bilirubin levels were analyzed in sera. In order to determine free radicals in liver injury, luminol and lucigenin chemiluminescence tests used. Oxidative stress was evaluated through superoxide dismutase, glutathione, malondialdehyde, Na+/K+-ATPase and 8-hydroxy guanosine levels. Furthermore, inflammation marker myeloperoxidase, apoptosis marker caspase-3, and fibrosis markers TGF- beta and hydoxyproline were investigated. The liver tissues were also examined for histological evaluations.Results: While PC treatment decreased AST and ALT levels which increased with BDL, oxidant damage parameters also decreased with this treatment. Conclusion: The present study, which is the first research for PC extract on cholestasis induced liver damage, demonstrated that PC extract could be a potential therapeutic agent against liver fibrosis and need further studies.
Citation - Scopus: 4
Effects of Computer-Based Balance Exercises on Balance, Pain, Clinical Presentation and Nerve Function in Patients With Diabetic Peripheral Neuropathy: a Randomized Controlled Study
(International Society of Musculoskeletal and Neuronal Interactions, 2024) Reyhanıoglu, D.A.; Yıldırım, G.; Sengun, I.Ş.; Kara, B.
Objective:To evaluate the use of a computer-based biodex balance exercise system (BBS) on balance, neuropathic pain, clinical presentation and nerve function in patients with diabetic peripheral neuropathy (DPN). Methods: A total of 32 participants with DPN were randomly assigned in a 1:1 ratio to an intervention group (IG) or control group (CG). The IG performed exercises using the BBS twice weekly for 8 weeks, while CG were informed regarding diabetes self-management. At baseline and after study completion, participants underwent balance (postural stability and fall risk) and neuropathic pain assessment (DN4 questionnaire) and were screened using the Michigan Neuropathy Screening Instrument and nerve conduction test. Results: Among the baseline participants, 14 in the IG and 13 in the CG completed the study. Balance training improved postural stability (overall, p<0.001), fall risk (p<0.001), neuropathic pain (p=0.01) and symptoms (p<0.001), and clinical presentation (p=0.02), but not nerve function, within the IG. At follow-up, IG displayed significantly improved stability (p<0.001) and fall risk (p=0.02) and decreased neuropathic symptoms (p=0.01) compared to the CG. Conclusion: Computer-based balance exercises improve balance, pain, and clinical presentation of DPN, but not nerve function, in patients with DPN. ClinicalTrials.gov ID: NCT05255497. © 2024, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.
Design and Synthesis of Thiosemicarbazides and 1,2,4-Triazoles Derived From Ibuprofen as Potential Metap (Type II) Inhibitors
(Elsevier Ireland Ltd, 2025) Yilmaz, Ozgur; Biliz, Yagmur; Ayan, Sumeyra; Cevik, Ozge; Karahasanoglu, Mufide; Cotuker, Reyhan; Kucukguzel, S. Guniz
In the present study, a range of novel thiosemicarbazides 4a-i and 1,2,4-triazoles 5a-i derived from ibuprofen, were synthesized. Structural elucidation of these synthesized compounds was performed utilizing a variety of spectroscopic methods, including FTIR, 1H NMR, 13C NMR and HR-MS. The synthesized compounds were tested for cytotoxicity in five different cancer cell lines (cervical cancer (HeLa), human breast cancer (MCF-7), human gastric adenocarcinoma (MKN-45), human metastatic prostate cancer (PC3) and human glioblastoma (U87)). The compounds were compared with healthy cells (NIH-3T3) and the most effective compounds were determined by means of the selectivity index. Thiosemicarbazides derived form ibuprofen 4i and 4d showed anticancer activity, while 1,2,4-triazoles derived form ibuprofen 5b, 5c, 5d, 5e, 5h, 5g showed anticancer activity in HeLa, MCF-7, MKN-45, PC3 and U87 cells. To test the stability of the protein-drug complexes all 18 compounds 4a-i and 5a-i were docked into the active site of the MetAP2 enzyme In general, computational inhibition constants values were correlated with the experimental values. The dynamic behavior of MetAP2-inhibitor complexes was analyzed using all atoms Molecular Dynamic (MD) simulations for 200 ns duration. MD revealed that the drugs bind in the active center of MetAP2 with stable RMSD and RMSF. In conclusion, in-silico results and in-vitro studies suggests that thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen may be novel anticancer drug candidates for treating cervical, breast, prostate, gastric and glioblastoma. Compounds provided induction of apoptotic proteins in the cell by inhibiting MetAP2 enzyme. Furthermore, the potential antioxidant activities of the compounds were evaluated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Among the compounds tested, 4a, 4b, 4e, 4f, 4h, and 4i exhibited values closely resembling the DPPH activity of the standards.
