Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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19. Yüzyıl İstanbul Endüstri Mirasına Palimpsest Kavramı Üzerinden Ontolojik Değerlendirme
(Atatürk Üniversitesi, 2025) Ural, Ayşe Gülçin
Eski yazılı parşömen kağıtlarının silinip üzerine yeniden yazılar yazılması, ancak eski yazı izlerinin hala görünüyor olması hali palimpsest olarak tariflenmektedir. Mekân üzerinden bu kavramı incelemek gerekirse; yeniden işlevlendirilen yapılar içinden eski işlevin ve yapım biçiminin izlerini hala görebilmek şeklinde yorumlanabilmektedir. İstanbul gibi büyük tarihe sahip bir kentte, yeniden işlevlendirilmeye ihtiyaç duyan pek çok tarihi yapı bulunmaktadır. Bu yapılar içinde palimpsest kavramının daha net bir şekilde algılanabileceği yapı tipinin endüstri yapıları olduğu düşünülmüştür. Bu nedenle çalışma İstanbul, Avrupa ve Anadolu yakasında bulunan 19. yy. endüstri yapıları ile sınırlandırılmıştır. Çalışmanın amacı ise İstanbul’da bulunan 19. yy. endüstri yapılarının 2024 yılındaki durumlarına göre palimpsest kavramı üzerinden değerlendirme ve sorgulama yapmaktır. Çalışmada veri toplama yöntemi olarak nitel araştırma yöntemlerinden genel tarama modeli, belgesel tarama modeli ve tarihsel tarama modelinden faydalanılmıştır. Kavramsal zemini oluşturmak için genel tarama modeli ile palimpsest kavramına ve mekân ontolojisine dair inceleme yapılmıştır. Belgesel tarama yoluyla, tespit edilen yapıların çeşitli özelliklerine dair veri toplanmıştır. Tarihsel tarama ile ise yapıların yapım yılından itibaren geçirdiği süreç ve 2024 aralık ayında ne durumda olduğuna dair tespit yapmak istenmiştir. Toplanan teknik veriler ve görseller hermenötik yöntem ile değerlendirilmiştir. Çalışmanın sonucunda İstanbul’da bulunan 19. yy. endüstri yapıları içinde 11 adet Avrupa yakasında, 4 adet Anadolu yakasında palimpsest olarak değerlendirilebilecek yapı tespit edilmiştir. Araştırma; İstanbul’da bulunan 19. yy. endüstri yapılarının 2024 yılındaki durumlarını listelemek açısından ve bu yapıları mekânın ontolojisi üzerinden değerlendirilerek palimpsest kavramı ile yorumlamak açısından gerekli görülmüştür.
Citation - WoS: 1
Citation - Scopus: 1
A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhiza Glabra L. Varieties Root Extracts
(Marmara University, 2025) Sen, Ali; Servı, Hüseyın; Barak, Timur Hakan; Tekin, Fethullah; Şener, Azize; Marzi, Mahdi; Gülmez, Gizem
Plants are the significant global interest as alternative treatment sources with their biologically activecompounds. This study compares the chemical composition and the antioxidant, antidiabetic, and antimicrobialproperties of ethanol extracts of G. glabra L. two different varieties from different regions. The phytochemicalcompositions was determined using GC-MS. Additionaly, total phenolic (TPC), flavonoid (TFC) and triterpene (TTC)contents were determined. Glycyrrhizic acid contents were analysed by HPLC. G. glabra var. glandulifera (GF1) showedthe highest antioxidant activity. All extracts had strong antidiabetic effects, besides GF1 showing the highest effect. TheMIC values was determined against 8 bacterial and 1 yeast strain and values ranged from 2.500 to 0.500; 2.500 to 0.714;2.500 to 0.714 for G. glabra var. glabra (GB), GF1, G. glabra var. glandulifera (GF2) respectively. Phytochemical studies haveshown that TPC was 100.60±5.06, 127.90±0.30, 69.01±0.30 mg GAE /g extract; TFC was 80.07±0.15, 25.35±0.0, 16.58±0.31mg KE/g and TTC was 217.30±6.05,172.40±2.17, 126.30±4.50 mg OE/g extract for GB, GF1, GF2, respectively. GF1 inparticular has the highest glycyrrhizic acid content. This study will contribute to the creation of new treatment strategiesand potential therapeutic agents in addition to the use of G. glabra L. in traditional treatments. Our study is also apreliminary study for future studies.
