Effects Of Exercise And Calorie Restriction On Brain And Testis İn Natural Aging Model;

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dc.authorscopusid58643357700
dc.authorscopusid56786320800
dc.authorscopusid59212971900
dc.authorscopusid58642874200
dc.authorscopusid57003746700
dc.authorscopusid57219245552
dc.authorscopusid6701398113
dc.contributor.authorHakgüder, U.
dc.contributor.authorÜstündağ, Ü.V.
dc.contributor.authorTüzüner, B.A.
dc.contributor.authorGenç, N.
dc.contributor.authorİpekci, H.
dc.contributor.authorÖzçelik, R.
dc.contributor.authorEmekli-Alturfan, E.
dc.date.accessioned2025-01-11T13:04:51Z
dc.date.available2025-01-11T13:04:51Z
dc.date.issued2021
dc.departmentFenerbahçe Universityen_US
dc.department-tempHakgüder U., Department of Biochemistry, Faculty of Dentistry, Marmara University, Istanbul, Maltepe, Turkey; Üstündağ Ü.V., Department of Biochemistry, Medical Faculty, Istanbul Medipol University, Kavacık, Istanbul, Turkey; Tüzüner B.A., Department of Biochemistry, Faculty of Dentistry, Gelişim University, Istanbul, Turkey; Genç N., Department of Medical Biochemistry, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey; İpekci H., Department of Biochemistry, Faculty of Dentistry, Marmara University, Istanbul, Maltepe, Turkey; Özçelik R., Department of Pharmacology, Faculty of Pharmacy, Marmara University, Haydarpaşa, Istanbul, Turkey; Tunalı-Akbay T., Department of Biochemistry, Faculty of Dentistry, Marmara University, Istanbul, Maltepe, Turkey; Şener G., Vocational School of Health Services, Fenerbahçe University, Istanbul, Turkey; Yarat A., Department of Biochemistry, Faculty of Dentistry, Marmara University, Istanbul, Maltepe, Turkey; Emekli-Alturfan E., Department of Biochemistry, Faculty of Dentistry, Marmara University, Istanbul, Maltepe, Turkeyen_US
dc.description.abstractThe aim of our study was to examine the effects of exercise and calorie restriction on various tissue damage and antioxidant parameters in the brain and testis of rats in a natural aging model. For this purpose, male Sprague-Dawley rats were the control group (C), the elderly (A), the elderly with calorie restriction (ACR), the elderly who were exercised (AE) and the elderly who were exercised with calorie restriction (ACRE), they were divided into 5 groups. The control group was composed of three-month-old animals. The other group consisted of 15-month-old rats. Exercise and calorie restriction were applied for 6 weeks. At the end of the experiment, lipid peroxidation (LPO), nitric oxide (NO), glutathione (GSH) levels and superoxide dismutase (SOD), catalase (CAT), glutathione-S-trans-ferase (GST) and tissue factor (TF) were determined in brain and testicular tissues homogenates. As a result of the study, the A group’s brain and testis LPO, NO levels and TF activity increased, GSH levels and SOD, CAT and GST activities decreased, when compared to the C group. As a result of our study, an increase in oxidant damage was observed with TF activity in the brain and testis in the natural aging model, and positive effects of exercise and calorie restriction on the antioxidant levels in the brain were determined, especially in aging. © 2021, Istanbul University Press. All rights reserved.en_US
dc.description.sponsorshipMarmara Üniversitesi, (SAG-C-YLP-131217-0662); Marmara Üniversitesien_US
dc.identifier.citation2
dc.identifier.doi10.26650/experimed.2021.899430
dc.identifier.endpage26en_US
dc.identifier.issn2667-5846
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85159357862
dc.identifier.scopusqualityQ4
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.26650/experimed.2021.899430
dc.identifier.urihttps://hdl.handle.net/20.500.14627/405
dc.identifier.volume11en_US
dc.identifier.wosqualityN/A
dc.language.isoenen_US
dc.publisherIstanbul University Pressen_US
dc.relation.ispartofExperimeden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgingen_US
dc.subjectAntioxidanten_US
dc.subjectBrainen_US
dc.subjectOxidanten_US
dc.subjectTestisen_US
dc.titleEffects Of Exercise And Calorie Restriction On Brain And Testis İn Natural Aging Model;en_US
dc.title.alternativedoğal Yaşlanma Modelinde Egzersiz ve Kalori Kısıtlamasının Beyin ve Testiste Etkilerien_US
dc.typeArticleen_US
dspace.entity.typePublication

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