Citation - WoS: 11
Citation - Scopus: 11
Synthesis, Antimicrobial Evaluation, and Molecular Modeling Studies of New Thiosemicarbazide-Triazole Hybrid Derivatives of (s)-naproxen
(Wiley-v C H verlag Gmbh, 2022) Han, M. Ihsan; Ince, Ufuk; Gunduz, Miyase Gozde; Kucckguzel, S. Guniz
The discovery of new antimicrobial molecules is crucial for combating drug-resistant bacterial and fungal infections that pose a dangerous threat to human health. In the current research, we applied a molecular hybridization approach to synthesize original thiosemicarbazide-triazole derivatives starting from (S)-naproxen (7a-7k). After structural characterization using FT-IR, H-1-NMR, C-13-NMR, and HR-MS, the obtained compounds were screened for their antimicrobial activities against Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Candida albicans ATCC 10231 and their isolates, as well. Although all compounds were found to be moderate antimicrobial agents, in general, their antibacterial activities were better than antifungal effects. Among the tested compounds, 7j carrying nitrophenyl group on the thiosemicarbazide functionality represented the best MIC value against S. aureus isolate. Finally, molecular docking studies were performed in the active pocket of S. aureus flavohemoglobin to rationalize the obtained biological data.
The Effects of Diaphragmatic Breathing Exercises on Individuals with Premature Ejaculation: A Randomized Controlled Trial
(Oxford University Press, 2025) Erkut, Umit; Karagözoğlu Coşkunsu, Dilber; Erkut, Kubra; Özden, Ali Veysel
Background There are no standardized, evidence-based rehabilitation protocols for premature ejaculation (PE) which hinders effective management, the development of validated patient-reported outcomes, regulatory oversight, and the potential benefits of targeted interventions. Aim To investigate the effect of diaphragmatic breathing exercises (DBE) on PE. Methods Sixty-two participants with PE were randomly assigned to Group I (n = 31) or Group II (n = 31). Both groups received behavioral therapy (BT) and pelvic floor muscle training (PFMT) twice daily, three days a week, for eight weeks. Additionally, Group I recieved DBE twice daily, every day, for eight weeks. Intravaginal ejaculation latency time (IELT) was calculated with a stopwatch, at the end of the 8th week (post-treatment), and at 1-year follow-up. Pelvic floor muscle (PFM) strength and endurance were evaluated with ultrasound, and changes in the in the autonomic nerves system (ANS) parameters (including the root mean square of successive differences [RMSSD], proportion of NN50 [PNN50], low-frequency [LF] power, and high-frequency [HF] power) were evaluated with an Elite HRV device at pre-treatment and post-treatment by a blinded assessor. Outcomes Primary outcome measurements were IELT, PFM strength and endurance, and changes in ANS paramaters. Results The study was completed by 29 participants (mean age = 31.4 ± 6.5 years) in Group I and 30 (mean age = 31.3 ± 7.6 years) in Group II. At post-treatment, all outcome measures showed significant improvements in both groups (P <.001 for all). Compared to Gropu II, Group I showed significantly greater improvements in IELT(P=0.12), RMSDD (P<.001), PNN50 (P=.003), LF Power (P<.001), HF Power (P=.003), strength(P<.001), and endurance (P<.001). The median IELT increase from baseline to post-treatment was 283 seconds (range: 84-870; 900%) in Group I and 204 seconds (range: 44- 581; 690%) in Group II. While IELT declined significantly from post-treatment to 1-year follow-up in Group II, no statistically significant change was found in Group I. Clinical Implications The effect of DBE on the ANS may help regulate the ejaculatory reflex. Strengths and Limitations This is the first study to apply breathing exercises with BT and PFMT in men with PE. Limitations include the lack of exercise adherence records beyond 8 weeks and the estimation-based IELT measurement at baseline. Conclusion Adding DBE, to BT and PFMT, yields better results in IELT (at 8 weeks and 1 year) and inreases PFM strength and endurance of PFM (at 8 weeks) in men with PE. © 2025 Elsevier B.V., All rights reserved.