Acute Serious Hepatitis of Unknown Cause in Children
(Galenos Publishing House, 2022) Kılbaş, E.P.K.; Altındiş, M.
On April 5, 2022, an increase in cases of acute hepatitis of unknown etiology was reported in previously healthy children under the age of 10 in the United Kingdom. Since there is no link between these patients, called acute non-HepA-E hepatitis, and viral hepatitis agents (hepatitis A, B, C, D, and E), the possible etiology, and pathogenesis of this emergency is being investigated. One of the alarming features of this epidemic is the high requirement for liver transplantation in a fraction of the cases. In cases other than hepatitis A, B, C, D, and E, a case definition is made by looking at a series of clinical pictures, including serum transaminase levels and age. As of August 26, 2022, 513 cases of acute hepatitis have been reported in Europe and 1,010 globally. Adenovirus was detected in 75% of cases tested in the UK, but data for other countries are still lacking. The role of other etiologic agents is still under investigation. The exact disease pathogenesis has not yet clear. Evidence of human-to-human transmission of the disease remains unclear. Epidemiological studies are critical in clarifying the uncertainties regarding the existence of links between the cases reported to date. Continuing the national and international surveillance activities of the countries in an organized manner is the most basic issue required for the elimination of the epidemic. Copyright © 2022 Tehran University of Medical Sciences.
Advances and Strategies in Biosensor-Based Diagnostics for Parasitic Infections: A Comprehensive Scoping Review
(Springer, 2026) Aminizadeh, Selva; Alizadeh, Gita; Alizadeh, Zahra; Khalilzadeh, Balal; Abidin, Zurina Zainal; Marzi, Mahdi; Rafiei-Sefiddashti, Raheleh
Parasitic diseases are among the most widespread infections worldwide, causing millions of deaths and illnesses each year. So rapid and accurate diagnosis is essential, requiring highly sensitive and specific tests. Biosensors can provide significant advantages over traditional diagnostic methods because of their specificity, sensitivity, speed, simplicity, ease of use, repeatability, and capacity for early-stage disease detection. Recent advances in modern diagnostic tools for detecting parasitic infections use nanomaterials such as gold nanoparticles, carbon nanofibers, and carbon nanotubes. These developments have significantly lowered detection limits to the picogram and femtogram levels. This review will cover recent advancements in biosensor-based diagnostic techniques in parasitology.
Citation - WoS: 3
Citation - Scopus: 5
Analysis for Two-Dimensional Inverse Quasilinear Parabolic Problem by Fourier Method
(Taylor & Francis Ltd, 2021) Kanca, Fatma; Baglan, Irem
In this work, two-dimensional inverse quasi-linear parabolic problem with periodic boundary and integral overdetermination conditions is investigated. The formal solution is obtained by the Fourier approximation. Under some natural regularity and consistency conditions on the input data,the existence, uniqueness and continuously dependence upon the data of the solution are proved by iteration method. The inverse problem is first examined by linearization and then used implicit finite difference scheme for the numerical solution. Also predictor corrector method is considered in the numerical approach. Some results on the numerical solution with two examples are presented with figures and tables. The sensitivity of the scheme with respect to noisy overdetermination data is illustrated.
Citation - WoS: 2
Citation - Scopus: 1
Analysis of Substance Use and Mental Disorder Diagnoses in Adolescents With a History of Delinquency: a Cross-Sectional Study
(Springer, 2024) Baysan Arabaci, Leyla; Dikec, Gul; Tas Soylu, Gulsenay; Bilac, Oznur; Uzunoglu, Gulcin; Ayakdas Dagli, Dilek
This study aimed to evaluate substance use and comorbid mental disorders in delinquent adolescents presenting to a child and adolescent psychiatry outpatient clinic. This study included 47 adolescents aged 15-18 years and had a history of delinquency. Data were collected using the Addiction Profile Index Adolescent Form (API-A) and an information form. Results indicated that the adolescents' mean age is 16.11 +/- 1.05 years, 78.7% had committed crimes against property and 34.0% against the person, and 34.0% were also victims of crime. Mean API-A total scores indicated that their level of substance use was low. In addition, mean API-A total scores showed significant differences according to the adolescents' migration status, age, economic status, school attendance, mental disorder diagnosis, duration of mental disorder, and type of offense (p < 0.05). The benefit provided by timely and appropriate psychosocial interventions may have a key role in solving this problem for adolescents and improving their future as adults.
