Protective Effects of <i>momordica Charantia</I> (bitter Melon) Against Methotrexate-Induced Kidney Damage

dc.authorid Cevik, Ozge/0000-0002-9325-3757
dc.authorid Sener, Goksel/0000-0001-7444-6193
dc.authorscopusid 26767983600
dc.authorscopusid 6504603410
dc.authorscopusid 24400636500
dc.authorscopusid 58295455800
dc.authorscopusid 55662834600
dc.authorscopusid 39061940500
dc.authorwosid Macit, Caglar/F-4532-2017
dc.authorwosid University, Aydin Adnan/Z-2790-2019
dc.authorwosid özbeyli, dilek/R-8421-2019
dc.authorwosid Cevik, Ozge/F-1326-2014
dc.contributor.author Şener, Göksel
dc.contributor.author Ozbeyli, Dilek
dc.contributor.author Cevik, Ozge
dc.contributor.author Cetin, Melisa
dc.contributor.author Sener, Goksel
dc.contributor.author Ozkan, Sevil
dc.contributor.other Eczacılık Meslek Bilimleri Bölümü
dc.date.accessioned 2025-01-11T13:04:13Z
dc.date.available 2025-01-11T13:04:13Z
dc.date.issued 2023
dc.department Fenerbahçe University en_US
dc.department-temp [Macit, Caglar] Istanbul Medipol Univ, Sch Pharm, TR-34815 Istanbul, Turkiye; [Ozbeyli, Dilek] Marmara Univ, Vocat Sch Hlth Sci, Istanbul, Turkiye; [Cevik, Ozge] Adnan Menderes Univ, Sch Med, Aydin, Turkiye; [Cetin, Melisa] Marmara Univ, Sch Pharm, Istanbul, Turkiye; [Sener, Goksel] Fenerbahce Univ, Fac Pharm, Istanbul, Turkiye; [Ozkan, Sevil] Univ Hlth Serv, Haydarpasa Numune Educ & Res Hosp, Clin Internal Med, Istanbul, Turkiye en_US
dc.description Cevik, Ozge/0000-0002-9325-3757; Sener, Goksel/0000-0001-7444-6193 en_US
dc.description.abstract Background Methotrexate is a cytotoxic chemotherapeutic agent that has severe side effects, such as nephrotoxicity. Momordica charantia is a bright yellow-orange fruity plant that has been shown to have antioxidant, antidiabetic, and anti-inflammatory properties. Objective This study scrutinized the protective effects of Momordica charantia extract against methotrexate-induced nephrotoxicity. Methods 24 Sprague Dawley male rats were divided into three experimental groups (8 rats in each): Control (C); Methotrexate (MTX); and Methotrexate plus Momordica charantia (MTX+MC). All rats were fed ad libitum and tap water. Methotrexate was administered at 20 mg/kg intraperitoneally as a single dose. In the MTX+MC group, MC was administered at a dose of 50mg/kg for 5 days orally. At the end of the 5th day, the rats were decapitated and kidney samples were taken to analyze glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and caspase-3 activity. Data was analyzed with GraphPad Prism 5.0. Results Findings showed that while there was a significant increase in MDA, MPO, 8-OHdG levels, and an essential reduction in GSH levels in the MTX-treated group when compared with the control group, bitter melon treatment significantly reversed MDA, MPO, and 8-OHdG levels (p< 0.001). GSH level elevation was observed in the MTX-MC group when compared to the MTX-treated group (p< 0.001). Conclusion This study showed that bitter melon is thought to have a protective effect against kidney damage caused by methotrexate. With future studies, we believe that the use of bitter melon extract as a protective agent in kidney damage caused by drug-induced oxidative damage will bring an innovative approach to treatment. en_US
dc.description.woscitationindex Emerging Sources Citation Index
dc.identifier.citation 0
dc.identifier.doi 10.2174/1574885518666230112110246
dc.identifier.endpage 236 en_US
dc.identifier.issn 1574-8855
dc.identifier.issn 2212-3903
dc.identifier.issue 3 en_US
dc.identifier.scopus 2-s2.0-85160608207
dc.identifier.scopusquality Q4
dc.identifier.startpage 231 en_US
dc.identifier.uri https://doi.org/10.2174/1574885518666230112110246
dc.identifier.uri https://hdl.handle.net/20.500.14627/325
dc.identifier.volume 18 en_US
dc.identifier.wos WOS:001016603900006
dc.language.iso en en_US
dc.publisher Bentham Science Publ Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 1
dc.subject Momordica Charantia en_US
dc.subject Protective Effect en_US
dc.subject Kidney en_US
dc.subject Methotrexate en_US
dc.subject Nephrotoxicity en_US
dc.subject Oxidative Damage en_US
dc.title Protective Effects of <i>momordica Charantia</I> (bitter Melon) Against Methotrexate-Induced Kidney Damage en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication
relation.isAuthorOfPublication 68ac39be-51c5-4820-a6c9-0bef06348d93
relation.isAuthorOfPublication.latestForDiscovery 68ac39be-51c5-4820-a6c9-0bef06348d93
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relation.isOrgUnitOfPublication.latestForDiscovery 5052e089-e75d-4aec-a280-6353973e4819

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