Sen, AliServı, HüseyınBarak, Timur HakanTekin, FethullahŞener, AzizeMarzi, MahdiGülmez, Gizem2025-12-102025-12-1020252630-634410.12991/jrespharm.17978642-s2.0-105024201800https://doi.org/10.12991/jrespharm.1797864https://search.trdizin.gov.tr/en/yayin/detay/1361063/a-comparative-study-of-biochemical-antimicrobial-effectsand-phytochemical-composition-analysis-of-glycyrrhizaglabra-l-varieties-root-extractsPlants are the significant global interest as alternative treatment sources with their biologically activecompounds. This study compares the chemical composition and the antioxidant, antidiabetic, and antimicrobialproperties of ethanol extracts of G. glabra L. two different varieties from different regions. The phytochemicalcompositions was determined using GC-MS. Additionaly, total phenolic (TPC), flavonoid (TFC) and triterpene (TTC)contents were determined. Glycyrrhizic acid contents were analysed by HPLC. G. glabra var. glandulifera (GF1) showedthe highest antioxidant activity. All extracts had strong antidiabetic effects, besides GF1 showing the highest effect. TheMIC values was determined against 8 bacterial and 1 yeast strain and values ranged from 2.500 to 0.500; 2.500 to 0.714;2.500 to 0.714 for G. glabra var. glabra (GB), GF1, G. glabra var. glandulifera (GF2) respectively. Phytochemical studies haveshown that TPC was 100.60±5.06, 127.90±0.30, 69.01±0.30 mg GAE /g extract; TFC was 80.07±0.15, 25.35±0.0, 16.58±0.31mg KE/g and TTC was 217.30±6.05,172.40±2.17, 126.30±4.50 mg OE/g extract for GB, GF1, GF2, respectively. GF1 inparticular has the highest glycyrrhizic acid content. This study will contribute to the creation of new treatment strategiesand potential therapeutic agents in addition to the use of G. glabra L. in traditional treatments. Our study is also apreliminary study for future studies.eninfo:eu-repo/semantics/openAccessAntibacterial ActivityAntidiabetic ActivityAntioxidant ActivityGlycyrrhiza Glabra LLicorice RootPhytochemical ContentArticle