Citation - WoS: 11
Citation - Scopus: 9
Antibiotic Use and Influencing Factors Among Hospitalized Patients With Covid-19: a Multicenter Point-Prevalence Study From Turkey
(Galenos Publ House, 2022) Sencan, Irfan; Cag, Yasemin; Karabay, Oguz; Kurtaran, Behice; Guclu, Ertugrul; Ogutlu, Aziz; Agalar, Canan
Background: Broad-spectrum empirical antimicrobials arc frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective. and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age +/- standard deviation of the patients was 65.0 +/- 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (372%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005). presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein >10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p <0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings.
Citation - WoS: 9
Citation - Scopus: 11
The Antioxidant, Anti-Inflammatory, and Antiplatelet Effects of ribes Rubrum L. Fruit Extract in the Diabetic Rats
(Wiley, 2022) Gulmez, Gizem; Sen, Ali; Sekerler, Turgut; Algul, Fatma Kader; Cilingir-Kaya, Ozlem Tugce; Sener, Azize
The prothrombotic and inflammatory state plays a significant role in the occurrence of cardiovascular complications in type 2 diabetes mellitus. In this study, the antidiabetic, anti-inflammatory, and antiplatelet potentials of the extracts obtained from Ribes rubrum were investigated. The antidiabetic, anti-inflammatory, and antioxidant activities of the ethanol and water extracts of R. rubrum were evaluated by in vitro methods. The total phenolic and flavonoid contents were also determined. The experimental diabetes model in rats was induced with streptozotocin (STZ). After hyperglycemia occurred, the ethanol extracts of R. rubrum (RRE, at 100 mg/kg and 500 mg/kg doses) were administered to the treatment groups for 14 days. Blood glucose, lipid profile, plasma, and pancreas tumor necrosis factor-alpha (TNF-alpha) levels were determined and compared at the end of the experiments. P-selectin levels and mitochondrial membrane polarization (MMP) of platelets were also measured. In vitro study, the RRE showed potent anti-inflammatory activity. Administration of RRE (at 100 mg/kg doses) to diabetic rats lowered blood glucose level insignificantly. The results showed that there was an increment in levels of TNF-alpha in plasma and pancreas tissue of the diabetic group compared to the control group. R. rubrum extract regulated and normalized their levels in plasma and pancreatic tissue. RRE at both doses significantly decreased platelet P-selectin levels and prevented STZ-induced loss of MMP in platelets. The results of current research indicate that RRE extract has potent anti-platelet and anti-inflammatory effects and may be beneficial in preventing diabetic complications. Practical applications Hyperglycemia causes dyslipidemia, advanced oxidative stress, platelet activation, and inflammation in diabetes mellitus. Plants with various medicinal properties are of worldwide interest for the treatment of diseases due to their biological activities. In this study, the antidiabetic, anti-inflammatory, and antioxidant effects of extracts of Ribes rubrum (%100 ethanol, 50% ethanol, water) were evaluated by in vitro and in vivo methods. The diabetes model was induced with streptozotocin (STZ). The rats were divided into control, diabetic control, R. rubrum-100 mg/kg, and R. rubrum-500 mg/kg doses groups. Blood glucose levels, tumor necrosis factor-alpha (TNF-alpha), platelet P-selectin levels, mitochondrial membrane polarization of platelets were examined. The present study has shown that R. rubrum has anti-inflammatory and antiplatelet activity. R. rubrum may be beneficial in the prevention and treatment of DM complications due to its anti-inflammatory and antithrombotic effects.
