Myrtle Improves Renovascular Hypertension-Induced Oxidative Damage in Heart, Kidney, and Aortic Tissue

dc.authorid Sener, Goksel/0000-0001-7444-6193
dc.authorid Goger, Fatih/0000-0002-9665-0256
dc.authorid Tunali-Akbay, Tugba/0000-0002-2091-9298
dc.authorscopusid 57474311300
dc.authorscopusid 57205720662
dc.authorscopusid 57203904440
dc.authorscopusid 57212083086
dc.authorscopusid 57200110754
dc.authorscopusid 55250649800
dc.authorscopusid 55662834600
dc.authorwosid Tunali Akbay, Tugba/AAS-4127-2020
dc.authorwosid Gögel, Fatih/HTR-3454-2023
dc.authorwosid Saygi, Halil/G-3563-2013
dc.authorwosid Yakut, Zatiye/ACP-2487-2022
dc.contributor.author Şener, Göksel
dc.contributor.author Ozcan, Ozan
dc.contributor.author Gurel-Gokmen, Begum
dc.contributor.author Cevikelli-Yakut, Zatiye Ayca
dc.contributor.author Saygi, Halil Ibrahim
dc.contributor.author Sen, Ali
dc.contributor.author Tunali-Akbay, Tugba
dc.contributor.other Eczacılık Meslek Bilimleri Bölümü
dc.date.accessioned 2025-01-11T13:00:34Z
dc.date.available 2025-01-11T13:00:34Z
dc.date.issued 2022
dc.department Fenerbahçe University en_US
dc.department-temp [Arslan, Sule; Ozcan, Ozan; Gurel-Gokmen, Begum; Tunali-Akbay, Tugba] Marmara Univ, Dent Fac, Dept Basic Med Sci, Istanbul, Turkey; [Cevikelli-Yakut, Zatiye Ayca] Trakya Univ, Pharm Fac, Dept Pharmacognosy, Edirne, Turkey; [Saygi, Halil Ibrahim; Erkanli-Senturk, Gozde] Istanbul Univ Cerrahpasa, Cerrahpa Med Fac, Dept Histol & Embryol, Istanbul, Turkey; [Sen, Ali] Marmara Univ, Sch Pharm, Dept Pharmacognosy, Istanbul, Turkey; [Goger, Fatih] Anadolu Univ, Med Plant Drug & Sci Res & Applicat Ctr AUBIBAM, TR-26470 Eskisehir, Turkey; [Sener, Goksel] Fenerbahce Univ, Vocat Sch Hlth Sci, Dept Pharmacol, Istanbul, Turkey en_US
dc.description Sener, Goksel/0000-0001-7444-6193; Goger, Fatih/0000-0002-9665-0256; Tunali-Akbay, Tugba/0000-0002-2091-9298 en_US
dc.description.abstract Renovascular hypertension is defined as the reduction in renal perfusion resulting in sustained hypertension. This study aims to investigate the possible effects of myrtle leaf extract (Myrtus communis L.) on, heart, kidney and aorta tissues in the experimental renovascular hypertension (RVH). 32 male Wistar Albino rats were divided into four groups as control, hypertension, hypertension+ramipril, and hypertension+myrtle leaf extract treatment groups. RVH model was induced by Goldblatt's 2-kidney 1-clip method. 12 weeks later than the treatment blood pressures were recorded and oxidant and antioxidant parameters, tissue factor activity, and histological analysis were determined in the kidney, heart, and aortic tissues. The blood pressure levels of the hypertension group significantly increased compared to the control group. Administration of myrtle leaf extract and ramipril significantly decreased the increased blood pressure. In the hypertension group, oxidative damage increased in the kidney, heart, and aorta tissues. In the histological evaluation of tissues in RVH, heart muscle fibres degenerated. Bowman capsule and glomeruli dilated and tubules damaged in the kidney. Myrtle leaf extract administration regenerated the damages and degenerations. The administration of myrtle leaf extract restored the impaired oxidant-antioxidant balance in the heart, kidney and aorta tissues of hypertensive rats. Myrtle leaf extract can be considered as an alternative antihypertensive treatment target in the prevention of oxidative stress-induced damage in renovascular hypertension. en_US
dc.description.sponsorship Marmara University Scientific Research Project Department [SAG-C-YLP-170419-0142] en_US
dc.description.sponsorship This study was funded by a grant from Marmara University Scientific Research Project Department (Project ID: SAG-C-YLP-170419-0142). en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citation 4
dc.identifier.doi 10.1007/s11756-022-01039-1
dc.identifier.endpage 1888 en_US
dc.identifier.issn 0006-3088
dc.identifier.issn 1336-9563
dc.identifier.issue 7 en_US
dc.identifier.scopus 2-s2.0-85125590108
dc.identifier.scopusquality Q4
dc.identifier.startpage 1877 en_US
dc.identifier.uri https://doi.org/10.1007/s11756-022-01039-1
dc.identifier.uri https://hdl.handle.net/20.500.14627/33
dc.identifier.volume 77 en_US
dc.identifier.wos WOS:000763853900001
dc.identifier.wosquality Q4
dc.institutionauthor Sener, Goksel
dc.institutionauthor Sener, Goksel
dc.language.iso en en_US
dc.publisher Springer en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 4
dc.subject Renovascular Hypertension en_US
dc.subject Myrtus Communis L en_US
dc.subject Myrtle Leaf Extract en_US
dc.subject Oxidative Stress en_US
dc.title Myrtle Improves Renovascular Hypertension-Induced Oxidative Damage in Heart, Kidney, and Aortic Tissue en_US
dc.type Article en_US
dc.wos.citedbyCount 4
dspace.entity.type Publication
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