Ameliorative Effects of Myrtus Communis L. Extract Involving the Inhibition of Oxidative Stress on High Fat Diet-Induced Testis Damage in Rats
(Taylor & Francis Ltd, 2024) Coskunlu, Busra; Koroglu, M. Kutay; Hersek, Irem; Ertas, Busra; Sen, Ali; Sener, Goksel; Ercan, Feriha
The possible protective effects of Myrtus communis L. (MC) extract on a high fat diet (HFD)-induced testicular injury in a rat model were investigated using histological and biochemical methods. Wistar albino rats were divided into three groups: a standard diet control group; a HFD group; and an HFD+MC group. The HFD and HFD+MC groups were fed with a HFD for 16 weeks. MC extract (100 mg/kg) was given orally five days a week to the rats in the HFD+MC group during the last four weeks of the experiment. Leptin, triglyceride, high-density lipoproteins, cholesterol, estrogen, testosterone, LH and FSH were analyzed in blood serum. Sperm parameters were evaluated from the epididymis. Testicular morphology, proliferative, apoptotic and NADPH oxidase-2 (NOX2)-positive cells were evaluated histologically. Testicular oxidative stress parameters were analyzed biochemically. In the HFD group, lipid and hormone profiles were changed, abnormal spermatozoa, degenerated seminiferous tubules with apoptotic and NOX2-positive cells were increased in number, and sperm motility and germinal proliferative cells decreased compared to the control group. Moreover, testicular malondialdehyde, 8-hydroxy-2-deoxyguanosine and myeloperoxidase levels increased, whereas glutathione and superoxide dismutase levels decreased in the HFD group compared to the control group. All these histological and biochemical features were ameliorated by MC treatment of HFD-fed rats. In conclusion, HFD caused alterations in sperm parameters and testicular morphology by increasing oxidative damage and apoptosis. MC extract may have potential protective effects by inhibiting oxidative damage.
Citation - WoS: 1
Citation - Scopus: 2
Investigating Body Image and Self-Esteem in Kidney Transplant Patients: a Qualitative Study
(Wolters Kluwer Medknow Publications, 2024) Akinci, N.; Varisoglu, Y.
Background:Kidney transplantation is one of the life-saving therapies for patients with end-stage renal disease, which affects a person's psychological, social, and physical well-being. How transplanted patients perceive their illness and their body can affect their physical and psychological recovery.Aim:This qualitative study was designed to evaluate self-esteem and body image in kidney transplant patients.Methods:The study involved 16 female renal transplanted patients. Data were collected using a two-part interview form developed by the investigators in accordance with the literature. We used Lundman's method to transcribe the interviews and coded the data from the interviews. The results of the study were discussed using the themes. The first three interviews were entered into MAXQDA, and then, additional interviews were analyzed.Results:Six main themes and 15 subthemes were generated based on the thematic analysis of the interviews with participants about body image and self-esteem. Themes included body acceptance, changes in body image, deterioration of social relationships, changes in self-esteem, spousal concerns, and organ perceptions. This study collected detailed data on body image, self-esteem, social relationships, and spouse/partner relationships after kidney transplantation.Conclusion:The change in participants' body image and self-esteem after kidney transplantation caused having negative feelings regarding sexual life, relationships, and social life and feeling unfamiliar with the transplanted organ.