Citation - WoS: 3
Citation - Scopus: 3
Antioxidants, Enzyme Inhibitory Activities, and Phytochemical Profiles of Seven Medicinal Plants Grown With Organic Farming Techniques
(Tubitak Scientific & Technological Research Council Turkey, 2023) Zor, Murat; Ozupek, Burcin; Pekacar, Sultan; Deliorman Orhan, Didem
In this study, the potential antihyperlipidemic, antidiabetic, and antiobesity effects of extracts obtained via infusion techniques from Artemisia absinthium L., Achillea millefolium L., Calendula officinalis L., Fumaria officinalis L., Mentha piperita L., Origanum onites L., and Urtica dioica L. grown with organic farming techniques were investigated using enzyme inhibition methods (alpha-glucosidase, pan-creatic cholesterol esterase, pancreatic lipase, and alpha-amylase). It is important that natural compounds or extracts to be used in the treat-ment of metabolic problems have antioxidant effects. The antioxidant effects of these species were tested in terms of ABTS and DPPH radical scavenging activity, ferric reducing power, and metal chelating capacity. Extracts (2 mg/mL) of M. piperita (91.43 +/- 0.90%) and O. onites (70.18 +/- 2.02%) showed potent inhibitory effects on the alpha-glucosidase enzyme. Among all species, only O. onites extract ex-erted an inhibitory effect on the cholesterol esterase enzyme close to that of reference compound simvastatin. While all extracts were effective in the tested antioxidant activity methods, it was determined that the M. piperita and O. onites extracts displayed particularly significantly strong activities in terms of ferric reducing power, ABTS radical scavenging effect, and metal chelating capacity. The total flavonoid and phenolic contents of all extracts were determined. The compositions of the most active extracts were analyzed for pheno-lic acids and flavonoids using RP-HPLC. The results of RP-HPLC analysis showed that the levels of ellagic acid (0.923 +/- 0.000 g/100 g extract) in the M. piperita extract and rosmarinic acid (0.813 +/- 0.003 g/100 g extract) in the O. onites extract were high. As a result, all species grown with organic farming techniques except U. dioica were found to have high antioxidant effects. In light of these findings, it was concluded that M. piperita and O. onites grown with organic farming techniques showed strong inhibitory effects in terms of the tested activities, especially for alpha-glucosidase and pancreatic cholesterol esterase, and that in vivo studies and activity-guided isolation studies should be conducted on these species in the future.
Citation - WoS: 1
Citation - Scopus: 2
Apocynin Exhibits an Ameliorative Effect on Endothelial Dysfunction/ Atherosclerosis-Related Factors in High-Fat Diet-Induced Obesity in Rats
(Marmara Univ, Fac Medicine, 2024) Ayci, Nurdan Bulbul; Ertas, Busra; Kaya, Rumeysa Keles; Sevinc, Sevgi Kocyigit; Amuran, Gokce Gullu; Ercan, Feriha; Cetinel, Sule
Objective: The aim of this study was to reveal the effect of apocynin (APO) on the factors involved in obesity-related endothelial dysfunction (ED) and atherosclerosis (AS). Materials and Methods: Male Wistar albino rats were divided into control (CNT), high-fat diet (HFD) and HFD+APO groups. HFD and HFD+APO groups were fed HFD for sixteen weeks. APO (25 mg/kg) was administered to the HFD+APO group for the last four weeks. The effects of APO on: AS-related metabolic parameters (triglyceride, total cholesterol, high-density lipoprotein-cholesterol, insulin and leptin), oxidative stress (OS), [ malondialdehyde, glutathione, nicotinamide adenine dinucleotide phosphate (NADPH)oxidase-2, oxidised-low-density lipoprotein (ox-LDL) and 8-hydroxy-2-deoxyguanosine], low-density lipoprotein and ox-LDL uptake potential (activin receptor-like kinase-1 and lectin-like oxidized low-density lipoprotein receptor-1, respectively), tissue inflammation inducible-nitric oxide synthase, nitric oxide), programmed cell death (terminal deoxynucleotidyl-transferase-dUTP-nick-end (alpha-smooth muscle actin), histology and ultrastructure of thoracic aorta were evaluated. Results: In obesity, APO had an ameliorative effect on metabolic parameters, OS, inflammation, ED, programmed cell death and oxLDL uptake potential, but not on foam cell formation and LDL uptake potential. Conclusion: Apocynin may improve ED and AS in obesity by suppressing OS-linked factors involved in the early stage of AS.
Citation - Scopus: 1
Aqueous Parsley (Petroselinum crispum) Extract Ameliorated Methotrexate-Induced Brain and Small Intestine Damage in Rats
(Ankara Univ, 2025) Saçan, Ozlem; Şener, Göksel; Yanardag, Refıye; Tunali-Akbay, Tugba; Sivas, Guzin Goksun; Karaoğlu, Sümeyye Yılmaz; Dursun, Ercan
Methotrexate (MTX) is a widely used antiarthritic and chemotherapeutic agent known to cause damage to various tissues. This study investigated the potential protective effects of parsley extract against MTX-induced brain and intestinal tissue damage. Sprague-Dawley rats were divided into control, control + parsley, MTX, and MTX + parsley. MTX (20 mg/kg, i.p.) was administered to the MTX and MTX + parsley groups. The control + parsley, and MTX + parsley groups were administered 2 g/kg parsley extract by oral gavage for five consecutive days. After the fifth day, brain and small intestinal tissues were taken. Total protein, nitric oxide, lipid peroxidation, glutathione levels, tissue factor, superoxide dismutase, and glutathione S-transferase activities were determined in these tissues. The protein profiles of the tissues were evaluated using SDS polyacrylamide gel electrophoresis. Parsley administration caused a decrease in lipid peroxidation levels in both tissues of the MTX group. On the other hand, glutathione level, glutathione-S-transferase, and superoxide dismutase activities were found to be increased. On the other hand, parsley decreased the nitric oxide level which was increased in the intestinal tissues of the MTX group. There was no significant change in brain nitric oxide level and tissue factor activity between groups. MTX and parsley administration altered protein expression, leading to the appearance or disappearance of specific bands in intestinal and brain tissues. In conclusion, parsley alleviated MTX-induced damage in brain and intestinal tissues by reducing lipid peroxidation and modulating antioxidant defenses.
Citation - WoS: 6
Citation - Scopus: 6
Artificial Intelligence in Nursing Practice: A Qualitative Study of Nurses' Perspectives on Opportunities, Challenges, and Ethical Implications
(BMC, 2025) Bodur, Gonul; Cakir, Hanife; Turan, Suzan; Seren, Arzu Kader Harmanci; Goktas, Polat
BackgroundThe study aims to explore nurses' views on the effects of artificial intelligence (AI) in nursing, focusing on their understanding, practical applications, ethical considerations, and perceived opportunities and threats.MethodsThis qualitative study used semi\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\:-$$\end{document}structured interviews to gain comprehensive insights from clinical nurses, adhering to the Standards for Reporting Qualitative Research for methodological rigor. After obtaining ethical approval, researchers conducted semi\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\:-$$\end{document}structured interviews with 25 clinical nurses. The interviews explored nurses' perceptions of AI, including its basic concepts, applications in nursing practice, ethical and social implications, and potential benefits and drawbacks.ResultsThe analysis identified four overarching themes: (1) Nurses' Conceptualizations of Artificial Intelligence, (2) Opportunities of AI in Nursing Practice, (3) Threats of AI in Nursing Practice, and (4) Ethical and Psychological Concerns in AI-Based Nursing Practice. The findings revealed that nurses had a foundational understanding of AI and its definitions. They acknowledged both the positive and negative impacts of AI technologies on their practice. Nurses expressed that AI could reduce workload, enhance patient care, and improve efficiency. However, they also articulated significant threats, including concerns over professional redundancy, emotional disconnection in caregiving, de-skilling, and the risk of dehumanizing the healthcare environment. Additionally, ethical and psychological concerns emerged, such as ambiguity in accountability, threats to data security and patient safety, unsuitability in psychiatric care contexts, staff surveillance anxiety, and risks of misuse or systemic bias.ConclusionThe study concluded that while nurses possess a basic understanding of AI, the effective and ethical integration of AI technologies in nursing requires targeted training, institutional preparedness, and robust interdisciplinary collaboration. To ensure AI complements rather than compromises nursing values, it is imperative to equip nurses with skills in digital literacy, ethical reasoning, and critical engagement with AI tools. The findings highlight the necessity of structured education programs and policy development that address both the technological and humanistic dimensions of AI use in healthcare. Future research should actively incorporate patient and public voices to ensure that AI-driven transformations in care remain aligned with the principles of patient-centeredness and human dignity.