Citation - WoS: 1
Citation - Scopus: 1
Does Working Style Affect the Occupational Balance and Life Satisfaction of Office Workers in Turkey? a Comparison Study
(Ios Press, 2024) Degerli, Medine Nur Ozata; Aydoner, Selen; Altuntas, Onur; Bumin, Gonca
BACKGROUND: The coronavirus outbreak (COVID-19) has caused various effects, changing people's lives and work styles. During this period, workplaces decided to work remotely, so people spent more time at home. Therefore, workers' personal and work lives were negatively affected. OBJECTIVE: This study planned to compare traditional and remote office workers' occupational balance and life satisfaction in Turkey during COVID-19. METHODS: Google Survey was used for data collection. Three hundred office workers (18-65 years old) from Turkey participated in the study. The occupational balance and life satisfaction levels of participants were assessed using the Occupational Balance Questionnaire (QB-Quest) and Personal Well-being Index-Adult (PWI-A). RESULTS: Data collected were analyzed statistically by the Independent Sample t-test. It was found that the remote office workers had lower levels of occupational balance (p = 0.02; r = -3.317) and life satisfaction (p = 0.01; r = -2.199) compared to the traditional office workers. CONCLUSION: Remote office workers were found to have lower occupational balance and life satisfaction than traditional office workers. In this period, when the way of working changes like COVID-19, it is crucial to determine office workers' occupational balance and life satisfaction and take precautions for their job performance and satisfaction.
Citation - WoS: 6
Citation - Scopus: 7
Respiratory Muscle Endurance in Obesity Hypoventilation Syndrome
(Daedalus Enterprises inc, 2022) Dusgun, Elif Sena; Aslan, Goksen Kuran; Abanoz, Ebru Seker; Kiyan, Esen
BACKGROUND: An increase in respiratory work load and resistance to respiration cause a decrease in respiratory muscle endurance (RME) in patients with obesity hypoventilation syndrome (OHS). We aimed to evaluate and compare RME in subjects with OHS and a control group using an incremental load test and compare the RME of subjects with OHS in whom noninvasive ventilation (NIV) was and was not used. METHODS: Forty subjects with OHS (divided according to body mass index [BMI] as group I: 30-40 kg/m(2); and group II: 6 40 kg/m(2)) and 20 subjects with obesity (control group: 30-40 kg/m(2)) were included in the study. RME was evaluated using the incremental load test, and respiratory muscle strength (RMS) was evaluated using mouth pressure measurements. The 6-min walk test, Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), EQ-5D Health-Related Quality of Life Questionnaire (EQ-5D), and the Obesity and Weight-Loss Quality of Life Instrument (OWLQOL) were performed. RESULTS: RME and RMS (%) in group I were lower than the control group (P=.001, P=.005, and P=.001, respectively). No significant difference was found between the 3 groups in terms of 6-min walk distance (6MWD) percentage predicted values (P=.98). RME in the NIV user group was higher than the non-user group (P 5.006). ESS, total PSQI, and FSS scores in the control group were less than group I (P=.01, P=.009, and P=.005, respectively) and group II (P 5.01, P <.001, and P <.001, respectively). The EQ-5D scores of the control group were higher than group II only (P=.005 and P=.005, respectively). There were no differences in OWLQOL between the groups (P=.053). CONCLUSIONS: RME was low in subjects with OHS but higher in those who used NIV. The incremental load test could be performed easily and safely in a clinic setting.