Assessment of Artificial Lighting Conditions in Sunlight-Deprived Classrooms
(Gazi Univ, Fac Engineering Architecture, 2025) Duyan, Fazila; Kaplan, Elif
Numerous studies on classroom lighting emphasize a close and significant relationship between students' concentration, comprehension of course content, and the efficiency of activities such as drawing, writing, and practices, with the lighting conditions. In this context, it is particularly important to properly design both the physical and psychological effects of artificial lighting, especially in sunlight-deprived classrooms. This study examines the artificial lighting conditions of a classroom located in the basement of a university building, which has no visual connection to the outdoors. The classroom is utilized by students from the departments of Architecture, Interior Architecture, and Industrial Design. The study investigates the effects of current artificial lighting on students, focusing on aspects such as visual perception satisfaction, light colour, illuminance level, glare, and the temporal light modulation effect. To assess students' perception of the existing lighting conditions, an online questionnaire was administered, and a total of 104 students (65 female, 39 male) who had previous experience with the classroom participated in the study. Technical measurements of the existing luminaires were conducted, and the classroom was digitally modelled using the DIALux Evo lighting software. The collected data were analysed using the SPSS statistical analysis program. The findings of the study indicate that students perceived the artificial lighting conditions as inadequate in terms of visual comfort. Moreover, based on technical measurements, simulations, and user evaluations, it was determined that the existing luminaires caused glare and temporal light modulation effects, negatively affecting the classroom environment.
Assessments of Energy, Macro and Micronutrient Intakes in Children and Adolescents With Type 1 Diabetes Mellitus
(Marmara Univ, Fac Medicine, 2023) Ozkaya, Volkan; Ozkaya, Sebnem Ozgen
Objective: This study aims at examining dietary intake in children and adolescents with type 1 diabetes mellitus (DM) and comparing the results with national dietary intake recommendations. Patients and Methods: One hundred fifty children and adolescents (52.7% female) with an average age of 12.2 +/- 3.1 years and with type 1 DM who were followed by the Pediatric Endocrinology Polyclinic participated in the study. Three-day food intake records and clinical information regarding the type 1 DM condition of the participants were obtained. Results: No gender-related significant difference was found among the participants regarding food intake. The percentage of energy derived from fat (average 39.6%) and saturated fat (16.1%) were higher than the recommended levels in both gender groups. The percentage of energy derived from carbohydrates (female 44.1 +/- 5.7%, male 43.0 +/- 6.8%) was below the recommended levels. The dietary fiber intake in children aged 6-10 years with type 1 DM met recommendations, whereas, it was below the recommended levels in other age groups. Micronutrient inadequacy was common in children and adolescents with type 1 DM. Conclusions: The authors believe that guidelines and programs are needed for children and adolescents with type 1 DM to reduce total fat and saturated fat intake, increase carbohydrate and dietary fiber intake up to the recommended levels, and prevent multiple micronutrient inadequacies.
Citation - WoS: 3
Citation - Scopus: 5
Association Between Carbohydrate Quality Index and Dietary Patterns, Sleep Quality, Anxiety Level, and Depression Symptoms: a Cross-Sectional Study
(Soc Chilena Nutricion, Bromatologia & Toxicologia, 2022) Yuksel, Aysun; Yilmaz-Onal, Hulya; Basturk, Berrak; Yalcin, Bahar
Aim: This study was conducted to determine the relationship between carbohydrate quality and sleep quality, depression, anxiety, stress and anthropometric measurements. Methods: The carbohydrate quality was calculated using the total fiber intake, ratio of whole grains to total grains, the ratio of solid carbohydrates to total carbohydrates, and the glycemic index. Sleep status was determined using the Pittsburgh Sleep Quality Index (PSQI) and nutritional status was determined by taking a 1-day food consumption record and food consumption frequency. Results: It was found that 20% of the participants with the highest carbohydrate quality had the highest sleep quality and the lowest body mass index. Conclusion: Adults should be informed that the quality of carbohydrates that they consume, was associated with better sleep quality and some micronutrients (potassium, magnesium, vitamin A-D-K-C-81-86, Folate) but no significant correlation was found between anxiety, depression, and stress scores
Citation - WoS: 5
Citation - Scopus: 5
The Association of Demographic, Psychological, Social and Activity Factors With Foot Health in People With Plantar Heel Pain
(Wiley, 2024) Gulle, Halime; Morrissey, Dylan; Tayfur, Abdulhamit; Coskunsu, Dilber Karagozoglu; Miller, Stuart; Birn-Jeffery, Aleksandra V.; Prior, Trevor