Citation - WoS: 1
Citation - Scopus: 1
A Single-center's Early Surgical Outcomes of Living Donor Liver Transplantation
(Elsevier Science inc, 2023) Anilir, Ender; Oral, Alihan; Atasoy, Alp; Civan, Hasret Ayyildiz; Topcu, Feyza Sonmez; Bayramoglu, Mert; Unal, Bulent
Background. Living donor liver transplantation (LDLT) has become an increasingly common surgical option because the number of cadaveric donors is insufficient to fulfill the organ needs of patients facing end-stage cirrhosis. Many centers are investigating different surgical techniques to achieve lower complication rates. We aimed to examine our complication rates in light of demographic data, graft data, and perioperative findings as a single-center experience. Methods. The study included one hundred and three patients who underwent LDLT for endvein, and bile anastomosis type rates; anhepatic phase; cold ischemia time; operation time; and blood product transfusion rates were analyzed. Biliary complications in patients with single or multiple biliary anastomoses, right or left liver transplants, and with or without hepatic artery thrombosis were analyzed statistically. Results. There was no significant difference in biliary complications between patients who underwent single or multiple bile anastomosis (P = .231) or patients receiving right lobe and left lobe transplants (P = .315). Although there was no statistically significant difference in the rate of portal vein thrombosis between the regular and reconstructed portal vein anastomosis groups (P = .693), the postoperative portal vein thrombosis rate was statistically higher in patients with left lobe transplants (P = .044). Conclusions. Vascular and biliary complication rates can be reduced with increasing experience.
Citation - WoS: 4
Citation - Scopus: 5
Mapping the Vascular and Muscular Topography of the Glabellar Region: Implication for Improving Safety and Efficacy of the Glabellar Injections
(Springer, 2024) Ismailoglu, Abdul Veli; Ismailoglu, Pelin; Aktekin, Mustafa
Background Botulinum neurotoxin (BoNT) and filler injections into the highly vascularized glabellar region for aesthetical purposes are extremely common. Injections into the glabellar region without precise anatomical knowledge of its vascular and muscular topography may pose the risk of severe complications.Objectives We aimed to improve the safety and efficacy of the glabellar injections by mapping the regional muscles and vasculature in relation to the medial canthus and the defined reference lines.Methods Meticulous dissection was performed to reveal glabellar region muscles and arteries under surgical microscope, in 16 hemifaces of whom arteries are injected with red-dyed latex. Location of the angular artery (AA) along with its branches was noted in relation to glabellar muscles.Results The AA was always located superficial to the levator labii superioris alaeque nasi muscle (LLSAN) and then coursed toward the medial canthus to anastomose with the supratrochlear artery deep to the origin of the depressor supercilii (DS). The AA gave subcutaneously located central and paracentral branches coursing close to the mid-face line in 14 out of 16 hemifaces. Variable muscular connections were also present between the LLSAN, the DS and the procerus (P) muscles. No arteries were detected at the base of the medial eyebrow to which the DS, the P, and the frontalis (F) inserted.Conclusions This study provides a detailed map of muscular and vascular anatomy of the glabellar region to facilitate safe and efficient filler and BoNT injections without complications.No Level Assigned This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Citation - WoS: 3
Citation - Scopus: 3
Collagen Peptides and Saccharomyces Boulardii Cncm I-745 Attenuate Acetic Acid-Induced Colitis in Rats by Modulating Inflammation and Barrier Permeability
(Wiley, 2025) Altinok, Oyku; Bas, Murat; Dolanbay, Elif Gelenli; Kolgazi, Meltem; Mert, Tugay; Uslu, Unal
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent episodes of inflammation and tissue damage, with limited treatment options. This study aimed to investigate the effects of collagen peptides and Saccharomyces boulardii on acetic acid (AA)-induced colitis. Thirty-six male Sprague-Dawley rats were randomly divided into the following four groups: normal control (NC), colitis control (CC), collagen peptide (CP; 0.6 g/kg/day), and S. boulardii (SB; 250 mg/day). Colitis was induced by an intrarectal administration of AA in all groups except NC, and treatments were administered daily for 7 days. The therapeutic effects were evaluated by assessing the disease activity index (DAI), colon mass index, macroscopic and microscopic tissue damage, histopathological changes, zonula occludens (ZO)-1 protein expression, and myeloperoxidase (MPO) activity. The results showed that CP and SB treatments substantially alleviated DAI scores (p < 0.05) and reduced the colon mass index. Colon macroscopic and microscopic damages improved compared to the CC group (p < 0.01). Histologically, both treatments reduced inflammatory cell infiltration, crypt damage, and ulceration, with CP showing a slightly more pronounced effect. Immunohistochemical analysis revealed significant restoration of ZO-1 protein expression in the treated groups, indicating improvement in intestinal barrier integrity (p < 0.01). Furthermore, MPO activity was reduced in both CP and SB groups, significantly in the SB group (p < 0.01). These findings are consistent with previous studies that highlight the anti-inflammatory and barrier-enhancing effects of collagen peptides and probiotics in UC models.