Background: Plantar Heel Pain (PHP) can be a debilitating musculoskeletal condition from which only 50% recover within a year due to poor understanding of the mechanisms explaining severity and predicting outcomes specific to PHP. Objective: To explore associations between biopsychosocial variables and the severity of people with PHP. Secondly, to determine what combination of self-reported factors distinguishes people with PHP from other foot pain (OFP). Methods: We collected data from 235 participants, including 135 (%57) PHP (age 44 +/- 12 years, 66% female) and 99 OFP (%43) (age 38 +/- 11 years, 57% female) using 5 demographic, 13 biomedical, 8 psychological, 3 social and 8 activity-related factors. These were tested in linear and logistic regression models. Results: Quality of life (QoL) (beta = 0.35; p < 0.001), education (beta = -0.22; p = 0.003), gender (beta = -0.20; p = 0.007), morning pain duration (beta = -0.18; p = 0.01) and disease duration (beta = -0.15; p = 0.040) were significantly associated with severity of PHP. The second model, without QoL, showed that having sensitisation (beta = -0.18; p = 0.002) and a higher level of morning pain (beta = -0.20; p = 0.01) are associated with severity. The logistic regression results revealed that people with PHP tend to have a systemic disease (OR = 3.34; 1.53-7.76), express more kinesiophobia (OR = 1.02; 1.01-1.14), are less likely to have previous injuries (OR = 0.40; 0.19-0.81), worse morning pain (OR = 1.02; 1.01-1.03) and standing pain (OR = 2.60; 1.39-4.87) compared to people with OFP. Conclusions: People with PHP have higher associated levels of a range of psychological, social and activity related factors than people with OFP. The findings highlight the importance of considering psychosocial assessments alongside physical examination.
Citation - WoS: 14
Citation - Scopus: 15
The Best Whey Protein Powder Selection Via Vikor Based on Circular Intuitionistic Fuzzy Sets
(Mdpi, 2023) Buyukselcuk, Elif Caloglu; Sari, Yigit Can
People try very hard to have a symmetrical, strong, and beautiful body. The human body needs high amino acids for muscle protein synthesis. Whey protein is a good choice that contains all amino acids, which increases muscle protein synthesis and improves body shape with resistance exercise. For this reason, those who do sports, especially professionals, prefer to use these products frequently. A large number of commercial whey protein powders are sold on the market, and to achieve maximum purpose, individuals want to use the best one. Intuitionistic fuzzy sets are used in order to minimize the negative effects of the uncertainty environment and ambiguous information encountered in the decision-making process on the solution. In this study, VIKOR, based on the circular intuitionistic fuzzy set, has been used to determine the best whey protein supplement. In line with the comprehensive literature review and expert opinions, the evaluation criteria affecting the selection process have been determined, and the solution of the problem has been focused.
Citation - Scopus: 3
Bibliometric Analysis of Publications on Stigmatization in Psychiatric Nursing Literature
(Kare Publishing, 2024) Dikeç, G.; Sarıtaş, M.; Oban, V.
Objectives: In the past two decades, the number of publications on stigma has increased in the literature. This study aimed to conduct a bibliometric analysis of publications related to stigmatization in the psychiatric nursing literature. Methods: In this study, a search was performed on the PubMed database on September 11, 2022, with the Medical Searching Terms “(Stigmatization [Title OR Abstract] OR Social Stigma [Title OR Abstract]) OR (Stigma [Title OR Abstract] OR Stereotyping [Title OR Abstract] OR Discrimination [Title OR Abstract]) AND (Psychiatric Nursing [Title OR Abstract] OR Nursing [Title OR Abstract]).” Between 1990 and 2022, 10,571 studies published in English, available in full text, and published in journals indexed with SCI, SSCI, and ESCI were found. Results: The number of published articles reached the highest number in 2020, with an increase of 4.05 times in 30 years; it was determined that 92.8% of the publications were of the descriptive study, and Happell was the most productive author in this field. Frequently, articles were published in the Journal of Psychiatric and Mental Health Nursing (n=762), Journal of Psychosocial Nursing and Mental Health Services (n=550), International Journal of Mental Health Nursing (n=480), Issues in Mental Health Nursing (n=445), and Journal of Advanced Nursing (n=429). It was determined that the top five most frequently repeated keywords were humans, female, psychiatric nursing, male, and adult, respectively. Conclusion: The findings obtained from this study can provide information about the number of publications, research types, researchers, and institutions, as well as give ideas for new research strategies in psychiatric nursing literature. Establishing cooperation between institutions and authors can guide psychiatric nurses in creating projects to reduce stigma. © 2024 by Journal of Psychiatric Nursing-Available.