Protective Effect of Artichoke (Cynara scolymus L.) Leaf and Receptaculum Extracts Against Hepatic Encephalopathy in Bile Duct Ligated Rats
(Springer/Plenum Publishers, 2025) Kam, Ozkan; Bebitoglu, Berna Terzioglu; Sener, Goksel; Oguz, Elif; Erdogan, Nurettin Fatih; Kilickap, Andac; Hatiboglu, Nebile
Hepatic encephalopathy (HE), complication of liver dysfunction, leads to neurocognitive impairments. Artichoke (Cynara scolymus L.) has been traditionally used for its antioxidant, anti-inflammatory and hepatoprotective properties. This study evaluates artichoke leaf and receptaculum extracts in cholestasis and HE in a rat model. Wistar rats were divided into 6 groups: sham-control, bile duct ligation (BDL), and BDL with low/high-dose leaf or receptaculum extracts. After BDL, physiological saline and extracts (250/500 mg/kg) were administered orally for 28 days. Cognitive activity was evaluated using Morris water maze and novel object recognition tests on day 28. Artichoke extract regulated liver enzymes and bilirubin at high-doses and significantly increased antioxidant enzyme activities reduced by BDL. Elevated 8-Hydroxyguanosine (8-OHdG) levels decreased in liver and brain tissues. Similarly, artichoke extracts reduced cytokine and hydroxyproline (HP) levels elevated by cholestasis. Following BDL, Na+/K+-ATPase levels in brain and liver tissues decreased, while artichoke extract reversed this. Artichoke, particularly high-dose receptaculum, improved impaired performance and increased time in the target quadrant after BDL. Both artichoke leaf and receptaculum extracts improved recognition. Artichoke treatments, especially high-dose receptaculum, reduced hepatic and neuronal damage and improved histological appearance. These findings highlight the therapeutic potential of artichoke extracts for liver fibrosis and related neurocognitive disorders.
The Relationship Between Health Literacy and Healthy Lifestyle Behaviors of Women With Preeclampsia
(Assoc Medica Brasileira, 2025) Kolcu, Merve; Akturk, Nur Bahar Kuru; Ozturk, Gizem; Akkus, Mine
OBJECTIVE: The aim of this studywas to explore the relationship between the levels of health literacy and healthy lifestyle behaviors in women with preeclampsia. This research was planned as a descriptive relational study. METHODS: The data were collected from 251 pregnant women with preeclampsia who were admitted to a training and research hospital between February and July 2024. The Patient Information Form, Health Literacy Scale, and Healthy Lifestyle Behaviours in Pregnancy Scale were used for data collection. RESULTS: The mean Health Literacy Scale total score of the women was 76.25 +/- 14.48, and the mean Healthy Lifestyle Behaviours in Pregnancy Scale total score was 110.17 +/- 17.57. A moderate positive correlation was found between the mean total scores of the scales (r=0.365, p<0.05). CONCLUSION: As health literacy levels increased amongwomen diagnosed with preeclampsia, the level of healthy lifestyle behaviors also increased. It would be beneficial to integrate the topic of health literacy into prenatal care and pregnancy preparation classes.

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