Citation - WoS: 2
Citation - Scopus: 3
Biological Activities of Etodolac-Based Hydrazone, Thiazolidinone and Triazole Derivatives on Breast Cancer Cell Lines MCF-7 and MDA-MB
(Wiley, 2025) Sevinc, Sevgi Kocyigit; Cikla-Suzgun, Pelin; Tiber, Pinar Mega; Kucukguzel, S. Guniz; Orun, Oya
In this study, several etodolac-based hydrazone, thiazolidinone, and triazole derivatives that we synthesized and characterized in our earlier research were tested against the hormone-responsive breast cell line MCF-7 and the triple-negative MDA-MB-231, as well as the murine origin fibroblast cell line L-929, at varying doses for their effects on cell viability and toxicity and for their inhibitory activity on cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) formation. Cell viability and apoptosis tests were utilized to assess the anti-cancer potential of etodolac and its derivatives after the cells were exposed to varied concentrations of synthesized compounds for three different time periods. ELISA and Western blot methods were used to detect protein levels. All synthesized compounds demonstrated higher anti-cancer activity at significantly lower doses compared to etodolac (half-maximal inhibitory concentration [IC50] of 0-50 mu M range in derivatives versus 0.5-1 mM range in etodolac). Except for SGK 242, which had a major toxic effect on all cells, the chemicals SGK 206 and SGK 217 had a twice-less impact on control murine L-929 fibroblasts. Similar to proliferation, low concentrations of SGK 206 and SGK 217 (25-50 mu M) significantly induced apoptosis in breast cancer cells but not in normal cells. Additionally, they inhibited COX-2 protein expression at 50 mu M, and SGK 206 inhibited PGE2 release more effectively than etodolac in cancer cells. The results of this study suggest that, in comparison to a healthy control group, the thiazolidinone derivative SGK 206 and the thiazolidinone derivative SGK 217 are more effective than etodolac when it comes to the breast cancer cell lines MCF-7 and MDA-MB-231. SGK 206 exhibits a low IC50 value, a distinct dose-response relationship, and strong apoptotic effects, particularly on MDA-MB-231 cells.
Citation - WoS: 5
Citation - Scopus: 7
Bitter Melon (Momordica charantia) Fruit Extract Ameliorates Methotrexate-Induced Reproductive Toxicity in Male Rats
(Marmara University, 2021) Kanpalta, Fatma; Özbeyli, Dilek; Sen, Ali; Cevik, O. Dağdeviren; Şener, Göksel; Ercan, Feriha
Objective: Methotrexate (MTX) is a drug commonly used for the treatment of malign neoplastic and inflammatory diseases. Anti-oxidant and anti-inflammatory effects of bitter melon (BM) were reported. The aim of this study was to examine the effects of BM fruit extract on MTX-induced testicular and epididymal damage. Materials and Methods: Sprague Dawley male rats were divided into three groups (n=8) as control, MTX and MTX+BM. A single dose of MTX (20 mg/kg) was injected intraperitoneally to the MTX and MTX+BM groups. BM fruit extract (600 mg/kg) was applied to the MTX+BM group orally for 5 days. Testes were examined for general histopathology, proliferating and apoptotic cells. The epididymis samples were used for the evaluation of sperm morphology. Oxidative and inflammatory markers were analysed biochemically. Results: Increased abnormal spermatozoa, degenerated seminiferous tubules with increased apoptotic cells and decreased proliferative cells were observed in the MTX group. TNF-α, IL-1β, 8-hydroxy-2-deoxyguanosine and caspase-3 levels increased, superoxide dismutase and catalase levels decreased in both testis and epididymis samples. All these histological and biochemical parameters were ameliorated in the MTX+BM group. Conclusion: Methotrexate causes testis damage by decreasing spermatogenic cells and increasing apoptosis through oxidative stress and inflammation. BM extract improves testis and epididymis damage with its possible anti-oxidant and anti-inflammatory effects. © 2025 Elsevier B.V., All rights reserved.

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